13 replies to this topic

[MacD]

Sorry if i am posting in the wrong section or this is common knowledge around here, but i just found this and thought some members might like to read it.


http://smarteconomy....-aid-hydra.html


Sample Extract -

Today, hydrated C₆₀ fullerene is the most effective radioprotector as compared to all other known radioprotectors in the world, for example, Amifostine (USA) and some substances based on fullerene C₆₀ supposedly being developed now in Japan, USA and other countries. As compared to any of them, hydrated fullerene C₆₀ is at least (!) 100 times more effective and completely harmless, irrespective of the duration of its application, without any risk of undesirable side effects and overdosage.

Edited by MacD, 04 May 2013 - 10:09 PM.

[AgeVivo]

any peer reviewed article?

[VP.]

There are a few peer reviewed studies with some promising results. The radiation doses received by workers at Fukushima were so low that you would not see any short term bio-markers in the subjects with a very small increase in life time cancer risk. Fullerenes would not make much difference.

http://www.ncbi.nlm....radioprotective

[JohnD60]

I think it is reasonable to conclude that you are implying if not actually stating that Fukushima workers consumed hydrated fullerene and that it was promoted by the Japanese government, else why why would you post about it.

But all I can conclude from that blog post is
1. A company in the Ukraine that sells hydrated Fullerene claims that it is protective against radiation damage
2. Said company sent a letter to some agency head in Japan offering to supply (sell?) said hydrated fullerene to exposed workers.

I highly doubt any Japanese government entity promoted the use of hydrated fullerene for radiation exposure

[Logic]

There are 13 papers referenced here:
http://www.zimbio.co...saster 25 years

And 69 papers HYFN referenced here:
http://www.longecity...post__p__523477

[niner]

From the smarteconomy link that MacD posted at the top of the thread:

At the present time, we have initiated the procedure of registering this product in Russia. We are also aware that developments with respect to the use of fullerenes, and those that are somewhat similar to ours, are also taking place in Japan and another countries. However, all of them are still far from completion and their application in terms of public health services.

In the capacity of emergency aid, we would like to provide you with 10,000 complimentary packages (5 tons) of our product.

I found it interesting that there are "developments" in various forms of C60 in other countries. I wonder what all is going on, aside from Grigoriy Andrievsky's hydrated fullerene in Ukraine, and presumably soon to be Russia. Are any of those c60-oo?

Also note that they are donating the material. It's certainly good publicity for them.

[Walter Derzko]

any peer reviewed article?

Yes

see anti-radiation effects of Carbon 60 Hydrated Fullerenes

https://www.research...tro_and_in_vivo

[Walter Derzko]

any peer reviewed article?

OFFICIAL REPORTS ABOUT PRECLINICAL, CLINICAL TRIALS AND TESTING ON RADIOPROTECTIVE, NON-GENOTIOXIC PROPERTIES OF WATER SOLUTION OF HYDRATED C60 FULLERENE (see on IPAC LLC site http://www.ipacom.co...bout-c60hyfn/70) and pdf-file with “Some important results from pre- and clinical trials of hydrated C60 fullerene”( http://www.ipacom.co...trials_en.pdf).

[Walter Derzko]

any peer reviewed article?

More

Directory - International publications about radioprotective properties of fullerenes contains:

1. Višnja BOGDANOVIĆ, Karmen STANKOV, Ivana IˇCEVIĆ, Dragan ŽIKI,Aleksandra NIKOLIĆ, Slavica ŠOLAJIĆ, Aleksandar DJORDJEVIĆ and Gordana BOGDANOVIĆ. FULLERENOL C60(OH)24 EFFECTS ON ANTIOXIDATIVE ENZYMES ACTIVITY IN IRRADIATED HUMAN ERYTHROLEUKEMIA CELL LINE. J. Radiat. Res., 49, (2008) 321–327

2. Aaron P Brown, Eun Joo Chung, Mary Ellen Urick, William P Shield, Anastasia L Sowers, Angela Thetford, Uma T Shankavaram, James B Mitchell and Deborah E Citrin. RESEARCH EVALUATION OF THE FULLERENE COMPOUND DF-1 AS A RADIATION PROTECTOR. Radiation Oncology, 2010, 9 p.

3. Borbala Daroczi, Gabor Kari, Mary Frances McAleer, Jeffrey C.Wolf, Ulrich Rodeck, and Adam P. Dicker. IN VIVO RADIOPROTECTION BY THE FULLERENE NANOPARTICLE DF-1 AS ASSESSED IN A ZEBRAFISH MODEL. Clin. Cancer. Res., 12(23) (2006) 7086-7091.

4. G Albarran, V.A. Basiuk, E.V. Basiuk, J.M. Saniger. STABILITY OF FULLERENE UNDER IRRADIATION. Advances in Space Research, 33 (2004) 72-75.

5. Sanja Trajkovi´c, Silva Dobri´c, Vesna Ja´cevi´c, Viktorija Dragojevi´c-Simi´c, Zoran Milovanovi´c, Aleksandar Dordevic´. TISSUE-PROTECTIVE EFFECTS OF FULLERENOL C60(OH)24 AND AMIFOSTINE IN IRRADIATED RATS. Colloids and Surfaces B: Biointerfaces, 58 (2007) 39–43.

