66 replies to this topic

[Doc Psychoillogical]

My goal is to compile as much information as possible, so I may make it easier on me as well as others to find any and all data and information regarding this topic.

Not only to save everyone time from web-surfing, rereading already discovered info and well, from brain farts.

Those times when its impossible to word what you want to look for in google.

For the sake of Searching, I've made the tile very general, for easy direction from any search engine to this site.

 

 

- Also Tagged specifically for Preferred and Popular Stimulants for this topic.

- I will provide the Data, Posts, Information and sites that I have already found.

- I would LOVE to this discussion topic to full of Vitamins, Supplements, Herbs, Prescriptions, OTC, and Food/Drink Personal experiences & Professional data, research, info, studies, interactions and posts.

 

PLEASE  PROVIDE DIFFERENT AND NEW POSTS, DATA, EXPERIENCES AND INFO!!

 

 

Take these supplements to increase the effects of the Adderall and reduce the come down.

Before
10-30 minutes before.
Magnesium Glycinate: 1x200mg Pill (2,000mg magnesium glycinate, which is equivalent to 200mg elemental Mg)
(Use the linked brand. Many brands or formulations of magnesium have low absorption rates)
R-ALA: 1x100mg (Reduces neurotoxicity)
ALCAR: 1x500mg (Reduces neurotoxicity)
L-Theanine: 1x200mg (Helps prevent tolerance buildup, however more for reduction of anxiety/paranoia/irritability)
CoQ10: 1x100mg ("Extremely long half life antioxidant, various beneficial effects on mitochondrial function")
1-2x Tums, or 1/2 teaspoon of baking soda mixed in a glass of water (Potentiates Adderall due to reduction in stomach acidity)

During
Sugary snacks. Aim to eat one every ~30 minutes. (Helps maintain blood glucose levels - you'll feel less tired and happier)
Seriously - it's mentioned below, but EAT AND DRINK!
Optionally: Dose one of each magnesium, R-ALA and ALCAR during.

After
To help you: Go to sleep easier and feel better tomorrow.
Magnesium Glycinate: 1x200mg Pill (2,000mg magnesium glycinate, which is equivalent to 200mg elemental Mg)
(Use the linked brand. Many brands or formulations of magnesium have low absorption rates)
R-ALA: 1x100mg (Reduces neurotoxicity)
ALCAR: 1x500mg (Reduces neurotoxicity)
Vitamin C: 1000-2000mg (The acidity of vitamin-c will help reduce the effects of Adderall, making it easier to sleep)
Melatonin: 5-10mg roughly 30 minutes before bed (Keep in mind we are using a higher dose here for it's antioxidant properties. Normal dosages should be .5mg to 1mg.)

If you are on a significant Adderall spree, consider replacing a re-dose of Adderall with Caffeine.

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VITAMINS & SUPPLEMENTS FOR HARM REDUCTION AND BASIC SELF-CARE WHILE USING STIMS
Listed in order of highest to lowest priority, IMO...
DOSE TWICE DAILY -- AM / PM
Chelated Magnesium - 200mg per dose. I use Doctor's Best brand, but whatever you get be sure to use high absorption "Chelated" and "NOT BUFFERED". High absorption magnesium contains elemental magnesium chelated with the amino acids glycine and lysine. This helps cells produce metabolic energy and helps you maintain a healthy heartbeat. Also reduces clenched jaw and grinding of teeth.
Green Tea = 500mg per dose. Green Tea's benefits are attributed to its catechin polyphenols, particularly EGCG (epigallocatchin gallate), a powerful antioxidant. I have no doubt that on top of promoting overall health, taking green tea helps reduce the negative aspects of come-downs. Another product known as L-Thenanine (Suntheanine) provides a lot of the same benefits.
Turmeric Curcumin (w/BioPerine) = 500mg per dose. Turmeric is the yellow spice that gives flavor to curried dishes, which is why India has a lower incidence of Alzhiemer's and Parkinson's -- because this "spice" has been proven to be neuroprotective, particularly in the areas of the brain known to suffer from the neurotoxic affects of methamphetamine.
Acetyl L-Carnitine (ALCAR) = 500mg per dose. This is a key amino acid that provides antioxidant protection and "energizes the mind". It is often taken in combination with R-Lipoic Acid (R-ALA) but I after some experimentation I decided the ALCAR is all I need.
N-Acetyl Cysteine (NAC) = 600mg. A sulfur-containing amino acid that acts as a stabilizer for the formation of protein structures, this is known to help reduce "skin picking" and help promote gluthione which in turn reduces irritability and agitation common among stim users on their way down. Also protects your liver and kidneys from toxicity.
Selenium = 100mcg per dose. A trace mineral that has been shown to be neuroprotective, reducing brain damage caused by neurotoxic drugs such as meth. Naturally found in various foods, Brazil Nuts contain high amounts. But be careful about your dosage, keeping it below 200mcg per day -- at high levels, over time selenium becomes toxic and can even be fatal.
Alpha GPC/Choline = 300mg per dose. This is a natural physiological precursor to acetyl-choline, a neurotransmitter that is involved in memory and other cognitive functions. Good for the brain.
Ubiquinol/CoQ10 = 50mg per dose. Another potent antioxidant, this one amps up your electron transport chain and strengthens mitochondrial physiology, allowing you to generate more ATP which any gym rat will confirm is our body's primary energy source. Note that Ubiquinol is the more bioavailable version of CoQ10 so it's preferable to Ubiquinone, the version of CoQ10.
Bacopa - 500mg per dose. My shrink recommended I try Bacopa Monnieri to help with my ADHD, because it's a natural adaptogen which means it helps stabilize your physiological processes and decreases cellular sensitivity when your mind and body are under a lot of stress (e.g. spun out for days with little or no sleep). It also has antioxidant properties and in the nootropics crowd it's thought to support learning, cognition, and memory.
Taurine = 1000Mg per dose. Helps take the edge off. Taurine is an amino acid that has been found to be important in the formation of bile salts, cell membrane stabilization, and eye health. Taurine is well known for its role in the modulation of neurotransmitter activity and its relaxing effect on the mood.
L-Arginine = 500mg per dose. Amino acid that stimulates the production of nitric oxide which supports vasodilation. Keeps your heart strong and reduces "stim dick". Take higher dosage if you want to maximize your potential for sustaining a hard-on while using. It ain't Viagra, but it will help.
Folic Acid = 800mcg per dose. This is a cheap B-complex vitamin that is a common part of multi-vitamins. It's not essential, but I think it helps my body absorb all these various substances.
EDIT: Moved this last item to bottom of the list due to questionable benefits. More info about the possible pros/cons in comments. If you check the Bluelight link near the top of this post it recommends L-phenylalanine and/or L-tyrosine with no hint of any concerns about doing so, but still... do you own research.
L-Tyrosine = 500mg per dose. L-Tyrosine is a non-essential amino acid that plays an important role in the production of neurotransmitters dopamine and norepinephrine. L-Tyrosine is known as the best/most effective supplement for dopamine production but you could also try other precursors such as L-phenylalanine, which some reports indicate is particularly helpful for meth users.
DOSE ONCE DAILY - PM ONLY (OR BEFORE BED)
Melatonin = 3 - 5mg. Helps you sleep. Also shown to reduce tolerance. EDIT: As pointed out in comments below, there are risks associated with taking melatonin on a regular basis, particularly at higher dosages. Use it within safe parameters.
Vitamin C = 500mg - 1000mg. Will help your body process and flush out the toxic elements of amphetamines faster -- if you go to the ER with an over dose of meth they will typically give you an IV of vitamin C.
FOR TOLERANCE REDUCTION AND STIM POTENTIATION
Tolerance is a bitch, and there's no way around it... but for me at least, these more risky drugs have undoubtedly made it possible for me to continue using on an almost daily basis for several months now without taking long breaks or huge doses. Even though my dose has increased over time it has been moderate enough to keep me using well under 3 grams a month, which is a lot less than most regular users and less than I was using back in the day.
Aside from the vitamins and supplements listed above (which may have some indirect tolerance or potentiation benefit), there are 2 somewhat more risky substances I have been taking specifically for tolerance reduction:
Mementine = 10mg - 20mg per day. Available as a prescription drug to treat alzheimer's, Mementine is also known to benefit stim users by reducing tolerance and lowering impulsive behavior associated with being spun out. I've been taking it regularly for over 3 months and its affects are undetectable to me save for the fact that my tolerance has been lower than it would be otherwise. I take a liquid form sublingually.
Selegiline (L-deprenyl) = 3mg - 5mg EDIT: every other day. I am hesitant to list this one because I have read that it is extremely dangerous to mix Selegiline with any form of stimulant, so much so that they suggest if you are crazy enough to try this combo be sure to put a card in your wallet that states "in the event of cardiac arrest medics be advised patient is on an moa inhibitor." So yeah, if you mix Selegiline with meth you are risking your life. But in the interest of truth, I must report that I was crazy enough to try this combo and have not found it to be fatal, or even to raise my heart rate. After reading extensively about it and preparing for the worst (got a heart/blood pressure monitor, and consulted with a doctor who was "on call" to help me if needed) I proceeded with extreme caution and have kept my dosage at 3mg - 5mg per day for 2 months now without a problem. The low dosage is an important safety factor, as doses over 10mg change the chemical equation and make you more likely to die of a heart attack. Also you can't eat aged cheese while on Selegiline, because something known as "the cheese effect" could trigger a hypertensive crisis. But for all the risks, it does have compelling benefits that include increasing your overall lifespan and staving off dementia and other cognitive deficits that come with old age. And I also believe it has also been part of reducing my tolerance to stims, so I have ordered a new supply in spite of the expense (approx. $100 per bottle for the liquid form).
EDIT: Even though I have increased my dosage over time, there is a clear difference between the effectiveness of the drug day-to-day when taking Mementine and/or Selegiline vs. not -- which is to say, when I was NOT taking anything for tolerance reduction, not only did my dosage skyrocket but at a certain point the drug just stopped working for me unless I took a substantial break.
CARING FOR YOUR TEETH AND SKIN
It's well known that stims can take a toll on your teeth and make your skin oily which causes break outs etc. Here's what I use to get these aspects under control:
BIOTENE MOUTHWASH. Great for keeping your teeth clean and designed to lessen 'dry mouth' and heal mouth sores. I've gotten into the habit of swishing a mouthful of this stuff every few hours. They also have a portable spray bottle and lozenges you can get. A bit pricey, but worth it.
COCONUT OIL. For your teeth, this stuff works wonders. I did a post a while back about it. Recent dentist appointment confirmed I have virtually no tartar or plaque build up, I believe in large part due to swishing a mouthful of coconut oil every night.
CETAPHIL BODYWASH. This stuff really made a dramatic difference for me, vastly improving my skin. Less sweating, less oil, less flaking, no more break outs... i can't recommend this product enough. I have a mild case of eczema so I got the version that is formulated for that but they have various formulas depending on your skin type etc.
OIL ABSORBING SHEETS BY KROGER OR CLEAN & CLEAR. I think these are made for women because it says "won't smudge makeup" on the label but these little blue sheets are AMAZING for wiping down your face and hands to remove excess oil. I love seeing how the sheets turn translucent with the oil they pick up off my skin, using several a day.

