57 replies to this topic

[Adamzski]

I can (and do) get by without much sleep (4-5 hours/night) during the work week, and I'm not drowsy during an active (working) day, but I seem to be able to sleep more easily and longer now, and more easily give in to sleepiness, when it's possible.

Exactly like I was, I did not feel so much more tired all the the time but when sleep called on me it was impossible to fight, I usually would be tired and consider or feel like going to bed but either general anxiety about not being successful yet or a specific reason like needing to get something done by the next day, these things would keep me from going to bed. But when I was taking C60 I did not care, It was like nothing could stop me from going to bed at night.

Edited by Adamzski, 09 January 2014 - 10:34 PM.

[katzenjammer]

Maybe it's causing low blood sugar? Perhaps mediated by some change precipitated by the c60?

Low blood sugar may explain the tiredness/fatigue as well as the headaches I've heard about on this board.

If you've already explored this possibility, sorry.

Edited by katzenjammer, 10 January 2014 - 12:31 AM.

[cuprous]

Can you folks who are getting fatigued from c60oo comment on your exercise capacity if you do exercise? By and large feedback from c60 has been positive vis a vis strength or endurance increases. What else are you noticing? Anything positive? It doesn't seem like folks are feeling sickly but fatigue is not a desired effect of a supplement that is supposed to be operating on the mitochondria!

[niner]

Can you folks who are getting fatigued from c60oo comment on your exercise capacity if you do exercise? By and large feedback from c60 has been positive vis a vis strength or endurance increases. What else are you noticing? Anything positive? It doesn't seem like folks are feeling sickly but fatigue is not a desired effect of a supplement that is supposed to be operating on the mitochondria!

Now that I think about it, there was a period after I started taking c60 when I did sleep more. I think it kind of faded away, though. It reminded me of when I was a kid- at night I'd get really sleepy, and I'd go to bed and sleep. There were a few days when I took a nap in the afternoon. I didn't even connect it to c60, although in retrospect it sounds kind of like what other people are reporting. Cuprous, regarding your question, I notice it in a lot of ways. When I'm doing something involving a lot of muscle work, like rowing a boat or shoveling snow, I feel like a machine that can just keep cranking out the power as long as I want. I used to be really bothered by postural hypotension, and c60 made that go away. My lungs are in better shape and I rarely get sick now. I wouldn't describe the sleepiness as fatigue at all. I have plenty of energy. The sleep thing was more like my body telling me that it wanted to sleep now, so I did. It almost always happened at night when I should have been heading off to bed anyway.

Maybe it's causing low blood sugar? Perhaps mediated by some change precipitated by the c60?

Low blood sugar may explain the tiredness/fatigue as well as the headaches I've heard about on this board.

If you've already explored this possibility, sorry.

No, it's not that. I know what low blood sugar feels like (not particularly good...) I think I remember one person who reported headaches, but no one else I can remember. Headaches are certainly not a common complaint with c60.

[cuprous]

Now that I think about it, there was a period after I started taking c60 when I did sleep more. I think it kind of faded away, though. It reminded me of when I was a kid- at night I'd get really sleepy, and I'd go to bed and sleep. There were a few days when I took a nap in the afternoon. I didn't even connect it to c60, although in retrospect it sounds kind of like what other people are reporting. Cuprous, regarding your question, I notice it in a lot of ways. When I'm doing something involving a lot of muscle work, like rowing a boat or shoveling snow, I feel like a machine that can just keep cranking out the power as long as I want. I used to be really bothered by postural hypotension, and c60 made that go away. My lungs are in better shape and I rarely get sick now. I wouldn't describe the sleepiness as fatigue at all. I have plenty of energy. The sleep thing was more like my body telling me that it wanted to sleep now, so I did. It almost always happened at night when I should have been heading off to bed anyway.

Niner, do you have any hypothesis as to this sleepiness? I also have felt (with emphasis on psychosomatic potential) more power while swimming or doing other strength and endurance activities (swimming is both) so have bought on to the notion of c60 being a net positive.

I too have experienced the vertigo sensations others have reported -- 10-20 seconds of odd disorientation coupled with sensations of something like nausea -- but they have not reappeared.