6. Li Xiao, Hiroya Takada, Kentaro Maeda, Mari Haramoto, Nobuhiko Miwa. ANTIOXIDANT EFFECTS OF WATER-SOLUBLE FULLERENE DERIVATIVES AGAINST ULTRAVIOLET RAY OR PEROXYLIPID THROUGH THEIR ACTION OF SCAVENGING THE REACTIVE OXYGEN SPECIES IN HUMAN SKIN KERATINOCYTES. Biomedicine & Pharmacotherapy 59 (2005) 351–358.

7. Loren K Mell & Benjamin Movsas. PHARMACOLOGIC NORMAL TISSUE PROTECTION IN CLINICAL RADIATION ONCOLOGY: FOCUS ON AMIFOSTINE. Drug Metab. Toxicol., 4(10) (2008) 1341-1350.

8. Q. Zhao, Y. Li, J. Xu, R Liu, W. Li. RADIOPROTECTION BY FULLERENOLS OF STYLONYCHIA MYTILUS EXPOSED TO γ-RAYS. J. Radial Biol., 2 (2005) 169-175.


Directory – Andrievsky G. and IPAC LLC publications about radioprotective properties of hydrated C60 fullerenes contains:

1. Grigory V. Andrievsky, Vadim I. Bruskov, Artem A. Tykhomyrov, Sergey V. Gudkov. PECULIARITIES OF THE ANTIOXIDANT AND RADIOPROTECTIVE EFFECTS OF HYDRATED C60 FULLERENE NANOSTUCTURES IN VITRO AND IN VIVO. Free Radical Biology & Medicine 47 (2009) 786–793.

2. G.V. Andrievsky, A.V. Zhmuro, L.V. Zabobonina. FIRST CLINICAL CASE OF TREATMENT OF PATIENT (VOLUNTEER) WITH RECTAL ADENOCARCINOMA BY HYDRATED C60 FULLERENES: NATURAL COURSE OF THE DISEASE OR NON-SPECIFIC ANTICANCER ACTIVITY? Message to the Symposium "Fullerenes in Biology and Medicine" of 197th Meeting of the American ECS (May 14-18, 2000, Toronto, Ontario, Canada). Abs# 700 (2 p.).

3. Analytical report IPAC LLC about C60HyFn non-toxicity (Russ), 25.02.2010, Kharkov, Ukraine, 2010, 12 p.(http://www.ipacom.co...alytical_ru.pdf).

4. IS FULLERENE TOXICITY A MYTH? NANOWERK Research and General News, August 15, 2007 (http://www.nanowerk....ewsid=2373.php# ).

5. OFFICIAL REPORTS ABOUT PRECLINICAL, CLINICAL TRIALS AND TESTING ON RADIOPROTECTIVE, NON-GENOTIOXIC PROPERTIES OF WATER SOLUTION OF HYDRATED C60 FULLERENE (see on IPAC LLC site http://www.ipacom.co...bout-c60hyfn/70) and pdf-file with “Some important results from pre- and clinical trials of hydrated C60 fullerene”( http://www.ipacom.co...trials_en.pdf).

[Turnbuckle]

 

any peer reviewed article?

Yes

see anti-radiation effects of Carbon 60 Hydrated Fullerenes

https://www.research...tro_and_in_vivo

 

 

 

Looking at the abstract--

 

The suppressing influence of C(60)HyFn on the formation of OH-radicals in water exposed to X-rays at doses of 1-7 Gy was assessed by determination of oxidation levels of coumarin-3-carboxylic acid. C(60)HyFn demonstrates apparent antiradical activity in vitro in the range of concentrations of 10(-11)-10(-6) M. Paradoxically, the .OH-removing efficacy of C(60)HyFn was in reverse correlation with fullerene concentration...

 

The second part of the present study was aimed to evaluate the overall radioprotective efficacy of C(60)HyFn in doses of 0.1 or 1 mg/kg b.w. injected intraperitoneally to mice either 1 h before or 15 min after lethal dose exposure of the X-ray (7 Gy) irradiation. Survival rate of the mice was observed at 30 day intervals after irradiation, while the weight gains of experimental animals were monitored as well. The most significant protective effect was demonstrated when 1 mg/kg dosage of C(60)HyFn was administered before irradiation. The outcome of the substance testing is 15% survival rate of irradiated animals at 30 days of observation, and prevention of noticeable weight loss characteristic for radiation impact, versus unprotected control animals. 

 

 

Which all seems less than exciting for 15% survival. And the 1mg/kg dosage is terribly expensive, right? For a two hundred pound man, this would be 91 mg. So how much would this cost?

[Kalliste]

"Paradoxically, the .OH-removing efficacy of C(60)HyFn was in reverse correlation with fullerene concentration..."

 

What does that mean?

[Turnbuckle]

I see once source selling a "concentrated solution" of hydrated fullerenes--"10 ml C60FWS, containing fullerene С60 in the concentrations: 14.4 mg/l (20 µM/l)" for $450.

 

This amounts to 0.144 mg at $3,125/mg. The cost to radio-protect one 200 pound man (to a 15% survival level) would then be $284,000. 

Edited by Turnbuckle, 28 February 2015 - 05:36 PM.

[normalizing]

i thought people on this forum buy their c60 from elsewhere for much cheaper. why give such expensive source

[shifter]

Is this talking about the same thing?

 

 

http://c60antiaging....homeopath-scam/