176 replies to this topic

[normalizing]

you know guys, start your own deprenyl thread. this one is about broad discussion regarding anti aging substances, but somehow its all discussion about one medication so far

[YOLF]

 

Gene Editing for $1550 plus some minor materials. If we don't need MAO-B at all, maybe we should just figure out how to knock it out.

Low MAO_B is associated with  attention deficit disorder, novelty seeking, impulsive, risky, thrill-seeking behavior. One wouldn't want to inhibit it altogether, perhaps just "dial it down".a bit.  Ref  Ref

 

I wouldn't say it's a bad thing. It would just require some adaptation. Novelty seeking is a good thing, I can't count the number of awesome things that I've learned when I've had the free time to let my curiosity run away with me. Big eye opening things I never would have understood that have given me a window into things I wouldn't otherwise be able to reach. You just have manage your time well. As for the rest, I suppose it depends on a spectrum of genetics that determine a particular balance of neurochemistry. But knowing this we can just make sure that everyone is also an Rs4680 AA (25% higher cognition and working memory) while we're at it, then there is that long term memory gene, a heterozygous trait that gives you 17% better long term memory. I think those are the ones that balance out risk taking with self control. Later we can figure out an optimal set of methylation genes so that we can all survive healthily with Rs1801133 AA.  And while we're at it, we can add the Heterozygous Klotho gene with all the benefits. That one seems to be pretty good as a stand alone, but as a germline affecting gene therapy, continuing generations would need to get it.

[YOLF]

you know guys, start your own deprenyl thread. this one is about broad discussion regarding anti aging substances, but somehow its all discussion about one medication so far

 

Early on there were lots of other things being discussed, deprenyl just has more controversy. It has lead to talk of gene therapies and the myostatin inhibition plasmid is now available for those looking to use myostatin inhibition for extended life and healthspan

 

Here's a new mention, acarbose, a diabetes drug, raises klotho and FGF23. I've got plans for testing it as part of a regimen. It obviously doesn't cure diabetes (permanently) and therefore won't cure aging, but it's got some good prospects as an adjuvant for slowing it similar to the way metformin can slow aging.and add a few years.

[William Sterog]

According to Nicholas Wade (A troublesome inheritance) african people has less monoaminoxidase promoters, resulting in a decreased MAO activity. If this is true, and MAO-B inhibition is so important in life extension, why African people doesn't live longer? 

[normalizing]

 

According to Nicholas Wade (A troublesome inheritance) african people has less monoaminoxidase promoters, resulting in a decreased MAO activity. If this is true, and MAO-B inhibition is so important in life extension, why African people doesn't live longer? 

 

 

probably because they live in africa or america and not asia where their lifestyle and diets will completely change their future

 

you know guys, start your own deprenyl thread. this one is about broad discussion regarding anti aging substances, but somehow its all discussion about one medication so far

 

Early on there were lots of other things being discussed, deprenyl just has more controversy. It has lead to talk of gene therapies and the myostatin inhibition plasmid is now available for those looking to use myostatin inhibition for extended life and healthspan

 

Here's a new mention, acarbose, a diabetes drug, raises klotho and FGF23. I've got plans for testing it as part of a regimen. It obviously doesn't cure diabetes (permanently) and therefore won't cure aging, but it's got some good prospects as an adjuvant for slowing it similar to the way metformin can slow aging.and add a few years.

 

 

whats the point of taking acarbose when one can take metformin which has longer use and safety profile?

 

[RWhigham]

why African people doesn't live longer? 

 

 

In the USA, diseases associated with vitamin D deficiency increase for whites as you go north.  Doesn't happen for blacks, Probably they don't get enough vitamin D anywhere.

Edited by RWhigham, 21 November 2017 - 09:07 PM.

[YOLF]

 

 

According to Nicholas Wade (A troublesome inheritance) african people has less monoaminoxidase promoters, resulting in a decreased MAO activity. If this is true, and MAO-B inhibition is so important in life extension, why African people doesn't live longer? 

 

 

probably because they live in africa or america and not asia where their lifestyle and diets will completely change their future

 

you know guys, start your own deprenyl thread. this one is about broad discussion regarding anti aging substances, but somehow its all discussion about one medication so far

 

Early on there were lots of other things being discussed, deprenyl just has more controversy. It has lead to talk of gene therapies and the myostatin inhibition plasmid is now available for those looking to use myostatin inhibition for extended life and healthspan

 

Here's a new mention, acarbose, a diabetes drug, raises klotho and FGF23. I've got plans for testing it as part of a regimen. It obviously doesn't cure diabetes (permanently) and therefore won't cure aging, but it's got some good prospects as an adjuvant for slowing it similar to the way metformin can slow aging.and add a few years.

