4029 replies to this topic

[Nattzor]

Hey Nattzor. I really liked the peptides...especially Cerluten and Pinealon. I will definitely be trying them again at some point.

TUS is still very experimental. The study I tried to copy used 8MHz http://www.ncbi.nlm....pubmed/22664271 and they have recently moved on to 2MHz as far as I can tell. http://apsychoserver...en_SPR_2013.pdf The Boston study is still going on if anyone wants to get paid $50 to try it out. http://neurotrek.youcanbook.me/

To be honest, I'm not sure if TUS works at all so it's def hard for me to say whether 3MHz would work or not. =) I think at this point tDCS and LLLT are better options.

Mind expanding more than "I really liked them"? :P

And re: TUS, I mailed one of those who did a study on it (the quantum consciousness guy) and asked about 3-3.3 MHz, hopefully he'll respond.

Unfortunately, that entire post is on my old Mac which is in storage at the moment. I think the studies that I listed in the exercise thread are a pretty good intro to some of the ideas though. http://www.longecity...s-and-exercise/

Any chance you can get the machine (and maybe upload it to the cloud, then you'll always have it)? Would be interesting to see your thoughts on it. Will check thread ofc.

[Metagene]

I'd have to say, I wholeheartedly recommend LostFalco to be on your podcast. He is the primary reason that I have made any dent in my HPPD symptoms, and a lot of the awesome work contained within this thread is based off the foundation he built in his original post.

This would be absolutely amazing.

[Dave Asprey]

Thank you! Funny, I woke up thinking the same thing today. Appreciate the confirmation!

[zeroskater6979]

I would really appreciate to hear about your Cerluten experiences Lostfalco. All of those russian peptides look interesting.

[Cognizant]

Hey guys,

First, I want to tell you all how impressed I am with what this thread is doing, in its piecing together and extrapolation of science with an emphasis on helping and/or improving the lives of others. The mentality that I see in this thread, and a few other threads on this site, is a constant reminder to me about the primary reason that I am pursuing medicine as a career. It is rare for me to actually comment on anything here, or even follow threads for an extended period of time, for I only do so when I am particularly interested in something or when I believe that the thread is on to something particularly amazing. What is happening in this thread fits the bill, so to speak, and I am really excited to start this regimen myself in the near future.

Second, I do have some concerns about this, which is mostly stack-interaction based. I am a long-time CILTEP user, and I was a long time Mr. Happy stack user (which I will be starting again when I get back to college next week). I am also a very long-time Piracetam and CDP user, along with many other Cholinergics and some Dopaminergics. I have also used Methylene Blue for periods of time in the past, though I know that I never got the dosage right which resulted in not very noticeable effects. My concerns lie with the fact that it has been recommended that Forskolin not be used, so as to not increase cAMP too much.

I was wondering whether I could start the protocol but keep the Forskolin in and watch out for signs of too much cAMP? In addition, I have PRL-8-53 and Coluracetam waiting for me in my residence at college, and I fully intend on starting this up, but I want to limit confounding variables, so I was wondering whether anyone has used these substances while "TULIPING"? In a perfect world it would be possible to differentiate the effects, both good and bad, from each substance/regimen, but I do not think that these very strong drugs and regimens will allow this.

Also, as for the effect on time required for sleep (ie. needing less time as you move forward with the regimen), I have found this to be of great interest, as the correlation between increasing ATP levels in the brain and amount of sleep required makes a lot of sense in light of what is known about what occurs during sleep (see: recent discovery of Glymphatic System - http://io9.com/the-r...-you-1447241194). This seems, to me, like a logical idea, that by increasing ATP we are signaling that we should be awake (re: the balance between ATP and Adenosine [which is a product of cellular metabolism]). What I would like to know is the following: 1) by stimulating brain mitochondria, are we not only increase ATP levels, thus increasing brain energy and cognition, but also increase the elimination of Adenosine (ie. phosphorylation, in order to put this substance back into stores, or elimination from the body); 2) by shortening the time we are asleep, which is great for getting work done and is something that I really want to pursue, are we sacrificing REM sleep (memory consolidation) and/or the necessary processes that occur during sleep for longevity (plague and waste removal from the brain)?