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[Area-1255]

Add Lemon Balm extract or Magnolia Officinalis for sleep and wind-down - those are more potent, other than that I agree with this stuff.

[Junk Master]

Add Lemon Balm extract or Magnolia Officinalis for sleep and wind-down - those are more potent, other than that I agree with this stuff.

 

 

I had surprisingly good results with Lemon Balm and Magnolia Officinalis, just a plain old Swanson's blend, when experiencing some insomnia due to mild PAW'S; so, I second the recommendation.

 

I do think if you use stims on a regular basis SAMe can help reduce "burnout."

 

Looks good though.  Good work.

[Doc Psychoillogical]

Neurotoxicity:
The theory about why amphetamine causes neurotoxicity is that dopamine is supposedly a relatively reactive molecule. It gets auto-oxidised into a reactive metabolite which then causes oxidative damage to the pre synaptic terminals of dopaminergic neurons. Unlike Parkinsons disease, the dopamine cell bodies don't actually die, but without the terminals, they can no longer release dopamine.

Lots of studies have been done on methods of inhibiting the cytotoxic effects of 6-hydroxydopamine (6-OHDA), and this is directly relevent to amphetamine toxicity because the mechanism of 6-OHDAs neurotoxicity is the same as the one proposed for amphetamine. Actually there are two mechanisms behind 6-OHDAs neurotoxicity, heres an abstract:

The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity. 6-OHDA has two ways of action: it easily forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive towards radical scavengers and iron chelators with the exception of desferrioxamine. We conclude that free radicals are not involved in the interaction between 6-OHDA and the respiratory chain and that the two mechanisms are biochemically independent, although they may act synergistically in vivo.

So one of the two reasons that 6-OHDA kills dopamine neurons is that it is easily converted into a free radical. I have posted studies on various substances which have been shown to prevent 6-OHDA neurotoxicity, so one can consider those studies to apply directly to amphetamine too.

Whether this is true or not, theres no harm in taking preventative measures. Here are some ways to protect against this type of neurotoxicity, as well as other forms of neurotoxicity and damage to other areas of the body such as the liver:

Antioxidants:

First and foremost, antioxidants will protect the brain cells against oxidative damage. Antioxidants also protect other organs such as the liver. This means that antioxidants that antioxidants prevent amphetamine induced neurotoxicity, assuming that the theory mentioned above is actually valid. This is the main part of this article since most of the damage caused by amphetamines boils down to free radical damage.

Firstly, a bit about antioxidants. Antioxidants protect cells in the body by neutralizing toxic free radicals. Its necessary to take a mixture of antioxidants because different types of antioxidants protect different parts of the body. Some anti-oxidants are water soluble, some fat soluble. Some anti-oxidants can penetrate membranes easily, some can't. Some anti-oxidants can readily cross the blood brain barrier, others can't.

Vitamin C is a water soluble antioxidant so it neutralises free radicals in the blood and aqueous areas surrounding the cells. Vitamin E on the other hand is a fat soluble antioxidant, so it protects fatty areas of the body such as the walls of the blood vessels. As a result, it prevents the hardening of arteries. Some antioxidants are soluble in both water and fat. Examples are alpha lipoic acid (ALA) and melotonin. Then there are antioxidants which are present inside the cells, and thus protect the cells from the inside. Glutathione is the bodies main endogenous antioxidant which protects the inside of cells. Unfortunately it doesn't get absorbed very well so ingesting glutathione doesn't work. Alpha lipoic acid is an analogue of glutathione which can penetrate cells and thus, protect the cell membrane and inner cell.

Co-enzyme Q10, also known as ubiquinone is a powerful fat soluble antioxidant, and because of its role in cellular respiration, it gets transported to the inner wall of the mitochondria, this gives it the unusual property of protecting the inner mitochondria (an area where protection is greatly needed) from free radical damage. Since the body uses energy from the mitochondria to produce its own endogenous antioxidants such as glutathione, protecting the mitochondria enables the body to produce adequate levels of these endogenous antioxidants. Another antioxidant which protects the inner mitochondria is beta-carotene. Co-enzyme Q10 also protects cholestrol against oxidation. Another powerful antioxidant used in the cellular respiration process is acetyl-L-carnitine (ALCAR). ALCAR protects the outer walls of the mitochondria.

In order to prevent amphetamine neurotoxicity, its essential to take anti-oxidants which can cross the blood brain barrier, and thus enter the brain where amphetamines act. Some powerful anti-oxidants which can readily cross the BBB are acetylcarnitine, alpha lipoic acid and melotonin.

The first antioxidant one should stock up on is vitamin C, because many other antioxidants rely on it in order to function properly. When many antioxidants such as vitamin E neutralise a toxic free radical, they themselves get converted into toxic free radicals, which if left unchecked, would go on to harm cells. Vitamin C on the other hand gets converted into a stable (non toxic) free radical so when an oxidized Vitamin E molecule comes into collides with a Vitamin C molecule, the oxidation chain comes to an end. Curcumin is a wonder substance when it comes to amphetamine use. Not only is it a powerful antioxidant which has been proven to protect against 6-OHDA damage, it also blocks CREB [12], which is one of the major pathways for tolerance to various drugs. CREB alters ones genes and is believed to play a role in long term changes caused by long term drug use[11]. PQQ is a powerful antioxidant which has been proven to protect against 6-hydroxydopa neurotoxicity.[1]

Melotonin like alpha lipoic acid, is a multipurpose antioxidant which is both water and fat soluble, penetrates cells, and readily crosses the blood brain barrier. Melotonin is a sleep inducing hormone, and can thus help counter amphetamine induced insomnia if taken at night time. Additionally, melotonin has been shown to protect the liver and even help repair liver damage. Melotonin is produced by the pineal gland in the absence of light hitting the retina, so its a good idea to use a blind fold for sleeping in order to maximize melotonin production in the brain.

Aspirin is a good antioxidant which has been shown to protect the brain against amphetamine related damage. It is also an anticoagulant so it helps counteract hypertension (a side effect of amphetamine) and prevents strokes and heart attacks etc. Thats why I always take aspirin along with dexedrine. Baby aspirin is all you need (higher doses are hard on the stomach).

Plant extracts such as grape seed extract and green tea extract are good because they contain a wide range of different anti-oxidants and classes essential nutrients such as flavonoids (nutrients with antioxidant and anti-inflammatory properties), isoflavones, carotenoids, essential fatty acids etc.

One should also know a bit about the bodies own endogenous anti-oxidants in order to know how to keep them at optimum levels. On top of protecting the mitochondria (explained above), another way to boost glutathione is by taking precursors such as acetylcysteine. The bodies antioxidant enzymes use zinc, copper, selenium and manganese so its a good idea to make sure one has enough of these trace elements in their body.


NMDA antagonists:

Another cause of brain damage is glutamate cytotoxicity. This happens when you have a surplus of glutamate in the brain, the glutamate overactivates the glutamate receptors and damages them. The 3 types of glutamate receptors are NMDA, AMPA and kainate.

NMDA antagonists protect the brain against this kind of damage and on top of that, they counteract tolerance to amphetamine. Magnesium is a partial NMDA antagonist so its a good idea to take a magnesium supplement every day. Full NMDA antagonist drugs like ketamine or DXM can of course be dangerous so shouldn't be combined with other drugs unless you know exactly what you are doing. Memantine is a safer option since it is a partial NMDA antagonist.

NMDA induced neurotoxicity seems to be caused, ultimately by the conversion of nitric oxide (a neurotransmitter released after the NMDA receptor is activated), therefore this kind of neurotoxicity can be prevented by blocking steps further down the cascade. For example, nitric oxide synthase (NOS) inhibitors such as methylene blue prevent NMDA excitotoxicity by inhibiting the cells ability to produce nitric oxide. NOS inhibitors also prevent tolerance to amphetamines. Note: methylene blue is also an MAOI, so it may not be safe to use in conjunction with amphetamines. The best way to block this damage, without interfering with the activity of glutamate receptors would be to block the action of superoxide itself. Co-Enzyme Q10 helps boost levels of superoxide dismutase, a class of enzymes which break down superoxide.


Protecting the Heart and Brain:
Amphetamine use causes some cardiovascular issues, and this can indirectly cause harm to the brain since its the cardiovascular system which carries the oxygen and other compounds needed to keep the brain cells alive and healthy. Thus, it is a good idea to take measures to prevent the risk of heart attack or stroke, and maintain a healthy cardiovascular system. Firstly, as mentioned in the anti-oxidant section, taking the right combination of anti-oxidants will protect the blood vessels. One factor which causes heart problems is oxidation of the arterial walls. Fat soluble antioxidants like vitamin E prevent this.

Oxidised LDL cholestrol also attacks artery walls so taking anti-oxidants like Co-Enzyme Q10 prevents this by shielding the cholestrol. Most people over 20 already have significant amounts of oxidized LDL cholestrol in the arteries, so another class of antioxidant called flavanoids can be used to reverse that. Flavonoids enter the blood vessel walls and dampen down the inflammation. A good flavonoid is quercetin.

Taking vasodilators may be a good idea in order to counteracting amphetamine induced vasoconstriction Gingko biloba is a decent vasodilator, which also contains powerful anti-oxidants. GABA activity induces vasodilation so boosting GABA levels is a good idea. GABA itself doesn't cross the blood brain barrier very well, but its picamilon can readily cross the BBB and boost GABA levels in the brain. Picamilon is basically a molecule of GABA binded to a molecule of niacin, which gets metabolised into GABA and niacin in the brain, so it can be considered a GABA and vitamin B3 supplement. It is an effective vasodilator. Boosting GABA levels will also help prevent glutamate excitotoxicity since GABA and glutamate balance each other out.

Anticoagulents such as aspirin help prevent blood clotting, and thus lower the risk of heart attack or stroke. One should be careful with stronger anticoagulents such as warfarin as they have a greater tendency to interact with drugs.

