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So You Think You Fucked Up Your Brain? A Story of Exploration, Panic, Placebos, and the Durability of the Brain

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#1 OneScrewLoose

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Posted 17 October 2016 - 09:03 PM


So I recently made this post in another thread, but seeing as how common it is for people to believe they fucked up their brains for life from just one drug or another, I thought this deserved to have it's own thread, something to refer those people to, to give them hope that this is likely not the case. It's a long one, so get some Adderall, sack up, and read.
 

Back in the end of 2010 I was feeling pretty good about myself. I had just gotten back from studying abroad, gained a newfound confidence, and resolved a lot of my social anxiety. I was getting new friends, being more social, and things seemed to be going swimmingly. Then I did something I for which I would hate myself on a daily basis, for the next 2 years.

 

I liked to experiment with drugs every now and then, but it wasn't too frequent of a thing for me (yet), as there was this part of me that would get numb, and felt the need to explore to resolve this. Around this time, I felt the need to explore again. So I had to choose a drug for my explanation, and this time around, I chose to take DXM, or Robitussin. It would be my first time taking it, and I always liked to do new drugs instead of repeating and old one, even if I liked it. It was a Saturday, right after a great thanksgiving and black Friday with the family. To make the trip more interesting and spiritual, I decided to do it in a forest with 2 friends. They’d be my sitters, as I would recommend anyone doing a new psychoactive drug to have a sitter. Well, we walked for a bit, and then I start dosing. I was a little nervous, so I started with 10 gel caps to see how I'd feel. This is a measly 150mg, which is the bare threshold for some of the psychoactive effects one gets from DXM. An hours passes and I feel nothing. Within the next hour, I separately take 5, and then 4 gel caps, interspaced to look for any effects. This brings me to a total of 285mg. I'd say this is a nice standard dose for a DXM trip, nothing too high, but nothing to sneeze at. I waited a couple hours, but strangely enough nothing seemed to happen all. No visuals, not even a body load. All I could say is felt 'something'. I couldn't describe that something, it was very minor, and certainly not worth 4-5 hours meandering in the forest. Disappointed, we went back to their car.

As soon as I sat down in the front passenger seat, it hit me all at once. I was high as a kate, and had problems controlling my body movements (this will happen with a high enough DXM dose, but if you're not used to it, can be quite scary) It was a very unpleasant experience at first, I felt shaky and disoriented, and as I said, my movement was restricted. I was breathing into a bag in case I’d throw up, as I felt extremely nauseous  My vision was distorted with starbursts from lights, and beams coming out of said lights. But once I calmed down after what seemed like one of the longest 45 minutes of my life, it became something quite pleasant. I started to feel a sense of heightened emotions, and as I remembered things from my past, all my memories became more pleasant, vivid and happier. This was great, I thought, to reimagine my life this way! Anyway, we went to a coffee shop for me to calm down, and over the next hour or so I returned to baseline. All’s well that ends well, I thought.

But that was only the beginning. You see for much of my life I had had this pain running through my body that no doctor could figure out (that I only figured out and got diagnosed this last month. Don't ask please, it's a bit personal), and for some reason, a day after the trip, it increased. The next day more. And then more and more and more. A week later, I was left crying and screaming in my bed, while my girlfriend watched helplessly. I went to the emergency room, they prescribed benzos that did nothing. My doctors could do nothing. Anti-depressants, anti-psychotics, nothing. All of them seemed to think that it was in my head. Even if it were, as if it being in my goddamn fucking head would make the torture hurt any less. Fucking idiots.

 

Three weeks after the trip, the visual distortions came back, and I developed HPPD (Hallucinogenic Persistent Perception Disorder), which included a lot of visual snow. Six weeks in I developed a spasm. All the while I was still in horrific pain, just lying in bed. This lasted two months, and the only time I’d get out is when my girlfriend would almost force me to get out and take me to the bookstore, just so I would be doing something. I had to drop out of my classes. And I was about to start a new job. But thankfully my boss was kind and let me start a month late. After two months, it was over, and I swore I’d never touch Robitussin again.