Sorry that was a long post, but I really do think that you all are onto something here, and it is this sort of life enhancement and preventive practice (if this regimen ends up somehow preventing or slowing down age-related mitochondrial degradation and failures of brain metabolism) that I want to implement into my future as a physician.

[BigPapaChakra]

^Thanks for the input and contribution - also interesting thoughts/observations. I've been largely taking the same route as you (I enjoy just reading everyone else's experiences and thoughts, and commenting when I find that I can offer something truly useful), and I'm also looking forward to applying some of the information in a future medical practice (going into Premed, probably with focus on psychiatry because I'm interested in how simple metals, minerals, and fat soluble vitamins can prevent and reverse psychiatric illnesses and perhaps enhance cognition, well-being, and what we consider consciousness). I wish I had a little bit more time to research because I'd save some money and then attempt a semi-Happy-CILTULIP protocol for this upcoming semester due to a ton on my plate (college, new job, working on a blog/app project, etc.). If you don't mind, could you please keep us updated with Coluracetam? It seems to be a viable route to managing or possibly reversing/curing HPPD due to it's cholinergic effects and possible long-term benefits (that can remain after discontinued use, apparently). Thanks.

I'd also like to chalk up there some things I recently found on NAD+/Nicotinamide Riboside:

"Summary

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but its causes are debated. We show that, during aging, there is a specific loss of mitochondrial, but not nuclear, encoded OXPHOS subunits. We trace the cause to an alternate PGC-1α/β-independent pathway of nuclear-mitochondrial communication that is induced by a decline in nuclear NAD+ and the accumulation of HIF-1α under normoxic conditions, with parallels to Warburg reprogramming. Deleting SIRT1 accelerates this process, whereas raising NAD+ levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. Thus, a pseudohypoxic state that disrupts PGC-1α/β-independent nuclear-mitochondrial communication contributes to the decline in mitochondrial function with age, a process that is apparently reversible."

(There was a nice infographic attached to the ^above^, but I couldn't post it due to being from a private forum - I may be ale to message it though...?)

http://jpet.aspetjou.../324/3/883.full NAD⁺ and Vitamin B₃: From Metabolism to Therapies
"The role of NAD⁺ metabolism in health and disease is of increased interest as the use of niacin (nicotinic acid) has emerged as a major therapy for treatment of hyperlipidemias and with the recognition that nicotinamide can protect tissues and NAD⁺ metabolism in a variety of disease states, including ischemia/reperfusion. In addition, a growing body of evidence supports the view that NAD⁺ metabolism regulates important biological effects, including lifespan. NAD⁺ exerts potent effects through the poly(ADP-ribose) polymerases, mono-ADP-ribosyltransferases, and the recently characterized sirtuin enzymes. These enzymes catalyze protein modifications, such as ADP-ribosylation and deacetylation, leading to changes in protein function. These enzymes regulate apoptosis, DNA repair, stress resistance, metabolism, and endocrine signaling, suggesting that these enzymes and/or NAD⁺ metabolism could be targeted for therapeutic benefit. This review considers current knowledge of NAD⁺metabolism in humans and microbes, including new insights into mechanisms that regulate NAD⁺ biosynthetic pathways, current use of nicotinamide and nicotinic acid as pharmacological agents, and opportunities for drug design that are directed at modulation of NAD⁺ biosynthesis for treatment of human disorders and infections."