There are also substances which directly protect the brain against hypoxia induced damage. Racetams such as piracetam and related nootropics protect the brain by enhancing the bioavailability of oxygen to neurons in the brain. Piracetam has been shown to drastically reduce the brain damage incurred by stroke victims, if administered shortly after the stroke. There is also some anecdotal evidence that piracetam counteracts amphetamine tolerance.


Protecting the Liver:
The majority of drug induced liver damage boils down to oxidative damage, therefore antioxidants are the most important factor for protecting the liver. The endogenous antioxidant responsible for protecting the liver against this damage is glutathione, liver damage occurs when the bodies natural glathione reserves are depleted faster than they can regenerate. Two powerful liver protecting supplements one should know about are milk thistle and acetylcystine. Milk thistle is the most powerful liver tonic known to man. It protects the liver against damage and even helps repair the liver. It works by increasing levels of glutathione which is a compound the liver uses to metabolise drugs.

Acetylcysteine is one of the bodies precursors for glutathione so it can used to boost glutathione levels. It is also a potent antioxidant in itself.

Replenishing Neurotrasmitters: Amphetamine causes dopamine and norepinephrine to be released and as a result, it causes these neurotransmitters to get depleted at a relatively rapid rate. The obvious way to replenish them is to take neurotransmitter supplements. To make dopamine and norepinephrine, the body starts with phenylalanine, it goes:
Phenylalanine -> Tyrosine -> Dopa -> Dopamine -> Norepinephrine -> Epinephrine
I think I left out a metabolite or two but they're the ones you should know about. The most direct way to replenish your dopamine is by taking l-dopa. It gets converted to dopamine quicker than l-tyrosine does. However, amphetamine doesn't just deplete dopamine and norepinephrine, it depletes all the neurotransmitters in the metabolic pathway. It also depletes phenethylamine which is another neurotransmitter that the body synthesises from phenylalanine. With this in mind, its a good idea to take phenylalanine supplements so that you replenish the starting material.

Upregulation/Downregulation:
One of the problematic long term changes amphetamine use is the downregulation of various receptors such as dopamine and adrenaline (which are binded to by both epinephrine and norepinephrine), and transporters such as DAT and VMAT[4]. DAT which transports dopamine back into the cell and VMAT2 which is used to transport monoamines (such as dopamine) in the cells back into synaptic vesicles (the neurotransmitters have to be in these vesicles before they can be released). According to some studies[4] methamphetamine also downregulates the enzymes tyrosine hydroxylase (used by the body to produce dopamine) and tryptophan hydroxylase (used to produce serotonin). Therefore taking substances which are known to upregulate/resensitise these receptors, transporters and enzymes may be a good idea. Long term nicotine upregulates dopamine receptors[3], but of course long term nicotine use may be a bad idea since it is fairly addictive.

Uridine upregulates D2 receptors.[2] Uridine seems to be hard to obtain, an alternative is citocoline which is metabolised into uridine (and choline). Supposedly (I can only find anecdotal reports, if anyone knows of any studies, can you post them) lithium upregulates both VMAT2 and D2/D3 receptors. Lithium of course can cause its own neurotoxicity, so one has to research this in depth before deciding to take it. Lithium orotate is far safer than conventional lithium drugs because it has a very high bioavailability, meaning one can ingest lower quantities of it.

Melotonin has been shown to prevent methamphetamine induced downregulation of tyrosine hydroxylase[8].

Substances which prevent 6-OHDA toxicity:
As I said, 6-OHDA neurotoxicity has the same mechanism of the supposed amphetamine induced neurotoxicity, so the studies done on it applies to amphetamines.

Anandamide has been shown to counteract 6-OHDA toxicity[7]. Anandamide is an endogenous cannabinoid so its possible that synthetic cannabinoids like THC have the same neuroprotective effect. As mentioned below, curcumin has been shown to protect against 6-OHDA damage.[5] Selegiline protects the brain against this kind of damage.[10]

Inhibiting Apoptosis:
Apoptosis is a built in self destruct mechanism for cells. Dopamine neurotoxins like 6-hydroxydopamine induce apoptosis, and according to some studies, amphetamines can do this too. So taking apoptosis inhibitors may be a good idea. According to some studies, curcumin protects the brain against 6-OHDA cytotoxicity.[5] Curcumin also protects the brain against ischemia induced apoptosis.[9] Resveratrol is an apoptosis inhibitor, as well as a powerful antioxidant. Red grapes and blueberries are two good sources of resveratrol.

Repairing the Brain
On top of protecting against damage occuring, its likely a good idea to take measures to reverse the damage that has already occured. Brain Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) are two substances involved in neuroplasticity, which help the brain recover from damage. Phosphatidylserine is good for boosting NGF activity. Acetylcarnitine and alpha-glycerophosphocholine (GPC) are two other substances that upregulate NGF receptors. It also enhances dopamine release, so it is a good substance to take during amphetamine withdrawal. I personally find that taking a combination of rhodiola rosea + phosphatidylserine counteracts some of my ADHD symptoms.

Centrophenoxine has been shown to remove lipofuscin deposits from cells, and help repair synapses. Centrophenoxine is metabolised into DMAE and parachlorophenoxyacetate. DMAE also clears lipofuscin from cells and boosts brain function. Lipofuscin is a fatty acid oxidation product which accumulates in cells with age, and excessive accumulation of it has been implicated in Parkinsons disease, Alzheimers and other neurodegenerative disorders, so removing it from brain cells aids the recovery process.

MAO-B Inhibitors:
Selegiline has been shown to protect against 6-OHDA toxicity.[10] If one is responsible and cautious enough, one should be able to figure out safe doses for combining amphetamines with selegiline.

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[Doc Psychoillogical]

Journal of Attention Disorders

Literature Review: Update on Amphetamine Neurotoxicity and Its Relevance to the Treatment of ADHD

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[Doc Psychoillogical]

...further study is needed to determine the effects of post-treatment with flavonoids such as the induction of dopamine and the regeneration of axons after damage in DA system of adult brain as well as the study on the mechanisms of flavonoids-induced effects in the adult brain.

Schematic representation of flavonoids-induced neuroprotective effects.

Many kinds of flavonoids can attenuate microglial activation and oxidative stress, and induce neurotrophic factors to protect dopaminergic neurons in the adult brain.

[Doc Psychoillogical]

The main nutritional deficiencies for ADHD are iron and zinc, and fatty acids are imbalanced. Hundreds of studies are on each of these. Here are a few.

Iron deficiency http://www.ncbi.nlm....pubmed/21585274 http://www.ncbi.nlm....pubmed/21186968
Zinc deficiency http://www.ncbi.nlm....pubmed/20034331
imbalances in lipids, fatty acids, and antioxidants http://www.ncbi.nlm....pubmed/18757191

Zinc plays an important role in BDNF expression. http://www.ncbi.nlm....pubmed/21615740 It's also has a role in assisting dopamine transporters, and as a NMDA receptor antagonist that blocks glutamate neurotoxicity which signals apoptosis (cell death), while boosting burst firing of ions needed for learning.

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[Doc Psychoillogical]

Nutrient effects on cognition and emotion food sources:

 

Brain foods: the effects of nutrients on brain function Fernando Gómez-Pinilla

 

www.ncbi.nlm.nih.gov/pmc/articles/PMC2805706/

 

 

Omega-3 fatty acids

- (for example, docosahexaenoic acid) Amelioration of cognitive decline in the elderly148; basis for treatment in patients with mood disorders80; improvement of cognition in traumatic brain injury in rodents81; amelioration of cognitive decay in mouse model of Alzheimer’s disease149,150 Fish (salmon), flax seeds, krill, chia, kiwi fruit, butternuts, walnuts

Curcumin

- Amelioration of cognitive decay in mouse model of Alzheimer’s disease123; amelioration of cognitive decay in traumatic brain injury in rodents89 Turmeric (curry spice)

Flavonoids

- Cognitive enhancement in combination with exercise in rodents92; improvement of cognitive function in the elderly151 Cocoa, green tea, Ginkgo tree, citrus fruits, wine (higher in red wine), dark chocolate

Saturated fat

- Promotion of cognitive decline in adult rodents4; aggravation of cognitive impairment after brain trauma in rodents88; exacerbation of cognitive decline in aging humans3 Butter, ghee, suet, lard, coconut oil, cottonseed oil, palm kernel oil, dairy products (cream, cheese), meat

B vitamins

- Supplementation with vitamin B6, vitamin B12 or folate has positive effects on memory performance in women of various ages152; vitamin B12 improves cognitive impairment in rats fed a choline-deficient diet153 Various natural sources. Vitamin B12 is not available from plant products

Vitamin D

- Important for preserving cognition in the elderly154 Fish liver, fatty fish, mushrooms, fortified products, milk, soy milk, cereal grains Vitamin E Amelioration of cognitive impairment after brain trauma in rodents102; reduces cognitive decay in the elderly119 Asparagus, avocado, nuts, peanuts, olives, red palm oil, seeds, spinach, vegetable oils, wheatgerm

Choline

- Reduction of seizure-induced memory impairment in rodents155; a review of the literature reveals evidence for a causal relationship between dietary choline and cognition in humans and rats156 Egg yolks, soy beef, chicken, veal, turkey liver, lettuce

Combination of vitamins (C, E, carotene)

- Antioxidant vitamin intake delays cognitive decline in the elderly157 Vitamin C: citrus fruits, several plants and vegetables, calf and beef liver. Vitamin E: see above

Calcium, zinc, selenium

- High serum calcium is associated with faster cognitive decline in the elderly158; reduction of zinc in diet helps to reduce cognitive decay in the elderly159; lifelong low selenium level associated with lower cognitive function in humans160 Calcium: milk, coral. Zinc: oysters, a small amount in beans, nuts, almonds, whole grains, sunflower seeds. Selenium: nuts, cereals, meat, fish, eggs 

Copper

- Cognitive decline in patients with Alzheimer’s disease correlates with low plasma concentrations of copper161 Oysters, beef/lamb liver, Brazil nuts, blackstrap molasses, cocoa, black pepper Iron Iron treatment normalizes cognitive function in young women162 Red meat, fish, poultry, lentils, beans

                                                                                                                                                                                                                                                  

Taurine, a substrate of taurine transporter, has functions as a neuromodulator and antioxidant and beta-alanine, a taurine transporter inhibitor, has a role as a neurotransmitter in the brain, and they were expected to be involved in depression-like behavior and antidepressant treatment.

These results suggested that taurine-supplemented diet had an antidepressant-like effect and beta-alanine-supplemented diet had an anxiolytic-like effect.

→ source (external link)

Edited by landen.Barry@yahoo.com, 27 September 2015 - 09:44 PM.

[Doc Psychoillogical]

...."formula" for keeping me from feeling any effects from, or possibly preventing, neurotoxicity.

