109 replies to this topic

[NootropicEU]

By the way, Phenotropil works wonders when I take it with Semax. Has anyone experienced that or it's just me?

[Semacan]

By the way, Phenotropil works wonders when I take it with Semax. Has anyone experienced that or it's just me?

Dear anony4mous

I have a boy he is 3,5 yers old. He is diognesed with Asperger Syndrome. (PDD-NOS)
I have been searching Semax to use my boy.

I will appreciate your more experiance with Semax
Any side effet you experiances.

Thanks,
Sema

[NootropicEU]

By the way, Phenotropil works wonders when I take it with Semax. Has anyone experienced that or it's just me?

Dear anony4mous

I have a boy he is 3,5 yers old. He is diognesed with Asperger Syndrome. (PDD-NOS)
I have been searching Semax to use my boy.

I will appreciate your more experiance with Semax
Any side effet you experiances.

Thanks,
Sema

Hi,

I have not experienced any side effects from Semax. Unfortunately I'm not qualified to give you medical advice.

I will try to ask a doctor who is familiar with SEMAX to post you more information about it.

[Semacan]

Dear Anony4mous,

Thank you very much for your attention and prompt return.

I'll appreciate if you can advise me your email adress to my my email address : semacan76@hotmail.com

Thanks,
Sema

[djh1208]

how many mg are there in the 1mL of the 1% solution? does it say on the bottle?

1ml of water = 1 gram of water. If I'm not mistaken that would mean 10mg of Semax for each ml of water. You get 30mg for 180$. The study blazewind pointed out talks has been dose using 50 microgram/day. I don't know if this is the recommended dosage but let assume it is.
I weight about 80kg.
80*50 = 400 microgram = 0.4 milligram.
30/0.4 = 75 dose.

But we have to consider that the mimimum we can take from the bottle each time is one drop of water which as a volume of 0.05 ml. Since there is 3 ml in one bottle, that mean a maximum of 60 dosage (and probably less than that in reality).
Can someone confirm that this is indeed the recommended dosage?

Automatic google translation from semax.ru. :

SEMAKS 0.1% - GUIDANCE ON THE APPLICATION

Indications and dosage «Semaksa 0,1%»:

In order to improve the efficiency of healthy people, improve memory, reduce stress, while asteno-neurotic disorders of different genesis
Scheme 1
«Semaks 0,1%» to 2 drops in each nasal passage for 10 - 14 days. It is recommended that 2 courses per year. The course of treatment: 1 фл.
Scheme 2
«Semaks 0,1%» to 3 drops in each nasal passage 2-3 times a day for 7 days. Recommended by 2 courses per year. The course of treatment: 2 фл.

Violations of memory and intelligence in the early stages of insufficiency of cerebral circulation, discirculatory encephalopathy, asteno-neurotic disorders in the somatic and neurological diseases
Scheme 1
«Semaks 0,1%» to 2 drops in each nasal passage 2-3 times a day for 21 days. We recommend 2-4 courses per year. The course of treatment: 3-4 фл.
Scheme 2
«Semaks 0,1%» to 2 drops in each nasal passage 6 times a day, every 2 hours for 5-7 days. We recommend 2-4 courses per year. The course of treatment: 2-3 фл

Postponed craniocerebral trauma and neurosurgical operations
«Semaks 0,1%» to 2 drops in each nasal passage 2-3 times a day for 14 days. Not applicable with psychomotor agitation, with caution if epileptic syndrome. The course of treatment: 2-3 фл.
Recovery after stroke
«Semaks 0,1%» to 5 drops in each nasal passage 6 times a day for 10 days. The cure: 10 фл.
Postnarkoznye disorders
«Semaks 0,1%» to 2 drops in each nasal passage 6 times a day for 5 days. Not applicable with psychomotor agitation, with caution if epileptic syndrome. The course of treatment: 2 фл.
Minimal brain dysfunction in children (including the syndrome of attention deficit with hyperactivity - SDVG)
«Semaks 0,1%» 1-2 drops in each nasal passage, 2 times a day for 30 days. We recommend 2-4 courses per year. The course of treatment: 2-4 фл.
Diseases of the optic nerve (optic nerve atrophy with glaucoma, focal lesions of the brain, neyropatii ischemic, degenerative neyropatii, optikomielite Deveka)
«Semaks 0,1%» of 2-3 drops in each nasal passage 2-3 times a day for 7-10 days, or by intranasal electrophoresis (ampacity 1mA, the drug is introduced to the anode, the length of exposure 8-12-15 minutes).
Semaks used as an additional neuroprotective in the treatment of diseases of the optic nerve. The course of treatment: 3 фл.

