14 replies to this topic

[sam7777]

I have thought for some time about the effects of long term allergies to processed foods. I am talking severe sufferers. Those who suspect that their autism/adhd/schitzo/fibro is caused or greatly aggravated by these food allergies.

As many of you know, these proteins, the gluten and casein, act like opioid in the body, mimicking the natural enkephalin and anadamide etc.

Well, also many people know that these compounds cause constipation and sedation, something that real narcotics do as well.

So I have considered.

a) you have a severe inflammatory chronic allergic reaction to these over many years, perhaps a decade that damages the villi of the stomach

b) you cannot feel a lot of the pain because the wheat and dairy sedate the pain and act as mood enhancers

c) you stop eating the dairy and gluten, but you have a biomechanical "set point" so to speak for the rate at which your digestive system processes food, that is totally adapted to compensate for these opioid like foods. Now you have IBS, and your gut is compensating for years of desensitization. It is in a hyper-visceral pain sensitive state.

d) the pain sensitivity causes an neuroendocrino-immuno cascade of cytokines and neurotransmitters, histamine, NGF, serotonin 5-ht3/ht4 receptor stimulation, tons of adrenaline- all leading to chronic dysregulation of the HPA-axis and psychological-physiological changes within the brain itself. The brain has to compensate to deal with the pain, and you become desensitized to emotion, sucked into a stupor and depression.

e) You realize that this condition closely resembles narcotic withdrawal. You may need opioids to make up for the lack of dairy and gluten.

f) In a separate post, I speculated on how oxytocin and endogenous opioids were more important for cognitive capacity than perhaps even dopamine. http://www.longecity...__fromsearch__1

Would someone in this situation have to take some low dose opioid to compensate? perhaps until the nuero-biomechanical aspect of the GI tract was reprogrammed?

[DaneV]

First of all there is absolutely no evidence that gluten or casein has anything to do with psychiatric disorders.

If a person is actually allergic to gluten (=celiac he/she will experience pain and other problems while still consuming gluten. The gluten peptides that have some similarities to opiates will certainly not stop these people from experiencing the intense pain (ask any sufferer and he/she will confirm).

[Raptor87]

How on earth would casein and gluten "act" like an opiate in the body? The only opiate you have is endorphins, and I can say that no endorphinproduction is sufficient enough to mask or hide away chronic inflammation or pain.

You may need opioids to make up for the lack of dairy and gluten.

HAHAH, there´s a scenario. Hey doc! I got addicted to heroineshots because I stopped drinking milk, please help me!

Just ask your doc to prescribe you some hyoscyamine if you have stomach issues due to stress or anxiety.

[sam7777]

I think you guys fell pretty far from understanding the point of this post, so let me reguide it before it falls into obscurity. I know there are people on this board who are familiar with this topic.

First of all there is absolutely no evidence that gluten or casein has anything to do with psychiatric disorders.

very, very untrue. I am hoping someone will post some articles, but I will list some shortly.

HAHAH, there´s a scenario. Hey doc! I got addicted to heroineshots because I stopped drinking milk, please help me!

Just ask your doc to prescribe you some hyoscyamine if you have stomach issues due to stress or anxiety.

You do not need to take an anti-cholinergic to treat your anxiety and stress...or stomach illness.... you need to stop ingesting the offending compound. That is sort of the entire principle behind natural healing and orthomolecular medicine and nutrition, and I believe is in concert with the immist philosophy and nootropic theme.

I am not saying people should take opioid narcotics.

I was illustrating a physiological principle for how the GI tract works, how it reacts to toxins, and how the diet affects the way the GI tract works. I am trying to illustrate why narcotic medication and street drugs are comparable to dairy and gluten at a molecular level in the way they affect the GI tract.

If you read carefully, you will see that there really is a potential case for people who have illnesses like fibromyalgia, ADHD, and asperger's to have an ongoing problem with trying to live a life that is gluten and dairy free, because of how devastatingly addictive the opioid compounds are to those with compromised digestive systems, i.e. leaky gut syndrome.