At least I thought it was over. It must have been some sort of complete nervous breakdown, because what happened over the next six months was even more horrific. I began to lose pieces of myself, perhaps due to the trauma of writhing in pain. I lost the ability to write cursive. I lost the ability to speak (vocalize) Spanish, although I could still read and write it. I lost much of my ability to drive, and had to be very careful on the road for the next two years as I reacquired it. My social anxiety went up to a level I’d never seen it at, so bad that I couldn’t even raise my hand up in class. This was just after giving presentations in a second language abroad. Worst of all, I lost all my social and conversational skills. All of them. With it, I lost almost all my friends and could not make new ones. People would give me weird looks when I would talk to them. Though I thought I was just saying the same stuff as before, it was apparently embarrassing babble that would cause people to widen their eyes, freeze, or just walk away. All that was left of my once growing social life was my one friend taking care of me, whom I could barely even converse with (due to my absent conversational skills), and my emotionally-abusive girlfriend.

 

The best way I’ve been able to describe this so far is a ‘nervous breakdown’. It seems fitting, but I’m still not sure what truly happened. My personality was all but wiped out. It took four years to fully rebuild my social skills, and for each part of my self lost, some of which I haven’t discussed, each required its own amount of years to reconstruct. I had to rebuild myself from scratch, essentially. For the first two years, I fell into an extremely deep depression, as I know longer knew who I was, and came close to killing myself. All I could think about was how much I was a fool for taking the Robitussin, and how I wished I hadn’t.

But I learned a lot about the mind during this whole time. Normally I would try a variety of supplements and drugs to try to alleviate my pain, but I didn’t touch anything new for over a year, out of fear of what happened. But by 2012 (maybe earlier) I began to experiment again. Some pharmaceuticals, some supplements. But something interesting happened. I noticed some of the drugs I was taking were exacerbating three symptoms: the HPPD, the spasm, and the social anxiety. At first I searched for the mechanisms as to why this would happen. But then things got stranger. It was seemed that the list of things that would exacerbate these three symptoms kept growing. And I became more and more convinced that I was very susceptible to placebo.

A lot of these drugs/supplements kept making the HPPD worse. Well, one night I was going for a walk around my neighborhood. I was looking around, and observing my visual distortions. And then, thinking about all the substances making it worse, I finally decided to tell myself, with absolute certainty that “the worsening of these symptoms you are experiencing from these drugs and supplements are 100% placebo without a sliver of doubt”. And you know what? After that statement, after that night, it never got worse again, no matter what I took, even hallucinogens. Though it didn’t get any better either, at least for a while. Now though, it’s in a weird place, where it seems to fluctuate.

The final straw was when taking green tea extract, it bumped up my social anxiety a bit. I was like, this is some complete bullshit. But now, that question that begged to be answered, that dared me to explore itself, whose voice was growing louder and louder, which I silenced out of fear, had finally come to the forefront. That nagging fucking question: was the Robitussin itself placebo? Well, I was scared to death to answer its call, but after all these placebos, the shutdown of the worsening of the HPPD, and now the green tea extract, I just had to find out.

 

So I went to the store, and nervously paced up and down the medicine isle. I finally grabbed some Robitussin off the shelf, with DXM as the only active ingredient, as one should (recreational use with additional ingredients such as Guanfacine can lead to harm). I got him with nervous, but determined energy. I was cautious at first, as I couldn't bare a repeat of last time. So I took a very small dose at first, and nothing happened, nothing at all, except the initial bitter taste in my mouth. After an hour, I bumped it up a notch, I took a half a capful. Once again, a whole lot of nothing. I thought I'd give it a rest for the night, and I decided it was time for some sleep. I went to sleep that night.

 

The next day, feeling like a boss from the lack of effects the previous night, I became more adventurous. After the usual morning ablutions and meal, I took a whole capful, and well guess what happened? So much more nothing! And then, I felt like the time had finally come. To through all fucks to the wind and see if it was the Robitussin that did me in what seemed like an eternity ago, or if it was my mind all along. I went balls deep and got high, taking a total of 200mg. Sure, it's not a huge high for DXM, but given the circumstances, it was quite intimidating for me. And other than the mild high nothing like the previous episode happened. I tried a few more times at higher doses, and I had no sort of collapse. It appears to have been some sort of placebo all along. My mind was ready for a meltdown.