Zakapyvanie «Semaksa 0,1%» is made strictly on the mucous membrane of nose, are encouraged to use in the morning and daytime

Each vial «Semaksa 0,1%» contains 60 drops of the drug.
The contents of the active substance in the 1st drop of the drug:
«Semaks 0,1%» - 0,05 mg

---------

SEMAKS 1% - GUIDELINES FOR THE APPLICATION

At the time ambulance:
at a time once introduced to 3 drops in each nasal passage.

At the stage of the hospital:
In the mean stroke severity at once entered on 2-3 drops in each nasal passage. Zakapyvanie spend 4-5 times a day at intervals of 2 hours.
«Semaks 1%» designate a day for at least 10 days.
Course of treatment: 3-5 фл.
In severe stroke at a time is introduced to 3-4 drops in each nasal passage. Zakapyvanie spend 4-5 times a day with an interval of 2 hours.
«Semaks 1%» designate a day for at least 10 days.
Course of treatment: 4-7 фл.

Each vial «Semaksa 1%» contains 60 drops of the drug.
The contents of the active substance in the 1st drop of the drug:
«Semaks 1%» - 0,5 mg

Overdosage drug «Semaks 1%». Phenomena drug overdoses so far been unable to identify even with a substantial increase in the single dose.

Anony4mous
The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"
It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.
Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.
As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.
I hope this is useful to everyone interested in this peptide.

[NootropicEU]

Anony4mous
The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"
It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.
Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.
As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.
I hope this is useful to everyone interested in this peptide.

Thanks for your reply. I believe this will be useful to many people.

I am wondering why is SEMAX not available in EU or USA yet? I have no doubts that it is effective, however I don't believe that many healthy individuals would be willing to spend over 80 USD for a bottle of SEMAX.

I understand that European drug approval procedures are very strict. Has any company tried to get SEMAX approved for medical use in EU or USA?

[djh1208]

Anony4mous
The best documented dosage of Semax in Acute Carotid Stroke (ischemic) is stated in the Study done by Gusev and Skvortsova and elaborated in its full extent in a textbook they authored : "Brain Ischemia"
It's available from Amazon.com. In short, they used 6 mg, 9 mg 12 mg and 18 mg per day for 5 days. The optimal dose appeared to be 12 mg as there was no significant improvement using 16 mg.
Mortality decreased by over 75% in mild to moderate as well as severe cases. For those interested in a quantitative analysis of how much the serum and Cerebrospinal fluid concentration of BDNF and NGF increased will find it there. This study also evaluated other biological parameters like TGF1beta, IL-10, IL-1beta, IL-8, Superoxide Dismutase(SOD), Bcl2 being the most important. The result give a strong indication on how Semax acts, and is the reason of its other indications. It positively modulates survival signals, attenuates cell suicide (apoptosis), fights free oxygen radicals and the inflammation process. I know not of any other nootropic that has been subjected to such extensive analysis indicative of their mode of action. In other words it is apparent why Semax works.
As the safety profile is extremely good, the LD50 (the dose at which 50% of the test animals die) is undeterminable. This means that in spite of increasing the dose HUNDREDS of times the therapeutic dose NONE of the animals died. Hence you find that the dosage for every indication is quite flexible. The effects are also proven to be dose-dependent . Gusev had 160 patients in his double blind placebo-controlled trial. 12 mg doses had better results than 6 or 9 mg. Over 12 mg had no added benefit as mentioned earlier. When taken by "healthy" persons the dosage each person responds to could well vary greatly. Some respond well to 0.2 mg per day. Increasing to 0.4 mg may give a better response but may also be wasted as 0.2 is the optimal dose for that particular person. Bodyweight does not play that big a factor as the brain has a relatively uniform weight.
I hope this is useful to everyone interested in this peptide.

Thanks for your reply. I believe this will be useful to many people.

I am wondering why is SEMAX not available in EU or USA yet? I have no doubts that it is effective, however I don't believe that many healthy individuals would be willing to spend over 80 USD for a bottle of SEMAX.