I dose 1.5mg once or a few times a week. I don't really adhere to a regimen as it seems like nobody has a clue as to what's optimal.

More to the point I think it is time I bought a blood glucose kit as I have also felt episodic sleepiness. Any causality with c60 is impossible to even hypothesize though as I take lots of supplements and tend to burn the candle at both ends.

It's blind conjecture but perhaps c60's recharging of certain cellular capabilities in turn reestablishes psychosomatic intelligence as to bodily state. Do we ever sleep as wonderfully as we did when we were much younger?

[kenj]

I can (and do) get by without much sleep (4-5 hours/night) during the work week, and I'm not drowsy during an active (working) day, but I seem to be able to sleep more easily and longer now, and more easily give in to sleepiness, when it's possible.

OK. I tried bumping up my dose to taking it everyday to test, and the last couple days I have REALLY been looking forward to some ZZZZZ's. Oh man. 6AM felt like 2AM like you wouldn't believe.

Before C60 I would get 6-7 hours of sleep and be rested, and while 'on' C60 it's really been hell to get up after 6 hours. :p I could EASILY sleep for 9-10 hours if possible.
However doesn't C60 'amplify' or at least interact with other substances? I take 5-HTP and melatonin (and other stuff) intermittently, so maybe -in my case- that plays a part.

[cuprous]

I can (and do) get by without much sleep (4-5 hours/night) during the work week, and I'm not drowsy during an active (working) day, but I seem to be able to sleep more easily and longer now, and more easily give in to sleepiness, when it's possible.

OK. I tried bumping up my dose to taking it everyday to test, and the last couple days I have REALLY been looking forward to some ZZZZZ's. Oh man. 6AM felt like 2AM like you wouldn't believe.

Before C60 I would get 6-7 hours of sleep and be rested, and while 'on' C60 it's really been hell to get up after 6 hours. :p I could EASILY sleep for 9-10 hours if possible.
However doesn't C60 'amplify' or at least interact with other substances? I take 5-HTP and melatonin (and other stuff) intermittently, so maybe -in my case- that plays a part.

If c60 is making you feel so lethargic in the AM then consider dropping the 5-HTP and melatonin? Seems like you are getting an over-adequate supply of somniferous agents.

[Adamzski]

Can you folks who are getting fatigued from c60oo comment on your exercise capacity if you do exercise? By and large feedback from c60 has been positive vis a vis strength or endurance increases. What else are you noticing? Anything positive? It doesn't seem like folks are feeling sickly but fatigue is not a desired effect of a supplement that is supposed to be operating on the mitochondria!

At the time and for a long time prior to taking it I was doing no exercise at all, no hardcore sex nothing, just sitting at a computer constantly and not even commuting as I work from home.
It sounds a little optimistic what some people seem to be saying that C60 amplifies everything either exercising or resting but who knows.

Did not feel sickly, when I was in Sydney I went through a sudden climate change Korea humid 30c+ to the middle of Sydney winters ~6c at its coldest. In AU it is colder than the actual temperature as we never use heating or cooling and don't wear/own warm clothes, I slept in a freezing factory with sick people all around me, I would usually expect to get sick under these circumstances.

Cant say I felt very much from the C60, the sleep is a positive to me.

[Skypp]

I am not one of you science geniuses out there in Longecity World, but I do read. Anyway, could it be that C60 is some kind of adaptagen in that it adapts to whatever a body might need and bolsters that area? Some people are sleeping more, some less. Inflammations have gone down, hair has grown back, or not... so many different responses. I do not think they are placebos responses, they are real. The spherical carbon atoms (a building block of all life) perhaps conform to rebuilding damage or deterioration in the body based on area of need or even intention. I am basing this on my own responses to C60 which was first to be sleepy, then very energized. It has repaired sun damage on my skin, and seems to have helped my animal family members too... wondering why no one here has mentioned using C60 in conjunction with Methylene Blue? Instead of the fish oil, I've occasionally done a dropper of C60. seems to be synergistic. Anyone else try it?

