cure heart disease

is my bikini rioting yet
on to the cardiology
graphic equalizer on the group strategies
TCA cycle makes atp; each of the stages is adjustable; published evidence that glucose mediated apoptosis raises three tca n lowers three tca cycle activities; find the optimized TCA tuning with a look at what superelders without heart disease have; basically if you think of the twelve TCA reactions as variable regarding leakage n amplitude whats the adjustment that will modify the gradual cytoshift to stiff or noncontractile tissue

Connective tissue has multiple mechanisms or formation; which are more cardiovascularly favorable
telling the golgi apparatus to make differently layered membrane material may make cardiovascular scar tissue soft rather than resistive
that bizarre thing where arthritics that eat cartilidge get better may be of value

regenerative breaking implant like a polymer njectable leaf spring that returns compressive energy from the LR n LL ventricles kind of like two nested bowls made of polymer or custom persons personal tissue regrown cartlidge with a spring between them

a bandpass filtered beta blocer with nootropic properties could be popular enough to reduce heart disease amongst the prediagnostic population
a graphic equalizer on adrenaline creates oppotunities to energetic while having more areas of calm; nootropic brings career value http://www.youtube.c...feature=related

just another cure for war; adrenic response can be adjusted for life with immunization technology depending on the bandpass effect you create reduced heart disease or a bunch of really calm people that would find being miffed a thing of the past
famous cia crack thing; famous third world passivation vaccine the pacifies while it longevizes Imagine all those Iraqis being calm from a childhood immunization

atrial fibrillation is dangerous as a result of blood flow rate plus clotting that occurs at low flow rates; a recognized treatment is to deliver anticoagulants; some of the anticoagulants are effective at 10mg dose; cardiac monitor cuffs are a common athletic item, these could transmit a capsule breaking electrical message to a very very small implant; it could even just solubalize pmma septum;basically the arm thing detects moderate t severe heart rhythm oddity; sends em puls to dissolable capsule; if person goes to fibrillation the drug grants additional clotless time to transport n treat; nice MEMS opportunity; people could get the cheap implant n wear the computer monitor cuff; not to put to fine a point on it but the volume of a TB test could accomodate 10mg plus a mems thing

a tooth item that monitored cardiac state plus energetically jabbed the patient with 10mg of drug is possible; more appealing would be a pad people put n their shoes that detected cardiac state n then energetically delivered a drug; car airbags save a few thousand lives each year but a foot airbag could save hundreds of thousands, plus you just toss it n your shoe n ignore it unitil there is an event; the tooth thing actual requires professional effort to place

this idea is really far out there: I've read about bacteria that precipitate silver crystals of predictable geometry http://news.bbc.co.u...ture/533416.stm ; I think its just possible that a purposeful heart muscle colonization that leaves little silver metal crystals on cardiac tissue creates a pattern of dots that can become electric with an EM field; the electricity acts as a defibrillator

pour liquid nto a cup; it goes up the sides; then stack two of them thats kind of like the animation at http://en.wikipedia....nciple_slow.gif anyway beyond the defibrillator would be cueing these two cups and their upside action as a programmable group of linked directionalities; where do the tiny situ electrodes come from microsurgery crystals or wavelength tuned bacterial precipitate silver crystals: yeah, you just use a catheter with cardiac bacteria, them dot the heart with colonies from different varieties that make crystals of varied EM stimulation wavelengths you can figure the brief course of immunosupressive drugs plus the catheter that looks like a loop with bubbles that you pull through; minimally nvasive, gives precise tuning of each aspect of function with far less current from a radio transmitter outside the body
ornate, but functional if it works

___________________________-->------BacA------BacB--BacC--<----BacM------BacW----/___________________________pull the sequence of bacteria on a tape past the nfection probe head

CeS or CeSe as cardiac drug mmmmmm protons the puzzle of strontium as a molecular Ca or Mg swap atom; I mean wikipedia says Unlike most other Class III antiarrhythmic drugs, ibutilide does not produce its prolongation of action potential via blockade of cardiac delayed rectifier of potassium current, nor does it have a sodium-blocking, antiadrenergic, and calcium blocking activity that other Class III agents possess. Thus it is often referred as a “pure” Class III antiarrhythmic drug. It does have action on the slow sodium channel and promotes the influx of sodium through these slow channels. Although potassium current seems to play a role, their interactions are complex and not well understood sodium, potassium, whats strontium or rubidium do to these ion pumps; clog them, modulate them, change their histogram of simultaneous pumping
different positive ions affect membrane ion pumps n actual molecule swap spots differently Competitive inhibition and selectivity enhancement by Ca in the uptake of inorganic elements (Be, Na, Mg, K, Ca, Sc, Mn, Co, Zn, Se, Rb, Sr, Y, Zr, Ce, Pm, Gd, Hf) by carrot (Daucus carota cv. U.S. harumakigosun).Ozaki T, Ambe S, Abe T, Francis AJ.
Japan Atomic Energy Research Institute, Tokai, Ibaraki, 319-1195, Japan.