I understand that European drug approval procedures are very strict. Has any company tried to get SEMAX approved for medical use in EU or USA?


Not as far as I know, the reason its not in the US is not hard to figure out. The were never the best of buddies,Russia and the US. As for the EU, I'm pretty sure that they would accept Semax more readily but bear in mind that Semax is produced by the Institute of Molecular Genetics, they are research and science oriented. They got their rocks off when they came up with the ACTH4-7-Pro-Gly-Pro molecule and it was proven efffective. Kudos, congratulations and on to the next molecule. No inkling of the potential commercial value, hence no efforts in that direction. Its the clinicians who introduced it at various forums (European Federation of Neurological Societies), World Stroke Congress among others. I attended one in Vienna in 2003 if I'm not mistaken. Another reason it is not registered in other countries is because documentation of the wealth of clinical work done is considered "classified" and locked in a vault for 15 years. Many do not understand that this is NOT the product of a Pharmaceutical company, but a Russian Government Institution of high repute. The whole freaking Govt is liable if the product bombs. Anywhere in the world the export price would be much lower than the domestic price. With Semax its the reverse.

I noticed some speculation on synthesizing Semax, likely through reverse engineering. The reason the Institute is not worried is because there are 7 to the power of 20 possible combinations to string the amino acids into a molecule. Run it by our biochemist friend and I think he'll agree. If we could get Amgen or Genentech interested, they might have the resources to do it.
Its frustrating the way so many people are kept from benefiting from Semax. Sad actually.

[Vultures]

It seems, that anony4mous is affilated with pharmacy1010. Their activity on this forum is focused on advertizing Russian substances, only 1010 sells (internationally) (3 or 4 times the retail price).

[NootropicEU]

It seems, that anony4mous is affilated with pharmacy1010. Their activity on this forum is focused on advertizing Russian substances, only 1010 sells (internationally) (3 or 4 times the retail price).

Show me at least one post where I recommend using 1010? Their prices are ridiculous, well maybe except for Noopept.

I have only purchased from them once and I will never do it again. There are many cheaper alternatives.

If I will ever have to advertise I will pay for it.


I am at least trying to bring something new and interesting to nootropics section. Perhaps you would like me to post questions like "Is piracetam effective? What choline do you take? Where to buy cheap modafinil? I am addicted to phenibut and etc.."

Edited by anony4mous, 12 September 2009 - 05:48 PM.

[Vultures]

1010 is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax - stuff you are promoting on this forum.

[NootropicEU]

1010 is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax - stuff you are promoting on this forum.

I agree, the only supplier for SEMAX is 1010. You can find several suppliers for cerebrolysin(austrian), noopept and phenylpiracetam. Just GOOGLE ;-)

[Vultures]

May be, I wasn't looking for it too much - I can buy all that stuff across the street...

[djh1208]

1010 is the only international supplier of cerebrolyzin, noopept, phenotropil, and semax - stuff you are promoting on this forum.

I agree, the only supplier for SEMAX is 1010. You can find several suppliers for cerebrolysin(austrian), noopept and phenylpiracetam. Just GOOGLE ;-)

For the record lets get the FACTS straight
Anony4mous is the only person on the forum who has used Semax in sufficient quantities to lodge an opinion.
He has also thoroughly researched the item.
Alleging he is advertising is ridiculous.

[drmz]

I have just received my package with Cerebrolysin, Russian Phenotropyl and SEMAX. It has been 3 hours since I have had 4 drops of SEMAX. The effect does not look like a placebo at all. It is very subtle, not stimulating. I don't have any foggy or speedy feeling, just clear ability to concentrate. Let's see what happens in the next few days. Btw, If anyone buys SEMAX, you have to keep it cold.

REVOLUTIONARY CEREBRAL REVITALISATOR Urgz...marketing bullshit

Do you have a placebo detector? ""The effect does not look like a placebo at all. It is very subtle, not stimulating"" How does a placebo effect look like and how on earth would you know the diference between a real and a placebo effect?

Can you list the in vivo human studies so far that justify the claims made?(double blind, placebo controlled studies that is) Seems to me that more studies, also outside russia, should have taken place for such a revolutionary product that was discovered in the 80's. Either the product is not that revolutionary or overlooked for 25+ years

Edited by drmz, 13 September 2009 - 11:08 AM.