 

 

whats the point of taking acarbose when one can take metformin which has longer use and safety profile?

 

 

Does Metformin affect Klotho or FGF23? I'm not aware of it doing so... Acarbose seems like the better choice imo, iirc both are inexpensive and legal for over the internet purchases.

[YOLF]

 

why African people doesn't live longer? 

 

 

In the USA, diseases associated with vitamin D deficiency increase for whites as you go north.  Doesn't happen for blacks, Probably they don't get enough vitamin D anywhere.

 

Epigenetic changes from abuses during slavery probably don't help either. Poverty, starvation/malnutrition, and lack of access to high quality medical care in past generations are all going to affect lifespans and these changes can persist until acted upon by another (unknown) force.

[recon]

According to Nicholas Wade (A troublesome inheritance) african people has less monoaminoxidase promoters, resulting in a decreased MAO activity. If this is true, and MAO-B inhibition is so important in life extension, why African people doesn't live longer?

probably because they live in africa or america and not asia where their lifestyle and diets will completely change their future

you know guys, start your own deprenyl thread. this one is about broad discussion regarding anti aging substances, but somehow its all discussion about one medication so far

Early on there were lots of other things being discussed, deprenyl just has more controversy. It has lead to talk of gene therapies and the myostatin inhibition plasmid is now available for those looking to use myostatin inhibition for extended life and healthspan

Here's a new mention, acarbose, a diabetes drug, raises klotho and FGF23. I've got plans for testing it as part of a regimen. It obviously doesn't cure diabetes (permanently) and therefore won't cure aging, but it's got some good prospects as an adjuvant for slowing it similar to the way metformin can slow aging.and add a few years.

whats the point of taking acarbose when one can take metformin which has longer use and safety profile?

Does Metformin affect Klotho or FGF23? I'm not aware of it doing so... Acarbose seems like the better choice imo, iirc both are inexpensive and legal for over the internet purchases.

Very good find. If acarbose truly activates klotho, that’d be really good of an addition.
I’ll look more into this.

[YOLF]

 

 

why African people doesn't live longer? 

 

 

In the USA, diseases associated with vitamin D deficiency increase for whites as you go north.  Doesn't happen for blacks, Probably they don't get enough vitamin D anywhere.

 

Epigenetic changes from abuses during slavery probably don't help either. Poverty, starvation/malnutrition, and lack of access to high quality medical care in past generations are all going to affect lifespans and these changes can persist until acted upon by another (unknown) force.

 

Babies aren't really delivered by "storks" for those who disagreed... For references, there was a recent rat study showing that they could change epigenetics for generations, but that wasn't the first, just the first paper to look at a dataset that way. Mothers take prenatal vitamins to ensure the health of their offspring. These changes are epigenetic, so without proper nutrition or with toxins or undiagnosed food intolerances or allergies, the health of newborns will be affected.

[sthira]

According to Nicholas Wade (A troublesome inheritance) african people has less monoaminoxidase promoters, resulting in a decreased MAO activity. If this is true, and MAO-B inhibition is so important in life extension, why African people doesn't live longer?

probably because they live in africa or america and not asia where their lifestyle and diets will completely change their future

To say "African People" is a bit broad. There are so many people living on so much terrain! But North African people have life expectancies roughly commensurate with much of the westernized world. HIV remains a killer all over the continent, especially in Central, East and West African countries. I've spent considerable time in Rwanda, Burundi, and Republic of Congo: be sure that there are many causes for hope in these beautiful places. Healthy culture based in science is moving faster than you may presume, and education -- particularly education in HIV and other infectious diseases-- remains key to helping people live longer lives with less (pointless) suffering.

https://www.statista...ancy-in-africa/

Babies aren't really delivered by "storks"

https://youtu.be/1uSjfot6FWU

Meanwhile, back on point: no "anti-aging substances" appear to be available yet. Furthermore, tweaking our hopelessly complicated metabolism, as is argued here and there ad infinitum, ain't the best way forward for human lifespan extension.

[YOLF]

But it's all we've got for the time being, so we might as well use it, it may even give us better results than other things which are presently available for lots of money like TAM818.

[normalizing]

these two are comparable to metformin and rapamycin; https://www.nutraing...ts-of-two-drugs

[sthira]

But it's all we've got for the time being, so we might as well use it, it may even give us better results than other things which are presently available for lots of money like TAM818.

"...Senolytics have the near-future potential to produce sweeping change and improvement in the treatment of age-related conditions. The degree to which removal of senescent cells is better than the vast majority of present day medicine is hard to overstate. Accumulation of senescent cells is one of the root causes of aging, and removing these cells is a form of rejuvenation, capable of partially turning back the progression of most of the common age-related medical conditions..."

https://www.fightagi...ted-conditions/

[recon]

these two are comparable to metformin and rapamycin; https://www.nutraing...ts-of-two-drugs

Other than those two, EGCG from green tea and apigenin seems to be convenient additions.