We investigated the uptake of inorganic elements (Be, Na, Mg, K, Ca, Sc, Mn, Co, Zn, Se, Rb, Sr, Y, Zr, Ce, Pm, Gd, and Hf) and the effect of Ca on their uptake in carrots (Daucus carota cv. U.S. harumakigosun) by the radioactive multitracer technique. The experimental results suggested that Na, Mg, K, and Rb competed for the functional groups outside the cells in roots with Ca but not for the transporter-binding sites on the plasma membrane of the root cortex cells. In contrast, Y, Ce, Pm, and Gd competed with Ca for the transporters on the plasma membrane. The selectivity, which was defined as the value obtained by dividing the concentration ratio of an elemental pair, K/Na, Rb/Na, Be/Sr, and Mg/Sr, in the presence of 0.2 and 2 ppm Ca by that of the corresponding elemental pair in the absence of Ca in the solution was estimated. The selectivity of K and Rb in roots was increased in the presence of Ca. The selectivity of Be in roots was not affected, whereas the selectivity of Mg was increased by Ca. These observations suggest that the presence of Ca in the uptake solution enhances the selectivity in the uptake of metabolically important elements against unwanted elements.

PMID: 15695849 [PubMed - indexed for MEDLINE]
CeO is a known longevizing ischemia resistance compound it is shown that CeO(2) nanoparticles provide an effective means to improve cellular survival in settings wherein cell loss due to oxidative stress limits native function, perhaps a membrane transport modulation drug could be built with positive side effects(yay I guessed near); the effect of CeCl is to weaken contraction; perhaps a CeO-R on cardiac muscle could block whatever Ce ion does thus strengthenin contraction from ion channel modulation ref says Treatment with CeO2 nanoparticles markedly inhibited progressive left ventricular dysfunction and dilatation
CeO2 acts like SOD on ROS which is like SOD blocking negative Ce ion contraction effect; thus between CeO2 n Ce ion there might be a CeS or CeSe compound that is beneficial

reactivized capillary beds sequester cholesterol drug; drinkable radiator fluid like cholesterol controlling drug polyvinyl acetate is bubblegum but with a name like polyvinyl acetate you know its just too nifty, anyway on to the radiator fluid idea: its possible to believe the circulatory system has a number of reactively typed surface areas(giant fractal from capillaries as a reaction type area; visible arteries as a different area) anyway there are two ideas: make the vast surface area of the capillary bed more reactive to "bad" cholesterol thus scrubbing it out of the blood minimizing deposition on big important arteries like the coronary arteries; capillaries are constantly renewed so the "bad cholesterol" gets phagocytocized (WBC eats the cholesterol) then goes to the liver prior to GI tract The other idea is to give people a pint of fluropolymer or polyvinyl lipofriuendly chelator that is say ten times more attractive as a "bad cholesterol" solvent; the pint of goo sequesters the cholesterol but has a pharamcodynamic excretion pathway; the ultimate would be an orally absorbable getter fluid Its kind of like what if you swallowed polyvinyl acetate of liquid molecular weight, then it got to the bloodstream;absorbs bad cholesterol;has a liver degradation pathway Its like a swallow your chewing gum seven year story gone scientific with the liquid gum actually residing as body fluid a while
if an oral to bloodstream cholesterol sequestrant drops "bad cholesterol" to a cardioprotective level it could be a cheap food additive; olestra like; a plausible mass cure; words from wikipedia:cholesterol binding resins have saved lives in proper studies

pink little dinosaur cardiology diagnostic: apparently genetically engineered tooth plaque is about to launch; there are such a variety of detectable mouth chemicals the engineered bacteria could react to creating a pink film on the teeth if there is anything truly predictive of a useful preventative treatment

numa numa: monamine oxidizes a n b are platelet surface factors; perhaps there is a thrombolytic blood drug that is a mood elevator like maoi B active deprenyl plus reduces artery occlusion

are hemophiliacs partially immune from cardiovascular disease as they have minimized clotting; if so then an irna that creates partial but beneficial hemophilia could be created amongst those with either diagnosed cardiomyopathy or just really noteable genetic susceptability; actually irna is now part of skin meds thus I'm sure irna approaches to clotting to minimize risk are going on

bile stasis demodulator: cholesterol becomes bile; its possible that upregulating the liver or making the gallbladder think it is less full than it ought to be with a drug will cause the body to scavenge more cholesterol from the bloodstream; this chemical causes liver growth http://www.ncbi.nlm....ubmed_RVDocSum; It might be possible to permanently change liver function with a brief drug dose that would confer lifelong reduced cholesterol; also a plausible mass cure

different arteries have different amounts of mechanical bend; finger arteries may have much better reconstruction chemistry than body cavity arteries; find those chems then apply to coronary arteries

gamma knife surgery to create fibrilation blocking lesions is nonnvasive and might work

I'm going to write this even though I know it won't work the undersink u bend that sequesters plumbing gunk could be reformed to be a kind of U shape with blood transport channels at rune angle to create a guaranteed flow rate on the side flow with a gunk trap at the much larger, and preferred wider arterial pathway; I've read that artificial tissue bladdr organs are now being grown n grafted to humans this rather near technologically; the point being that the side channel always prevents ischemia from clots; multiple side channels make sense; kind or reminds me of the aorta but with the biggest lumen (pipe hole) better but optional; they could attach these to various arteries a decade prior to typical atherosclerotic even timing to prevent MI pulmonary embolism or stroke; now the big question is can these be made with endoscopy plus an automated mechanism like the precision of a sewing machine or a lasik machine; a possible benefit is that the thing could be grown from cytes that have been gene modified to have minimal plaque formation like endothelium-derived relaxing factor (EDRF http://answers.yahoo...d=1006042420931 then placed

