23 replies to this topic

[xm_suarez]

I'm looking for a bit of guidence here. A family member of mine (49 yo male) has been struck by cancer. It has been detected in the lungs, head/neck and liver. It probably originates from the lungs (he's a smoker) and test results are being awaited for more details.

 

He has been progressively losing muscle function in the lower body these last few weeks/months which is how (eventually) the cancer was detected. Doctors think the mass in the head/neck is causing the paralysis and he underwent his first radiation therapy targetting that area yesterday.

 

Things are looking grimm so I have been searching the internet and these forums for ways to improve his odds but I'm afraid I'm a little out of depth here so I would really appreciate ANY input.

 

I have read about Sodium Selenite, ketogenic diet, B17 and DCA among other things...

 

Again, any type of input would be really appreciated.

 

 

 

 

 

[resveratrol_guy]

Unfortunately it sounds like this thing has spread beyond the point at which remission is medically plausible. OTOH, there are surely therapies that will extend life and indeed extend healthspan. In a such a desperate situation, the following search terms come to mind: graviola (soursop) (allegedly causes demyelination as its price for antitumor activity), carbon 60 olive oil, indole-3-carbinol, bitter gourd, pterostilbene, resveratrol, filgrastim, cancer immunotherapy, 99% dark chocolate, moringa oleifera, ExAblate ultrasound surgery (Yoav Medan), and irreversible electroporation of tumors. And needless to say, a hardcore low-sugar organic vegetable juice regimen. (But would you want to spend your last months or years drinking radish and broccoli juice?)

 

With some lung cancers, beta carotene accelerates tumor growth, so this may complicate the vegetable intake recommendation, although the same vegetables which are rich in this compound also invariably provide other antitumor compounds as well.

 

Other than that, he may want to contact the Cryonics Institute for a lottery ticket to resurrection.

 

I wish him the best, under the circumstances.

 

Edited by resveratrol_guy, 11 November 2014 - 03:01 AM.

[Logic]

A friend of mine had lymphoma (now cured?) that went into remission with conventional therapy and then came back.
He used the stack recommended here:
http://www.lef.org/Protocols
plus Mebendazole:
http://www.longecity...ndpost&p=593124 (Read the whole thread; the dog lived to old age after being given 2 weeks to live)
and 'Low dose Lithium' Orotate (highly protective of healthy cells, but kills pre/cancerous cells)

My friend says his lymph nodes throbbed for about a month and then just stopped. He applied for life insurance and got it even though they were aware of the Lymphoma and checked for any trace of it thoroughly without finding any trace of it.

I would also read 'Slaying two dragons with one stone - How to prevent cancer and aging with the same strategy'you can find part 1. 2 & 3 here:
http://www.anti-agin...lls.com/page/4/
 
This is also VERY interesting:
http://www.longecity...therapy-target/

That is enough reading until we know exactly what cancer it is.

[resveratrol_guy]

and 'Low dose Lithium' Orotate (highly protective of healthy cells, but kills pre/cancerous cells)

That's surprising if it's true, considering that Lithium upregulates mTOR, according to the brain chart. Perhaps that's the case because it also upregulates autophagy. OTOH, bitter gourd inhibits mTOR (but also purportedly upregulates autophagy) and is considered to be anticancer and probably prolongevity. Or maybe this just goes back to the factoid that better brain health is conducive to longer life, for commonsense reasons.

Edited by resveratrol_guy, 11 November 2014 - 02:56 PM.

[xm_suarez]

Thanks a lot guys. I will look into your suggestions.

[resveratrol_guy]

Logic, I've been reading your threads linked above. There's a lot to absorb there, and it looks like high-value information for anyone confronted with cancer. In particular, on 5/13/2013, you said "Its important to use a multiple substances to fight cancer; so as to block all means of mutation/escape IMHO." I just want to echo those brilliant words here, lest common sense get lost in the myriad of therapy options. It never did make sense to me that cancer therapy is almost invariably of the extend-and-pretend variety: try drug X until your cancer cells find a way around it, then try Y, then Z... then die. Whereas, if one were to take X, Y, and Z all at once, the probability of the cancer (which is, among other things, an analog quantum computer) finding a way around X and Y and Z before getting killed by the immune system or by virtue of its own dysfunction would appear to be a lot less. But this conflicts with the "conservative" do-almost-nothing approach of conventional medicine.

 

So to put it simply, the serial-vs-parallel therapy tradeoff is basically the choice between (1) a high likelihood of death after a series of drugs which will likely extend life for months-to-years while at fantastic cost to finances and personal comfort vs (2) severely uncomfortable and perhaps equally expensive strong medicine for a short while with an elevated short term mortality rate but an increased probability of total remission. It's not an easy decision, and depends on the cancer and therapies in question, but it's important for people to understand that this choice actually exists, whereas option #1 is generally presented as the only choice apart from just giving up.