I’ve since been high on Robitussin 100-200 times, with doses at 500mg and above, and I’ve never had an incident other than great highs. It’s now my favorite recreational drug (and it’s legal!). When it’s working at its best, it’s like being wrapped in a warm blanked on a pink fluffy cloud. As a tangent, my favorite trip was probably hallucinating the room I was in as a 2D pop-up book. The third dimension was lost, and everything in front of my, like the lamps in the corner of the room, all of a sudden appeared next to me. Good times.

 

As I said, tt turns out that it was all placebo and psychogenic. What people don't realize is that theirs no shame in that. The mind is an incredible machine that we don't understand, that processes things in incredible ways we don't understand. That my mind was ready and willing for this to happen and needed and excuse, well, that's just the way things were in my life at the time. Perhaps was coincidence, and very likely to happen in some fashion anyway. Maybe it wouldn't have, who knows?

 

It’s also a reminder of something we always spout, though many of us don't fully grasp it, but always seem to forget when it comes to applying it to our own biases, that correlation does not imply causation. But we don’t like to apply this to ourselves. If we took a pill/medicine/supplement/crystal healing, and then something and something happened, then by God, that was the fucking cause, cause placebos don’t work on me. I’m a STRONG-MINDED individual and I don’t have to worry about any of that placebo nonsense. And that timing, it’s too perfect to not be causative! Never mind that correlation/causation nonsense.

 

What a lot of people don’t realize is that being susceptible to placebos and hypnosis has nothing to do with strength. It’s a trait that seems to be randomly distributed in 33% of the population as far as high-susceptibility, and there are no corresponding traits like character, strength, gender, extroversion, or anything else that seem to go along with it.

So that's my story. It taught my quite a bit about myself and about humanity. I now well know that I am quite susceptible to placebo and hypnotic suggestion, and I have no shame in this. In fact, this can have some advantages in meditation. It's just the way I'm wired, and if it's the way you're wired, don't worry, it doesn't make you weak.

I can tell you that there's no available drug or supplement, OTC or prescription, that taken within a reasonable dose, will damage you in one dose. That's your mind ready to do something, as mine was. There are drugs that can damage your brain over time, with repeated use. These include, but are not limited to:

First-Gen Antipsychotics

MDMA and other Serotonin Releasing Agents (without proper precautions)

Repeated use of NMDA antagonists (DXM, Ketamine), without time in between
Opiates
Cocaine

And others. But none that I can think of in a single dose. So if you're brain has been 'ruined' in a single dose, or a few doses of a substance that's not known to cause this. Just relax, rethink things, and trying to find an underlying mechanism.


Edited by OneScrewLoose, 17 October 2016 - 09:06 PM.

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#2 Flex

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Posted 18 October 2016 - 02:25 AM

Yes, I´ve read recently in (iirc) reddit/drugnerds that DXM fucked people up enduringly! As You´ve said, of course not after one single or a few times per Year but several times.

personally, I wont touch that. tried it once a low dose and I didnt liked it.



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#3 jack black

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Posted 18 October 2016 - 02:57 AM

interesting story, thanks for posting. i still think DXM toxicity could have killed some neurons.



#4 OneScrewLoose

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Posted 18 October 2016 - 07:25 AM

You're welcome. DXM is only neurotoxic with repeated use within a 2 weeks span. Like, you're taking it once a day, once a week, etc...I believe once every two weeks is the cut off mark for your NMDA receptors to recover, but I'd have to look into that just to be sure. Also, clonidine can prevent NMDA-antagonist-based neurotoxicity. I can go look up the study if you guys ask really nicely.


Edited by OneScrewLoose, 18 October 2016 - 07:26 AM.