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predefibrillation auto narcolepsy I think it might be possible to detect eeg anomalies hours prior to defibrillation; a computer detects these then has the patient sleep; kind of stress or physiological avalance circuitbreaker but what about movement or emotional stress with just a few minutes of predictive time

thinking high compliance
does nerve or vagus nerve strobing do anything; like does the repetive stimulation of the vagus nerve affect cardiac measures with time; different than acute, more like a stimulation every few minutes, or half an hour of stimulation per day adjusts ekg; is there any normal ekg variant that predicts abscence of near future arrrythmia; I'm finding high compliance cardiac modulators; music has mild published ekg modifications although it would have high compliance; a vagus nerve stimulator might have specific effect; aromatherapy is published


Influence of music on heart rate variability and comfort--a consideration through comparison of music and noise.Umemura M, Honda K.
Department of Management Science, Science University of Tokyo, Shinjuku-ku, Tokyo, 162-8601 Japan.

By considering three kinds of music and noise, this research investigates the influence of music on the living body by comparing the difference of influence on heart rate variability and comfort when subjects listen to music and are exposed to noise. We used two pieces of classical music, rock music, and noise recorded by a tape recorder. The following conclusions were made from the findings of the research: 1) Hearing classical music results in a small variance of Mayer Wave related Sinus Arrhythmia (MWSA) component and Respiratory Sinus Arrhythmia (RSA) component compared with a body being at rest. This is because the sympathetic nerve is suppressed by the sound of classical music. With rock music and noise, however, the MWSA component increases and the RSA component decreases. 2) From a psychological evaluation, we found that classical music tends to cause comfort and rock music and noise tend to cause discomfort. 3) A correlation was found between the balance of the MWSA component and the RSA component and the psychological evaluation. As the comfort increases, the variance of MWSA decreases; as discomfort increases, the variance of MWSA increases.

Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity.Hayano J, Sakakibara Y, Yamada M, Ohte N, Fujinami T, Yokoyama K, Watanabe Y, Takata K.
Third Department of Internal Medicine, Nagoya City University Medical School, Japan.

We analyzed the spectral components of RR interval variability under controlled respiration (15 breaths/min) in 56 patients (age range, 35-73 years) referred for coronary angiography; 14 patients had multivessel disease (group M), 21 had one-vessel disease (group S), and 21 had nonsignificant disease or normal coronary artery (group N). There were 43 healthy controls (age range, 36-71 years) (group C). The patients had no clinical evidence of heart failure, hypertension, diabetes mellitus, or acute stage of infarction and had taken no medication for 3 days. The autoregressive power spectral density of RR interval variability contains two major components, respiratory sinus arrhythmia (RSA) (0.25 Hz) and Mayer wave-like sinus arrhythmia (MWSA) (0.04-0.15 Hz), which have magnitudes that are quantitative markers of cardiac vagal activity and sympathetic activity with vagal modulation, respectively. We represented the magnitudes by the coefficient of component variance (CCV), which provided the amplitude relative to the mean RR interval. The age- and sex-adjusted mean of CCVRSA significantly decreased with advancing angiographic severity (1.64 +/- 0.09%, 1.66 +/- 0.12%, 1.22 +/- 0.13%, and 0.81 +/- 0.16% for groups C, N, S, and M, respectively) (p = 0.0001). The CCVRSA was unrelated to left ventricular function, previous myocardial infarction, or stenosis of any specific artery including the sinoatrial and atrioventricular node arteries. The CCVMWSA decreased only in group M (p = 0.0462). These results indicate that coronary artery disease is associated with vagal dominant impairment in autonomic cardiac function and that reduction in the vagal cardiac function correlates with the angiographic severity.


breath technique modifies ekg thus the idea: cardiovascular fitness karoake

Hemodynamic observations on a yogic breathing technique claimed to help eliminate and prevent heart attacks: a pilot study.Shannahoff-Khalsa DS, Sramek BB, Kennel MB, Jamieson SW.
The Research Group for Mind-Body Dynamics, Institute for Nonlinear Science, University of California, San Diego, La Jolla, CA 92093-0402, USA. dsk@ucsd.edu

