Maxwatt,
To Max or anyone who has arthritis would you consider using DMSO/resveratrol directly to the hands or feet and report if it makes any difference with your condition? Kudos to Missminni for her brave and hopefully wise self experimentation. : )
My order has been shipped. I will let you know in a week or two when I've had a chance to try it.
Maxwatt, could you try pure DMSO first? It's supposed to have anti-inflammatory properties by itself, right?
That my plan. Also, the solubility of resveratrol in DMSO is given as 16 g/l, so a 30 ml bottle, in a 70% solution of DMSO in water such as I will use (fewer chance of side effects that pure DMSO) so I assume a 30 ml bottle should hold (.7*16mg * 30) = 336. I'll mix in a little less, say 300 mg. Then one dropper-full, which holds 1ml, will administer 10 mg. Two years ago we would have thought this was a huge amount. Since we are bypassing first-pass liver metabolism it should be the equivalent of much more. I also think that tissue lipids will take up resvratrol, so not all of it will go into circulation. This is perhaps desirable for administering to the site of inflammation, so we'll see.
The discrepancy between this amount, and what Missminni self-administered by applying it to her skin where it had been sprayed with a 70/30 DMSO/water mix does not agree with the calculated amount of resveratrol that will dissolve in DMSO. Either she was mistaken as to the amount she used, or more resveratrol was delivered than the calculation allows. I believe she is a competent observer; she stated she used 1/8 tsp. I have weighed this amount, and found it to fall between 100 and 250 mg, depending on clumping, packing, rounding, etc.
Either solubility is higher than the published 16 g/l, or something else is going on. I surmise that the DMSO on the surface of her skin acted as a port hole; the DMSO was taken up by lipids in her tissues, and the DMSO served as a pipeline through which she poured resveratrol into her body. This is something else for us to test.
We should all thank Missminni for getting us to reconsider DMSO. I am going to be careful to limit the amount I use to avoid nosebleed. Also, I take vitamin K, which should minimize bleeding.
TOBAR asked about sublingual administrationI looked into this previously. The buccal and sublingual mucosa will take up hydrophobic lipid substances, but the amount is limited by the surface area available, which is not much. The amount one can absorb this way is small, I recall on the order of 10 mg I did not pursue this further, but again there is a discrepancy between what I could absorb under my tongue, with a bit of alcoholic beverage in my mouth, and the theoretical limit. Was the alcohol soluble-izing the resveratrol, so a similar diffusion pump to what I hypothesized for missminni was at work? Or was I somehow swallowing the powder without noticing? (Unlikely, it was a lot of powder, but still possible.)
But to answer Tobar's quest and question for a sublingual delivery method: alcohol, both isopropyl and ethanol, is used in transdermal carriers. No doubt it enhances sublingual absorption. 30 ml, or one ounce, of spirits has been shown to be life-extending for men and women, and up to twice that for men. (Men have more alcohol dehydrogenase, it's genetic and unfair, but still some women can drink me under the table. It's the luck of the draw from the gene-pool.) So if you can tolerate alcoholic beverages, wthout a genetic predisposition toward alcoholism, the following should be feasible.
I think the simplest method of sublingual administration would be to put half a tsp of powdered resveratrol under your tongue --the 98% or more variety-- and sip a little vodka or other spirit-- suitably mixed with water say, so the concentration doesn't hurt you mouth -- and just hold the liquid in your mouh as long as you can. Take another sip, and repeat until the bolus of resveratrol under your tongue is gone. To be sure, you will have swallowed some, but I think you will have gotten as much sublingually as is possible.
LongeCity