[Adamzski]

You say that it has repaired sun damage on your skin. Do you have photos of this that you are using to compare? How much would you say that your skin has improved and how long have you taken C60 and at what dosage/frequency?

I will be buying some Methylene Blue in the next few days and will have C60 within a few weeks, will be interesting to see if there are any effects. I have not seen anyones reports of taking them together.

[Skypp]

Little shy of posting pictures of my freckles online...lol. I do not have extensive sun damage, just very fair-skinned and I live in Southern California. I am taking about one dropper a day of C60. There seems to be some synergy with MB. I'm still experimenting, but this is my basic protocol:

Morning: 1) 2 drops of MB (from a company called "animal + pharm" got it on ebay, good pure stuff) in a glass of Pelegrino mixed with 1/2 packet of EmergenC powder. 2) I also mix in a few drops of Willard water to make it work better. 3) Fish Oil or C60 4) 1 AlCar capsule, and Piracitam. I do the same about three times per day. I'm liking the C60 with it, seems to give the weirdest most prolonged productivity I've ever experienced... up at 5:45 am and working, not at all tired, until late evening and able to do creative thinking and make quick, accurate decisions. Another thing is that I used to be incapacitated by stress. My go-to relief for any extreme stress was sleep, too much of it, followed by foggy brain. A lot of things that used to cause me stress (just living in a big city and all that goes with it) no longer throw me off. I feel extremely directed and suffer less from feeling indecisive or allowing my philosophic thoughts to take over my brain such that I cease to actually do stuff. Can this all be attributed to MB and/or C60? I rather doubt it. I believe that both substances work in some kind of mechanism with one's intention and true will. That is why there are such varied experiences. This is not metaphysical, but the real dynamic of body/mind. We cannot expect simple empirical experiments to yield the whole truth. Even the rats on C60 reacted somewhat differently. Humans have mind which cannot be taken out of the equation or you are left with only a half truth. What am I saying? These things have enormous potential to take humans to a new level. If you are negative and angry, it might take you further into that, or at the very least, nothing will happen. C60 is a very interesting molecular formation. It bears a lot of resemblance to the esoteric "flower of life" also known in Cabala. Perhaps if you combine your intake with a very clear idea of what you want...

[Skypp]

These forums are so mysterious, you try to share some experiences and thoughts in an honest way, and somebody gives you the thumbs down. Why? Because you tried to offer what you knew in a forthright manner? Yuck. I'll go back to my little corner now. Have fun with your "logic".

[Invariant]

Welcome to the internet, Skypp. Don't let a single downvote get to you, it doesn't mean anything. Who knows what the reason for it was. Remember though, that it is very difficult to communicate philosophical thoughts clearly, and it is quite easy to come across as "rambling" when you try to compact it into a single paragraph on an internet forum..

Regarding your experiences, I must say they sound rather like the effects of piracetam. Could that be it? I certainly notice increased productivity and wakefulness on it.

[Logic]

I too noticed an increase in sleep.
It was as though I was 6 year old again in that I would be busy and all of a sudden just keel over and sleep like a rock for a while. Falling asleep at night was as easy as it used to be at the age of 6 too.

As the repair work is done during sleep I just figured that the internal repair systems had been boosted and wanted to get to work..?
Could that be the case?

Edited by Logic, 22 January 2014 - 04:53 PM.

[ambivalent]

I recently ingested a small amouunt of c60 for the first time in several months and felt pretty sleepy over a couple of days, though my patterns are irregular so hard to state with real conviction. I also wondered whether it was, as you say, to force us into repair mode.

[Skypp]

Welcome to the internet, Skypp. Don't let a single downvote get to you, it doesn't mean anything. Who knows what the reason for it was. Remember though, that it is very difficult to communicate philosophical thoughts clearly, and it is quite easy to come across as "rambling" when you try to compact it into a single paragraph on an internet forum..

Regarding your experiences, I must say they sound rather like the effects of piracetam. Could that be it? I certainly notice increased productivity and wakefulness on it.

Hi~ I've taken Piracetam for years and I like it, but these particular effects are new. I'm beginning to see (feel) that both MB and C60 work by enhancing things you may already be taking. If you combine C60 with MB, it doesn't make you sleepy. If you take C60 at night with melatonin or magnesium, you sleep as deeply as a child.