This means, that without some sort of substitution to make up for the damage done by the past unhealthy diet, ongoing psychiatric problems and digestive issues are a scientifically probable outcome.

This could be controlled through interval training, because high intensity exercise releases and promotes ongoing increased levels of endogenous endorphins. Exercise will also reverse chronic inflammation. But, it would still be good to look for supplements and herbs to treat ongoing levels of discomfort. There are other foods that could act to control the symptoms, without the addiction or further allergenic effect.

And in more severe cases, I completely justify the use of medication like Tianeptine, Depreynl, or medical marijuana because of how it prevents pain. Ever wonder why marijuana treats GI tract problems so well? Anandamide and cannibinoid receptors play at least some part in the equation.

The bottom line, is that for the unlucky few, these dairy and gluten derivatives are debilitating and leave chronic conditions. It works all too well for Monsanto, Archer Daniel Midland, McDonalds, etc to sit and deny the hell out of the negative effects of the "Standard American DIet" so they can inturn justify the corrupt FDA and USDA with policy that allows for such absurd marketing campaigns as putting "contains riboflavin essential for child development" on some contrived breakfast cereal that contains 40 grams of refined cane sugar per serving...

[DaneV]

very, very untrue. I am hoping someone will post some articles, but I will list some shortly.

Enlighten me... I`ve never seen valid research validating any correlation between the two.

[sam7777]

Here is a start.

!

http://www.youtube.com/watch?v=ENmc9kHnvbo&feature=relmfu

The sickening thing, is that this agricultural scientist who goes into an in depth discussion with Dr. Mercola, actually carefully explains all of the advance science, the microbial ecology, plant-pathogen relationships, soil fertility, disease resistance, human gastroenterology, nitrogen cycling dynamics, and most importantly the mineralogy aspect- the enzyme function required by plants and humans to properly produce energy and live!

Many of these areas, I have researched in the academic journals, written on, and had reviewed by doctorates, and have presented some while in school, this Dr.Don Huber will explain the fundamental environmental dynamic processes, essentially the biological, physical, and chemical principals that prove the process that leads to syndromes like autism, Alzheimer, ADHD...

So if it is not the gluten and the casein itself, it is the contaminants in the dairy and wheat that are unseen, or it is the glyphosate and other herbicide, and agricultural pollutants you are so unaware of....

Suddenly, in a fit healthy body, seemingly innocuous foods like dairy and wheat become major offenders to the immune system, because something in the agricultural system has gone in and disabled the immune system....

The CDC predicted cancer rate for those being born today, is that 1 in 2 will get cancer in their lifetime... Cancer being a result of a disabled immune system....

And to think, these herbicides are fat soluble!?

The average morbidly obese person has twice as many fat cells, and never loses those fat cells, only shrinks them. That means once you are fat, you are twice as good at storing big agribusiness' petrochemical derived herbicidal enzyme inhibiting, carcinogenic, tetrogenic compounds in your bodies fat cells. It is no wonder you get so big and fat! Your body is trying to keep it out of your organs so you don't keel right over!

It kills the soil microbiology leading to disease ridden plants requiring yet even more herbicide. This same ability to kill the soil microbiology works when it gets in the human gut and kills off all of your gut bacteria, leading you exposed to things like XMRV, parasites, and E.coli.

The soil is overused and loaded with anahydrous ammonium nitrate, leading overtime to the depletion of the vitamins and 35 other essential minerals. The enzyme inhibiting functions of the herbicides further render the other minerals in the soil as being non-bioavailable in form...

Maybe some of you will start to think at a deeper, broader level, about what it is that is impairing your mind.

Edited by sam7777, 20 December 2011 - 04:08 AM.

[Raptor87]

Look, we are all against processed food on some level. But you need to get the fact that casein and gluten doesn't work as an opiate in the body, not on a molecular level, not on any level!

