Ok so i found a very reliable source for this and will be placing an order for myself next week, anyone interested in chucking can pm me
#1
Posted 21 December 2013 - 02:46 PM
Ok so i found a very reliable source for this and will be placing an order for myself next week, anyone interested in chucking can pm me
#2
Posted 21 December 2013 - 04:25 PM
sponsored ad
#3
Posted 21 December 2013 - 04:40 PM
http://pubs.acs.org/....1021/jm101206p
when they refer to it's lead they mean 7,8DHF
#4
Posted 21 December 2013 - 04:53 PM
Ok, I'll send you a PM tomorrow, or PM me if you like.
#5
Posted 22 December 2013 - 02:14 AM
Just want to let you know that I'm also trying to get this. I think a combination of this and NSI-189 and maybe even Cerebrolysin would be like nectar of the gods. Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often. Effects should be impressive.A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
http://pubs.acs.org/....1021/jm101206p
when they refer to it's lead they mean 7,8DHF
#6
Posted 22 December 2013 - 12:57 PM
I think you are on the wrong track when you think the effects of such drugs on neurogenesis are directly linked to their antidepressive effect. I believe it's the calcium signalling that matters.Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often.
BTW, if someone should run out of money he/she could try butyric acid supplements, which raise BDNF expression in an epigenetic way.
#7
Posted 22 December 2013 - 01:53 PM
Just want to let you know that I'm also trying to get this. I think a combination of this and NSI-189 and maybe even Cerebrolysin would be like nectar of the gods. Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often. Effects should be impressive.A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect
http://pubs.acs.org/....1021/jm101206p
when they refer to it's lead they mean 7,8DHF
I agree although I have taken the oral form of cerebrolysin and couldn't continue due to extreme insomnia, but i'm prone to that anyway. It's amazing to think these drugs are literally physically changing the brain in a positive way, not just the chemical or electrical signalling. The only reason ssri's have any antidepressant effect is because they mildly effect the glucocorticoid receptor which mildly increases bdnf. A potent bdnf mimic or booster which does so directly without affecting other systems could effectively treat so man disorders including just general brain fog. It is possible that it could even increase cognition beyond the natural default position.
#8
Posted 23 December 2013 - 04:00 AM
I think you are on the wrong track when you think the effects of such drugs on neurogenesis are directly linked to their antidepressive effect. I believe it's the calcium signalling that matters.Just since 7,8-dihydroxyflavone is a full agonist at the TrkB site it should be used like once a week or so. Not too often.
BTW, if someone should run out of money he/she could try butyric acid supplements, which raise BDNF expression in an epigenetic way.
The calcium signalling is what regulates gene transcription yeah but mimicing or increasing bdnf takes care of all that upstream from it
#9
Posted 23 December 2013 - 09:32 AM
Some phospholipases activate PI3K independent from their production of IP3/DAG, and some can even translocate to the nucleus before doing so.The calcium signalling is what regulates gene transcription yeah but mimicing or increasing bdnf takes care of all that upstream from it
#10
Posted 23 December 2013 - 09:45 AM
#11
Posted 21 February 2014 - 06:48 AM
I'm also interested in 7,8-dihydroxyflavone. Mainly because its potent protection of dopamin producing neurons.
#12
Posted 21 February 2014 - 07:01 AM
#13
Posted 21 February 2014 - 08:03 AM
I will ask again has anyone found a good chemical analysis company? i'm just going to send them the rest of the money for the rest of the product anyway(for the sake of time) but i still want to have a third party analysis done. It looks extremely legit though , that's as much as i'll say right now!
Sk who have you spoken to that has tried it? i wasn't aware anyone had, i'd like to hear their experiences
#14
Posted 21 February 2014 - 04:40 PM
He's not directly associated with this site and is a former academic researcher from Arizona.
#15
Posted 21 February 2014 - 06:03 PM
Edited by sk_scientific, 21 February 2014 - 06:03 PM.
#16
Posted 22 February 2014 - 10:13 AM
#17
Posted 22 February 2014 - 09:14 PM
From those with whom I've spoken, there wasn't a perceived benefit in semi-acute dosing. But this is merely subjective feedback from few individuals on a short term schedule.
