6 replies to this topic

[DareDevil]

Hi Longecity Friends,

 

Zoledronic acid is a substance normally prescribed to patients with severe cases of Osteoperosis. It comes in a 4 milligram dose diluted in 5 milliliters of sterile saline solution. Its administration is usually done in a hospital setting with the 4 milliliters diluted into 100 milliliters of IV solution which is administered intravenously over 15 minutes.

 

However, this particular substance interested me by virtue of certain other characteristics such as its life extension abilities. Given its widespread use among a population of patients sufferin from Osteoperosis, its effectiveness was tested on many people in comparison to control groups. These studies pointed to an unexected side effect. Those given Zoledronic acid outlived the control group by an average of 5 years.

 

Apparently this was the result of the action of Zoledronic acid on stem cells, which is boosts and rejuvinates, in layman's language. Here is a link to an article about this:

 

https://www.ncbi.nlm...les/PMC4832316/

 

For this reason I ordered a single dose of 4mg (0.8mg/ml) Zoledronic acid from Ukraine for self-administration.

 

http://ukrainianmall...ja-kislota.html

 

This item arrived quickly and I then decided to self-administer it first diluting it in an additional 5ml of injectable saline solution and injecting it subQ over approximately 1 minute. While this is not the usual injection protocol, it is often the case that the elderly with poor veins are administed IV solutions subQ instead, with no problems other than the slower speed of delivery of larger quantities of liquids.

 

1. This is a potent medicine not to be self-administed lightly. One must be aware of all counter-indications and side effects. I do not recommend repeating this experiement.

 

2. The side effects I encountered were very strong and unexpected. I imagine that in hospitals people are kept in a hospital room for several days after receiving this drug. My side effets lasted 3 days at an intense level and only completely disappeared after a week.

 

3. It was indicated that it could have flu-like effects. I can attest that it was like the worst flu I ever had, with very high temperature fever for almost 24 hours, to the point that a friend was so worried she called the firemen to rescue me. I managed to talk them down and about 6 hours later I was doing better.

 

4. Documentation states that one can have aching joints. My knees and elbows felt fine but my entire spine and the center of my back felt like they had been hit by a truck. I could barely move without intense pain and it was very sharply painful to breathe, causing me to take tiny respirations so as to not distend my chest. For about 24 hours I could hardly move. This was alarming as it wasn't expected. One thing was for sure, this drug wasn't neutral. Its entire range of effects however isn't yet know to me in my own experimental setting.

 

To conclude, I did this experiment for three purposes. I'm getting older and could have weakening bones, meaning that strengthening them with the primary function of Zoledronic acid can't hurt. The side effects seemed limited and benign, at least on paper. I wanted my stem cells to be as healthy as possible before undergoing stem cell treatment in a clinc. And finally, this substance carries the promise of extending our life span by 5 years possibly. Who wouldn't like to life an extra few years at the small expense of temporary discomfort?

 

This resumes my experience with Zoledronic acid, which I injected 10 days ago and that hasn't shown a tremendous visible difference in my health or wellbeing at this early date. I do hope it wasn't for nothing, having among my objectives not just age extension, but eventually at least limited age reversal.

 

FWIW

 

DareDevil

 

[adamh]

Wow you are a dare devil aren't you? Why not administer it 10% at a time over 10 days? That would have probably eliminated most of the side effects or reduced them considerably. Was the life extention from just one dose? Spreading it out might make it more effective, hard to say 

[DareDevil]

Yes you could be right, but the hospital protocol is injecting it over 15 minutes in a single IV infusion. I wanted to respect that protocol as closely as possible because it is only with this indication that there has been evidence collected that it can increase our life expectancy. Please note that there are rare cases of dental and jawbone issues such as osteonecrosis of the jaw, but this is rare and can occur when taking much heavier doses for cancer prevention. Here's the link to a similar topic in another forum section where it's discussed:

 

http://www.longecity...id/#entry817186

[Andey]

You know that you need to inject it every 3 to 4 weeks arent you ? ) You should not expect any rejuvenation effect either, its more like slowing the pace in what negative effects appear.
Evidence about biphospates treatment is somewhat conflicting. Some studies shows decrease in all cause mortality, some not.

[DareDevil]

Hi Andrey,

 

I recall talk of a single injection not a series. I will try to find the sources for reference.

 

DD

[Andey]

Hi Andrey,

 

I recall talk of a single injection not a series. I will try to find the sources for reference.

 

DD

 

Yep, you are right. There is 5mg dosage that is approved for once a year treatment.

[Andey]

Little disclaimer.

You are the brave soul ) but I would not advice to repeat your administration protocol.Not all drugs are supposed to be taken subq as many of them inflict local reactions.   Acids... are escpecially prone to that. Oral bisphosphonates for example used with great caution to not burn esophagus. Like been upright for few hours and take it with great volume of water.

Although there are some studies exist that have used zoladronic acid subQ in animals but subQ usuaily means more dilution and longer administration time compared to IV.  IV means that it get diluted even more with blood.

Zoladronic acid is supposed to be diluted in 50ml of saline (additional to 8ml that goes in the package) with IV infusion for 15 mins. And you have done it subQ less diluted and faster than IV...

I think there is a good chance that your adverse reaction to it is linked somehow to the way you administered it.

 

Glad that you get away with it, but, please, be carefull in a future

Cheers

 

Edited by Andey, 30 May 2017 - 12:31 PM.