2x400mg Magnesium Oxide
1x100mg CoQ-10
2x500mg Taurine
1x B-Complex Vitamin
1x100mg 5-HTP
2x10mg Vinpocetine
1x100mg DMAE
1x500mg L-Tyrosine
2x350mg Choline
1x Omega-3 "950"
1x200mg Alpha Lipoic Acid
2x Glucosamine Chondroitin MSM

Also, because I work out, I consume 1oz of water per lb of body weight (175oz a day minimum), and 1 gram of protein per lb of body weight (harder to do, usually 150-200grams of protein a day). The protein shakes have a lot of essential amino acids in them as well, so they're good for you....

→ source (external link)

[Doc Psychoillogical]

Great for Post Stimulant/Before Bed Supplementing!!

Effervescent Vitamin C - Magnesium Crystals

Supplement Facts
Serving Size 1 level teaspoon (approx. 6 g)
Servings Per Container about 30
Amount Per Serving

Vitamin C (as ascorbic acid)
4500 mg
Vitamin B6 (as pyridoxine HCl)
4 mg
Magnesium (as magnesium carbonate)
250 mg
Other ingredients: none.
Non-GMO

Dosage and Use
Drink one (1) level teaspoon mixed in eight ounces of water, without food, followed by an additional eight ounces of water all at once, or as recommended by a healthcare practitioner.
Take up to three times per week.

→ source (external link)

[Doc Psychoillogical]

VERY EXCITING TOPIC HITS OVER ONE THOUSAND VIEWS!!

 

Please people if you have any KNOWLEDGE, share the LOVE!

 

 

Because ARE viewing and reading the info 

 

 

 

 

Attached Files

•  thank4watch.jpg   39.41KB   1 downloads

Edited by landen.Barry@yahoo.com, 23 October 2015 - 09:46 PM.

[Doc Psychoillogical]

Here is an update on Dextroamphetamine (If you are taking) and If you do not use this medication disregard this post:

 

IMO there is an apparent and very noticeable difference in effectiveness when it comes to the Generic Manufacturer.

 

The Manufacturer Barr is a complete failure and poorly synthesized formula of Dextroamphetamine.

 

On the other hand, there is hope! A Manufacturer by the name of Mallinckrodt Inc. has perfected there formula and is easily twice as effective as the Barr Generic.

 

So if you do have the option, make the switch, you will be surprisingly satisfied!

 

[PalmAnita]

Just anecdotal experience, but I've found that antioxidant Emoxypine to be the very best supplement to use with dopaminergic stimulants. Can't tell about prescription ones really because in the last time I have only been using isopropylphenidate which is currently a RC but it's already patented for ADHD use and while it will take the usual many years before we might ever see it available off the pharmacy unfortunately, it's very probably at least as safe as methylphenidate and much cleaner. Doesn't increase pulse or blood pressure at all in the lower dosages and it isn't jittery / caffeine-ish either - side effects I get very pronounced with the classical MPH. 

 

But to come back to the topic, the Emoxypine abolishes a great deal of the rebound and after-effects / hangover, when taking the recommended 125mg with every dosage of IPH it's almost non-noticeable!

 

Seeing that it's an antioxidant and has been shown to raise dopamine levels in studies by an unknown (?) effect, I'd speculate that it lowers the (auto)oxidation of dopamine which is responsible for a good part of the neuronal stress resulting from psychostimulants as well as the neurotoxicity from e.g. methamphetamine if I'm right. 

 

Can't prove that it works for everybody, but it's certainly a worthy thing to try when using dopaminergic stimulants! Would love to read your experiences with it too.

Edited by dopamimetiq, 22 November 2015 - 08:28 AM.

[Doc Psychoillogical]

Just anecdotal experience, but I've found that antioxidant Emoxypine to be the very best supplement to use with dopaminergic stimulants. Can't tell about prescription ones really because in the last time I have only been using isopropylphenidate which is currently a RC but it's already patented for ADHD use and while it will take the usual many years before we might ever see it available off the pharmacy unfortunately, it's very probably at least as safe as methylphenidate and much cleaner. Doesn't increase pulse or blood pressure at all in the lower dosages and it isn't jittery / caffeine-ish either - side effects I get very pronounced with the classical MPH. 

 

But to come back to the topic, the Emoxypine abolishes a great deal of the rebound and after-effects / hangover, when taking the recommended 125mg with every dosage of IPH it's almost non-noticeable!

 

Seeing that it's an antioxidant and has been shown to raise dopamine levels in studies by an unknown (?) effect, I'd speculate that it lowers the (auto)oxidation of dopamine which is responsible for a good part of the neuronal stress resulting from psychostimulants as well as the neurotoxicity from e.g. methamphetamine if I'm right. 

 

Can't prove that it works for everybody, but it's certainly a worthy thing to try when using dopaminergic stimulants! Would love to read your experiences with it too.

 

Very much enjoyed reading your post!

As for the Emoxypine; I see it resembles vitamin b6 and also has a pretty impressive wide range of medicinal properties. That being said, I will test trial it in conjunction with Prescribed Dextroamphetamine. I'll trial Log a week's worth of effects and my experience, and post it here.

 

Admittedly, appears to be a promising addition!

[NinefingerJoe]

I've found high dose Vitamin C and a chela lares magnesium supplement tremendously helpful in the comedown from (prescribed) amphetamine. [plus dextromethorphan 60mg daily for dopamine upregulation]
Chelated sorry - posted from my phone

[NinefingerJoe]

@Mr. Psychillogical I prefer the Sandoz version myself - they taste sweet, like blueberries. Sort of.

[Doc Psychoillogical]

UPDATE

 

Recently prescribed Gabapentin & Klonopin for anxiety, in addition to existing Dexedrine script.

 

Very much enjoyed the combo of Klonopin+Dexedrine, but the Gabapentin not cause beneficial effects to the combo.

 

Of the three, the Klonopin+Dexedrine is most effective.

 

Also how you time the doses are EXTREMELY important!(Dexedrine before Klonopin)

 

Didn't see any noticeable difference in Gabapentin+Dexedrine vs Dexedrine alone in terms of combination benefits or side effect reduction.

 

Most likely would use Gabapentin as a backup supply if klonopin supply runs out too soon. 

 

[chris106]

Just anecdotal experience, but I've found that antioxidant Emoxypine to be the very best supplement to use with dopaminergic stimulants. Can't tell about prescription ones really because in the last time I have only been using isopropylphenidate which is currently a RC but it's already patented for ADHD use and while it will take the usual many years before we might ever see it available off the pharmacy unfortunately, it's very probably at least as safe as methylphenidate and much cleaner. Doesn't increase pulse or blood pressure at all in the lower dosages and it isn't jittery / caffeine-ish either - side effects I get very pronounced with the classical MPH. 

 

But to come back to the topic, the Emoxypine abolishes a great deal of the rebound and after-effects / hangover, when taking the recommended 125mg with every dosage of IPH it's almost non-noticeable!

 

Seeing that it's an antioxidant and has been shown to raise dopamine levels in studies by an unknown (?) effect, I'd speculate that it lowers the (auto)oxidation of dopamine which is responsible for a good part of the neuronal stress resulting from psychostimulants as well as the neurotoxicity from e.g. methamphetamine if I'm right. 

 

Can't prove that it works for everybody, but it's certainly a worthy thing to try when using dopaminergic stimulants! Would love to read your experiences with it too.

 

That's funny - I had incredible results with the exact same combination a few weeks back! Looks like it's one of those rare synergies made in heaven?
It was the closest to a sustainable and fuctional stim I have ever tried (and I tried quite a lot).

I even got my Vyvanse subscription renewed because of it, as soon as i was out of IPH - but as it turns out it doesn't work well with the Vyvanse at all, which is realy frustrating!

 

So maybe Emoxypine by design works better with Dopamine re-uptake inhibitors like MPH/IPH than with plain agonists (Amphetamines)?
 

Edited by chris106, 17 December 2015 - 09:53 PM.

[Doc Psychoillogical]

 

Just anecdotal experience, but I've found that antioxidant Emoxypine to be the very best supplement to use with dopaminergic stimulants. Can't tell about prescription ones really because in the last time I have only been using isopropylphenidate which is currently a RC but it's already patented for ADHD use and while it will take the usual many years before we might ever see it available off the pharmacy unfortunately, it's very probably at least as safe as methylphenidate and much cleaner. Doesn't increase pulse or blood pressure at all in the lower dosages and it isn't jittery / caffeine-ish either - side effects I get very pronounced with the classical MPH. 

 

But to come back to the topic, the Emoxypine abolishes a great deal of the rebound and after-effects / hangover, when taking the recommended 125mg with every dosage of IPH it's almost non-noticeable!

 

Seeing that it's an antioxidant and has been shown to raise dopamine levels in studies by an unknown (?) effect, I'd speculate that it lowers the (auto)oxidation of dopamine which is responsible for a good part of the neuronal stress resulting from psychostimulants as well as the neurotoxicity from e.g. methamphetamine if I'm right. 

 

Can't prove that it works for everybody, but it's certainly a worthy thing to try when using dopaminergic stimulants! Would love to read your experiences with it too.

 

That's funny - I had incredible results with the exact same combination a few weeks back! Looks like it's one of those rare synergies made in heaven?
It was the closest to a sustainable and fuctional stim I have ever tried (and I tried quite a lot).

I even got my Vyvanse subscription renewed because of it, as soon as i was out of IPH - but as it turns out it doesn't work well with the Vyvanse at all, which is realy frustrating!

 

So maybe Emoxypine by design works better with Dopamine re-uptake inhibitors like MPH/IPH than with plain agonists (Amphetamines)?
 

 

This has really peaked my interest, I enjoy an experimental supplement cycle. I see the benefits;

 

And here comes the BUT..

• Modulates the receptor complexes of the brain membranes, i.e. benzodiazepine, GABA, acetylcholine receptors by increasing their binding ability.

Changes the monoamine level and increases the dopamine content in the brain​

 

On a personal note:

 

Mechanisms of action has a broad spectrum of pharmacological effects to be implemented, at least on two levels - the neuronal and vascular. It has a powerful anti-ischemic, neuroprotective, antihypoxic, nootropic, Wegetotropona, antistress, anxiolytic, anticonvulsant, and other actions....

Sounds like a wonder, when researchers in the past claimed Aspirin, to be a cure all. That being said, It's has peaked my interest tremendously!

So..

@dopamimetiq

@chris106

Are there any reliable Suppliers, food sources, etc..?

Edited by Mr. Psychillogical, 18 December 2015 - 07:27 AM.

[Doc Psychoillogical]

ONE QUICK QUID PRO QUO:

 

ISOPROPYLPHENIDATE, a piperidine based stimulant drug.