OBJECTIVE: This pilot study investigated the hemodynamics of a yogic breathing technique claimed "to help eliminate and prevent heart attacks due to abnormal electrical events to the heart," and to generally "enhance performance of the central nervous system (CNS) and to help eliminate the effects of traumatic shock and stress to the CNS." DESIGN: Parameters for (4) subjects were recorded during a preexercise resting period, a 31-minute exercise period, and a postexercise resting period. SETTINGS/LOCATION: Parameters for subjects were recorded in a laboratory at the University of California, San Diego. SUBJECTS: Parameters for 3 males (ages 44, 45, 67) and 1 female (age 41) were recorded. One (1) subject (male age 45) had extensive training in this technique. Interventions: This yogic technique is a 1 breath per minute (BPM) respiratory exercise with slow inspiration for 20 seconds, breath retention for 20 seconds, and slow expiration for 20 seconds, for 31 consecutive minutes. OUTCOME MEASURES: Fourteen beat-to-beat parameters were measured noninvasively and calculated for body surface area to yield: stroke index (SI), heart rate (HR), cardiac index, end diastolic index, peak flow, ejection fraction, thoracic fluid index, index of contractility, ejection ratio, systolic time ratio, acceleration index, and systolic, diastolic, and mean arterial pressures (MAPs). Left stroke work index (LSWI) and stroke systemic vascular resistance index (SSVRI) were calculated. RESULTS: We report on SI, HR, MAP, LSWI, and SSVRI and how they can help to describe hemodynamicstate changes. This technique induces dramatic shifts in all hemodynamic variables during the 1 BPM exercise and can produce unique changes in the postexercise resting period after long-term practice that appears to have a unique effect on the brain stem cardiorespiratory center regulating the Mayer wave (0.1-0.01 Hz) patterns of the cardiovascular system. CONCLUSIONS: Preclinical studies are warranted to examine the possible long-term effects of this technique that appear to reset a cardiorespiratory brain-stem pacemaker. We postulate that this effect may be the basis for the purported yogic health claim.

the homocysteine thing i before e except after c; weird is weird; homocysteine is different
gene therapy is always a thinking opportunity; there is the famous more than 2/3 transfection of muscle tissue study; it feels as if the R group on cysteine could be modified with gene therapy; N-acetyl cysteine is highly beneficial; enzymatic acetylation of body fluid cystein that outcompetes the production of "bad" cystein on the same base molecules feels very possible transgenic sheep which can make their own cysteine have been developed; if reducing homocystein actually reduces mortality then a gene therapy vaccine could be of value; I'm rather thrilled that reducing homocysteine upregulates collagen elastn, proteoglycans; reducing homocysteine may act as a beauty pill or vaccine that maintains younger amounts of these chemicals; a beauty pill or vaccine is a much more popular idea than just a cardiovascular benefit;niacin is currently a fresh cosmeceutical; I added it to sunscreen as well when I found some; It had some visible effectiveness; http://en.wikipedia....lk:Homocysteine even suggests that optimized minimal homocysteine may reduce miscarriages


rate of change of atherosclerosis _/- or / ; do the various regions of the curve respond differently to different treatments, uh huh its _/- no Jama says / on a ^ curve

The histologically topographic comparisons on atherosclerosis progression among three anatomical sites, mid-thoracic and lower abdominal aorta and left anterior descending coronary artery (LAD) were performed using a young population (age 15-34 years) from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. METHODS AND RESULTS: The histological classification based on the American Heart Association grading scheme showed that in the thoracic aorta type 2 lesions (numerous macrophage foam cells with fine particles but no pools of extracellular lipid) appeared in the first 10-year age group, with no significant change in prevalence in the next 10 years.

maybe its puberty; women develop diseases later 15- to 34-year-old subjects because fatty streaks are prevalent and fibrous plaques begin to appear in this age group

If it puberty a blunt strategy is cypoterone acetate plus the gnrh cascade blockers

Or these people could just test this functional atherosclerosis vaccine on people

freund's adjuvant; mooshed TB mycobacteria coupled with Cu oxidized Lipoprotein reduces atheosclerosis
Effect of immunization against ox-LDL with two different antigens on formation and development of atherosclerosis.
(Theory: TB is special because it colonizes the nteriors of living cytes; thus immune response form is unique as most antibodies n Tcytes just dont reach mycobacterium; that which does has unique useful system properties; so the question is it mycobacterium because of its hidey form or is it mycobacterium humoral immunity generally that minimizes athersclerosis; could I grind up a variety of different non nfectious mycobacterium n get a range of results some even more atherosclerotic preventative than TB; is it the virulence or the genus species that matters

wikipedia says Mycobacteria can colonize their hosts without the hosts showing any adverse signs. For example, billions of people around the world are infected with M. tuberculosis but will never know it because they will not develop symptoms. although Asgary uses rabbits, active TB rather than mooshed TB causes atherosclerotic symptoms among rabbits; Asgary vaccine find research to decide if it works on people


Asgary S, Saberi SA, Azampanah S.
ABSTRACT: BACKGROUND: Several studies were pointed to oxidized LDL (ox-LDL) as one of the main immunogenes which have important roles in primary lesions of atherosclerosis. In this study, by immunization against ox-LDL with two different antigens in an animal model (rabbit) and consideration of its effect on two different dietary regimens; we tried to clear relation between immune system and atherosclerosis. Materials and Methods LDL was isolated from hypercholesterolemic rabbits plasma and oxidized with MDA or Cu++. Rabbits were divided to three groups and immunized with MDA-LDL or Cu-LDL or phosphate-buffer (PBS) as a control group. Immunization was repeated after 2, 4, 6, and 8 weeks and concentration of antibodies against ox-LDL was measured in each stage. After immunization, rabbits in each group were divided to two subgroups based on the dietary regimen ( fed normal or high cholesterol diet). At the beginning and the end of the study, biochemical factors were measured. Also, fatty streaks in aorta and left and right coronary arteries evaluated. RESULTS: Immunization with Cu -LDL and MDA-LDL induced statistically significant antibodies against ox-LDL. In hypercholesterolemic rabbits immunized with MDA-LDL the level of cholesterol, LDL-cholesterol, triglyceride, fasting blood sugar and fatty streak lesions in aorta and right coronary arteries were significantly decreased as compared with non-immunized high-cholesterol group. Immunization with Cu -LDL in hypercholesterolemic rabbits significantly decreased triglyceride, fasting blood sugar, cholesterol and CRP. No significant differences were detected in the fatty streak lesions in this group as compared with non-immunized high-cholesterol diet. In groups under normal diet immunized with MDA-LDL or Cu -LDL no significant effect on biochemical factors and atherosclerotic lesions were observed. CONCLUSIONS: This study indicates that although the effect of produced antibodies in several methods and different dietary regimens is different, immunization against ox-LDL is antiatherogenic.