(from another forum) "I found this review of Niagen on Amazon.com which speaks to it's use nootropically:

What everyone says B-12 should feel like

By Gabriel Sanchez on December 4, 2013
Amazon Verified Purchase

I truly didn't expect the kind of energy that I got from Niagen. Add to that the neuroprotection and I'm sold. I noticed it gives me a slight headache unless I take extra magnesium. With those 2 combined it pretty much wiped out my need for other nootropics. Niagen + Magnesium Citramate + a little coffee and I can concentrate all day long. It's a shame that so much of the marketing for this is geared towards athletes, anyone looking to focus shouldn't overlook this."

Edited by BigPapaChakra, 02 January 2014 - 09:15 PM.

[Cognizant]

Of course, BPC, I will keep you all updated. I actually ordered the 48 LED apparatus this afternoon, so I should be using that by the end of next week.

I plan on doing this in stages: 1) I will add Coluracetam and PRL-8-53, alongside of my normal CILTEP and Choline stack (as well as the Mr. Happy stack), and keep track of the effects; 2) After a week, or so, of this I will then add in the LEDs, according to LF's whole brain protocol; 3) If this seems like it is working well after a few weeks, I will then add PQQ and CQ10 to potentiate the LED. If this all goes as planned, I should have this stack in a high functioning state by a 1/3 of the way through this upcoming semester.


Also, have you guys looked into other adjunct substances? One that looked interesting, especially since it is not very expensive and has potential anti-aging benefits (ie. anti-Alzheimers), is Centrophenoxine. According to the study below, it helps to increase Glucose uptake in the brain, specifically the glial cells, whose function is being better understood daily. "The data suggest that the meclofenoxate-induced reduction of lipofuscin accumulation has a positive effect on cell metabolic functions and causes a delay of the cellular aging of the human glia cells in vitro."
http://www.ncbi.nlm..../pubmed/6191765

In addition, with regards to CQ10, I have read that there is an age-dependent difference in metabolism of Ubiquinone to Ubiquinol (re: apparently, under the age of 35-40, the metabolism is very efficient, relatively, and, thus, Ubiquinone, which is significantly cheaper, can be taken. How true is this in practice? When I do buy the Mitochrondrial supplements, I want to maintain high efficacy at the lowest financial cost - ie. make this stack as marketable and practical to everyone as possible, a point that has been mentioned in the past by LF.

[Droplet33]

Hi Cognizant,

If you plan on trying to combine CILTEP and MrHappy stack at full dosage, i'd suggest you at the very least to pick some Tryptophan (available on iherb). Tryptophan is a amino acid necessary to create serotonin in the brain and this combo make you go through it a LOT faster!!! Temporary brain fog and slight depressive state seems to be the end result .

Abelard said this combo was in a "development" stage and people should be careful playing with it.

And unless i'm mistaken, from what Abelard said, combining Coluracetam with CILTEP doesn't work quite right together.

Edited by Droplet33, 02 January 2014 - 10:44 PM.

[lostfalco]

Mind expanding more than "I really liked them"? :P

Sure man. The two main things that I noticed were endurance (I could play more dual n-back games in a row without getting tired...though my scores didn't improve) and task switching (I found it VERY easy to jump from thought to thought and from task to task without skipping a beat).

I'm a little hesitant to recommend the peptides outright because the science behind them hasn't been extensively replicated and there are a lot of unknowns...however, I still find them extremely fascinating and will keep following the research as more is learned about them.

I also think that we have some very interesting bioenergetic avenues directly in front of us to pursue. I'm currently looking into these three especially and would love to hear feedback that any of you guys have. =)
1. Nicotinamide Riboside/Nicotinamide Mononucleotide http://www.longecity...620#entry632574
2. Microcurrent Therapy http://www.longecity...560#entry628020
3. Cardiolipin/Linoleic Acid (optimizing the inner mitochondrial membrane) http://www.longecity...500#entry625794

I'd have to say, I wholeheartedly recommend LostFalco to be on your podcast. He is the primary reason that I have made any dent in my HPPD symptoms, and a lot of the awesome work contained within this thread is based off the foundation he built in his original post.