 

[Logic]

Thx RG.

Yes; attacking the cancer from every angle you can certainly makes the most sense to me.
One drug may kill off 99.9% of the cancerous cells, but there will always be 1 or 2 that by pure chance will have a mutation that allows then to survive the treatment. Then the cancer comes back and is immune to whatever worked the 1st time.

Here is another interesting perspective that fits in well with the re-starting mitochondria idea:
http://www.longecity...ndpost&p=685159

[resveratrol_guy]

Warburg reversion -- awesome! But I think Longecity mostly nailed the NAD+ connection in 2009 or earlier in this thread.

 

More to the point, what does that mean for the OP, and more importantly, all the lurkers with equally daunting cancer challenges? Should desperate people with Warbug-like (anoxic/hardwall/hypovascuarized) cancers consider taking Niagen, or is there some more preferable substance?

 

Edited by resveratrol_guy, 15 November 2014 - 04:47 AM.

[Logic]

Warburg reversion -- awesome! But I think Longecity mostly nailed the NAD+ connection in 2009 or earlier in this thread.
 
More to the point, what does that mean for the OP, and more importantly, all the lurkers with equally daunting cancer challenges? Should desperate people with Warbug-like (anoxic/hardwall/hypovascuarized) cancers consider taking Niagen, or is there some more preferable substance?

 
Hoo-Boy! 

I think Niacin Riboside would be better if it were more stable and also slowly cleaved  to NA and Ribose in the gut as NR is:
http://www.longecity...sing-nad-as-nr/

Then we have the AMPK activators that increase NAD+ of which Telmisartan and P7C3 are interesting.
http://www.longecity...mpk-activators/

[resveratrol_guy]

"in the gut"... reminds me that we've totally neglected the role of probiotic bacteria in (anti)inflammatory signalling, which is secondary to the main gears that you're talking about, but might possess underappreciated leverage over dietary choices, via the hijacking of hormonal feedback loops (particularly dopamine reward pathways). In other words, it's one thing to tell cancer patients what to eat, and quite another to get them to comply, in part due to gut bacteria with their own agendas.

 

Beyond these 2 cents, frankly, I can't keep up with you. I need to read a few thousand posts first. Please keep posting your cancer insights here. Sooner or later, they might help a lot of people, and this is as good a thread as any, for this field that keeps changing daily.

 

[Logic]

Thx again RG and thx for the Resveratrol and Nampt link, but I don't want to hijack xm_suarez's thread. He needs short, concise answers to his questions.
Perhaps I will start a new thread.

Do you have info on exactly what cancer your family member has xm_suarez's?

[niner]

I'm sorry to hear about your family member, xm_suarez; that's a difficult condition.  This paper is the most important one I've seen in a long time.   It deciphers the relationship between mitochondrial ROS and tumor invasiveness and metastasis.  Importantly, it shows that these processes can be stopped by potent mitochondrial antioxidants.  There is a growing body of evidence that mitochondrial antioxidants are anti-cancer in general, particularly when combined with an anti-Warburg strategy.  There are two mitochondrial antioxidants that are easy to obtain.  One is called MitoQ, and the other is C60 olive oil.  Of these two, C60 olive oil is a lot less expensive, has better pharmacokinetics and appears to be more potent, but MitoQ has been around a lot longer and is one of the ones used in the paper.  (The other was MitoTEMPO)  A lot of people on this forum take c60 olive oil, and a few use MitoQ.  Because your family member's cancer has already metastasized, Other strategies besides an anti-metastatic one are important.  One problem with mitochondrial antioxidants is that they would protect cells from radiation, so you might want to bring them in after the radiation treatments are complete. 

[APBT]

I’d like to echo the other contributions too.

 

Sulforaphane may be worth investigating:  http://scholar.googl...l=en&as_sdt=0,5

 

This product is a standardized extract yielding ~10 mg of bioactive sulforaphane per 1000 mg of broccoli sprout powder (capsules are available too).

https://www.cell-log...exd.asp?id=6940

 

[APBT]

Here’s a mega-thread about cancer treatments in general  Cancer Knowledge

[aribadabar]

First, I am sorry to hear this, xm_suarez. I am sure it is a very stressful time for you and your family.

 

 

 

 

Sulforaphane may be worth investigating:  http://scholar.googl...l=en&as_sdt=0,5

 

This product is a standardized extract yielding ~10 mg of bioactive sulforaphane per 1000 mg of broccoli sprout powder (capsules are available too).

https://www.cell-log...exd.asp?id=6940

 

Dr Greger suggests that young fresh broccoli sprouts seem better than BroccoMax, another sulforaphane supplement.