-From a pharmacological stance, I see it to be the less effective DRI drug of class.

-What I suspect, the concurrent use with a more powerfully acting DRI. Such as;

- Amphetamine or Methylphenidate can lead to EXTREMELY potentated effects due to their dopaminergic action occurring in synergy!

 Maybe blissful, or an adrenal hell storm

 

 

Edited by Mr. Psychillogical, 18 December 2015 - 07:47 AM.

[Doc Psychoillogical]

Gabapentin(Neurontin) as a Tolerance reducer to dextroamphetamine?? Via calcium channels/ions

 

 

Gabapentin inhibits calcium currents in isolated rat brain neurons.

http://www.ncbi.nlm..../pubmed/9680261

 

A summary of mechanistic hypotheses of gabapentin pharmacology.

http://www.ncbi.nlm..../pubmed/9551785

 

http://www.ncbi.nlm....pubmed/10566977 D-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment.

The present study examined the effects of nicotinamide on the D-amphetamine (AMPH)-induced dopamine (DA) depletion and energy metabolism change in the rat striatum. In chronic studies, co-administration of AMPH with desipramine, a drug that retards the metabolism of AMPH, (10 mg/kg, intraperitoneal [i.p.], respectively) caused a significant decrease of striatal DA content measured 7 days later. Pretreatment with nicotinamide (500 mg/kg, i.p.), the precursor molecule for the electron carrier molecule nicotinamide adenine dinucleotide (NAD), attenuated this effect of AMPH, whereas itself exerted no long-term effect on striatal DA content. In acute studies, a decrease in striatal adenosine triphospate/adenosine diphosphate (ATP/ADP) ratio was found 3 h after co-injection of AMPH and desipramine. However, nicotinamide pretreatment blocked the reduced striatal ATP/ADP ratio and resulted in a striking increase in striatal NAD content in AMPH-treated rats. Furthermore, nicotinamide was noted to increase striatal ATP/ADP ratio and NAD content in saline-treated rats. These findings suggest that nicotinamide protects against AMPH-induced DAergic neurotoxicity in the striatum of rats via energy supplement.

 

GABAergic drugs inhibit amphetamine-induced distractibility in the rat.

Agmo A1, Medrano A, Garrido N, Alonso P.

Author information

 

Abstract

Drugs facilitating GABAergic neurotransmission have been reported to block some behavioral actions of dopaminergic stimulation but not others. The present experiments were performed with the purpose to extend the range of behaviors in which the interaction between GABA and dopamine have been studied. The ability of the GABAB agonist baclofen and the GABA transaminase inhibitor sodium valproate to block the enhanced distractibility produced by amphetamine was evaluated in a procedure especially designed for analyzing drugs' effects on distractibility. Briefly, rats were trained to traverse a straight runway with a sucrose solution as reinforcement. Once the response had been acquired, an additional runway ending in an empty box was connected. The time spent investigating this additional runway is the measure of distractibility. Male rats treated with amphetamine, 1 mg/kg, displayed an increase of the time spent in the additional runway. Baclofen, 2.5 and 5 mg/kg, and sodium valproate, 100 and 200 mg/kg, had no effect on distraction behavior when administered alone. However, when these drugs were administered together with amphetamine, 1 mg/kg, they completely inhibited the effects of the stimulant on distractibility. These data show that distractibility is similar to discrimination learning with regard to the capacity of GABAergic drugs to block the effects of dopaminergic stimulation. It is different from locomotor activity, however, where GABAergic drugs are ineffective in this respect.

 

Edited by Mr. Psychillogical, 14 January 2016 - 05:04 AM.

[Doc Psychoillogical]

TruthSpeaker's Safer use of stimulants faq


The Basics
-Drink water: your body gets massively dehydrated from stimulants such as Speed or X. A lot of neurotoxicity and damage can be reducted if you ONLY STAY HYDRATED! Products such as gaterade that supply Sodium and Potassium back to the body are very useful in staying hydrated.
-Eat foods! Primary fruits with B, C, E, or K vitamins, fibers found in whole wheat bread or apples help take pressures off the heart - Your body needs food to survive, period. No food intake = no glucose in your body to carry out even the basic functions of survival, such as cellular respiration.
-Avoid strenous exercise/keep cool: checking your heart rate every so often gives you an idea on how concerned you should be, you don't want to be running while peaking on stimulants and die of a stroke. A nasty way to go. Keeping cool also helps your body protect itself from overheating.
-Try to Sleep! This one is huge, not only does sleep help prevent amphetamine psychosis, but regenerates your body and helps your mind take in more material. Don't plan on remembering a lot of the material you crammed if you haven't slept in over 24 hours. Possible Rx sleep aids are Trazadone and the benzo class, and OTC meds such as bendrayl (Diphenhydramine), and motion sickness pills (Dimenhydrinate) help reduce nausea and vomitting. I've heard Tylenol PM works fine as well. Natural supplements such as melatonin, 5-htp, and magnesium may also help you fall asleep easier.
Note: benzos and anti-nausea products such as bendrayl can contribute to memory loss, which might lead you to forget some of the material you studied the previous night.
Helpful Supplements
-Magnesium: NMDA antagonist, prevents/reduces the tolerance of amphetamine, reduces muscle tension, is also believed to relieve stress and helps reduce jaw tension. Magnesium/Calcium levels also appear to be abnormal after amphetamine use, mostly the level of magnesium in your body drop while the levels of calcium stay the same. Magnesium can be found primary in banannas.
-Vitamin C/E: an obvious choice, helps in maintaing the body, relieves stress, antioxidant, helps fight off disease, required for normal growth of body, helps body recover faster. Vitamin C is found in oranges and most other fruit such as watermelons, lemons, apples, grapefruits...
-B vitamins (niacin, riboflavin, folic acid, etc): functions in the breakdown of carbohydrates into glucose (provding more energy for those days you feel exhausted after use), functions in the breakdown of fats and proteins (which aids the normal functioning of the nervous system). Pretty much just contribute to an increase in mood and energy.
-Melatonin: used as a sleep aid after use, may also function in reducing stress and curing insomnia.
-Dietary Fibers: takes some pressure off of your heart by helping lower blood pressure. As contributes to heart health, gastrointestinal health, diabetes, immune function and weight management. Dietary fibers are found everywhere, wheat bread, certain fruits (apples, peaches, etc), cereal.
Maintaining the body's "pleasure" neurotransmitters
-The 2 primary receptors affected by abusing amphetamines are dopamine and serotonin. Dopamine is the body's "reward center", rewarding the body with happy feelings caused by success. (winning a championship, love, etc) By stimulating your body's rate of production of these 2 receptors, you shorten the "crash" time and recover much faster.
-Generally, we use precursors to the certain neurotransmitters to increase production of that certain neurotransmitters. Take the precursor 5-htp for example. Normally tryptophan would produce 5-htp, which would in turn produce serotonin. By taking precursors you pretty much "skip" a step in enzyme production, enabling faster production of the product.
Producing more dopamine
-Too much dopamine has been linked to Schizophrenia, and too little has been linked to Parkinson's disease. I believe this rapid depletion of dopamine in amphetamine/stimulant habitual users is what leads to the "shakes" of stimulant abuse, as you see parkinson patients shaking involuntary all the time.
-NADH (nicotinamide adenine dinucleotide) a precursor to dopamine, pretty much just a supplement you can take to help produce more dopamine at faster levels.
-L-TyrosineL prescursor to dopamine and the adrenal hormones norepinephrine and epinephrine. Pretty much just increases alterness since the adrenal hormones help overall physical ability, also helps treat depression, which all precursors of dopamine should theoritically do. Vitamins C and B6 have been recommended in addition to taking L-Tyrosine.
-Another believed dopamine precursor is SAM-e (S-adensoyl-L-methionine), how this works I'm not sure right now, can anyone clear this up?
Producing more serotonin
-5-htp: a famous and much talked about supplement. Serves as the precursor to serotonin. It is generally used to treat depression, isomnia, headaches and suppresses appetite.
-SRRI's - brand names include prozac (Fluoxetine), Zoloft (Sertraline), Molipaxin (Trazadone), the list goes on. They are prescribed for depression and anxiety disorders such as OCD, and ADD. SSRI's work by increasing the amount serotonin chemical messengers in the brain. SSRI's should not be on a constant basis. Generally, the only people who would use SSRI's to get back on track are people who have been rolling on E or tweaked on Meth for days straight. SSRI's can take up to days to weeks to kick in, so some may "preload" with SSRI's a week before a meth or E binge.
-It is probaly unwise for anyone under normal conditions to take most SSRI's for a stimulant comedown. Trazadone is the only one I can think of that might be useful since it will pretty much knock you out.

-Usually one should be careful with how much serotonin they force their body to produce. Neither high or low concentrations of serotonin has been linked, as of yet, to cause depression.
Stimulant tolerance prevention
-This thread pretty much explains all of it in detail, very precise
-For the lazy, pretty much the only type of drugs that will prevent amphetamine/meth tolerance are NMDA antagonists such as DXM, Ketamine, Magnesium and others such as Memantine and Acamprosate.
-Taking these drugs WILL NOT reduce tolerance or prevent it completely. Taking these types of drugs will only partially help prevent tolerance from onsetting as fast as it normaly would.
Note: Tolerance levels develop very rapidly in amphetamines, it is very common for amphetamine tolerance to increase as much as 100% per day of a amphetamine binge.
Other drugs in helping amphetamine comedown/abuse
-Benzodiazepines: covers the user in a "blanket" after amphetamine/stimulant use. Very helpful in falling asleep and reducing anxiety. Benzos can also cause respiratory depression and low blood pressure, thus making it useful in fighting hypertension.
-Unfortunely, there are some major drawbacks to benzos. Benzos can cause amnesia, which will pretty much just erase the previous night from your memory. Benzo addiction is also a bitch, most people describe it as the WORST withdrawal symptoms you will ever face. Some symptoms of the wd's include tremors, seizures, or even coma.
-Some examples of benzodiazepines include valium, xanax, and kolonopin. Benzos are generally safe, and people claim that they are hard to get addicted to, especially if you are using it only when you comedown from stimulants.
-Bendadryl (Diphenhydramine) - help reduce nausea and vomitting, as well as causes drowziness, which may help the user fall asleep. Also may be used as an anti-anxiety and as an anti-parkison pill (helps reduce the "shaky" feeling you get after speed use). Another variation of bendrayl is dramamine (Dimenhydrinate), which is proclaimed -50% as potent as diphenhydramine.
-Some people report that they sleep they receive while on drugs such as bendrayl is very erratic and consists of nightmares. Benadryl also may cause respiratory depression.
-GHB (Gamma hydroxy butyrate) - people call this liquid X, the positive effects of this in relation to stimulant safety include muscle relaxation and lowered heart rate. Other effects caused by this drug are: Intoxication, increased energy, happiness, desire to socialize, loss of coordination due to loss of muscle tone, and possible nausea.
Bad effects of this drug include drowsiness, dizziness, amnesia, vomiting, loss of muscle control, respiratory problems, and loss of consciousness.
-I've also heard that using certain opiates such as vicodin the night after you have used the amphetamine can help you sleep better and will lower your heart rate. I have tried this, and I ended up puking 3 times throughout the night.
-Kava Kava, marijuana, salvia and other herbal psychodelics may also reduce some negative aspects of stimulants and help in reducing anxiety.
-Alcohol, primarily red wine might also help. Red wine has been shown to reduce hypertension and assist in helping maintain the cardiovascular system.