This would be absolutely amazing.

haha Thanks Papa and Meta...those checks I promised to send you guys in return for making me look good are in the mail. =)

[lostfalco]

I would really appreciate to hear about your Cerluten experiences Lostfalco. All of those russian peptides look interesting.

No problem. Tbh, I was really surprised that I actually 'felt' something when I took them. I wasn't expecting to at all. As I mentioned to Nattzor, I noticed enhanced endurance and task switching abilities primarily...but I'm still a little hesitant to fully recommend them until more research is published.

[Cognizant]

I appreciate the concern, Droplet, and, luckily for me, I am a Neuroscience major, so the basics of the neurotransmitter pathways are something I am quite familiar with. As it happens, I have run both of these stacks together before in the past, but I never got what I wanted from the Mr. Happy stack and, so, I discontinued it. The proposed neurogenesis, while I fully believe that it is real, is not something that is always very obvious, in a subjective "I can feel it" sort of way. It is the combination of the LED and the Mr. Happy stack that I hope will allow neurogenesis to have a stronger effect.

Also, when I was younger, I was a bit more adventurous with nootropics, and, as a result, I foolishly mixed a few too many Dopaminergic and PDE Inhibitors together with a very negative effect, which is very unsurprising, considering the potentiation of stimulants while on Mr. Happy. As for coluracetam and PRL-8-53, we will have to see how it fairs. I have used CILTEP for so long now that I will definitely be able to notice negative interactions.

As an aside, I stopped Piracetam today, due to what Joe wrote on his blog about it being either not very efficacious or even negative for cognition, and so we will have to see what happens. I definitely am noticing a bit of brain fog, but since I have taken it for years I would expect there to be significant changes in NMDA/AMPA receptors, for good or for bad, which homeostasis will take care of over the next few days.

I hope that, through more experimentation, we can further this regime, though it is definitely better to take things slowly, especially since this is more uncharted territory, both with the substances and the devices involved.

Edited by Cognizant, 02 January 2014 - 11:25 PM.

[Droplet33]

I appreciate the concern, Droplet, and, luckily for me, I am a Neuroscience major, so the basics of the neurotransmitter pathways are something I am quite familiar with.

Great! I saw your post and just jumped on the keyboard to warn you, without knowing .

I'm barely crawling on the floor, as knowledge on nootropics goes, especially compared to you! I have experienced the "wall" (massive drop of serotonin precursors after full dose of "Happy Stack" along CILTEP with Zembrin) that Abelard talked about, not too long ago, so i jumped so that someone doesn't get hit by it without some tryptophan laying around, ugh.

So far, i am currently trying to figure things out on my own, Short of lowering the "happy" dosage to 70-75% in both uridine and DHA,(with some benefits in regard to mental clarity and alertness: no more coffee needed, lol!), can't say i'm having much success.

Oh and happy new year everyone BTW :D!

Back to topic..

Edited by Droplet33, 03 January 2014 - 03:36 AM.

[Slayers]

On January 3rd I burned my arm by a popcorn kettle pot at work. Once I got home I applied LLLT to the wound for five minutes and the pain completely subsided.

[Dave Asprey]

On January 3rd I burned my arm by a popcorn kettle pot at work. Once I got home I applied LLLT to the wound for five minutes and the pain completely subsided.

It shrinks nerve inflammation, raises nitric oxide levels, and reduces scarring. Amazing on nausea and jaw pain too.

[hephaestus]

Interesting, how do you use it to treat nausea?

[Dave Asprey]

Just put it over the gut...the pulse rate of the laser matters. Solid works, flashing rapidly can have a different impact.

[Strangelove]

Any update from the members that TULIP has a positive impact? Does the positive effects increase over time or there is a ceiling of the effects after a while?

I tried once more, unfortunately I got very tired, got over it, but I did not came back any different, I am still fighting a chronic infection with antibiotics and other means, and my body and brain is certainly not at its best.

