10 replies to this topic

[alc]

http://www.eurekaler...u-cpe031516.php

 

and IDUNN Tech web site (french only for now):

 

http://idunntechnologies.com/

 

"Longevity Extension by Phytochemicals"

 

http://www.mdpi.com/...-3049/20/4/6544

 

caveat: study done in yeast

 

I wish the "475 per cent and/or 369 per cent" increase in lifespan can be translated to humans ... just dreamin' ...

 

 

[Florian Xavier]

0% chance

[Florian Xavier]

or maybe like 5%

[Logic]

I don't know if the active ingredient in willow bark that is responsible for this lifespan extension is salicylic acid, but it is very likely given the increase in metabolism of yeast given the willow bark extract. It is worth noting that willow bark extract was the most potent of all 10,000+ ingredients with lifespan extension features that the team tested. It is also worth noting that the extract extended both average and maximum lifespan several-fold, and it is the latter that is the goal of most anti-aging research.

Btw, there are several other studies showing lifespan extension from aspirin and pure salicylic acid. I have already posted some of them on the forum.
The willow bark extract (PE21) was standardized for 25%+ salicin, which is a pro-drug for salicylic acid and has action very similar to aspirin.
Salicin - Wikipedia, the free encyclopedia
The concentration that had the strongest life extending effect was 0.1% of the extract as part of the diet. I emailed the authors and the response I got was that the human equivalent dose of would be 41mg/kg and 82mg/kg of the willow bark extract, which was standardized to 30% salicin. So, this means 12.5mg/kg or 25mg/kg salicin for a human daily. Now, salicin is a prodrug for salicylic acid just like aspirin, but the good news is that you need less aspirin to get the same levels of salicylic acid than by ingesting salicin. The coefficient is about 0.63 for aspirin, so the above doses of salicin would equate to about 7.9mg/kg and 15.75mg/kg aspirin daily. This corresponds pretty well to the optimal therapeutic aspirin doses seen clinically - i.e. 500mg - 1,500mg daily.
http://www.epsce.com/userfiles/A Novel More Potent Salicin Content.pdf
"...A typical 500 mg dose of aspirin is equivalent to 794 mg of salicin [7]. To round off these numbers, 800 mg of Salicin is equivalent to 500 mg of Aspirin; it will take approximately 38 drops of White Willow buds to equal the 500 mg of aspirin and 19 drops as an alternative to 250 mg of aspirin. All of this is just an approximation and not an exact certification but helps us how to gauge therapeutic levels."
Reference [7] from above quote: Rational Phytotherapy: A Physicians' Guide to Herbal Medicine | Annals of Internal Medicine

https://raypeatforum...most-400.10141/

[Florian Xavier]

so if it's aspirin, it doesn't work on humans.

[resveratrol_guy]

so if it's aspirin, it doesn't work on humans.

 

Aspirin has plenty of well studied benefits in humans, the sum of which are probably somewhat life-extensive. The interesting suggestion here is that the optimal dose for that purpose is an order of magnitude higher than what we've been told to take by the medical establishment, namely 81 mg/day. That dose is sufficient to inhibit clotting, but it may not be sufficient to achieve some of these other benefits.

 

Aspirin is not without its downsides: (1) increased susceptibility to ulcers, even if you take the enteric-coated variety (because it suppresses protective mucous in the digestive tract), (2) bleeding the lungs (related to rye's syndrome), and (3) poor clotting (usually desirable but sometimes fatal).

[Logic]

Aspirin is not without its downsides: (1) increased susceptibility to ulcers, even if you take the enteric-coated variety (because it suppresses protective mucous in the digestive tract), (2) bleeding the lungs (related to rye's syndrome), and (3) poor clotting (usually desirable but sometimes fatal).

Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase.
http://www.longecity...ndpost&p=750581

..Aspirin also interferes with absorption of vitamin C, and regular use of aspirin can deplete your gastrointestinal lining of vitamin C (3). Taking equal doses of vitamin C and aspirin decreases the amount of stomach damage that occurs when compared to taking aspirin alone, according to research done at a German university (4)...

http://www.longecity...ndpost&p=761825
(Read Niner's reply, further down and the post below it too)

 

Aspirin is a telomerase activator

http://www.longecity...rase-activator/

Edited by Logic, 03 April 2016 - 10:21 PM.

[Antonio2014]

Mmm what a deja vu...

 

Every so often along comes a new over-hyped drug candidate with studies showing it extends life in laboratory animals. People throw away common sense and buy the stuff for a few years until the hype wears off in the face of more scientific evidence that throws doubt upon the early claims, and the realization that, like all the preceding drug candidates, this latest one also does next to nothing to impact the progression of aging in humans.

 

It helps greatly to realize that life span and health are much more plastic in short-lived species than in comparatively long-lived species such as we humans. All sorts of things extend life in lower animals by a large amount yet have no such result in humans. Consider calorie restriction for example, which extends life by 40% in mice, but certainly doesn't do as much in humans. Did you know that ibuprofen use meaningfully extends life in a number of species to a an equal or greater level than metformin, a currently hyped drug candidate to slow aging? Or that aspirin has sizable effects on life span in short-lived species as well? Yet clearly neither of those extends human life span to anywhere near the same degree, despite decades of use and a great deal of data on its effects.

 

https://www.fightagi...o-does-aspirin/

[resveratrol_guy]

Mmm what a deja vu...

 

Every so often along comes a new over-hyped drug candidate with studies showing it extends life in laboratory animals. People throw away common sense and buy the stuff for a few years until the hype wears off in the face of more scientific evidence that throws doubt upon the early claims, and the realization that, like all the preceding drug candidates, this latest one also does next to nothing to impact the progression of aging in humans.

 

It helps greatly to realize that life span and health are much more plastic in short-lived species than in comparatively long-lived species such as we humans. All sorts of things extend life in lower animals by a large amount yet have no such result in humans. Consider calorie restriction for example, which extends life by 40% in mice, but certainly doesn't do as much in humans. Did you know that ibuprofen use meaningfully extends life in a number of species to a an equal or greater level than metformin, a currently hyped drug candidate to slow aging? Or that aspirin has sizable effects on life span in short-lived species as well? Yet clearly neither of those extends human life span to anywhere near the same degree, despite decades of use and a great deal of data on its effects.

 

https://www.fightagi...o-does-aspirin/

 

Indeed. I think it's well established at this point that short-lived species experience greater life extension from the same drug than do long-lived species. For us, I think it's more about extending healthspan, although I wouldn't rule out bona fide life extensive drugs or therapies in the future.
 

[Logic]

I think basically, lived species don't have the junk that builds up in and around cells.

AGEs, Metals, lipofuscin, Amyloid etc.
I think that if one can eliminate the above; These substances may become more interesting.

 

I note that aspirin is a mild copper chelator so should help with metal buildup and AGEs slightly.

[corb]

I think basically, lived species don't have the junk that builds up in and around cells.

AGEs, Metals, lipofuscin, Amyloid etc.
I think that if one can eliminate the above; These substances may become more interesting.

 

I note that aspirin is a mild copper chelator so should help with metal buildup and AGEs slightly.

 

They don't.

That's the reason researches wasted a good 25 years trying to cure rats with "Alzheimer" and after a number of "successful" cures realized their genetic model is completely useless.

 

Modeling how we age onto animals especially short lived ones is more or less a waste of time. Or at least so far it has not shown significant success.