The biggest problem for GI- problems is stress and anxiety. Then hyoscyamine is a great drug. If you know that you dont have any allergies or are sensitive to some foods then give it a shot, might help you if your stomach issues are anxiety related.

What I dont understand is your post in relation to GMO?

Isn't Dr.Huber a homoeopath? Personally I find those people paranoid who build up big theories through pseudoscience. People who are inclined to believe them are people who are uneducated or are paranoid themselves. Personally I believe that additives in food is a cause for neural problems but that's a different issue and besides, as long as there isnt any real scientific proof then Im holding my opinion before Im sure.

You are worried about Gluten and dairy but then recommend Deprenyl and Tianeptine? Cannabis works on the parasympathetic nervous system, this includes GI- tracks. It activates our intestines and food processing. It also works somewhat as hyoscyamine by relaxing our nerves locally in our GI- system. I dont know if cannabis affects our dopamine system but that's another cause for GI- movement.

If you are worried then start eating ecological food!

[nupi]

Also, Vitamins do not come from the soil...

[Raptor87]

Btw: E-Coli isnt a parasite in the human intestine, our relationship is symbiotic.

Edited by Brainfogged, 20 December 2011 - 12:13 PM.

[sam7777]

You guys seem to continue to fall far from the mark on simple things...

I know what E.coli is. E.coli has to be maintained at a level, and if it gets out of hand it then becomes a problem. There are also multiple strains. Every time a giant recall happens, it is over a strain that is not native to the human gut.

Dr. Don Huber is not a homeopath, and he is not a medical doctor. He is an agronomist. These claims I am posting are substantiated, not in medical literature, but in the environmental sciences and agricultural academic journals more than anything. So, at least direct claims about certain aspects of glyphosate are so far unsubstantiated, the underlying mechanisms being put forward are well substantiated and documented with other chemicals and pesticides.

There is a very large field between regulatory law, chemical fate and transport of contaminants, and pubic health epidemiology. This data is not just something wild and out of the air. What data exists, is very, very well known of by agencies like FIFRA, and certainly any agronomists. Agronomists understand more about the fundamental sciences that explain how these pesticides and chemicals could get so out of hand than any medical doctor could ever understand. It is not going to do you any good to make an argument about the safety of these things based purely on toxicology data and medical science. Why? People will not even admit that it gets into the body the first place. All I see are more and more cover up attempts. It is what has gone on with the American Medical Association since the beginning of time...practically.

The regulatory situation got out of control when people started allowing pharmaceutical safety trials and pesticides registration to be fast-tracked and set up for safety and toxicology studies by conflicting interests. It is the same flawed system that has allowed glyphosate and prozac to come to be, then..essentially.

The scientific process for these has become far more litigious than scientific. In the court system, you are innocence until proven guilty. Yet, somehow really good lawyers for these lobbyist goons seem to continue to mislead the public with their "absence of evidence IS an evidence of absence" dogma. So what you are telling me is that, because there is no absolute direct proof admissible in court through the scientific data that a degenerative neurological and gastrointestinal condition can be created over time, that it is OK to continue saying this stuff is 100% safe. Because there is quite a lot of accusations and evidence against everything I am highlighting in this post. Res ipsa loquitur - the facts speak for themselves because here you have so many people developing allergies, getting pissed off about processed foods, and the ever growing market response to the "ecological foods" you propose.

I think there is plenty of proof. To not say anything about the use and abuse of the pesticides that lead to the compromising of the gut- leading to the food sensitivities to dairy, that the dairy may contain unaccounted viruses and superbugs created in a confined unsanitary environment, is it negligence? Is it conjecture? Someone has to bring up evidence or at least make an arguement against the suppose lack of evidence because these issues are far to grave to just assume that the safety of the foods are not at question.