For the people that have a good effect there is any kind of positive benefits in real life? Academics, relationships, work e.t.c

[sv3ngali]

Hey guys, my Mum has just severely 'pulled' her back. She has had the Doctor out who says it's 'probably' tissue damage, and they he doesn't think that there is a potential slipped disc etc...

I am fortunately in the possession of a 48 LED 850nm IR device, has anyone had good feedback/experience/routine from using such device on muscle/tissue/back pain?!

At the moment, the Doctor's are just pumping my Mum full of anti-inflammatory tablets...

Any help would be hugely appreciated.

[rikelme]

Hey guys, my Mum has just severely 'pulled' her back. She has had the Doctor out who says it's 'probably' tissue damage, and they he doesn't think that there is a potential slipped disc etc...

I am fortunately in the possession of a 48 LED 850nm IR device, has anyone had good feedback/experience/routine from using such device on muscle/tissue/back pain?!

At the moment, the Doctor's are just pumping my Mum full of anti-inflammatory tablets...

Any help would be hugely appreciated.

Sorry to hear that... hope she'll get better soon! Just put the LEDs on the spot that hearts and move it slightly around for 10 minutes or until pain goes away, whichever comes first.

[montana2012]

Any update from the members that TULIP has a positive impact? Does the positive effects increase over time or there is a ceiling of the effects after a while?

I tried once more, unfortunately I got very tired, got over it, but I did not came back any different, I am still fighting a chronic infection with antibiotics and other means, and my body and brain is certainly not at its best.

For the people that have a good effect there is any kind of positive benefits in real life? Academics, relationships, work e.t.c

The LEDs make me sluggish, and VERY irritable every time. They destroy my sleep as well. Unfortunately I didn't see improvement in mental performance/ENDURANCE. ATP is pretty fundamental, it should work equally for everyone. I am yet to add PQQ in the coming days and see how that turns out.

Best,
Steve

Edited by montana2012, 06 January 2014 - 10:28 PM.

[lostfalco]

Hey guys,

First, I want to tell you all how impressed I am with what this thread is doing, in its piecing together and extrapolation of science with an emphasis on helping and/or improving the lives of others. The mentality that I see in this thread, and a few other threads on this site, is a constant reminder to me about the primary reason that I am pursuing medicine as a career. It is rare for me to actually comment on anything here, or even follow threads for an extended period of time, for I only do so when I am particularly interested in something or when I believe that the thread is on to something particularly amazing. What is happening in this thread fits the bill, so to speak, and I am really excited to start this regimen myself in the near future.

Thanks Cognizant...really cool to hear that you're on the same page and that you're pursuing medicine! I look forward to hearing how TULIP goes for you and also learning from your knowledge as a neuroscience major. Neuronal mitochondria and the role of ATP in the brain are fascinating areas of research. I'd love to hear your thoughts here.

Second, I do have some concerns about this, which is mostly stack-interaction based. I am a long-time CILTEP user, and I was a long time Mr. Happy stack user (which I will be starting again when I get back to college next week). I am also a very long-time Piracetam and CDP user, along with many other Cholinergics and some Dopaminergics. I have also used Methylene Blue for periods of time in the past, though I know that I never got the dosage right which resulted in not very noticeable effects. My concerns lie with the fact that it has been recommended that Forskolin not be used, so as to not increase cAMP too much.

I was wondering whether I could start the protocol but keep the Forskolin in and watch out for signs of too much cAMP?

I know that Opaque reported headaches when adding full CILTEP and I've had pretty good results just using Artichoke. I usually try to err on the side of taking as few things as possible but it sounds like you're a pretty experienced noot user, so I think it's def up to your discretion here.