blood rheology
I am trying to think of a better idea than this: of all the components of breast milk some are lipid solubalizing agents; these might be well tolerated ntravenously as blood rheology modifiers plus have rapid drug approval status; are there natural blood detergents not so as to scrub, more to make rheology favorable


lipoprotein as hemoglobin; transport preferential different cholesterol http://en.wikipedia....iki/Cholesterol with different length /\/\/\ methylheptan part = a food oil that blocks cholesterol transport; kind of like long n short cholesterol that swaps benefically with the lipoproteins with cholesterol that are known as good n bad cholesterol if it works they could make a pill to modify the body's cholesterol synthesis to the short or long form ...maybe... or maybe not Two molecules of farnesyl pyrophosphate condense with reduction by NADPH to form squalene

bisphosphonate impedes farnesyl which goes on to make lanosterol which makes all steroids; bisphosphonates must turn the knob down on everything aha:Statins are another class of drugs that inhibit the HMG-CoA reductase pathway. Unlike bisphosphonates, statins do not bind to bone surfaces with high affinity, and are thus not specific for bone; statns reduce heart disease even amongs cholerolnormic person

that idea about how upregulating CYP3a4 which metabolizes all steroids, notably cholesterol will reuce blood cholesterol thus reducing atherosclerosis as well as cardiac mortality; find a human friendly form like st johns wort; st johns wort upregulates YP3A4 2/5

notes:
upregulate the CYP3A4 liver enzymes that scrub all steroids as well as cholesterol from the blood; measure the effect on atherosclerosis as well as cardiac related death

perhaps this will have effects like statins that reduce cholesterol as well as cardiac related deaths

Now here's the idea: upregulate the cyp3a4 liver enzymes that scrub all steroids as well as cholesterol from the blood; measure the effect on atherosclerosis as well as cardiac related death, use a genetically common food to immunize as much of th earths population is willing like Rice-based mucosal vaccine as a global strategy for cold-chain- and needle-free vaccination http://www.ncbi.nlm....Pubmed_RVDocSum
The herb St johns wort raises CYP3A4 2/5
the cerebroprotective ischemia drug and discussed nootropic phenytoin raises CYP3A4

either of these materials are predicted to reduce cholesterol, atherosclerosis as well as cardiac related deaths

Amazingly there are zero papers at pubmed.org with search items [atherosclerosis, CYP3A4] or [cardiac, CYP3A4] that talk about how the amount of this liver enzyme affects atherosclerosis or heart disease; it's like researchers were studying "the kitchen sink" dids lots of research on faucets n sponges but did zero research on the size of the drain, or the effect of a bigger drain

basically I think if a person want to write a great med school app or do something that rapidly confers full professor status it would be studying if more liver CYP3A4 means less heart disease

any immunization that creates immune response to the body's CYP3A4 minimizers may amplify CYP3A4 creating less atherosclerosis; a heart disease vaccine

they should verify if st johns wort is cardioprotective

review article rescued this idea with: 1: Ann Med. 2007;39(5):359-70. Links
Cytochrome P450--physiological key factor against cholesterol accumulation and the atherosclerotic vascular process. Several compounds induce P450 and other genes regulating cholesterol balance and prevent or regress atherosclerosis

St Johns wort is cardiac friendly http://www.ncbi.nlm....Pubmed_RVDocSum but a significant reduction of such pathological findings under treatment with hypericum extract. It should be emphasized that this favorable feature of safe cardiac activity was achieved with 1800 mg of hypericum extract The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug http://www.ncbi.nlm....Pubmed_RVDocSum The results indicate that the derivatives found in Hypericum perforatum have possible antiatherogenic potential

I could write to that Iranian researcher

alfia the anesthesiologist cardiac researcher 19 of 20 cardiac surgeries have cognitive effects; what about amplifying the metabolic strata that processes the anesthetic drug

any immunization that creates immune response to the body's CYP3A4 minimizers may amplify CYP3A4 creating less atherosclerosis; a heart disease vaccine I could write to that Iranian researcher

cyp3a4 amplifiers may have impulsiveness moderating functions


a tidy person would list a roster of cyp3a4 ideas like
cyp3a4 gene control
cyp3a4 heme modification
cyp3a4 regeneration enzyme chemistry; kind of like ssris a drug that modulates the regeneration of cyp3a4 might create an oscillating reaction curve stay on course notch

make research more productive: recently I noticed that two decades had passed since people figured out upregulating liver enzymes blocks atherosclerosis; I was recently thrilled to note that a researcher had gotten around to combining high density lipoproteins with immunoreactive material to create an atherosclerosis reducing vaccine; work that could have been done a half century ago; I also note lots of awesome, appreciated detailed science