I recently ingested a small amouunt of c60 for the first time in several months and felt pretty sleepy over a couple of days, though my patterns are irregular so hard to state with real conviction. I also wondered whether it was, as you say, to force us into repair mode.

Try taking a dropper of C60 in the morning with good, brewed tea or coffee, and/or methylene blue. You will not be sleepy. If you take it at night with cal/mag and melatonin, you will drop into deep sleep very quickly.

[Skypp]

I too noticed an increase in sleep.
It was as though I was 6 year old again in that I would be busy and all of a sudden just keel over and sleep like a rock for a while. Falling asleep at night was as easy as it used to be at the age of 6 too.

As the repair work is done during sleep I just figured that the internal repair systems had been boosted and wanted to get to work..?
Could that be the case?

My personal experience is that the sleepiness from C60 is repair sleep. If you feel good when you wake up, it is most likely repair sleep. If you feel groggy and tired all day, it wasn't quality sleep. For many, many reasons, many modern humans are sleep deprived. This has to do with the room not getting dark enough (any light in the retina, even with closed eyes, will keep you from getting into a deep sleep). Electromagnetic pollution from cell phones and computers, not enough exercise and low quality diet are also reasons for not sleeping well. If C60 is helping you sleep deeply, you may need it and not even know that you you did.

[Adamzski]

I too noticed an increase in sleep.
It was as though I was 6 year old again in that I would be busy and all of a sudden just keel over and sleep like a rock for a while. Falling asleep at night was as easy as it used to be at the age of 6 too.

As the repair work is done during sleep I just figured that the internal repair systems had been boosted and wanted to get to work..?
Could that be the case?

That is exactly as I would describe it, I could sleep on busses and even caught myself dozing off sitting at a bus stop.
I have never in my life been the type of person to even fall asleep watching TV or sitting in a comfy chair etc

What would make people think that the sleep is a good thing?

Is there any other substance or treatment that makes you sleep along with some benefit?

If you went to your doctor and said that suddenly I need to sleep all the time and I am sleeping 12 or more hours per day they would be concerned and want to get to the bottom of whats happening.

[katzenjammer]

So, I now know what people mean by the c60 induced sleepiness; at first it had me very wired and I really had to go off it for a while and ramp up back slowly. Unable to sleep, etc. But then over the course of a month or so I started developing the sleepiness/unusual tiredness that has been spoken of in this thread.

So, I took some NT Factor - had a bottle, and it never really did much for me - and it seems to have completely eliminated the abnormal sleepiness/fatigue. This is the stuff I mean (I hope it's okay to post this) http://ntfactor.com/...magedCells.aspx

So if this stuff works for other people on c60, perhaps it may point to what is going on to cause this unwonted side effect?

EDIT: I should also mention that it's been 5 days since I started taking NT additionally; this energizing effect hasn't lessened, if anything I feel better everyday. Of course, this could still be placebo. Methinks time will tell.

EDIT II: I don't personally think this c60-induced tiredness is a "good sleepiness" - I have long experience with IPA/GRF peptide-induced sleepiness, which is transient and profound and leads to the kind of sleep one regularly experienced as a child. I know what that feels like.

THIS is not that sort of thing; as I see it, the c60-induced sleepiness is more akin to a profound and unrelenting fatigue; to me it feels very much like what aging in others looks like how it feels: diminishing, chronic, never quenched through sleep, etc.

Edited by katzenjammer, 19 February 2014 - 06:22 PM.

[Hebbeh]

If C60/EVOO has some effect on protein folding, it could explain the connection to sleep (especially in older or previously sleep deprived individuals) among other possible positive health effects.

http://www.scienceda...40220132538.htm

Study in fruitflies strengthens connection among protein misfolding, sleep loss, and age

Date:
February 20, 2014

Source:
University of Pennsylvania School of Medicine

Credit: Jini Naidoo, Ph.D., Perelman School of Medicine

Protein misfolding is a characteristic of several age-related neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and as it turns out, also associated with sleep deprivation.