→ source (external link)

Edited by Mr. Psychillogical, 11 February 2016 - 06:46 AM.

[Doc Psychoillogical]

I updated the list I gave you with explanations explaining how truly sufficient these natural medicines are in restoring brain health after taking adderall for however long. I hope it helps you.

L-Tyrosine 100mg:
Replenishes the depleted Dopamine; Dopamine is responsible for positive mood, appetite, and overall healthy brain function. Deficiency of this neurohormone/transmitter leads to depression, moderate to severe depression, nervousness, severe anxiety, and even parkinson's disease. It is a precursor to the actual chemical of Dopamine, so NEVER should be mixed with Adderall/Vyvanse. You cannot actually take a supplement of Dopamine itself because it will not absorb into the liver properly. That is why L-Tyrosine or L-Dopa is its sufficient alternative, since they move pass the Liver, into the bloodstream to finally be converted as Dopamine.

Vitamin C 300mg: This is an antagonist of Adderall/Vyvanse or any amphetamine for that matter, and will help detoxify your body of the drug. Trust me, I've known plenty in rehab who have been given vitamin C for dextoxification of Methamphetamine as well as Dextroamphetamine. It is also an antioxidant and helps the body absorb iron; yay!

Vitamin B6 10mg: Many claim that Vitamin B besides creating a healthy
Pantothenic Acid 10mg - Also known as B5 and is critical in the metabolism and synthesis of carbs, proteins, and fats.

Magnesium 250-750mg:
This will potentiate the effects of Adderall if used together, and could be very dangerous. Amphetamine has the ability to damage brain cells when used in unhealthy doses. Magnesium repairs Nerve and Muscle function, but also fortunately lessens a patient's tolerance to Dopamine-Agonist medications. -- Make sure you do not mix Magnesium with Adderall due to its ability to intensely potentiate its Adderalls effects to dangerous levels. --

Zinc 50mg: It is well known that amphetamines as well as other stimulants like Cocaine cause a loss of libido, sometimes more seriously than others. If you combine Zinc and Magnesium it contributes strongly to the male and female sex drive as well as repairs poor circulation and neurological damage.

CoQ10 30-100mg: Studies with CoQ10 have mostly focused on its benefit involving certain types of cardiovascular diseases, including congestive heart failure and hypertension. However, CoQ10 has also been evaluated for high cholesterol and in diabetes. Amphetamine causes hypertension in some, elevating blood pressure tremendously; long term this isn't good for your heart. CoQ10 strengthens your heart, and people who use Adderall on a regular basis without healthy breaks could develop hypertension, and those who are older in years have a higher risk of stroke or heart attack; CoQ10 may help prevent this with proper exercise (Don't during the peak effects of your Adderall) -- Also, Please Make sure you do not take this drug with Adderall either since it may potentiate dopamine in the brain causing adverse reactions --

5-HTP 50mg: is a natural supplement that converts in the brain into serotonin. Serotonin is an important brain chemical involved in mood, behavior, appetite, and sleep! Serotonin is also involved in impulse control. For instance, low serotonin levels may lead to addictive behavior such as gambling or other habits caused by weak will power. Serotonin is known as 5-HT, or 5-hydroxytryptamine, and is found in many places in the body particularly the brain, gastrointestinal system, and blood cells. -- DO NOT MIX WITH PROZAC, EFFEXOR, ZOLOFT, LEXAPRO OR ANY OTHER ANTI-DEPRESSANT, IT MIGHT POSSIBLY KILL YOU BY RELEASING A TOXIC LEVEL OF SEROTONIN IN YOUR BRAIN -- Many tragedies are caused by drug interactions due to the malpractice of M.D.'s not properly educating patients regarding SSRI's/SNRI's.

Aspirin 325mg:
We all know what aspirin is, but we must remember it can prevent strokes and heart attacks as well as ischemic attacks (mini-strokes). Aspirin is an antiplatelet medicine that decreases blood clot formation by preventing the smallest blood cells (platelets) from sticking together and forming blood clots. Adderall as I said earlier, may increase the risk of Heart Attack and Stroke when used over a long period of time or if it is abused regularly; I wouldn't recommend the latter. If you take one Aspirin today, you will have improved circulation, less headaches, and much less chance for stroke or heart attack.

Melatonin 3mg:
Melatonin is a natural hormone released from the pineal gland each night to help us sleep. Melatonin secretion is enhanced in darkness and decreased by light exposure. As we age, melatonin production decreases. One of the common uses of melatonin is for occasional sleep problems. This helps me get to sleep after taking 1 or 2 and it only takes me 45 minutes to gently fall asleep. It is all-natural, and I know those of us prescribed to Adderall have trouble sleeping; do we really want to add another narcotic to our regimen just to sleep? I do not, so I use Melatonin nightly since it is already naturally occurring in the body and safe. It also makes my dreams intensely vivid and fascinating.

Anyways, I'm not a professional, I'm just someone who has had a fair share of obsessive reading in psychiatric and natural medicine. My grandfather was a psychiatrist and I find it very interesting. I also find it interesting that every psychdoc I've been to seemed completely ignorant of the benefits of natural vitamins in replenishing psychiatric and personality disorders ALL caused by similar chemical balances. I'm not being objective, just my honest opinion.

Please be careful -- If you are taking any other medications I do not know about let me know before you mix these supplements with them.

→ source (external link)

[Doc Psychoillogical]

A Brief Guide to Non-medical Psychostimulant Use
Draft published July 23, 2015
The goal of this guide is to provide an overview of how to optimally ingest psychostimulants for studying. I will attempt to provide general, non-technical guidance in order to promote an effective and safe method to take psychostimulants. By psychostimulants I refer to the common pharmaceutical amphetamine formulations such as Adderall and Ritalin.

Dextroamphetamine
Non-medical use of psychostimulants including amphetamines and methylphenidate is widespread during midterms and finals[3][4][5]. Studies show a prevalence between 35.5%[1] to 72.8% [2]. This is granted, and I do not need to provide references in the endsnotes to prove such — but the study titled Tweaking and Tweeting: Exploring Twitter for Nonmedical Use of a Psychostimulant Drug (Adderall) Among College Students is just delectably worded. However, most students have little or no idea how to properly dose the various psychostimulants that are commonly available. First, I will discuss the basics of some common varieties of amphetamine-based stimulants:
Adderall — is composed of a mixture of the salts of the stereoisomers of amphetamine: 75% dextroamphetamine / 25% levoamphetamine. D-AMPH is notably more potent, euphoric. Amphetamine salts are available in 5mg, 10mg, 15mg, 20mg, and 30mg tablets.
Adderall XR — is an extended release capsule composed of the same 75% D-AMPH / 25% L-AMPH ratio. These are available in 5mg, 10mg, 15mg, 20mg, 25mg, and 30mg gelatin capsules.
Vyvanse — or lisdexamfetamine is a prodrug for D-AMPH. Lisdexamfetamine is inactive as it must be broken down by enzymes which cleave the L-Lysine from the dextroamphetamine releasing the D-AMPH. It is available in 10mg (pink), 20mg (ivory), 30mg (white/orange), 40mg (white/blueish green), 50mg (white/blue), 60mg (blue/aqua) and 70mg (blue/orange) capsules.
Ritalin — methylphenidate.
Ritalin XR — methylphenidate.
Concerta — a specially formulated methylphenidate extended release capsule that is available in 18, 27, 36, and 54mg varieties.
Less commonly prescribed stimulants:
Focalin — dexmethylphenidate is a more potent stereoisomer of methylphenidate available in 2.5, 5, and 10mg tablets.
Focalin XR — dexmethylphenidate available in 5, 10, 15, 20, 25, 30, 35, and 40mg varieties.
Dexedrine — dextroamphetamine in its pure form. Available in 5, 10, and 15mg capsules.
Desoxyn — this is likely the hardest to come by, desoxyn is the brand name for prescription methamphetamine tablets (5mg) that are only indicated for ADHD and as a anorectic for obesity.
Then there are a large variety of illegal stimulants or those with grey-legality such as the fluorinated amphetamines (2-FA, 3–FA, 4-FA, 2-FMA, 3-FMA etc….) Certain fluorinated amphetamines are far more recreational and “functional” such as 4-FA which may act as a partial serotonin releasing agent in addition to being a reuptake inhibitor of dopamine, serotonin and norepinephrine [3][4]. Therefore, at higher dosages 4-FA has qualities more akin to MDMA — complete with bruxism, hyperthermia, empathogenic enhancement etc… 3-fluoroamphetamine [3-FA] and 2-fluoromethamphetamine [2-FMA] are similar in potency and effect to dextroamphetamine or methamphetamine. That’s all I will mention here, for now. For further anecdotal reports see this reddit thread.
D-AMPH’s half-life is roughly 9–12 hours, L-AMPH’s half-life is 11–14 hours, while methylphenidate’s half-life is only 2–3.5 hours. This means if you take even 5mg of adderall at 7PM, don’t expect to sleep until 4–6AM. This is of course without any sleep aids, but amphetamine can easily disrupt sleep quality regardless. This is why planning is important. If you take adderall for an exam, then it would be best if you take it 1–1.5h before your exam. If you are taking amphetamines to study for an exam, then study for your exam roughly the same time every day. This will better condition you to perform well.
Taking amphetamines on an empty stomach is good, but to further potentiate the duration and effect make sure your stomach is not acidic by avoiding things like orange juice before and during ingestion. Ingesting alkaline substances like antacids such as Tums (calcium carbonate) or Gaviscon (sodium/potassium bicarbonate) can increase the potency of amphetamines. However, because of the anorectic effects of amphetamines it is usually good to have a high protein meal before dosing — otherwise you are likely to go most of the day without eating.
Amphetamines can certainly keep you awake studying all night, but this will be detrimental in the long run. You begin sleeping at odd, irregular hours and soon — even with a large supply of amphetamines — you will become physically and mentally burnt out. This is not recommended. Amphetamines enhance focus, cognition, and your ability to stay awake for hours — yet balance is still needed. “The dose makes the poison” is a univeral maxim for pharmacological investigation (and arguably a philosophical notion not unlike the Aristotelian “golden mean”, a middle between two extremes). Well, by taking amphetamines you are already entering the extreme but by doing this you must respect the drug.
Tips on how to Properly Take Psychostimulants
Don't take “too much” — meaning, if you have no tolerance to amphetamines there is no need to take an entire 20 or 30mg adderall. The beneficial effects of amphetamines are on a continuum; that is at a certain point the negative effects (anxiety, headaches, irritability) will outweigh the positives. One model of understanding this comes from the Yerkes-Dodson Law which states that performance is enhanced with greater arousal. Grantedly, the Yerkes-Dodson law comes from rudimentary studies with mice in the early 20th century but the following graph is a rough approximation of the principle:

A somewhat poor albeit useful diagram of the Yerkes-Dodson law
Titrate your dosage with increments of 5–7.5mg if it’s amphetamines and by increments of 10–15mg for methylphenidate. Psychiatrists usually don’t prescribe amphetamines above 60mg/d and 60–80mg for methylphenidate. Total doses (if you are amphetamine naive) should not exceed 20–30mg daily, or 40–50mg for methylphenidate. This is a guideline, not a rule.
Hydrate frequently and attempt to eat before taking larger doses as dopaminergics can greatly reduce appetite.
See supplements and sidepoints below for additional tips to enhance either acute or chronic psychostimulant use.
Perhaps take a look at this blog entry by a psychiatrist (or my highlights below), who manages to give mostly solid advice on how to take amphetamines in order to study effectively: How To Take Ritalin Correctly
Here’s pretty much all the pertinent parts of his article:
That said, the key to amphetamines and Ritalin is to stop thinking of them as stimulants, and to think of them as reinforcers.
Let’s conceptualize how these drugs work. Imagine getting a brain scan while you are performing a task. The parts of your brain you are using for the task will light up, brighter than those you aren’t using.
Now you drink coffee (1). The whole brain lights up brighter, proportionally.
Now you take amphetamines. The parts of your brain that you are using light up brighter, but the parts you aren’t using go darker. Get it? Caffeine is a global brain stimulant, while amphetamines focus your attention, reducing distraction.
This is entirely selective and controlled by you. You have to decide what you want to focus your attention on. If it’s reading, the reading parts of your brain will be brighter. But if you stop reading and decide to talk to your friend on the phone, you know, the hot one with the hotter roommate, then you’ll be more focused on that (obviously). Attention is always decreased when it is split among several tasks. In other words, you can only concentrate on one thing at a time, even though it may feel like you are doing two things at once.The power of amphetamines is this: you take them again, in the same dose, 30 minutes before your test.
In a metaphoric sense, taking the amphetamines during the test, under the same circumstances as you had been previously studying, will “remind” the brain of that context. If you see a question that “resembles” something you studied, your mind will be primed to recall it better.
Remember I said you can only concentrate on one thing at a time, that attention decreases when it is split? The trick here is to make everything about studying into one large “thing.”
Here’s an example: if you listen to a symphony, you will hear music. Musicians, however, hear both the music and every single instrument. They can attend to each instrument individually and simultaneously hear how each instrument fits into the larger context. A non-musician can’t do that. If he’s concentrating on the oboe, he doesn’t “hear” the violas.
Studying has to become a large symphony, everything doing its part correctly, expectedly. So on performance day (testing) you play the same symphony. You’re not trying to concentrate on each part, if you’ve practiced enough it should be second nature. The amphetamine helps facilitate this.
Supportive Supplements:
Magnesium glycinate can attenuate and reduce bruxism (jaw clenching and teeth grinding). Magnesium is also potentially useful in helping to reduce long term amphetamine tolerance. Magnesium glycinate is a chelated form of magnesium that will not produce gastrointestinal side effects unlike many magnesium supplements that usually contain magnesium oxide. (Magnesium is also a generally useful supplement regardless of amphetamine use).
Amphetamine has the potential to cause oxidative damage to neuronal cells, but regardless of neurotoxicity of amphetamine and its metabolites the following antioxidants are useful: CoQ10, Vitamin C, Acetyl-L-carnitine and ALA (alpha lipoic acid). Acetyl-L-carnitine (ALCAR) is synergistic with ALA and itself a mild stimulant and relatively well studied supplement.
Melatonin is an endogenous hormone that serves as an antioxidant and regulator of a large variety of bodily processes, notably as a regulator of circadian rhythm. 500–750mcg before bed will assist in sleep initiation.
Amphetamines (especially in larger doses) can cause erectile dysfunction. In most cases L-arginine can easily resolve flaccidity. Agmatine is also an option that can be useful in this area.
Monoamine-oxidase inhibitors (MAO-i)
MAOi’s occur in various plants such naturally as harmala alkaloids — examples of such plants would include Banisteriopsis caapi (Yaje) and Peganum harmala (Syrian Rue). Yaje is a necessary compound within Ayahuasca, as N,N-dimethyltryptamine (DMT) will not be active orally due to it being quickly metabolized and destroyed by monoamine-oxidase in the gut. MAOi’s will greatly potentiate any amphetamine or monoaminergic drug.
Shulgin made an extract from 28g of Peganum Harmala and reported it in TiKHAL under entry #13 Harmaline. Here is an excerpt of his bioassay below:
This time it came on very fast. That tremendous buzz on the other side of which are the wondrous realms of the subconscious. The most memorable impressions from this trip were of weird animals. I imagined myself spinning on a merry-go-round of strange winged creatures. I started to feel very sick and negotiated my way to the bathroom to face the inevitable — voiding from both orifices simultaneously. It proved cathartic, and released me to experience the state more fully. I remember traveling to jungle-like places, full of imagery of vines, fountains, and animals. Minutes seemed like hours as I roamed in these spaces. Though the sensory effects were very disturbing when I got up, given high dose level, I could easily ignore my body when laying down and traveling in my mind.
MAO-i’s are generally something you should definitely avoid in conjunction with taking amphetamines, as are mixing other recreational drugs such as cocaine (which would dull or block many of the enhancing effects of amphetamine? or potentially double the euphoria [conflicting studies/anecdotes as the mechanism of action of cocaine is not quite determined but cocaine and methylphenidate have similar mechanisms of action]) — etc… see the following regarding cocaine:
Dopamine reuptake transporter (DAT) “inverse agonism” — A novel hypothesis to explain the enigmatic pharmacology of cocaine
Cocaine’s short half-life of 30min-1h is an extremely poor choice for studying. This should be obvious!
Also smoking cannabis while on amphetamines can easily become more anxiogenic than cannabis alone. Additionally, drinking alcohol with amphetamines is not advised.

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[Doc Psychoillogical]

One year of stimulants in college. My thoughts and advice... (self.Drugs)

Some of these things are opinions and may not necessary apply to anyone but myself, however there will be a lot of generalization in this list.
Adderall is addictive, even for people who legitimately have ADHD and have used their meds since they were young children. I am not in that category, but have never met anyone who didn't admit this.
Most doctors that i've seen do not believe people who have ADHD are even capable of getting high from their meds. This leads to somewhat reckless prescribing of stims.
The most amphetamine the average person can take in a sustainable manner is around 50mg. Note: "the average person". Your mileage may vary.
If you are taking amphetamines you would probably be better off with total abstinence from caffeine and tobacco. I get a lot more out of my script by doing this, have much softer comedowns, feel happier and healthier, and get much better quality of sleep.
All the amphetamine in the world doesn't mean jack shit if you don't get at least 6 hours of sleep and 2 solid meals per day. Minimum. You'll feel better the more sleep and food you get. I try to get a solid 8 or 9 hours of sleep and munch all day.
Don't pull all nighters, they will break your body down, cause your tolerance to skyrocket, and in general fuck shit up.
Amphetamines will, at first, make you actually want to do things that you consider work. This will go away after a while, but not entirely. Do not try to compensate by upping the dose. Doing so will just make the problem worse. Instead, you're just gonna have to learn to do shit that you don't want to.
If you have trouble sleeping, see your doctor and get that shit solved right away. I use clonidine and melatonin, and it works alright for me. I am thinking of asking for gabapentin as an additional med.
You won't always feel like eating but you have to. A good way to get your calories when you don't feel like eating is by drinking whole milk and eating cliff bars. Beef jerky, pasta, omelets, juice, shakes, and gatorade are good ways to get calories as well.
Take whatever vitamins you feel is appropriate, just don't go overboard with dozens of obscure nootropics. Take at least a normal multi-vitamin, it'll reduce comedowns and stress. I take one multivitamin, one vitamin C tab, one Omega-3 supplement, and two iron supplements in the morning (I have low blood-iron). I take melatonin and magnesium before bed (both help a tad with sleep).
Stimulants can make switching between tasks very difficult. It will always be "one more second/game/flashcard/whatever". Learn how to watch out for this and always think "what am I doing right now, and should I still be doing this or should I be starting something else".
If you cannot moderate yourself with your own meds, see if a trustworthy close friend or SO can distribute your meds to you. Thats what I do. My girlfriend gives me one pill every morning. If I have a packed day, then we discuss two but she has veto power.
This one is an opinion, but I find vyvanse to be very much superior to adderall or adderall XR. The come-up is much smoother which I find substantially less addictive. It can't be snorted crushed, plugged or even IV'd for a faster experience. It is what it is and you just have to accept it. Less of a rush also means you don't do as many things you regret in manic euphoria. Then, vyvanse also lasts all day without the up/down bipolar feeling of adderall, and it ends with a much milder comedown. The fact that vyvanse only uses dextroamphetamine as opposed to levoamphetamine supposedly means more dopamine is released compared to epinephrine and norepinephrine. I believe this reduces the stressed out feelings I get from adderall. Finally, less people ask you for vyvanse yet it is worth much more.
Stay hydrate. Try to use water fountains.
Stimulants can take away the "gross, I haven't showered or brushed my teeth feeling". As gross as it is you may have to remind yourself to take care of you hygiene.
Try not to mix booze with stims. It will fuck with your head if you do it to much and/or too hard.
Do not take stimulants everyday for an unending period. I personally need at least one day off per week to recharge, catch up on sleep and food, and to just relax. Not taking days off reduces the effectiveness of stims and leads to anxiety.
To elaborate about the consequences of not getting enough sleep... with enough stimulants you would be hard pressed to feel tired or miss class. You can make yourself feel fine even when you have only a couple hours of sleep per night. You won't notice until afterwards, when you are getting enough sleep, that you have little to no memory or recall of this sleep-deprived state. In that state you become irritable and have wild mood swings. You become OBSESSED with things that you give zero fucks about normally. I mean fucking obsessed researching stupid shit you truly, truly don't care about, and then you barely even remember what you learned during your obsession. Stay the fuck away from this place, it takes a toll on your body, mind, and relationships and it is why my girlfriend now distributes my meds to me.
Smoking on amphetamines causes synergistic addiction to both cigs and amps. Try to stay away from here.
On the flip side, amps make quitting cigs much easier. It feels like it accelerates the timeline for withdrawal. One week of no cigs on amps feels like one month without amps. However, amps also boost the cravings for cigs during withdrawl.
It is very easy to make mistakes like spending all your time making flashcards and no time learning the flashcards.
Smoking too much weed with amps can hurt (maybe damage) your heart. Pay attention to it while blazing on stims.
More sleeping advice on stims. Eat a big meal before bed, have a fan for white noise, keep the room cold, get a wide bed so you can stretch and not wake up you SO, try to do pushups/situps/run/ect around 6pm, keep the room dark, try melatonin - it helps a little, keep hydrated and well fed, and finally try taking a shower if you can't sleep. Start out with a cool shower, and then gradually make it colder and colder one turn at a time until you feel numb and the water doesn't feel cold anymore. Then switch to warm and slowly make it hotter and hotter until it burns. Switch back and forth between hot and cold and after a while it becomes hypnotic and you get very sleepy. Then get a big glass of milk and go back to bed.
In a pinch, 25mg of diphenhydramine can put you to bed. But, this can only be done occasionally because tolerance builds very fast.