You all are being trained to think in the most unintuitive manner possible. Your college education could be invaluable to you, but they are training you to only believe absolutely what you are told or what is documented. If you cannot learn to question things based on inference, I do not think you can change a damn thing. Here you have mass disease and outbreaks of chronic illness, well documented pesticides such as DDT, well documented soil deterioration, environmental damage caused by agriculture, and 60 years of court battles and a pissed off public. But then some corrupt lawyer or statistician gets up on the stand as an expert witness and paints the picture about how "the safety ratio is so safe that our paper states that in only .001 % would the error safety account for this LD50 being inaccurate" This is a parlor trick. In science, you look for the unseen element. This is your burden of proof, and you have to figure out what "it" is.

I cannot understand how people fall into this belief and rationale pattern, where if something is very lethal to different organisms and shows a great deal of cytotoxicity across many species and spectrum, that all of the sudden put in another situation it loses those properties. This is where statistics become a weapon against ignorant people. Because it is the genetics, the biochemistry, the underlying principles that tell a scientist in his gut, that in that new situation no good can come of that said toxic substance. It has the physical properties and propensity to cause a problem. Yet, this is ignored, and only when overwhelming statistical data can disprove a highly likely scenario are any changes made.

Cancer is not common, it is not OK to get cancer. Autism is not common, it is not OK. The need for anti-depressants is not OK, it is not common.

The doctor tells you -"Well your tests are all negative, you do not seem to be unhealthy, the medicine does not respond, I guess you are a hypochondriac-but here let me prescribe you Prozac and ambian just for the hell of it"

Same exact story for 10's of millions of Americans. The medical community ignores things because it cannot establish what they are, so it claims they are not real. This is not a scientific process, it is a convenient, corrupt, money making process. There exists a cause and effect relationship, but the industry is going to continue to ignore and silence it.

You take the same kind of situation and apply it to a different scenario. Say the military is testing out a group of new missiles. But in 1000 different trial runs, it is found out that there is a 15% rate of failure to detonate. The problem is, the lead scientists are on a fixed budget, and after 2 years no direct mechanism or proof has been determined that would explain the failure. Does the military OK the missiles for standard use and service, or do they spare no expense to determine an exact cause. If someone has enough monetary interest in something, they will establish a substantiated burden of proof for why something is either safe or unsafe. They are not just going to let it keep happening unaddressed.

No one wants to eat this crap, and so it is no surprise that organic foods, farmer markets, and specialty foods with "insert hated ingredient"-free are becoming a huge money making ploy. Yea I will eat my ecological food. But I am going to explain to people WHY. I am going to explain to people why their health is threatened. Because this whole movement should not be just a money making ploy. There should be real changes to try to take this country's agricultural system back from the corporate devil's who stole it back in the WWII era and decided to feed the world pesticide drenched nutrient deprived foods from massive monocultures with little regard to how the food effects peoples health, the environmental quality deterioration caused by agricultural pollution, or the massive subsistence that agriculture has on the use of fossil fuels. The interstate system was practically MADE to support our agricultural system.

We cannot just keep eating the crap diet we are being fed. The cancer rate is becoming a something to where you are just expected to get cancer and deal with it. Like a common cold. How do you think it got to be that cancer could be accepted as common?

[sam7777]

A Peptide Found in Schizophrenia and Autism Causes Behavioral Changes in Rats

• Zhongjie Sun
  
• J. Robert Cade
  
• University of Florida, USA

Abstract

In a previous study we showed that β-casomorphin-7 (β-CM7) is taken up by brain regions relevant to schizophrenia and autism. The present experiment was designed to find whether β-CM7 has any behavioral or analgesic effects in rats. About 65 seconds after treatment with different doses of β-CM7, rats became restless and ran violently, with teeth chattering and with rapid respiration. Seven minutes later, the rats became inactive with less walking, distancing themselves from the other rat in the same cage, and sitting in, or putting their head against, the corner of the cage. The sound response was reduced and social interaction was absent. One hour later, the rats showed hyperdefensiveness. The above behavioral effects of β-CM7 did not occur when rats were pretreated with naloxone (2 mg/kg, IP). The rats receiving saline did not show any behavioral changes throughout the 2 hour period of observation. β-CM7 also demonstrated analgesic effects, which could be blocked by naloxone. The results suggest that β-CM7 may play a role in behavioral disorders such as autism and schizophrenia.