Pulling an "all-nighter" before a big test is practically a rite of passage in college. Usually, it's no problem: You stay up all night, take the test, and then crash, rapidly catching up on lost sleep. But as we age, sleep patterns change, and our ability to recoup lost sleep diminishes.

Researchers at the Perelman School of Medicine, University of Pennsylvania, have been studying the molecular mechanisms underpinning sleep. Now they report that the pathways of aging and sleep intersect at the circuitry of a cellular stress response pathway, and that by tinkering with those connections, it may be possible to alter sleep patterns in the aged for the better -- at least in fruit flies.

Nirinjini Naidoo, PhD, associate professor in the Center for Sleep and Circadian Neurobiology and the Division of Sleep Medicine, led the study with postdoctoral fellow Marishka Brown, PhD, which was published online before print in the journal Neurobiology of Aging.

Increasing age is well known to disrupt sleep patterns in all sorts of ways. Elderly people sleep at night less than their younger counterparts and also sleep less well. Older individuals also tend to nap more during the day. Naidoo's lab previously reported that aging is associated with increasing levels of protein unfolding, a hallmark of cellular stress called the "unfolded protein response."

Protein misfolding is also a characteristic of several age-related neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and as it turns out, also associated with sleep deprivation. Naidoo and her team wanted to know if rescuing proper protein folding behavior might counter some of the detrimental sleep patterns in elderly individuals.

Using a video monitoring system to compare the sleep habits of "young" (9 days old) and "aged" (8 weeks old) fruit flies, they found that aged flies took longer to recover from sleep deprivation, slept less overall, and had their sleep more frequently interrupted compared to younger control animals. However, adding a molecule that promotes proper protein folding -- a molecular "chaperone" called PBA -- mitigated many of those effects, effectively giving the flies a more youthful sleep pattern. PBA (sodium 4-phenylbutyrate) is a compound currently used to treat such protein-misfolding-based diseases as Parkinson's and cystic fibrosis.

The team also asked the converse question: Can protein misfolding induce altered sleep patterns in young animals. Another drug, tunicamycin, induces protein misfolding and stress, and when the team fed it to young flies, their sleep patterns shifted towards those of aged flies, with less sleep overall, more interrupted sleep at night, and longer recovery from sleep deprivation.

Molecular analysis of sleep-deprived and PBA-treated flies suggested that PBA acts through the unfolded protein response. PBA, Naidoo says, had two effects on aged flies: it "consolidated" baseline sleep, increasing the total amount of time slept and shifted recovery sleep, after sleep deprivation, to look more like that of a young fly.

"It rescued the sleep patterns in the older flies," she explains.

These results, Naidoo says, suggest three key messages. First, sleep loss leads to protein misfolding and cellular stress, and as we age, our ability to recover from that stress decreases. Second, aging and sleep apparently form a kind of negative "chicken-and-egg" feedback loop, in which sleep loss or sleep fragmentation lead to cellular stress, followed by neuronal dysfunction, and finally even poorer-quality sleep.

Sleep recharges neuronal batteries, Naidoo explains, and if a person is forced to stay awake, those batteries run down. Dwindling physiological resources must be devoted to the most critical cell functions, which do not necessarily include protein homeostasis. "Staying awake has a cost, and one of those costs is problems with protein folding."

Finally, and most importantly, she says these results suggest -- assuming they can be replicated in mice and humans -- that it may be possible using drugs such as PBA to "fix sleep" in aged or mutant animals.

"People know that sleep deteriorates with aging," Naidoo says, "But this might be able to be stopped or reversed with molecular chaperones." Her team is now looking to determine if a similar situation exists in mammals and if better sleep translates into longer lifespan.

Story Source:
The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.

Journal Reference:

• Marishka K. Brown, May T. Chan, John E. Zimmerman, Allan I. Pack, Nicholas E. Jackson, Nirinjini Naidoo. Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiology of Aging, 2013; DOI: 10.1016/j.neurobiolaging.2013.12.005

Edited by Hebbeh, 21 February 2014 - 02:22 AM.