#5 Junk Master

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Posted 20 October 2016 - 04:40 PM

Nice!  Thanks for sharing.  Also, I'm glad you are obviously doing much better.

 

Always enjoy your posts.

 

BTW  My favorite story about the durability of the brain is a people who have undergone hemispherectomies, literally having half their brains removed (usually to stop seizures), and have gone on to become chess champs, bowling champs, and experienced little change in their personality.

 

https://www.scientif...ter-than-whole/



#6 Dichotohmy

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Posted 21 October 2016 - 05:18 AM

I respect the honesty in your story and realize that some (I would argue tiny) cohort of people really do have legitimate somatic symptom disorder and are highly suceptible to placebo and other "powers of the mind."

On the other hand, its impossible to really know, or disprove, that your recovery was due to something you never recognized, or otherwise happened on its own. I personally find "powers of the mind" explanations unsatisfying due to how easy and surprisingly common proponents claim it is to think oneself ill. Why isn't the inverse also true and that its so hard to think oneself into excellent health? Is this supposed to mean self-sabotage instinct is more powerful than the instinct of self preservation? If one has a strong anxiety responce that is to induce somatic symptomology, such as due to anxiety overriding accurate self analysis and metacognition, how would that person ever know he or she did not get better due to an unknown reason versus whatever psychological reason he or she attributes to the recovery?

#7 Doc Psychoillogical

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Posted 23 October 2016 - 07:30 AM

L-taurine, theanine, magnesium and pregnenolone are all NMDA receptor interacting, with varying potencies of course. 


Edited by Mr. Psychillogical, 23 October 2016 - 07:31 AM.


#8 OneScrewLoose

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Posted 23 October 2016 - 06:39 PM

I respect the honesty in your story and realize that some (I would argue tiny) cohort of people really do have legitimate somatic symptom disorder and are highly suceptible to placebo and other "powers of the mind."

On the other hand, its impossible to really know, or disprove, that your recovery was due to something you never recognized, or otherwise happened on its own. I personally find "powers of the mind" explanations unsatisfying due to how easy and surprisingly common proponents claim it is to think oneself ill. Why isn't the inverse also true and that its so hard to think oneself into excellent health? Is this supposed to mean self-sabotage instinct is more powerful than the instinct of self preservation? If one has a strong anxiety responce that is to induce somatic symptomology, such as due to anxiety overriding accurate self analysis and metacognition, how would that person ever know he or she did not get better due to an unknown reason versus whatever psychological reason he or she attributes to the recovery?

Easy, mon ami. If it were really the Robitussin that harmed me initially, the results would have been replicable, like any scientific finding. They most certainly were not. It was an open and shut case. Did you really read what I wrote? I am not sure what you're really going on about here.

 

L-taurine, theanine, magnesium and pregnenolone are all NMDA receptor interacting, with varying potencies of course. 

What does this have to do with anything?



#9 pamojja

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Posted 23 October 2016 - 07:48 PM

Easy, mon ami. If it were really the Robitussin that harmed me initially, the results would have been replicable, like any scientific finding. They most certainly were not. It was an open and shut case. Did you really read what I wrote? I am not sure what you're really going on about here.

 

That would only be the case if a person were a never changing entity. We aren't. There could have been vulnerabilities and other factors at play during your first experience years ago, which are now no more.



#10 OneScrewLoose

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Posted 24 October 2016 - 03:27 PM

Then we'd have to throw out every longitudinal study due to noise. 



#11 pamojja

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Posted 24 October 2016 - 06:21 PM

Then we'd have to throw out every longitudinal study due to noise. 

 

Just don't mistake a statistical mean for something it isn't.



#12 OneScrewLoose

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Posted 24 October 2016 - 11:25 PM

Despite a high sample rate, we are relying on some type of internal biological consistency when we perform these studies, are we not?



#13 pamojja

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Posted 25 October 2016 - 09:34 AM

Despite a high sample rate, we are relying on some type of internal biological consistency when we perform these studies, are we not?

