Be careful in mixing modafinil with anything else.
Could you elaborate on that? I almost exclusively use modafinil in combinations with other stuff, except have never mixed with strong stimulants or high dose or potency nootropics.
I'm glad to see this log restored. I was fine with how stargazer was originally doing it, since he didn't think the risks were that high, however, accurately measured doses are of course preferred. Any sort of feedback about a substance is better than none at all, and these sort of experiments shouldn't be so heavily discouraged without having some backup for what the specific risks are.
"Modafinil induces the cytochrome P450 enzymes CYP1A2, CYP2B6 and CYP3A4, as well as inhibiting CYP2C9 and CYP2C19 in vitro. It may also induce P-glycoprotein, which may affect drugs transported by Pgp, such as digoxin."
"Many drugs may increase or decrease the activity of various CYP isozymes in a phenomenon known as enzyme induction and inhibition. This is a major source of adverse drug interactions, since changes in CYP enzyme activity may affect the metabolism and clearance of various drugs. For example, if one drug inhibits the CYP-mediated metabolism of another drug, the second drug may accumulate within the body to toxic levels, possibly causing an overdose. Hence, these drug interactions may necessitate dosage adjustments or choosing drugs which do not interact with the CYP system. Such drug interactions are extra important to take into account when using drugs of vital importance to the patient, drugs with important side effects and drugs with small therapeutic windows, but any drug may be subject to an altered plasma concentration due to altered drug metabolism.
A classical example includes anti-epileptic drugs. Phenytoin, for example, induces CYP1A2, CYP2C9, CYP2C19 and CYP3A4. Substrates for the latter may be drugs with critical dosage, like amiodarone or carbamazepine, whose blood plasma concentration may decrease because of enzyme induction."
http://en.wikipedia....il#Pharmacologyhttp://en.wikipedia....Cytochrome_P450In other words, modafinil can have an impact on the rate you metabolise other drugs.