[niner]

Thanks for that report, Hebbeh. I was wondering if there was a biological pathway that we develop in our late teens that allows us to stay awake, even when our body would prefer we didn't. What if there was, and c60 interfered with it? That could explain both the sleepiness that we've noticed from c60 as well as suggesting yet another mechanism by which it could contribute to longevity. I wonder how much Baati's rats slept, compared to controls...

[cuprous]

EDIT II: I don't personally think this c60-induced tiredness is a "good sleepiness" - I have long experience with IPA/GRF peptide-induced sleepiness, which is transient and profound and leads to the kind of sleep one regularly experienced as a child. I know what that feels like.

THIS is not that sort of thing; as I see it, the c60-induced sleepiness is more akin to a profound and unrelenting fatigue; to me it feels very much like what aging in others looks like how it feels: diminishing, chronic, never quenched through sleep, etc.

Subjective reports are usually to be taken with a grain of salt or dismissed outright. In our case they're pretty much all we've got. The more subjective comments we can get on the nature of the feeling of sleepiness, the quality of the subsequent sleep, and overall sense of well being the better of we'll be.

Your description of what it feels like to you is quite apt and also a bit worrisome. We all know how the elderly will nod off pretty much anywhere. Is the tendency to nap that some of us are feeling the beneficial conk-out of a 6 year old or the somniferousness of a degrading biological system?

[katzenjammer]

EDIT II: I don't personally think this c60-induced tiredness is a "good sleepiness" - I have long experience with IPA/GRF peptide-induced sleepiness, which is transient and profound and leads to the kind of sleep one regularly experienced as a child. I know what that feels like.

THIS is not that sort of thing; as I see it, the c60-induced sleepiness is more akin to a profound and unrelenting fatigue; to me it feels very much like what aging in others looks like how it feels: diminishing, chronic, never quenched through sleep, etc.

Subjective reports are usually to be taken with a grain of salt or dismissed outright. In our case they're pretty much all we've got. The more subjective comments we can get on the nature of the feeling of sleepiness, the quality of the subsequent sleep, and overall sense of well being the better of we'll be.

Your description of what it feels like to you is quite apt and also a bit worrisome. We all know how the elderly will nod off pretty much anywhere. Is the tendency to nap that some of us are feeling the beneficial conk-out of a 6 year old or the somniferousness of a degrading biological system?

indeed, well.... I suppose for me the relentless nature of it has me thinking it's the latter (fatigue not healthy sleepiness); it doesn't come in waves; nor does sleep itself seem to really "quench" it. I hope I'm wrong to be honest. On the other hand, the phospholipids I'm taking really seem to help - A LOT. Again, this is indeed very subjective; however, my experience is that subjective/placebo type responses wear off rather quickly.

Edited by katzenjammer, 21 February 2014 - 02:18 PM.

[RickyFitts76]

So, I now know what people mean by the c60 induced sleepiness; at first it had me very wired and I really had to go off it for a while and ramp up back slowly. Unable to sleep, etc. But then over the course of a month or so I started developing the sleepiness/unusual tiredness that has been spoken of in this thread.

So, I took some NT Factor - had a bottle, and it never really did much for me - and it seems to have completely eliminated the abnormal sleepiness/fatigue. This is the stuff I mean (I hope it's okay to post this) http://ntfactor.com/...magedCells.aspx

So if this stuff works for other people on c60, perhaps it may point to what is going on to cause this unwonted side effect?

EDIT: I should also mention that it's been 5 days since I started taking NT additionally; this energizing effect hasn't lessened, if anything I feel better everyday. Of course, this could still be placebo. Methinks time will tell.

EDIT II: I don't personally think this c60-induced tiredness is a "good sleepiness" - I have long experience with IPA/GRF peptide-induced sleepiness, which is transient and profound and leads to the kind of sleep one regularly experienced as a child. I know what that feels like.

THIS is not that sort of thing; as I see it, the c60-induced sleepiness is more akin to a profound and unrelenting fatigue; to me it feels very much like what aging in others looks like how it feels: diminishing, chronic, never quenched through sleep, etc.