Also, as for the effect on time required for sleep (ie. needing less time as you move forward with the regimen), I have found this to be of great interest, as the correlation between increasing ATP levels in the brain and amount of sleep required makes a lot of sense in light of what is known about what occurs during sleep (see: recent discovery of Glymphatic System - http://io9.com/the-r...-you-1447241194). This seems, to me, like a logical idea, that by increasing ATP we are signaling that we should be awake (re: the balance between ATP and Adenosine [which is a product of cellular metabolism]). What I would like to know is the following: 1) by stimulating brain mitochondria, are we not only increase ATP levels, thus increasing brain energy and cognition, but also increase the elimination of Adenosine (ie. phosphorylation, in order to put this substance back into stores, or elimination from the body); 2) by shortening the time we are asleep, which is great for getting work done and is something that I really want to pursue, are we sacrificing REM sleep (memory consolidation) and/or the necessary processes that occur during sleep for longevity (plague and waste removal from the brain)?

These are excellent questions and the glymphatic system is an extremely fascinating discovery. I'll have to read back over some of the sleep research and get back to you. =)

[lostfalco]

Any update from the members that TULIP has a positive impact? Does the positive effects increase over time or there is a ceiling of the effects after a while?

I tried once more, unfortunately I got very tired, got over it, but I did not came back any different, I am still fighting a chronic infection with antibiotics and other means, and my body and brain is certainly not at its best.

For the people that have a good effect there is any kind of positive benefits in real life? Academics, relationships, work e.t.c

The LEDs make me sluggish, and VERY irritable every time. They destroy my sleep as well. Unfortunately I didn't see improvement in mental performance/ENDURANCE. ATP is pretty fundamental, it should work equally for everyone. I am yet to add PQQ in the coming days and see how that turns out.

Best,
Steve

Hey Steve, sorry to hear that man. Have you tried extremely low dose LLLT? Joe Cohen has reported good results with as little as 10 seconds per spot. http://selfhacked.co...review-of-lllt/

Also, there is definitely no requirement of lasering before bed if it's ruining your sleep. Have you tried at various times of the day?

[lostfalco]

^Thanks for the input and contribution - also interesting thoughts/observations. I've been largely taking the same route as you (I enjoy just reading everyone else's experiences and thoughts, and commenting when I find that I can offer something truly useful), and I'm also looking forward to applying some of the information in a future medical practice (going into Premed, probably with focus on psychiatry because I'm interested in how simple metals, minerals, and fat soluble vitamins can prevent and reverse psychiatric illnesses and perhaps enhance cognition, well-being, and what we consider consciousness).

That's cool Papa...seems like a good route for you.

I'd also like to chalk up there some things I recently found on NAD+/Nicotinamide Riboside:

Thanks for the info man. I just took my first test dose (250mg) of Niagen today to see how my body responds. So far so good. Nothing amazing to report but nothing negative either. Still trying to decide exactly how I'm gonna dose this.

[lostfalco]

In addition, with regards to CQ10, I have read that there is an age-dependent difference in metabolism of Ubiquinone to Ubiquinol (re: apparently, under the age of 35-40, the metabolism is very efficient, relatively, and, thus, Ubiquinone, which is significantly cheaper, can be taken.

This is very interesting Cognizant. Do you happen to have a study on this?

[lostfalco]

Here is an excellent illustration that describes the relationship between mitochondria and synaptic transmission. http://www.ncbi.nlm....8785/figure/F1/

The full text study is definitely worth a read. http://www.ncbi.nlm....les/PMC3858785/

Here are a few representative quotes. =)

With such high energy demands, neurons rely heavily on the proper functioning of mitochondria.

Mitochondria are also involved in other neurobiological processes including neural differentiation, neurite outgrowth, neurotransmitter release, and dendritic remodeling.

Because regions of highest energy consumption in the neuron are located at the synapses, mitochondrial transport and distribution are critical, since diffusion of ATP from the center of the neuron would be too slow and inefficient.

Mitochondria use the dynein and kinesin motor complexes to move in the retrograde and anterograde directions, respectively.

