7 replies to this topic

[BandOnTheRun]

I was reading recently that Ginkgo Biloba is a significant telomerase activator.
I also read that it increases the life expectancy of rats.
That telomerase activating increases with dosage and it is not toxic.


http://www.sciencedi...031938497004642
http://www.ncbi.nlm....pubmed/17312453

[Guinevere]

Out of curiosity, has there been any evidence that telomerase overexpression induces tumorigenesis?

[Daniel Cooper]

Out of curiosity, has there been any evidence that telomerase overexpression induces tumorigenesis?

 

Or, was there any evidence that Ginkgo Biloba increased turmorigenesis in these rat studies? A different approach to answer the same question perhaps.

[Skyguy2005]

 

 

Or, was there any evidence that Ginkgo Biloba increased turmorigenesis in these rat studies? A different approach to answer the same question perhaps.

 

 

No, not really. The male rats, if I remember correctly, did have more tumours of the liver and some other organs. But the extract itself was highly questionable. Also, the doses that showed the most effect, was 2000mg/kg, a ridiculously high dose. That's equivalent to 100 grams of leaf per kilo of body mass. In fact this may be interpreted as saying the substance is relatively benign. The female rats even had *reduced* mortality, also.

 

A couple of other studies showing mutagenicity of Ginkgo Biloba extract in the testes turned out to be using a highly dodgy extract from Egypt (despite claiming to be EGB761). More about this here:

 

"http://www.sciencedi...44711313003619"

 

They also elaborate on testing of EGB761 in mice, rats, and rabbits, at doses of 100-1000 mg/kg (high doses). It had no ill effects whatsoever in these animals.

 

Yes Ginkgo Biloba has some potential as a Telomerase activator, although it hasn't been studied that much.

Edited by Skyguy2005, 25 October 2014 - 07:06 PM.

[Logic]

In the other in vivo study rats receiving between 50 and 200mg/kg lived significantly longer.
http://www.sciencedi...031938497004642

That works out at between 8.1 and 32.4 mg/kg for a HED using the formula here:
http://www.longecity...animal-studies/
http://www.longecity...nimal-to-human/

So an upper dosage of 2270 mg of EGb 761 per day for a 70g human should do the trick.

[troi+]

telo-100 contains ginkgo biloba

[pone11]

In the other in vivo study rats receiving between 50 and 200mg/kg lived significantly longer.
http://www.sciencedi...031938497004642

That works out at between 8.1 and 32.4 mg/kg for a HED using the formula here:
http://www.longecity...animal-studies/
http://www.longecity...nimal-to-human/

So an upper dosage of 2270 mg of EGb 761 per day for a 70g human should do the trick.

 

Here is full text for the science direct study:

http://www.sciencedi...031938497004642

 

Is EGb available in any of the human supplements being sold as Ginkgo Biloba?

 

Would any human feel comfortable taking 2270 mg of GB per day?  Wow, that is pretty over the top.

[Logic]

 

In the other in vivo study rats receiving between 50 and 200mg/kg lived significantly longer.
http://www.sciencedi...031938497004642

That works out at between 8.1 and 32.4 mg/kg for a HED using the formula here:
http://www.longecity...animal-studies/
http://www.longecity...nimal-to-human/

So an upper dosage of 2270 mg of EGb 761 per day for a 70g human should do the trick.

 
Here is full text for the science direct study:
http://www.sciencedi...031938497004642
 
Is EGb available in any of the human supplements being sold as Ginkgo Biloba?
 
Would any human feel comfortable taking 2270 mg of GB per day?  Wow, that is pretty over the top.

 

Well the lower dose is 567mg and some people are eating 33-75 grams of Astragalus per day!

http://www.longecity...ndpost&p=675789
http://www.longecity...ndpost&p=580624
 
EGb 761:
http://www.schwabeph...oducts/tebonin/

I also recommend Purslane. Its classified as a weed and grows everywhere, (someone may pay you to eat it) s you wont find a cheaper telomerase activator anywhere.

http://www.ncbi.nlm....pubmed/17764668
http://www.longecity...43655-purslane/

http://nutritiondata...products/2604/2
http://www.nutrition...m/purslane.html