I'm a technologist I'd like to have scientists create a channel of immediate prospective application; a little like the anonymous column Nature magazine features; this is different than the grant wording where they say why their their thing may apply to a specific purpose; I guess you coukd call it reality optional relevance titillation

hypothesis
methods
results
discussion
Kickstart

everyone's peer scientists might make those brave leaps to application if they put a relevance titillation section as a standard part of their papers

here ill make one up

the f3 key shares functional morphology with the 3 key but not the shift key

method:
Using the minimal keyboard randomization model 7 grams of f3 keys were isolated from the upper portions of 70 Kg of computer keyboards, sorted with an optical alphaspectrometer then divided into fractions of 99 pt purity

700 grams of 3 keys (sigma-aldritch) were layered on a 300 cm sheet of acrylamide gel; contained, then linearly accelerated at 3 Gs for about half an hour. The faceplantogram was passaged through several rinses of toluene leaving only the morphology profile on the gel

results:
on adhesion angle tests with a placing vibrator at 2 cycles per second f3 keys adhered to the faceplantogram at .9 specificity while shift keys adhered with .1 specificity

discussion:
Our results support the idea that the f3 key shares functional morphology with the 3 key but not the shift key; f as well as f3 are members of the character set
the work of dvorak et al suggest that only morphologically variant keys are function keys as well as the hypertrophied "mouse" key

Kickstart
ever since the publication of the Alt-tab phenomenon (wow) researchers have been asking if perhaps the keys are more than mere shapes; our natural revealed knowledge about the entire human genome suggests the tiresome "codon" word production analogy
I like to think that the morphological characteristics matter right now
there are a couple ways: attach groups of "mouse" keys to your feet to double or triple rolling velocity; perhaps as a new kind of shoe for clinical or even recreational practice; I've got a dubious feeling about actually gluing keys to the monitor to create "words" but gluing just a particular key to the monitor then splicing the monitor power cord through a pair of key nested zinc fingers could create a kind of "power switch" perhaps giving the organism the ability to hibernate or have a more efficient metabolism

mostly their ideas
purposeful use of friendly arterial flora minimize surface corrosion

stem cytes or tissue from more than centenarians that lack heart disease

yogacyclase drugs;

food based atherosclerosis immunization suggests that drugs to treat persons currently over 30 as they develop heart disease will be beneficial
Both cyp3a4 upregulation as well as niacin workalikes cure whats there
I wonder if a sustained release platelet factor could be given as a once every three years; I think depo provera is a couple yearable a year fda approved likely tested much farther suggesting a person medicate each 24 hrs for three years seems wacky; maybe a cosmaceutical that had a first pass metabolism product that was platelet active; if the foundation is to be dermatologically adequate it must be neutral; plus think of "edge gel" applied daily it could prevent millions of cardiac events but must be medically neutral at the absorption point
Gillette Vital Edge [edit, delete]
cardiovascular protectant: like getting millions of people to take acetylsalicylic acid daily
(0) [vote for,
against]



Gillette Vital Edge gives you fresh cool lather that actually uses your body's chemistry to protect your heart
while the foam is all over your face platelet drugs linked to passivation molecules are absorbed

these go though the liver called first pass metabolism to become cardioprotective

Gillette Vital Edge users like acetylsalicylic acid users have a quarter fewer cardiac events, perhaps a third fewer events if a better drug like a modified coumadin is used

technology: I think coumadin is much stronger than acetylsalicylic acid thus 2 or 3 milligrams absorption provides benefit

Grandiose Hype: possibly more effective than a national healthcare system at reducing mortality (US n Europe numbers are just a little different; a quarter reduction of a disease that effects two out of three people might be larger than that difference

that triple blade vibrating razor thing was worth billions this is public domain though

popular culture: I've read humorists wondering what would come after the multiblade vibrating razor as the New Tech to provide product difference at a value that justifies the premium

they could even have a mecha looking dispensa cap that filled with gas such that the container would only deliver a certain amount over an hour period to keep depilatory enthusiasts from absorbing too much drug


math

we all know heart muscles lack the ability to become tired; but do they; is there anything that heart muscle does to recharge between high n medium output periods; how does the body availability or tissue cyte availability of those chemicals affect durability

less cardiovascular work more skinnier pill; a person visiting a physician with cardiovascular disease might be plump; part of it is that the heart has to do more output because of body size; a pill that reduces the body's cardio force or cardio rate while also cause them to be skinny would treat two disease things; beta blockers of course block adrenalin - they do part of this; so a skinnifying beta blocker would be beneficial
propanolol molecule linked to a thyroid drug; wikipedia says Beta-blockers do not treat, but rather mask, common symptoms of hyperthyroidism; be skinny, be calm, have less heart disease; propanolol is less beneficial than Carvedilol; Carvedilol carvedilol appears to produce favorable effects on insulin sensitivity and glycemic control and can therefore be considered as more efficacious adjunctive treatment than propranolol in hyperthyroidism

a revision of the rhythm drug Amiodarone might be very beneficial Due to the iodine content of the agent (37.3% by weight), abnormalities in thyroid function are common. Amiodarone is structurally similar to thyroxine (a thyroid hormone), which contributes to the effects of amiodarone on thyroid function; perhaps there is skinnifying rhythm restoring drug lurking here