Health Implications of Milk Containing
β-Casein with the A2 Genetic Variant
Stacey J. Bell, D.Sc., R.D.
Research and Development, Ideasphere, Inc., 56 Amherst Road, Belmont, MA 02478
Gregory T. Grochoski
Chief Science Officer, Ideasphere, Inc., 3133 Orchard Vista Drive, SE, Grand Rapids, MI 49546
Andrew J. Clarke
Chief Executive, A2 Corporation Limited, 58 College Hill, Ponsonby, Auckland 1001, New Zealand

Milk from dairy cows has long provided a high quality source of protein and selected micronutrients such as calcium to most
populations. Recently, a relationship between disease risk and consumption of a specific bovine β-casein fraction either A1
or A2 genetic variants has been identified. Populations, which consume milk containing high levels of β-casein A2 variant,
have a lower incidence of cardiovascular disease and type 1 diabetes. Furthermore, consumption of milk with the A2 variant
may be associated with less severe symptoms of autism and schizophrenia. The mechanism of action focuses on β-casein
A1 and related forms preferentially that are able to produce a bioactive opioid peptide, β-casomorphin-7 (β-CM-7) during
digestion. Infants may absorb β-CM-7 due to an immature gastrointestinal tract. Adults, on the other hand, appear to reap
the biological activity locally on the intestinal brush boarder. β-CM-7 can potentially affect numerous opioid receptors in the
nervous, endocrine, and immune systems. Whether there is a definite health benefit to milk containing the A2 genetic variant
is unknown and requires further investigation.

β-CMs appear to be absorbed through the gastrointestinal
tract of newborns and young infants (Sun et al., 1999; Sun and
Cade, 1999; Sun et al., 2003). Adults, despite consuming bovine
casein and showing β-CM-7 production in the gastrointestinal
tract, fail to have circulating β-CMs (Svedberg et al., 1985). If β-
CMsdo get absorbed through the gastrointestinal tract, they must
then localize in the central nervous system to produce an effect on
the respiratory or endocrine system. Newborn infants have more
permeable gastrointestinal tracts and immature nervous systems,
making them more likely candidates than adults to experience
the opioid effects of β-CMs from bovine casein, which has been

the case in animal studies (Umbach et al., 1985; Singh et al.,
1989). Besides, most infants consume nearly all of their nutrition
from formula based on bovine milk, whereas adults have a more
varied diet, of which only a small percentage is contributed by
milk. Some adults may have more permeable guts than others
(e.g., Crohn’s disease, Irritable Bowel Syndrome) and may be
more affected by β-CMs than adults with normal functioning
gastrointestinal tracts.

Antibodies to bovine β-casein were detected in recently diagnosed
(<2 weeks) patients with type 1 diabetes and in adults with
latent autoimmune diabetes compared to age-matched controls
(P =0.01) (Monetini et al., 2002). Similarly, patients with celiac
disease had levels of these antibodies comparable to patients
with type 1 diabetes. Both conditions share similar pathogenic
events including abnormal HLA-haplo types. Perhaps, the increased
immune responses to dietary antigens from cow’s milk
triggered each disease. This study supports a relationship between
type 1 diabetes and antibody response to β-casein from
cow’s milk.
A German group explored antibody formation to bovine milk
(Padberg et al., 1999). Patients with type 1 diabetes had the highest
titers compared to their siblings and parents, and to healthy
controls. For all groups, there was an inverse relationship between
antibodies raised specifically to the A1 and A2 proteins
and age (P < 0.001). The highest concentrations of anti-casein
A1 antibodies were found among patients with diabetes, but
they were present in the other groups. These findings suggest
that patients who develop type 1 diabetes may have a defective
immuno-tolerance to cow’s milk antigens.