“Other top performing compounds included ginsenoside, the active component of ginseng, allantoin, a compound found in yams, the omega-6 fatty acid gamma linolenic acid (GLA) apigenin, a compound found in many plants including chamomile, celery and EGCG, or epigallocatechin gallate, a compound found in green tea.

The researchers also used their bioinformatics approach to evaluate combinations of some of these compounds, to see if they exhibited synergistic effects. They found that some combinations outperformed the single compounds in their statistical analysis, with a combination of withaferin A, ginsenoside and GLA showing promise.”

[YOLF]

these two are comparable to metformin and rapamycin; https://www.nutraing...ts-of-two-drugs

Ashwagandha and Ginseng...

 

What are the MoAs of Ginseng? Ashwaganda is a serotonergic... I'm not sure it exactly parallels metformin. For ashwaganda, all I'm seeing is skin healing... but maybe they'd stack well?

 

 

 

Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of ...

Source: Drugbank

[YOLF]

 

But it's all we've got for the time being, so we might as well use it, it may even give us better results than other things which are presently available for lots of money like TAM818.

"...Senolytics have the near-future potential to produce sweeping change and improvement in the treatment of age-related conditions. The degree to which removal of senescent cells is better than the vast majority of present day medicine is hard to overstate. Accumulation of senescent cells is one of the root causes of aging, and removing these cells is a form of rejuvenation, capable of partially turning back the progression of most of the common age-related medical conditions..."

https://www.fightagi...ted-conditions/

 

So shouldn't we all be taking senolytics? Quercetin and others are food based and appear to be effective. '

 

There's a difference between doing what you can on your own now and waiting until you're doctor can do something for you. Plastic surgery, laser eye surgery, and plenty of other things are available, but they are very expensive and the result you're going to get for your money will likely be disappointing, at least that's how I feel about it. But, if I can slow and improve some things, then when I do decide to get plastic surgery, I'll be happier with my results and know what doesn't have to be done with surgery. There is plenty that you can be sold at quite an expensive price that may later realize could have been done with something alot less expensive, or alot more sustainable. That's what it's all about. You won't achieve lasting results waiting for people to tell you what to do.

 

I've taken quercetin at therapeutic doses for some time now. I've synergized it with lots of things. It's good, but I wouldn't expect too much from it alone. You're going to look younger when these things come around and see better benefits if you have more youth to work with when you get there. Views like this are too conservative and will lead to being old and paying through the nose later. Slowing aging is a must and we don't know how effective these treatments are going to be. Maybe they only work on the inside, maybe they make your skin look horrible... we don't know yet.

[YOLF]

these two are comparable to metformin and rapamycin; https://www.nutraing...ts-of-two-drugs

Ah, a computer modelling study has determined that these are good for antiaging based on Metformin and Rapamycin... Ok, now it's making more sense. Ok, so now they need to do some validation with human trials and see if they work by the same mechanisms.

[normalizing]

both of them are herbs used for sexual health and stamina. i wonder if that is exactly what boosts healthspan at least in males anyway so it doesnt really make them that special

[YOLF]

both of them are herbs used for sexual health and stamina. i wonder if that is exactly what boosts healthspan at least in males anyway so it doesnt really make them that special

Whose AI did the choosing?

[normalizing]

what do you mean? they are popular for sexual health. tons of refferences on google if you are curious. thats all i am saying, if they are good for men's health, maybe thats why it makes their lives better

[YOLF]

My question wasn't meant to be taken that way, I was just wondering who the company was who had the AI, that would help in determining their methodology and way of thinking so we can see what aspects of metformin these are likely to have.

[Lightning Laurie]

Yeah, me too on NR+ trans resveratrol LEF .. great to hear I'm not the only one

[Lightning Laurie]

https://www.sierrasci.com/projects
http://defytimetam.com
https://www.sierrasci.com/projects
http://defytimetam.com

[MikeDC]

https://stemcellres....3287-018-0857-6

 

Late addition of Nicotinamide Riboside in cell culture maintained telomere length better than control and other substances.

 

I think this is the first direct measurement of NR's effect on Telomere length. 

Attached Files

•  telomere.GIF   15.94KB   0 downloads

[YOLF]

Does it say what percent HeLa NR is capable of? That would give us a better comparison of potency.

Edited by YOLF, 26 April 2018 - 08:20 PM.

[normalizing]

mikedc keeps spamming all threads that mention NR and he has been excessively advertising it in them. just look at his rating, -335 its just some troll boy that supports chromadex and they promise to pay him in bitcoins one day so he can afford the latest research chem from online