hyperoxia may be cardiobeneficial as a muscle remodelling; drug that either makes more hemoglobin or more RBC plus coumadin; after middle age hemoglobin drops noticeably; Adult women: 12-16 gm/ Women after middle age: 11.7-13.8 gm/ a erythropoietinish pill that brings this up to young amounts might be like hyperoxia; causes less cardiovascular work necessary to live; effect of blood viscosity might be neutral if elederly have fewer rbcs than younger people; valuable pubmed says Low absolute hematocrit values during follow-up were associated with cardiovascular (CV), non-CV and HF mortality, HF and non-CV hospitalizations, and cardiac ischemic events

there are nonhuman mammals that have higher efficiency hemoglobins than humans; use the 7/10 effecitive muscle gene therapy protocol to make these better hemoglobns; a vaccination like procedure might hyperoxygenate the cardiovascularly challenged minimizing the effects of cardiovascular disease
A variant hemoglobin, called fetal hemoglobin (HbF, α2γ2), is found in the developing fetus, and binds oxygen with greater affinity than adult hemoglobin

acclimated to high altitudes, the concentration of 2,3-Bisphosphoglycerate (2,3-BPG) in the blood is increased, which allows these individuals to deliver a larger amount of oxygen to tissues


cpr
video training is effective; swap license fee with training to create millions more more first responders
CPR may be changed to give more rescues
pressurize the body to force blood to brain: sit on legs or squeeze stomach
sympathetic nervous system novelties may act opposite fibrillation; research these
Sympathetic stimulation of the lungs and smooth muscle surrounding the bronchi results in bronchial muscle relaxation; its possible that a bronchial response to water would modulate the rest of the sympathetic nevous system
CPR A!BC does the hiccup cure(!) work: it can disrupt heart function; can it disrupt fibrillation; try this on lab mammals;
maybe a shout plus funnybone twanging; maybe there's a martial arts pressure point;
research unusual arm or leg postures: with anesthatized mammals it has been shown that movement of the knee joint within its normal physiological range has no effect on blood pressure or heart rate. However, forced movement beyond the normal physiological range produces significant increases in these parameters
Baroreflex sensitivity is associated with order of magnitude higher survival after MI; if Baroreflex sensitivity matters during MI, which would be strange yet could be associated with entire system resistance to ischemia during the ambulance ride, it could be modulated; mechanically activated specialized neurons at the cardiac muscle control Baroreflex sensitivity; it is possible that a different stretchier compression stroke could affect Baroreflex sensitivity

technology
People with age or genetic risk may benefit from Baroreflex practice while awake or asleep
3ms/mm hg is minimal; perhaps a cycling inflatable cuff that created 3 ms/mm hg shifts of blood pressure mechanically could be worn while asleep to prompt the Baroreflex effect to cycle n strengthen thus giving the benefit of movement fitness on MI survival absent actually doing fitness activities upgrading the Baroreflex sensitivity to respond confers better than an order of magnitude of survivability

Baroreflex modifying defibrillator paddles; if Baroreflex sensitivity matters during MI perhaps paramedics could have a sonic component that affect the mechanically activated specialized neurons (baroreceptors) the sonic Baroreflex activating component could be like a piezo item on the defibrillation paddles

Idea that won't work unless there are personal alarm handyphones: sonic stimulation of baroreceptors with a handyphone program

better than CPR a mouth product like plaque colorizers that told people when their cardiac epinepherine was predictive of MI; hearts act like glands make their own stimulants;detecting if the heart gland is making the right amount of stimulants may be predictive of cardiac anomoly or MI; its possible cardiac produced ep also produces particular detectable chemicals; if the toothpaste turns a different color it means the person has cardiac EP risk; thats only better if cardiac EP is MI predictive; it would predict CHF but people with CHF knoiw they have CHF


If Baroreflex sensitivity affects ischemia during transport then paramedics might have a sonic stimulator that they put on the chest which stimulates the mechanically activated specialized neurons (baroreceptors)


nifty idea We developed a cardiopulmonary resuscitation (CPR) instruction programme using motion capture animation integrated into cellular phones. We compared the effectiveness of animation-assisted CPR instruction with dispatcher-assisted instruction in participants with no previous CPR training RESULTS: The AA-CPR group had a significantly better checklist score (p<0.001) and time to completion of 1 CPR cycle (p<0.001) than the DA-CPR group. In an objective assessment of psychomotor skill, the AA-CPR group demonstrated more accurate hand positioning (68.8+/-3.6%, p=0.033) and compression rate (72.4+/-3.7%, p=0.015) than DA-CPR group. However, the accuracy of compression depth (p=0.400), ventilation volume (p=0.977) and flow rate (p=0.627) were below 30% in both groups. CONCLUSION: Audiovisual animated CPR instruction through a cellular phone resulted in better scores in checklist assessment and time interval compliance in participants without CPR skill compared to those who received CPR instructions from a dispatcher Idea: countries with national medical care could ask either CPR proficiency or a doctor fee once per year; ID cards are also optional organ donor cards; waiving the registration fee at licensing with CPR qiuz is a state to state option; tens of millions of first responders; yearly: pubmed notes that video or live training abilities show diminished ability after a few months that CPR onscreen quiz could remedy

