DMAE is often confused as a bioavailable source of choline because it can cross the BBB. Studies show that DMAE is not converted into acetylcholine past the BBB (study here). It's true that it is structurally similar to choline, but it is missing a methyl group. The liver can methylate it into choline. Thus, DMAE is considered a way to reduce overmethylation by some nutritionists.
After its conversion into choline, it can be phosphorized by Choline Kinase into phosphocholine and eventually become phosphatidylcholine after 3 more reactions. Therefore DMAE is a poor source of choline when compared to other sources like choline, phosphatidylcholine, CDP Choline, and Alpha GPC. DMAE, however, is shown to be effective for a variety of other purposes such as removing lipofuscin and as a general stimulant. Further implication as a stimulant exists due to its tolerance build up with repeated use.
I do notice a stimulating effect with DMAE if taken sublingually, mixed with a drink, or in high doses. I bought some because it was cheap and have been meaning to try it for a couple reasons. I knew it wasn't the best source of choline, but it was studied as a treatment for attention span and general fatigue. It's kind of nice to have around to just throw in a glass of water with some lemon juice and use it in place of an energy drink. But I was thinking about the methylation thing...
In order to make the most of DMAE, should I be taking it with a methyl doner such as TMG (trimethylglycine)?
Or perhaps is that why I get a stimulating effect from DMAE?
Edited by devinthayer, 27 June 2011 - 07:25 PM.