 

Take for example the kind of internal biological consistency assumed in standard of care based on evidence based medicine against CVD:

 

 

Statins Given for 5 Years for Heart Disease Prevention (With Known Heart Disease)

 

83 for mortality

 

In Summary, for those who took the statin for 5 years:

 

Benefits in NNT

  • 1 in 83 were helped (life saved)
  • 1 in 39 were helped (preventing non-fatal heart attack)
  • 1 in 125 were helped (preventing stroke)

Harms in NNH

  • 1 in 100 were harmed (develop diabetes*)
  • 1 in 10 were harmed (muscle damage)

*The development of diabetes is one such unanticipated harm found in a recent large study and it seems likely therefore that this applies to the data above, although this is a best guess.

 

Blood Pressure Medicines for Five Years to Prevent Death, Heart Attacks, and Strokes

 

125 for mortality

 

In Summary, for those who took anti-hypertensives:

Benefits in NNT

  • 1 in 125 were helped (prevented death)
  • 1 in 67 were helped (prevented stroke)
  • 1 in 100 were helped (prevented heart attack*)

Harms in NNH

  • 1 in 10 were harmed (medication side effects, stopping the drug)

*fatal and non-fatal myocardial infarction and sudden or rapid cardiac death

 

Aspirin to Prevent Cardiovascular Disease in Patients with Known Heart Disease or Strokes

 

333 for mortality

 

In Summary, for those who took the aspirin:

 

Benefits in NNT

  • 1 in 50 were helped (cardiovascular problem prevented)
  • 1 in 333 were helped (prevented death)
  • 1 in 77 were helped (prevented non-fatal heart attack)
  • 1 in 200 were helped (prevented non-fatal stroke)

Harms in NNH

  • 1 in 400 were harmed (major bleeding event*)

*Required hospital admission and transfusion

 

Coronary Stenting for Non-Acute Coronary Disease Compared to Medical Therapy

 

None for mortality

 

In Summary, for those who received the stenting:

 

Benefits in NNT

  • None were helped (life saved, heart attack prevented, symptoms reduced)

Harms in NNH

  • 1 in 50 were harmed (complications such as bleeding, stroke, kidney damage)

In short, it takes about 83 patients taking cholesterol-lowering drugs for 5 years,

125 patients taking blood-pressure lowering drugs,

333 patients taking aspirin, to each save 1 premature death after 5 years.

 

The probability of dying on the spot by playing Russian roulette in comparison is only 1 out of 6, and multiple times more consistent.

 

Therefore to 'rely' on a internal biological consistency subjectively, is really nothing more than betting on a slight probability. Objectively lives are indeed saved, if enough are taking these drugs.

 

Admittedly, betting on winning in a lottory has countless times less consistency. ;)



#14 OneScrewLoose

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Posted 25 October 2016 - 11:10 AM


On the other hand, its impossible to really know, or disprove, that your recovery was due to something you never recognized, or otherwise happened on its own. I personally find "powers of the mind" explanations unsatisfying due to how easy and surprisingly common proponents claim it is to think oneself ill. Why isn't the inverse also true and that its so hard to think oneself into excellent health? Is this supposed to mean self-sabotage instinct is more powerful than the instinct of self preservation? If one has a strong anxiety responce that is to induce somatic symptomology, such as due to anxiety overriding accurate self analysis and metacognition, how would that person ever know he or she did not get better due to an unknown reason versus whatever psychological reason he or she attributes to the recovery?

 

I just reread this, and well, I'm not exactly sure what you're trying to get at. I'm pretty sure I wrote a clear story, but I think you're reading into it too much, and seeing things that aren't there. So, I'll lay it out for you, just to make sure we're not talking over each other's heads. My only two theses are:

 

1) The initial Robitussin trip simply corresponded to a psychological nervous breakdown, or triggered one that was about to happen anyway.

2) The only nocebo effects that I truly suffered were the ones that exacerbated the three symptoms I mentioned.

The recovery was a process of recovering from a nervous breakdown. I'm not sure what you're getting at. 

 

I was simply inspired to write this post by a thread where someone claimed that taking Tryptophan ruined them. It was obviously coincidental, and I've seen a lot of posts on Longecity blaming the taking of substance for one's own destruction when confounding variables are involved.