 

Could you update plz on your experience with c60 + nt factor. 5 days is a short time and i too an getting this extreme tiredness. I'm 10wks on c60. First 8 were great. Thank you
 

[Nietzsche]

My first couple of days on c60 I basically passed out (not literally, just REALLY tired) at 4-6pm in the afternoon (a few hours after I dosed the c60) and woke up the following late morning/early afternoon. So about 20 hours one time, a little less another time, and in both instances I could have kept sleeping.

 

This happened on sub-MG doses, I dosed for a few days my first week then stopped and will try weekly dosing until this vial is gone.

 

I'm curious as to whether people think this was a good sign or not. It can't possibly be a coincidence as this has never happened to me before, ever. Perhaps I just needed the sleep...

[bariotako]

c 60 is very dangerous, you can get a cancer 

[Nietzsche]

There seem to be lots of people on this forum who just mark posts as "Dangerous" or "Pointless" without contributing anything substantive to the conversation. Any explanations regarding how explaining that c60 made me sleepy is "Dangerous" would be welcome.

 

Perhaps we can continue to talk about c60's effects on sleep, since that's what the topic is about...

Edited by Nietzsche, 29 March 2018 - 05:44 AM.

[RickyFitts76]

So I'm still curious about why c60 went from such a postive to negative response within my body over time. I have been researching other sod2 mimics as i do have that gene SNP. Please forgive my mistakes in correct labels or anything else when i'm trying to explain things. I have a brain injury from anti depressants as well as chronic fatigue and brain fog. I do ok if i'm typing my thoughts out but i will probably be way off a lot while using this forum. 

Anyway, i recall early on in my descend into chronic fatigue one of my tests saying my iron levels where really high. I remember thinking that was strange at the time as i didn't eat a lot of meat and even had a stint being vegan trying to see if that helped my fatigue. Fast forward 8yrs and after doing my23andme test one of the recommedations for something that came up was manganese supplementation. I started that sometime towards the end of 2017 maybe. Christmas day i begun  taking c60 and had a positive response straight away. Energy, mood, cognitve ability. This had happened before earlier in the year but after two or three days it started making me tired. Well this time, i took it daily for 8wks and had a great summer hear in australia. So much fun after being so

limited for so long due to my health. I also could drink beer like a sailor without consequences it seemed, which was totally new in my 41yrs. But after a while i started to not feel the same. Energy, mood etc faded and then after a couple weeks, even taking 1ml would have a very energy and mood zapping response. I was taking 5ml previously no probs. I would space out my use, increaseing each time by a further day. Eventually i got up to 2wks break and gave up. Was over the 3day consequences each time. But now thinking back, i recall i was supplementing with manganese during this time on c60 and leading up to it, and haven't any other time. I don't know how long exactly afterwards but it would have been no  more than 3wks from when i ran out of manganese, the c60 stopped giving positive results and became increasingly negative. 

I'm no scientist, have zero education, just a guy trying to work this shit out and have some quality of life. I know there's a relationship and interaction between iron and manganese in the body, and i know that the sod2 pathway has manganese as a key part of it. I don't understand it fully but i believe the superoxide is the metabolic waste from energy production in the mitochondria. I and a percentage of others who have the sod2 polymorphism snp have significant less ability to produce the enzyme to deal with this and other oxidive stresses. A domino effect of other issues can and does happen but won't list. So, c60 seems to be one of the few things that mimic the action and roll of this enzyme which felt amazing to me. I've searched online a lot this weekend for anything that might explain this hunch or suspicion to be possible and ive come across this one here.  http://www.jbc.org/c...4/34/22633.full

I can type pretty well, my injury doesn't affect that too much. But my working memory has been smashed so reading is a real strain. I was hoping someone who has a personal interest and shared similar experience with c60 could take a look at it and tell me what they think. Of course i'm hoping it might ultimately be the answer to this strange problem with c60 we're having, but also know good chance there isn't and apologies in advance if it's just a waste of time.

I know i can just start supplmenting with manganese again to know, but it's the weekend and i can only get it to me online which may take close to a week to arrive. Even longer to build up in my system. In meantime, can't hurt to rule out a theory.

cheers.

Edited by RickyFitts76, 12 August 2018 - 10:48 AM.