[NootropicEU]

I have just received my package with Cerebrolysin, Russian Phenotropyl and SEMAX. It has been 3 hours since I have had 4 drops of SEMAX. The effect does not look like a placebo at all. It is very subtle, not stimulating. I don't have any foggy or speedy feeling, just clear ability to concentrate. Let's see what happens in the next few days. Btw, If anyone buys SEMAX, you have to keep it cold.

REVOLUTIONARY CEREBRAL REVITALISATOR Urgz...marketing bullshit

Do you have a placebo detector? ""The effect does not look like a placebo at all. It is very subtle, not stimulating"" How does a placebo effect look like and how on earth would you know the diference between a real and a placebo effect?

Can you list the in vivo human studies so far that justify the claims made?(double blind, placebo controlled studies that is) Seems to me that more studies, also outside russia, should have taken place for such a revolutionary product that was discovered in the 80's. Either the product is not that revolutionary or overlooked for 25+ years

"REVOLUTIONARY CEREBRAL REVITALISATOR"

- That is a quote from their website and I did not paste it.

Do you have a placebo detector? ""The effect does not look like a placebo at all. It is very subtle, not stimulating"" How does a placebo effect look like and how on earth would you know the diference between a real and a placebo effect?

This was my subjective report. I had great results with semax. My condition has improved significantly, however I will not go into details as it is personal.

Can you list the in vivo human studies so far that justify the claims made?(double blind, placebo controlled studies that is) Seems to me that more studies, also outside russia, should have taken place for such a revolutionary product that was discovered in the 80's. Either the product is not that revolutionary or overlooked for 25+ years

I did not claim anything and I have no interest to prove that it works. I only posted my subjective report.

If I will ever get any interesting information about SEMAX I will post it here.

[Negcreep]

Ive just got hold of some 0.1% Semax. On taking 4 drops I quickly develop a kinda spaced out feeling with headache, which lasts for 3-4 hours. Its not exactly pleasant. I think I might be sensitive to it as some have reported feeling nothing with the 0.1% at all. I'm gonna try taking it 2 drops at a time and see if I can reduce the headache, and get some benefit from this stuff.

[pedr0vsky]

There's a new pharmacy selling semax. the price is the same that pharmacy1010, but since pharmacy1010 has run out of semax...
i was wondering if anybody has bought semax, or anything else from this guys? are they trustworthy?

http://www.apteka-dr...erc-3ml-n1.aspx

Thanks

Edited by pedr0vsky, 17 September 2010 - 09:35 PM.

[MajaMV]

Hi,
My 45 year old best friend had a sudden heart failure and by pure stroke of good luck stayed alive after NOT breathing for 7-8 mins. She has been in a coma for almost 5 weeks. Although all her vital functions are preserved, she is not waking up.
Semax was suggested as a possible therapy for her knowing it helps in ischemic cerebral conditions.
Due to having seizures after the incident, she has been on Keppra (levetiracetam).
Does anyone know about any possible interaction between Keppra and Semax?
Many thanks
Maya

[Ark]

I like taking 8 nasal pumps of 1% semax before Judo Practice and when going to explore ghost towns. *to remained focused

[Ichoose2live]

Phenylpiracetam, Phenotropil, Fenotropil, Carphedon

Fenotropil has a positive effect on metabolism and blood circulation within the brain. It stimulates the Redox processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in Ischemic areas of the brain. Moreover, it increases noradrenaline, dopamine, and serotonin brain levels. It does not affect GABA levels and is not associated with GABA A- and -B receptors. It produces no significant effect on spontaneous brain activity.

Fenotropil has no effect on the respiratory and cardiovascular systems. However, it produces a mild diuretic effect and anorexic activity in the exchange application.
Fenotropil provides a moderately stimulating effect on motor responses and improves physical performance. The moderate awareness-inducing effect of the drug is combined with anxiolytic activity. Fenotropil improves mood and has analgesic effects, increasing the pain threshold. Additionally, it has an adaptogenic effect, increasing the organism's resistance to stress in conditions of increased mental and physical stress and fatigue. Furthermore, it increases resistance to freezing hypokinesia.