Edited by OneScrewLoose, 25 October 2016 - 11:28 AM.


#15 iseethelight

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Posted 25 October 2016 - 10:03 PM

LOL your reaction wasn't placebo guy.  Your body wasn't used to the drug and there was also other factors involved like other supplements you might have been taking at the time, your state of health or supplements you might be taking now . Blaming people's suffering on placebo is a disrespect to a lot of us suffering from real conditions. Placebo does exist but usually not to that extent.

 

I've also had poor responses from supplements that I was able to later take when I mix them with other supporting supplements. 

 

Just be happy you're cured. 

 

The mind is powerful and plays a big part in the curing process but your body also plays a major part. That's like the people calling depressed people pussies and claiming it's all mental. I'd like to smack them across the face. 


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#16 OneScrewLoose

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Posted 01 November 2016 - 01:58 AM

Where do I blame anyone's suffering on placebo? Did you even read my post, or did you just spew on the keyboard?

 

 


I just reread this, and well, I'm not exactly sure what you're trying to get at. I'm pretty sure I wrote a clear story, but I think you're reading into it too much, and seeing things that aren't there. So, I'll lay it out for you, just to make sure we're not talking over each other's heads. My only two theses are:

 

1) The initial Robitussin trip simply corresponded to a psychological nervous breakdown, or triggered one that was about to happen anyway.

2) The only nocebo effects that I truly suffered were the ones that exacerbated the three symptoms I mentioned.

The recovery was a process of recovering from a nervous breakdown. I'm not sure what you're getting at. 

 

I was simply inspired to write this post by a thread where someone claimed that taking Tryptophan ruined them. It was obviously coincidental, and I've seen a lot of posts on Longecity blaming the taking of substance for one's own destruction when confounding variables are involved.

 

Read. It. Closely.

Then try running your mouth off.


Edited by OneScrewLoose, 01 November 2016 - 01:58 AM.


#17 NG_F

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Posted 01 November 2016 - 04:18 AM

 


On the other hand, its impossible to really know, or disprove, that your recovery was due to something you never recognized, or otherwise happened on its own. I personally find "powers of the mind" explanations unsatisfying due to how easy and surprisingly common proponents claim it is to think oneself ill. Why isn't the inverse also true and that its so hard to think oneself into excellent health? Is this supposed to mean self-sabotage instinct is more powerful than the instinct of self preservation? If one has a strong anxiety responce that is to induce somatic symptomology, such as due to anxiety overriding accurate self analysis and metacognition, how would that person ever know he or she did not get better due to an unknown reason versus whatever psychological reason he or she attributes to the recovery?

 

I just reread this, and well, I'm not exactly sure what you're trying to get at. I'm pretty sure I wrote a clear story, but I think you're reading into it too much, and seeing things that aren't there. So, I'll lay it out for you, just to make sure we're not talking over each other's heads. My only two theses are:

 

1) The initial Robitussin trip simply corresponded to a psychological nervous breakdown, or triggered one that was about to happen anyway.

2) The only nocebo effects that I truly suffered were the ones that exacerbated the three symptoms I mentioned.

The recovery was a process of recovering from a nervous breakdown. I'm not sure what you're getting at. 

 

I was simply inspired to write this post by a thread where someone claimed that taking Tryptophan ruined them. It was obviously coincidental, and I've seen a lot of posts on Longecity blaming the taking of substance for one's own destruction when confounding variables are involved.

 

 

OSL...I think what you may be failing to realize in your contrasted example, is that  People that complain or become depressed that they have lost several types of executive functioning  have been feeling compromised for a long period of time. Weeks ,months , even years. Whether it's from L-trypt or MDMA, Long term Opiate abuse etc.. I agree and you yourself have written it takes  perhaps 2 weeks of that high dose to have significant  influence on Neuronal death. The point you've shown only indicates that some of your first time symptoms may be attributed to a placebo but maybe not. Obviously you wouldn't dare take said dose for  3-4 mos to see if you have mild to moderate " permanent " brain damage lol.