Well.. were these depressed or cognitively impaired people? If they were healthy people, that's not very indicative of its use for ameliorating neuro(psychiatric) issues.
#18
Posted 23 February 2014 - 06:51 AM
oh i think i know who you mean his name starts with n? i would love to have his contact info to compare notes that would be much appreciated SK
Please check your private messages. I will be sending you his email address shortly.
From those with whom I've spoken, there wasn't a perceived benefit in semi-acute dosing. But this is merely subjective feedback from few individuals on a short term schedule.
Well.. were these depressed or cognitively impaired people? If they were healthy people, that's not very indicative of its use for ameliorating neuro(psychiatric) issues.
You make an excellent point, but all I have to contribute is based upon someone else's subjective experience. Personally, had I the resources, I too would like to obtain this compound and try it out.
#19
Posted 23 February 2014 - 08:23 AM
#20
Posted 23 February 2014 - 08:53 AM
Also, do you hear the NGF "ear-ring"?
Edited by sk_scientific, 23 February 2014 - 08:54 AM.
#21
Posted 23 February 2014 - 09:43 AM
#22
Posted 23 February 2014 - 07:52 PM
#23
Posted 27 February 2014 - 10:21 PM
#24
Posted 27 February 2014 - 10:38 PM
#25
Posted 28 February 2014 - 01:22 AM
#26
Posted 07 March 2014 - 08:42 AM
definitely not cured in three days lol but i feel a lot better and it really feels like it is changing my brain for the better
That's great! Have the effects persisted? Would really appreciate an update, however short
#27
Posted 07 March 2014 - 09:22 PM
#28
Posted 07 March 2014 - 11:57 PM
Yes, the positive effects have persisted so far, i tried not taking it yesterday and didn't feel great all day and i had trouble sleeping last night.Been feeling better toda since i took it, I have noticed a metalic taste in my mouth lately i dunno if that's related in some way or not.
Good! Have you considered joining the Dihexa group buy? I'd imagine if one were to respond well to 7,8-DHF, there's a high likelihood of the same response happening with Dihexa (although it's MoA seems a bit unclear; it does have similar properties to BDNF&7,8-DHF - synaptogenesis).
Also, how is affecting dissociative symptoms? Or is it more of a general improvement?
#29
Posted 08 March 2014 - 03:53 PM
I didn't even think about dissociative symptoms which is a good thing, it hasn't been an issue lately the only real issue it left untouched is social anxiety, i'm going to add 98% icariin into the mix in different dosages to see if that helps. i'd like to build a small stack of flavonoids that cover all the core symptoms of anxiety/depression to offer something to our members(and others) that is reliable and effective. The fact that it's natural is just a plus i have no major preference, it does make sense that flavonoids would be effective though, plants are a huge melting pot of chemical diversity much more diverse than the labs of our society. Animals and plants evolved together but plants have been around longer and are more chemically diverse, many of our brain chemicals most likely developed in plants first and were incorporated into the brain and then changed slightly over time. It's no coincidence that frogs/toads and mushrooms both produce tryptamines, or for that matter humans and mushrooms.
A quick update i spoke to the company after being ignored for quite a while and they said it was being sent out right away.
Here are a few flavonoids i am looking into
nobiletin- http://www.ncbi.nlm....les/PMC3613093/
deoxygedunin- http://www.plosone.o...al.pone.0011528
icariin- http://www.ncbi.nlm....pubmed/21256148
or more specifically icaritin- http://www.ncbi.nlm....pubmed/24333105 http://yadda.icm.edu...63-1bbd382f89a0
oroxylin a- http://www.ncbi.nlm....pubmed/23543630
amentoflavone- http://www.ncbi.nlm....pubmed/22944105
2′-Methoxy-6-methylflavone
3-Hydroxy-2'-methoxy-6-methylflavone
6,3'-dinitroflavone
sponsored ad
#30
Posted 08 March 2014 - 05:01 PM
Good to know it's being sent out as I'm eager to try it
Edited by formergenius, 08 March 2014 - 05:01 PM.
Also tagged with one or more of these keywords: bdnf, hippocampus, neurogenesis
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users