With the advent of Phenotropil, marked improvements were noted in vision (an increase in sharpness, brightness, and field of view). Fenotropil improves blood flow to the lower extremities. Fenotropil stimulates the production of antibodies in response to the antigen, indicating that it has immunostimulator properties but at the same time does not cause the development of immediate hypersensitivity reactions and does not alter the allergic inflammatory reaction of the skin caused by the introduction of foreign proteins. In the exchange application, Phenotropil does not develop drug dependence and tolerance. The drug is not marked in the development of withdrawal syndrome.
Actions of Fenotropil are seen after a single application, which is important when the drug is used in extreme conditions. Phenotropil significantly enhances the action of other Nootropic drugs.

Fenotropil is not metabolized in the body and excreted, unchanged in form. About 40% is excreted in the urine and 60% in bile and sweat. The half-life is 3-5 hours.
The average single dose is 150 mg (100-250 mg); the average daily dose is 250 mg (200-300 mg). The maximum daily dose is 750 mg. The multiplicity of reception is 1-2 times a day. A daily dose of 100 mg can be taken one time a day (morning), while doses exceeding 100 mg should be taken in two doses. The duration of treatment ranges from two weeks to three months. The average course of treatment is 30 days.

http://medi.ru/doc/3101.htm
http://www.phenotropil.ru/pub/

Edited by Ichoose2live, 01 March 2011 - 01:06 AM.

[Healthy Tony]

Can any of the semax users attest to any long term effects that remained after cessation of the drug? At almost $200 per bottle I want to do some research before testing this stuff.

[Ark]

Semax is good!

[Healthy Tony]

Semax is good!

Well I imagined that it is some pretty strong stuff based on the positive reviews in this thread, but I was wondering if you notice any cognitive improvements after cessation of the drug.

[Ark]

Semax is good!

Well I imagined that it is some pretty strong stuff based on the positive reviews in this thread, but I was wondering if you notice any cognitive improvements after cessation of the drug.

unknown

[Healthy Tony]

Semax is good!

Well I imagined that it is some pretty strong stuff based on the positive reviews in this thread, but I was wondering if you notice any cognitive improvements after cessation of the drug.

unknown

I'm sorry for asking so many questions, but do you mean scientifically unknown or subjectively unknown?

[Logan]

If this stuff works I hope the price will go down. Do you know what's the real price of Semax in Russia? (not after an online pharmacy take a huge profit).

Prices in Russian pharmacies - SEMAX 0.1 % - 8 GBP, SEMAX 1 % - 36 GBP.

Did you get the 0.1 or 1%?

They only sell the .1%. Unfortunately, there are no suppliers for the 1%.

This nootropic is supposedly available in the Ukraine and Belarus (who may have less strict exporting than Russia). Pharmacy1010 is apparently based out of the Ukraine...

Not sure if anyone posted that you can get Semax in 1% solution since I have not yet read through the thread.

http://www.google.co...JwsQRjQ&cad=rja

Edited by MorganM, 09 March 2011 - 05:44 AM.

[Thorsten3]

Where do you buy this stuff? I have previously ignored these sorts of compounds with the exception of afobazol but these two sound very promising, almost too good to be true.

Source and price are the main problems.. anyubody know any sources?

[Logan]

Where do you buy this stuff? I have previously ignored these sorts of compounds with the exception of afobazol but these two sound very promising, almost too good to be true.

Source and price are the main problems.. anyubody know any sources?

I guess you didn't see the link I posted right above your post.

[Thorsten3]

Where do you buy this stuff? I have previously ignored these sorts of compounds with the exception of afobazol but these two sound very promising, almost too good to be true.

Source and price are the main problems.. anyubody know any sources?

I guess you didn't see the link I posted right above your post.

Lol

Jeez it looks like I may need some of this stuff. I did follow the link but I didn't really have a look around. If I did I would have discovered that they were selling the stuff too. Thanks anyway bro.

[Logan]

Where do you buy this stuff? I have previously ignored these sorts of compounds with the exception of afobazol but these two sound very promising, almost too good to be true.

Source and price are the main problems.. anyubody know any sources?

I guess you didn't see the link I posted right above your post.

Lol

Jeez it looks like I may need some of this stuff. I did follow the link but I didn't really have a look around. If I did I would have discovered that they were selling the stuff too. Thanks anyway bro.

Which one are you interested in, phenylpiracetam, or Semax or both? I don't know how good either will be, I'm more interested in trying Semax since I'm having some early success with piracetam. You never know until you try.

What do you mean by thanks anyway? You do know this guy is selling phenylpiracetam, noopept, semax, and selank?

Edited by MorganM, 09 March 2011 - 08:42 PM.