  People that try everything to perform and function pre "suspected" drug-induced damage, are stating and showing that they are nowhere near to prior functioning. This could be from years or months of Propecia, followed by permanent libido, erectile dysfunction, brain-fog effects. Unlike in your DXM example and claim, short term...1-2 weeks would NOT cause significant  dihydrotestosterone mitigation or a profound loss of  5-alpha reductase expression in penis or brain. Long term use of L-Tryptophan or < 5HTP  can cause calcification, regurgitation and stenosis in Aortic and other heart valves. 

 

My point is apart from some very toxic chemicals, most of the damage that a few members have been experiencing was in fact caused by the drug in question, being the culprit. Eliminating other drugs taken during, blood tests and other modalities are obviously necessary to rule out the red herring causation.

  A few toxic chems can damage or kill after a single dose.Drug Interactions  causing death or gross brain damage would be quite obvious from a massive heart attack or stroke, death from respiratory suppression etc.. The effects we don't see right away can be a PRES or hypertensive crisis that causes a smaller infarct or  hemorrhage. Toxic drugs or ergot derivatives which will cause valvulopathies. Propecia for 1+ years may cause permanent libido and erection issues. SpO2 which is 70% and lower for weeks or months will cause perm brain damage ie) say from opiate abuse or Opiate-benzo-gaba  co-administration. Amp or Ritalin  abuse can cause dopaminergic cell loss, receptor down regulation etc..

 

 Getting an MRI can screen for the smallest infarcts or bleeds, Echocardiogram, EKG and contrast perfusion stress test can rule out any serious heart damage BUT some damage from Drugs or mixing of or toxic repeated amounts DO in fact cause functional and micro structural changes that are not in fact a placebo.

 

"It's all in your head " is a grey area goto line because it's not grossly evident or visible yet is most definitely and seriously there. Placebo effect  cannot  exist for months or years after months of cessation from said drug, unless from a withdrawal process.



#18 NG_F

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Posted 01 November 2016 - 04:40 AM

Nice!  Thanks for sharing.  Also, I'm glad you are obviously doing much better.

 

Always enjoy your posts.

 

BTW  My favorite story about the durability of the brain is a people who have undergone hemispherectomies, literally having half their brains removed (usually to stop seizures), and have gone on to become chess champs, bowling champs, and experienced little change in their personality.

 

https://www.scientif...ter-than-whole/

 

Yes but that's only within the ages of 2-10 while the human brain is in a highly developing  period (sponge) with tonnes of Neuro-plasticity and regrowth  potential, where the other hemisphere can  pick up the slack but even THEN there will be contralateral loss of the opposite hand and universal diminution of visual field of view . Both eyes are effected because the optic tracts cross at a junction , called the chiasm, which is an "X" like wiring that takes the left eye crossing into the right occipital lobe and vice-versa. However, say for example the left hemisphere is removed, then signal will arrive to the right occipital lobe but will be weak because left sided pre-chiasm is damaged and the right eye will be effected because post chiasm  will not have a left occipital lobe to  connect to.

 

Anyone after 20 will  have gross defects, even with a portion of the brain removed, Of course location plays a big role but frontal lobe would be the most devastating for obvious reasons.



#19 Junk Master

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Posted 02 November 2016 - 04:32 AM

Can't argue that.

 

Except to say that's why I'd rather have a bottle in front of me than a frontal lobotomy.

 

 



#20 normalizing

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Posted 02 November 2016 - 05:17 AM

not sure of DXM's toxicity, but it helped opiate addiction and withdrawal more than once. i suppose its toxicity was exerted through the mechanism of cutting you off drugs, like castration of the pleasure centers?



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#21 alexhughes73

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Posted 09 November 2016 - 12:04 AM

This is all very interesting. Does anyone know anything about gabapentinoids (specifically Lyrica in my case) and their potential to cause permanent issues after short term, high-dosage recreational use? This is something that's been really bothering me lately and I'm pretty much just asking around everywhere for some useful, scientific insight. 

 







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