2 replies to this topic

[zorba990]

http://www.clinicale...68-7083-4-4.pdf

[Logic]

This is very interesting zorba990, but to get a reaction here generally takes some copy-pasting as most users seem loth to 'leave the reservation'.

Abstract:
Butyrate is a short chain fatty acid derived from the microbial fermentation of dietary fibers in the colon. In the last
decade, multiple beneficial effects of butyrate at intestinal and extraintestinal level have been demonstrated. The
mechanisms of action of butyrate are different and many of these involve an epigenetic regulation of gene
expression through the inhibition of histone deacetylase. There is a growing interest in butyrate because its impact
on epigenetic mechanisms will lead to more specific and efficacious therapeutic strategies for the prevention and
treatment of different diseases ranging from genetic/metabolic conditions to neurological degenerative disorders.
This review is focused on recent data regarding the epigenetic effects of butyrate with potential clinical
implications in human medicine.
Keywords: epigenome, histone deacetylase inhibitor, short chain fatty acids


Diet (fibers)--> Intestinal microflora (butyrate-producing bacteria)--> Butyrate production--> Epigenetic regulation of gene expression involved in:

Anticarcinogenic and chemopreventive effects
Anti-inflammatory effects
Effects on obesity, insulin resistance
Effects on cardiovascular diseases
Effects on immune system
Effects on inherited disorders
Neuroprotective effects
Effects on stem cells

Edited by Logic, 16 July 2013 - 01:30 PM.

[zorba990]

Thanks logic. I'm a bit swamped this week....