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[Doc Psychoillogical]

ADHD
Attention deficit hyperactivity disorder (ADHD) is the most common psychiatric disorders in children, and one of the most common problems in adults, affecting between 5-10% of the population.

ADHD is characterized by persistent short attention span, distractibility, disorganization, procrastination and problems with forethought, judgment and impulse control.

Having “untreated” ADHD affects nearly every aspect of a person’s life and has been associated with school underachievement, family conflict, drug abuse, legal difficulties and poor work performance. ADHD is involved with low self-esteem, chronic stress, failure and even suicide.

The standard treatment for ADHD in both children and adults is stimulant medications, such as Ritalin or Adderall. These medications are helpful for many people, but they also make many others with typical ADHD worse. Sometimes negative reactions to these medications can be extreme, such as hallucinations, violent outbursts, volatile temperaments, psychosis and suicidal behavior.

6 Types

Here are the 6 different types of ADHD, each with different brain function issues and treatment protocols.

Type 1: Classic ADD

Symptoms: primary ADD symptoms plus hyperactivity, restlessness, and impulsivity.

SPECT: usually low activity in prefrontal cortex during an activity requiring concentration

Supplements: multiple vitamin, NeuroEPA fish oil, L-tyrosine or DL-phenylalanine

Medications: stimulant medications (such as Adderall, Concerta, Ritalin, or Dexedrine)

Type 2: Inattentive ADD

Symptoms: primary ADD symptoms plus low energy and motivation, spacey, and internally preoccupied. Type 2 is diagnosed later in life, if at all. It is more common in girls. These are quiet kids and adults, often labeled lazy, unmotivated, and not that smart.

SPECT: usually low activity in prefrontal cortex during activities requiring concentration and low cerebellar activity

Supplements: multiple vitamin, NeuroEPA fish oil, L-tyrosine or DL-phenylalanine

Medications: stimulant medications (such as Adderall, Concerta, Ritalin, or Dexedrine)

Type 3: Overfocused ADD

Symptoms: primary ADD symptoms plus cognitive inflexibility, trouble shifting attention, stuck on negative thoughts or behaviors, worrying, holding grudges, argumentative, oppositional, and a need for sameness. Often seen in families with addiction problems or obsessive-compulsive tendencies.

SPECT: usually high anterior cingulate activity plus low prefrontal cortex activity during activities that require concentration

Supplements: multiple vitamin, NeurOmega fish oil, 5HTP, L-tryptophan or St. John’s Wort plus L-tyrosine

Medications: antidepressant Effexor, or a combination of an SSRI, like Prozac, and a stimulant

Type 4: Temporal Lobe ADD

Symptoms: primary ADD symptoms plus a short fuse, misinterprets comments, periods of anxiety, headaches or abdominal pain, history of head injury, family history of rages, dark thoughts, memory problems, and struggles with reading. Often seen in families with learning or temper problems.

SPECT: usually low temporal lobe activity plus low prefrontal cortex activity during activities that require concentration

Supplements: multiple vitamin, NeurOmega fish oil, GABA or taurine for irritability, or Brain Vitale or NeuroMemory for memory issues.

Medications: Stimulants, by themselves, usually make people with this type more irritable. Effectively treated with a combination of antiseizure medications (such as Neurontin) and stimulants.

Type 5: Limbic ADD:

Symptoms: primary ADD symptoms plus chronic mild sadness, negativity, low energy, low self-esteem, irritability, social isolation, and poor appetite and sleep patterns. Stimulants, by themselves, usually cause problems with rebound or cause depressive symptoms.

SPECT: usually high deep limbic activity plus low prefrontal cortex at rest and during activities that require concentration

Supplements: multiple vitamin, NeurOmega fish oil, SAMe or DL-phenylalanine

Medications: Stimulating antidepressants, such as Wellbutrin.

Type 6: Ring of Fire ADD

Symptoms: primary ADD symptoms plus extreme moodiness, anger outbursts, oppositional, inflexibility, fast thoughts, excessive talking, and very sensitive to sounds and lights. I named it Ring of Fire after the intense ring of overactivity that I saw in the brains of affected people. This type is usually made much worse by stimulants.

SPECT: marked overall increased activity across the cortex, may or may not have low prefrontal cortex activity

Supplements: multiple vitamin, NeurOmega fish oil, NeuroLink (contains 5HTP, GABA and L-tyrosine)

Medications: Anticonvulsants (such as Neurontin) and SSRI medication, or the use of the novel antipsychotic medications such as Risperdal or Zyprexa.

Common Treatments for All Types

1. Take a 100% multiple vitamin everyday. Studies have reported that they help people with learning and help prevent chronic illness. NeuroVite was formulated specifically for our own patients.

2. Adults, take 2,000 - 4,000mg of high quality fish oil a day (1,000 - 2,000mg for children). For types 1 and 2 NeuroEPA from the Amen Clinics is a high quality brand. For types 3-6 NeurOmega is best.

3. Eliminate caffeine from your diet. It interferes with sleep and helping the other treatments work.

4. Intense aerobic exercise daily for 30-45 minutes. For kids, if you cannot find a safe exercise (no brain injuries please), take them on long, fast walks.

5. Turn off the television and video games, or limit them to no more than 30 minutes a day. This may be hard for kids and teens, but it can make a huge difference.

6. Food is a drug. Most people with ADD do best with a higher protein, lower simple carbohydrate diet. Barry Sears book, The Zone is a good place to start.

7. In dealing with kids, employees, even spouses ““ NO YELLING! Many people with ADD are conflict or excitement seeking, as a means of stimulation. They can be masters at making other people mad or angry. Do not lose your tempers with them. If they get you to explode their unconscious, low energy prefrontal cortex lights up and likes it. Never let your anger be their medication. They can get addicted to it.

8. Test ADD kids and adults for learning disabilities. They occur in up to 60% of people with ADD. The local schools are often set up to do this for school age children.

9. Apply for appropriate school or work accommodations (see Healing ADD on how to do this properly).

10. Never give up seeking help.



At Porter Academy

Students with ADD or ADHD generally do well at Porter Academy due to our 1) multi-sensory learning activities that better engage any child, 2) our small groups and individualized attention, 3) our shorter rotations to accomodate shorter attention spans, and 3) our frequent movement breaks and bilateral/mid-line crossing activities. iLs also has proven beneficial for students with ADHD by stimulating areas of the brain associated with attention, further developing those nerve networks.

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[Doc Psychoillogical]

CANNOT EMPHASIZE HOW MUCH SUCCESS I HAVE EXPERIENCED WITH THIS STACK:

Citicoline

Arginine

Selenium

Zinc Glycinate

D3

Magnesium lys-bi-glycinate

Theanine

Pregnenolone.

Chalk it up to personal brain chemistry or synergy but WOW one week in and still going very very strong. And yet i feel and behave as I normally do, just internal Bliss...hope its not psychosis....

 

[medievil]

UPDATE

 

Recently prescribed Gabapentin & Klonopin for anxiety, in addition to existing Dexedrine script.

 

Very much enjoyed the combo of Klonopin+Dexedrine, but the Gabapentin not cause beneficial effects to the combo.

 

Of the three, the Klonopin+Dexedrine is most effective.

 

Also how you time the doses are EXTREMELY important!(Dexedrine before Klonopin)

 

Didn't see any noticeable difference in Gabapentin+Dexedrine vs Dexedrine alone in terms of combination benefits or side effect reduction.

 

Most likely would use Gabapentin as a backup supply if klonopin supply runs out too soon. 

I used to be prescribed the combination, still get clonazepam prescribed and use it in combination with stimulants, its a benzo that works in the background and ideal in combination wth stims.

 

Im not a fan of gabapentin or pregabalin as i dont get any therapeutic effects but i do use pehnibut daily

[medievil]

 

 

 

- I would LOVE to this discussion topic to full of Vitamins, Supplements, Herbs, Prescriptions, OTC, and Food/Drink Personal experiences & Professional data, research, info, studies, interactions and posts.

As reply to your first post, jeezes christ, antioxidants can turn pro oxidant, thats a shitload of antioxidants you dont know the outcome off, with so many antioxidants, i would except some counteracting oxidative stress but the rest to turn pro oxidant, amphetamine is just one thing, this is like a ganbang with only one bitch

[medievil]

...further study is needed to determine the effects of post-treatment with flavonoids such as the induction of dopamine and the regeneration of axons after damage in DA system of adult brain as well as the study on the mechanisms of flavonoids-induced effects in the adult brain.

Schematic representation of flavonoids-induced neuroprotective effects.

Many kinds of flavonoids can attenuate microglial activation and oxidative stress, and induce neurotrophic factors to protect dopaminergic neurons in the adult brain.

Amphetamines wont cause any neurotoxic damage, that said you do need flavonoids with antioxidant effects, dont focus on antioxidants that means shit but flavonoids with many neuroprotective effects, grapeseed extract is loads of antioxidant effects which can protect against toxitcy. Neurotrophic factors have nothing to do with neuroprotection as an aside