A lack of sufficient ATP undermines a large number of energy-dependent cellular processes including kinase/enzymatic activity, proteasomal protein turnover, transmembrane biochemical gradients, and membrane potentials, all leading to a collapse of cellular functional integrity and deterioration of cell conditions.

As the primary energy user consuming half of the ATP in the brain, sodium pump activity is highly sensitive to ATP levels.

Given that the brain is the major energy consumer in the body, and neurons rely heavily on ATP production for development and function, even a slight impairment in energy metabolism can have drastic effects on the brain. In line with this, mitochondria and bioenergy defects have long been proposed as the mechanism underlying chronic neuronal dysfunction and death, and an increasing amount of evidence has been accumulated in support of the hypothesis.

Excitatory glutamatergic synaptic transmission is the major energy-consuming cellular process in the brain. Therefore, it is critical for neurons to couple synaptic activities with energetic metabolism, and to have adaptive mechanisms in response to metabolic stress and neuronal overexcitation.

Edited by lostfalco, 07 January 2014 - 04:19 PM.

[macropsia]

To any who have used them: did the effect of the peptides (i'm thinking of cerluten and pinealon) seem to persist beyond the course of administration?

-there seem to be suggestions from the inventor that they would/do, but whether this would translate to something subjectively noticeable I can't tell.

Edited by macropsia, 07 January 2014 - 05:56 PM.

[lammas2]

I have experimented a bit with Pinealon. However, I definitely can't give you a clear answer. The effects are quite subtle and could easily be caused by placebo effect or other substances I'm taking. I must also add, that every course of Pinealon was taken at the time of huge daily stress. Maybe it helped me to cope with the stress? Who knows... Soon I will get my masters degree and then I will try another course in a rather stress-free environment.

Are you taking the peptides? Do they have any effect on you?

[BigPapaChakra]

I'm highly interested in peptides (cerebrolysin seems awesome), so if anyone else has experience please share!

I should be getting a script filled out for the Fisher Wallace CES device (my doctor didn't know the exact paperwork needed, otherwise I'd already have one), and I'll be experimenting with that and updating everyone. I'm largely going to direct my research towards one thing at a time from now on, experiment with that, and utilize that to learn about other things (similar to LostFalco's comments earlier in this thread about Modafinil/BPC used to study nootropics). By the way, is there any real reason to not use low doses of Modafinil at my age? It seems like there is typically always the vague "if you're under (insert age), your brain isn't developed and you should't experiment with that", yet, all of our experiences and dietary choices also effect our brains in direct ways, so there's no way in avoiding changing your brains structure or function. Any input would be greatly appreciated.

Lastly, any experiences with NADH? Thanks!

[Nattzor]

I'm highly interested in peptides (cerebrolysin seems awesome), so if anyone else has experience please share!

I'm quite amazed that some peptides can survive in the stomach (noopept and the russian bioregulators). And yeah, cere seems awesome.

I should be getting a script filled out for the Fisher Wallace CES device (my doctor didn't know the exact paperwork needed, otherwise I'd already have one), and I'll be experimenting with that and updating everyone. I'm largely going to direct my research towards one thing at a time from now on, experiment with that, and utilize that to learn about other things (similar to LostFalco's comments earlier in this thread about Modafinil/BPC used to study nootropics). By the way, is there any real reason to not use low doses of Modafinil at my age? It seems like there is typically always the vague "if you're under (insert age), your brain isn't developed and you should't experiment with that", yet, all of our experiences and dietary choices also effect our brains in direct ways, so there's no way in avoiding changing your brains structure or function. Any input would be greatly appreciated.

I bought a cheap CES ($18 or so, shipping take ages though), probably not very good though. It only has 1-15 Hz though. Will update when I get and have used it for a while. Also looking at cheap ultrasound unit, but looks like they are too weak.

[hephaestus]

I thought noopept had really poor oral bioavailability?