 

Another avenue to explore is medicinal mushrooms - high-potency extracts of Reishi, Turkey Tail, Agaricus Blazei, the AHCC blend...powerful immunoboosters.

 

 

[xm_suarez]

Thanks to everyone who has posted so far , I'm digesting the information right now.

 

 

Do you have info on exactly what cancer your family member has xm_suarez's?

 

Yeah they ran a blood test last week and it's Small-cell carcinoma.

[Logic]

A quick search of the forum:
http://www.google.co...gsc.q=carcinoma

Vit K2 looks like something to get straight away.
If I remember correctly K2 as a short half life and has to be dosed often, but do another forum search on that.

I would also say start with LEF's stack (read the preceding write-up) and Mebendazole but its difficult to recommend a stack when the person is already on anti-cancer meds xm_suarez.
What is the person already taking and are they open to alternate treatments?
http://www.lef.org/P...Cancer/Page-les

Edited by Logic, 18 November 2014 - 12:50 PM.

[Mind]

My brother-in-law had testicular cancer and pre-cancerous indications in his kidneys. He did the Budwig diet and now is clear of all signs of cancer. He lost weight and exercised as well, which probably helped. No guarantee he will stay cancer free, but seems to have worked thus far.

[xm_suarez]

About Curcumin: http://www.ncbi.nlm....pubmed/19359593

 

Is this study sound or should I disregard?

 

 

A quick search of the forum:
http://www.google.co...gsc.q=carcinoma

Vit K2 looks like something to get straight away.
If I remember correctly K2 as a short half life and has to be dosed often, but do another forum search on that.

I would also say start with LEF's stack (read the preceding write-up) and Mebendazole but its difficult to recommend a stack when the person is already on anti-cancer meds xm_suarez.
What is the person already taking and are they open to alternate treatments?
http://www.lef.org/P...Cancer/Page-les

 

I don't know about doses but right now he takes: Tramadol, Pantoprazol , Tamsulosin, Movicol, methylprednisolone, Lormetazepam and Enoxaparin Sodium. He's also receiving chemotherapy since about a week and a medicine to deal with some side effects but I don't have the details about that right now. (Sorry for lack of information, I will get the specifics asap.)

 

 

This is also VERY interesting:
http://www.longecity...therapy-target/

 

Seems interesting yes. You can buy this stuff over the internet while it's still in testing phase?

 

 

There is a growing body of evidence that mitochondrial antioxidants are anti-cancer in general, particularly when combined with an anti-Warburg strategy.

 

This basically involves starving cancer cells by limiting Glucose levels if I understood right? Is there anything more to it?

[Logic]

Curcumin:
Good find xm-suarez. I was unaware of any studies showing a pro cancer effect for Curcumin.
Here are 2 threads discussing this:
http://www.longecity...on-by-curcumin/
http://www.longecity...enhancer/page-2

IMHO you can disregard this study.
I have seen a similar pattern with many substances. First positive results then later studies showing negative results.
I get the feeling that certain large companies will stop at nothing to stamp out competition to their, way more profitable, 'solutions' and often find substances that fall prey to this pattern t be the most beneficial ones available.
BHT comes to mind.

Tramadol, Pantoprazol , Tamsulosin, Movicol, methylprednisolone, Lormetazepam, Enoxaparin Sodium, chemotherapy:
Wow; that's a long list! I have no idea how these interact with each other, let alone a stack like that recommended by LEF.org.
The two patients who had success with LEF's and my advice, were not taking any 'conventional' medicine.
As such I cannot make any recommendations.
My advice is to look into the effects and side effects of each of these and compare them to the effects of the constituents of things in LEF's stack.
Post your findings and questions here and people may be able to give advice.

Its a lot of work, and at the end of the day only the person with the cancer will decide on the course of action they take, so it may all be for nought.

Anti-CD47 antibody [B6H12.2] (ab3283):
Yes its available. see the first lnk in this post:
http://www.longecity...ndpost&p=588134

anti-Warburg strategy:
No; see post #7
It involves Getting mitochondria working properly again with the substances linked in post #9 and possibly C60oo, ITPP and PQQ.

Here's a recent post on Nicotinamide Riboside and cancer:
http://www.longecity...s-liver-cancer/

ITPP:
http://www.longecity...-supply-to-tis/

[xm_suarez]

I haven't made a lot of progress this week because the difficulty of the subject, the vast amount of information and the contradictions between a lot of it, and being constantly confronted with "sceptics" who's main objective seems to be shattering hope, containing the status-quo and generally being a wise ass became increasingly frustrating and got to me. I don't want to stay passive however and wait for either a miracle or the inevitable so I'm trying to get my shit together.

