2 replies to this topic

[Logic]

I am trying to drum up interest in a Nilotinib group buy.
It occurred to me that I am not well known in the Brain Health sub-forum and that people here may be more interested:
 

"This drug, in very low doses, turns on the garbage disposal machinery inside neurons to clear toxic proteins from the cell. By clearing intracellular proteins, the drug prevents their accumulation in pathological inclusions called Lewy bodies and/or tangles, and also prevents amyloid secretion into the extracellular space between neurons, so proteins do not form toxic clumps or plaques in the brain,” says the study’s senior investigator, neuroscientist Charbel E-H Moussa, MB, PhD...

...Nilotinib "offers a unique and exciting strategy to treat neurodegenerative diseases that feature abnormal buildup of proteins in Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia, Huntington's disease and Lewy body dementia, among others."

 

http://explore.georg.../news/?ID=70332
 
Nilotinib increases endogenous parkin levels, boosting autophagy.
Parkin is also selectively recruited  to impaired mitochondria and promotes their autophagy.
This makes it interesting for longevity in general IMHO.
http://www.ncbi.nlm....les/PMC3975659/
http://www.ncbi.nlm....les/PMC2592826/

So if you know anyone with:

• Parkinson’s disease
• Alzheimer’s disease
• Amyotrophic Lateral Sclerosis (ALS)
• Frontotemporal Dementia
• Huntington's disease
• Lewy body dementia
• etc

See the group buy thread here:
http://www.longecity...roup-buy/page-2

[Logic]

Nilotinib group buy:
http://www.longecity...ndpost&p=765364
 
If you are interested in acquiring Nilotinib prices are as follows:

• Nilotinib $ 8.61 per gram.
• 3rd party testing: $ 600 divided by the number of people that commit to the buy.
• 6 people have committed to the group buy so far, so $600/6 = $ 100 each. I am working on 6 people. ie: add $100 to the above cost.
• Postage from the testing lab has to be added and will differ depending on you location.

So far the following people have committed to the group buy:

• resveratrol_guy                   100 g     $ 961.00  
• ceridwen                              30 g      $ 358.30      
• Logic                                    30 g      $ 358.30     
• noot_in_the_sky                  50 g       $ 530.50
• LongLife                              100 g     $ 961.00
• Der Springende Punkt         20 g       $ 272.20 

Persons who has paid so far:

• resveratrol_guy
• Logic
   

If you are interested please PM me with your address and I will supply my Paypal Email address and the cost of postage from the lab and the lab's details.

• If a minimum of 200 grams is not reached I will refund those who have paid.
• If the number of people is less than 6: More money will have to be paid in for testing.
• If the number of people is more than 6: I will refund the difference.

Timeline:

• Arrival at testing lab after payment of the supplier: 4-6 working days.
• Testing and splitting/packaging for end destination: 5-7 working days.
• Postage to final destination:  unknown.

I am holding thumbs that the buy will be successful, so do contact anyone you think may be interested to bring the cost down as much as possible.

[Logic]

Group Buy Target reached!
 
People who have paid:

• resveratrol_guy 100g
• LongLife 100g
• Der Springende Punkt 20g
• noot_in_the_sky 58g
• Logic 30g
• rikelme 10g
• ceridwen 77g
• Alex_G 30 g
• 'other buyer' 200g (wants to remain anonymous)

 
Total: 625 grams
That means that we have reached our target.  Thx everyone!  
I will be ordering the Nilotinib on Mon, Mar 21 at 0H00 GMT.
(That's at 8pm Sunday night in New York)
Any funds received after this time will have to wait for the next Nilotinib group buy.