[sam7777]

Table 3 Proposed mechanism for the relationship between β-casein and the
risk of type 1 diabetes
Mechanism Explanations
Elevated β-casein
antibodies; heightened
immune responses to
β-casein (17)
1. Increased gut permeablilty
2. Susceptibility-associated HLA haplotypes
3. Opioid peptides produced from β-casein
provide cross-reactive antigens to the islet cell
components of the pancreas, thus activating
an autoimmune reaction by the lymphocytes.
4. The sequence homologies of bovine β-casein
and several beta-cell components (e.g.,
GLUT 2, p69 carboxypeptidase) are
autoantigens to type 1 diabetes. In addition,
the beta-cell-specific glucose transporter
GLUT-2 shares 5 consecutive amino acids
with bovine, but not human, β-casein.
Uniqueness of β-casein A1
allele in producing
β-CMs with opioid
properties (Elliot 15)
β-CM may inhibit human intestine lymphocyte
proliferation, thereby suppressing:
• the development of gut-associated immune
tolerance, or
• defense mechanism toward enteroviruses

Investigators at the University of Florida postulated that
β-CM-7 reaches the brain cells and lead to symptoms associated
with schizophrenia, autism, and SIDS (Sun et al., 1999; Sun and
Cade, 1999; Sun et al., 2003). The IgG antibody titers to β-CM-
7 are present in more than 90% of patients with schizophrenia
and in 86% of patients with autism. Blood and cerebral
spinal fluid also contained significantly higher concentrations of
β-CM-7 than normal. These elevated levels may come from deficient
or defective enzymes that cleave the β-CM-7 peptide,
from increased permeability of the intestinal mucosal, or both
of these mechanisms. However, in order confirm that β-CM-7
is actually related to these conditions, it may be necessary to
further characterize the report that it crosses the blood brain barrier
(BBB) in a carrier-dependent way (Banks and Kastin, 1987;
Pasi et al., 1993). On the other hand, it may be possible that
the entire peptide of β-CM-7 need not cross the BBB to induce
these conditions, and that only a subset of the peptide is required
to cross.

Rats infused with different concentrations of β-CM-7 had
various areas of the brain tested for its presence using FOSlike
immuno-reactivity (Sun et al., 1999). Multiple sites were
considered “affected by β-CM-7” if an increased number of
stained cells were present in the region compared to the number
of stained cells following an infusion of saline. Several areas of
the brain appeared to be affected by the β-CM-7. For example,
the occipital and temporal cortex, which are speech centers, were
strongly affected. Both schizophrenia and autism patients have
abnormal speech patterns. In addition, a disruption in normal
serotonin, dopamine, and γ -aminobutyric acid (GABA) activity
has been associated with associated with decreased or absent
social interactions, which are characteristic of these conditions.
Areas of the brain that produce these neurotransmitters were also
affected. Thus, it appears that β-CM-7 has is somehowrelated to
these conditions. This peptide not only comes from cow’s milk,
but also is produced from eating gluten-containing products.