 

My list of potential anti-cancer substances contains ~80 herbs, vitamins, medicines and other things as of now (including every suggestion in this thread) and keeps getting longer. I realize there's no point in trying to create the "perfect" stack so I will just start with a list of stuff that holds a reasonable amount of promise, based on the information I have seen so far, to get something concrete going and hopefully some of the people on here who are much more knowledgeble than me can give some input.

 

So here goes:

 

 

Vitamin C: 4 – 12 g daily.

One of the more well known and suggested substances. Part of the LEF stack.

 

 

Vitamin D3: 2000 – 10 000 IU daily with food, based on individual blood testing. Optimal blood levels of vitamin D are 50 – 80 ng/ml.

Also one of the more well known and suggested substances and part of the LEF stack.

 

 

Curcumin: 600mg-900mg/day of "Theracurmin" as suggested by http://truttmd.com/c...te-theracurmin/.

 

 

Polysaccharide K (PSK): 3000 mg daily of a 40% polysaccharide extract.

PSK is isolated from the fruitbody of Trametes versicolor ,also known as Turkey Tail Mushroom which has been suggested in this thread. Part of the LEF stack.

http://en.wikipedia....olysaccharide-K.

 

Quercetin: 1000 – 3000 mg daily.

"Like many other bioflavonoids, Quercetin has anti-oxidant, anti-artherogenic, and anti-carcinogenic properties." (http://examine.com/s...ents/Quercetin/)

Part of the LEF stack.

 

 

Mebendazole: 1.5 g of MBZ following chronic dosing of cimetidine at 400 mg three times a day for 30 days as mentioned in this interesting and recently published article: http://dash.harvard....df?sequence=1. 

"Several studies show mebendazole exhibits potent antitumor properties. MBZ significantly inhibited cancer cell growth, migration and metastatic formation of adrenocortical carcinoma, both in vitro and in vivo.[12] Treatment of lung cancer cell lines with MBZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release.[13] MBZ induced a dose- and time-dependent apoptotic response in human lung cancer cell lines,[14] and apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.[15]" (http://en.wikipedia....iki/Mebendazole)

 

 

Wogonin: 15 mg/kg to 60 mg/kg wogonin per day was used in this study: http://www.plosone.o...al.pone.0106458.

"Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects" (http://www.ncbi.nlm....ubmed/17404065.) and "Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells." (http://www.ncbi.nlm....pubmed/17404065.). Etoposide is part of the chemotherapy he is getting. Wogonin is a flavonoid found in Chinese scullcap.

 

 

MitoQ: No clue about dosage.

"MitoQ is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage." (http://en.wikipedia.org/wiki/MitoQ)

Used in this study earlier mentioned in this thread: http://www.cell.com/...247(14)00527-0#

Edited by xm_suarez, 29 November 2014 - 01:03 AM.

[xm_suarez]

@Logic: Thank you for the input and I will check out Nicotinamide Riboside and ITPP.

Edited by xm_suarez, 29 November 2014 - 01:02 AM.

[Logic]

Ye there are always a lot of nay-sayers etc. Print out the abstracts and keep them on hand for such occasions.
Giving them the abstract/s and asking them if they would argue with Dr/Prof XYZ from Harvard medical (or wherever) and pointing out that a peer reviewed, published study means that persons of equal qualification to the study writer have already done so, generally helps.

When they ask why he docs aren't using it; ask em if they would tell the world about a discovery that made their jobs defunct and would get em fired as they would no longer be needed.

Dont back down! You are doing a great job of the research and have some serious literature to back it up.
There is even a recent study on NR and cancer

Mebendazole:
Thanks for that nice summary/paper. I hadn't seen it yet.

Curcumin:

See Trutt's comment on November 7, 2013 at 6:00 am at the same link:
"...I’ve learned more about Theracurmin since writing this post, and I’m probably going to have to retract the post. It looks like Theracurmin seriously misleads with the way they present their data. The short version is, they give you the impression that their awesome absorption is of free curcumin, when actually it is of curcumin metabolites– which are much easier to measure from any brand. Furthermore I have now seen a Theracurmin trial in pancreatic cancer which shows no activity despite the tremendous “absorption”– and in the (very) fine print it turns out that it’s not free curcumin at all… which is probably why there is no effect. So I’m now back to recommending Longvida instead… certainly for Alzheimer’s and probably for cancer prevention too..." - See more at: http://truttmd.com/c...h.sfJKjKtf.dpuf

I would go with the BCM95 and add a teaspoon of Turmeric and EVCO to increase bioavailability some.

Vit C
is somewhat overhyped IMHO. I would not go above about 3 grams of buffered/time release C.

I am holding thumbs.

[Logic]

I forgot piperine/pepper in the Curcumin stack above as I thought BCM95 contained it.

Have you read this thread?
http://www.longecity...nowledge/page-9

Also look up/Google Ginger.
'Ginger cancer pubmed' gives good results.