REFERENCES

Elliott, R.B., Harris, D.P., Hill, J.P., Bibby, N.J., and Wasmuth, H.E. 1999.
Type 1 (insulin-dependent) diabetes mellitus and cow milk: Casein variant
consumption. Diabetologia. 42:292–296.
Monetini, L., Cavallo, M.G., Manfrini, S., Stefannini, L., Picarelli, A., DiTola,
M., Petrone, A., Bianci, M., LaPresa, M., DiGiulio, C., Baroni, M.G., Thrope,
R.,Walker, B.K., IMDIAB group, and Pozzilli, P. 2002. Antibodies to bovine
beta-casein in diabetes and other autoimmune diseases. Horm. Metabl. Res.,
34:455–459.
Padberg, S., Schumm-Draeger, P.M., Petzoldt, R., Becker, F., and Federlin, K.
1999. The significance of A1 and A2 antibodies against beta-casein in type-1
diabetes mellitus. Dtsch. Med. Wochenschr., 124:1518–1521.
Pasi, A., Lansel, N., Bernasconi, C., and Messiha, F.S. 1993. Beta-casomorphinimmunoreactivity
in the brain stem of the human infant. Res. Common Chem.
Pathol. Pharmacol., 80:305–322.
Phelan, S., Hill, J.O., Lang, W., Dibello, J.
Sun, Z., Cade, J.R., Fregly, M., and Privette, R.M. 1999. β-casomorphin induces
Fos-like immunoreactivity in discrete brain regions relevant to schizophrenia
and autism. Autism., 3:67–83.
Sun, Z., and Cade, J.R. 1999. A peptide found in schizophrenia and autism
causes behavior changes in rats. Autism., 3:85–95.
Sun, Z., Zhang, Z., Wang, X., Cade, R., Elmir, Z., and Fregly, M. 2003. Relation
of β-casomorphin to apnea in sudden infant death syndrome. Peptides.,
24:937–943.
Svedberg, J., de Hass, J., Leimenstoll, G., Paul, F., and Teschemacher, H. 1985.
Demonstration of beta-casomorphin immunoreactive materials in in vitro digests
of bovine milk and in small intestine contents after bovine milk ingestion
in adult humans. Peptides., 6:825–839.
Umbach, M., Teschemacher, H., Praetorius, K., Hirschhauser, R., and Bostedt,
H. 1985. Demonstration of a beta-casomorphin immunoreactive material in
the plasma of newborn calves after milk intake. Regul. Pept., 12:223–230.

[hippocampus]

very, very untrue. I am hoping someone will post some articles, but I will list some shortly.

Enlighten me... I`ve never seen valid research validating any correlation between the two.

there are many studies implicating that there may be connection.
http://www.ncbi.nlm....ophrenia gluten

+read this article: http://www.ncbi.nlm..../pubmed/2851166

[#1hit]

Health Implications of Milk Containing b-Casein with the A2 Genetic Variant
Stacey J. Bell, D.Sc., R.D.
Research and Development, Ideasphere, Inc., 56 Amherst Road, Belmont, MA 02478
Gregory T. Grochoski
Chief Science Officer, Ideasphere, Inc., 3133 Orchard Vista Drive, SE, Grand Rapids, MI 49546
Andrew J. Clarke
Chief Executive, A2 Corporation Limited, 58 College Hill, Ponsonby, Auckland 1001, New Zealand

... Recently, a relationship between disease risk and consumption of a specific bovine b-casein fraction either A1
or A2 genetic variants has been identified. Populations, which consume milk containing high levels of b-casein A2 variant,
have a lower incidence of cardiovascular disease and type 1 diabetes. Furthermore, consumption of milk with the A2 variant
may be associated with less severe symptoms of autism and schizophrenia. The mechanism of action focuses on b-casein
A1 and related forms preferentially that are able to produce a bioactive opioid peptide, b-casomorphin-7 (b-CM-7) during
digestion.... b-CM-7 can potentially affect numerous opioid receptors in the
nervous, endocrine, and immune systems. Whether there is a definite health benefit to milk containing the A2 genetic variant
is unknown and requires further investigation.

What caught my eye in this study was the dichotomy between the A1 and A2 variants of B-casein. Does this suggest that there is a such thing as good milk and bad milk? What determines if milk has A1 or A2 B-casein? I ask because I do drink milk, but only raw milk from grass fed cows, and I was wondering if perhaps there is a proven difference between the proteins in this milk compared to factory farm, antibiotic ridden, growth hormone tainted grocery store milk.

Edited by Michael, 06 July 2013 - 01:12 PM.

[dsohei]

to the original poster, yes you are on the right track but effects can be different individually. this is why some people use low-dose naltrexone to alter the endorphin/opioid pathway and help their immune systems while dealing with auto-immune disorders. it may be proven in the future that autism, schizophrenia, etc are also auto-immune disorders as many of these people get degrees better when they stop eating all grains, dairy, etc.