It is possible that during the 20th century CPR was a 19 out 20 crummy, with just a patient 1-year survival with favorable neurological outcome; no figures on how many survive w neurological change; anyway about a quarter of people got CPR that had heart attacks; basically CPR as taught to the current number of people works on a heart attack per 99 people; crazed idea: sit on or compress their legs; that forces more blood to the brain plus elevate their feet
Sympathetic stimulation of the lungs and smooth muscle surrounding the bronchi results in bronchial muscle relaxation; its possible that a bronchial response to water would modulate the rest of the sympathetic nevous system;is it sympathetic each way or sympathetic plus a different nerve
whomp:
CPR A!BC does the hiccup cure(!) work: it can disrupt heart function; can it disrupt fibrillation; try this on lab mammals; with anesthatized mammals it has been shown that movement of the knee joint within its normal physiological range has no effect on blood pressure or heart rate. However, forced movement beyond the normal physiological range produces significant increases in these parameters
airway
! maybe a shout plus funnybone twanging; maybe there's a martial arts pressure point; the gag reflex might have effect;itd be nice to think of a pleasant startle
breathing
compression

The prolific sympathetic innervation of the heart permits synthesis of about 90% of the myocardial norepinephrine requirements within the organ one can think of the heart as an endocrine gland that synthesizes and releases a hormone, norepinephrine, as needed to allow the circulation to respond appropriately to changing metabolic demands of body tissues http://www.icnr.com/...ousSystem.html; what if there were a color dot or mouth rinse that told people when their cardiac ep was predictive of MI hearts act like glands make their own stimulants;detecting if the heart gland is making the right amount of stimulants may be predictive of cardiac anomoly or MI; congestive rather different than MI heart failure was associated with profound depletion in cardiac norepinephrine concentration
MI goes the other way
The response was abolished by atropine, which proved its vagal origin, and was associated with survival. A rapid reanalysis of the animals tested until then demonstrated that VF during transient myocardial ischemia was always preceded by an increase in heart rate, probably mediated in part by an excitatory cardio-cardiac sympathetic reflex, whereas survival was associated either no change or a reduction in heart rate


Baroreflex sensitivity (BRS) strongly predicts survival of people after MI http://www.sns-web.o...09/article.asp; what affects Baroreflex sensitivity (BRS) among the normal population; movement activities; but is there a drug or even a physicial activity or posture at the site of an MI; Baroreflex might be either predictor or cause; if cause then CPR that modifies Baroreflex at the site may be of benefit wikipedia says when the baroreceptors are activated (by an increased blood pressure) things happen; thus an nflateable cuff or compression then noncompression of the stomach or legs might cause the Baroreflex to activate thus modifying cpr response; wikipedia says The baroreceptors are stretch-sensitive mechanoreceptors. When blood pressure rises, the carotid and aortic sinuses are distended, resulting in stretch and therefore activation of the baroreceptors. Active baroreceptors fire action potentials ("spikes") more frequently than inactive baroreceptors. The greater the stretch, the more rapidly baroreceptors fire action potentials; that strongly suggests the possibility of modifying Baroreflex during assisted compression CPR; its possible that a compression technique that places Baroreflex at the higher survival form;The BRS of the patients who died was markedly lower (2.4±1.5 vs 8.2±4.8 ms/mm Hg, P =0.004) compared to that of the survivors. The risk of dying was 17 times greater for those patients who 1 month after MI had a depressed BRS; the BRS is a dynamic risk measure with time yet I wonder if forcing high vitality BRS at CPR time might be beneficial

basically a drug that makes the body play Baroreflex sensitivity (BRS) feedback thingy at higher amplitude might be protective amongst the general population; 20th century CPR with near ten patients living per 99 is crummy; an MI survival drug might change that (note The risk of dying was 17 times greater for those patients who 1 month after MI had a depressed BRS)
3ms/mm hg is minimal; perhaps an inflatable cuff that created 3 ms/mm hg shifts of blood pressure mechanically could be worn while asleep to prompt the Baroreflex effect to cycle n strengthen thus giving the benefit of movement fitness on MI survival absent actually doing fitness activities I mean upgrading the Baroreflex sensitivity to respond confers better than an order of magnitude of survivability

if Baroreflex sensitivity matters during MI perhaps paramedics could have a sonic component that affect the mechanically activated specialized neurons (baroreceptors) in the aortic arch, carotid sinuses, and elsewhere that monitor changes in blood pressure then tell the brain things; the sonic Baroreflex activating component could be like a piezo item on the defibrillation paddles

sonic modulation works as a result of The baroreceptors are stretch-sensitive mechanoreceptors. When blood pressure rises, the carotid and aortic sinuses are distended, resulting in stretch and therefore activation of the baroreceptors. Active baroreceptors fire action potentials more frequently than inactive baroreceptors. The greater the stretch, the more rapidly baroreceptors fire action potentials.

perhaps there is a beauty creating vaccine
the immune system is effective on a lot of things; perhaps collagenase immunity would keep tissues throughout the body younger n younger looking longer
a particularly blunt but effective use of the immune response is this paper http://www.lipidworl.../content/6/1/32 describes an immunization effective against atherosclerosis; mosshed TB bacteria known as Freund's adjuvant plus low density lipoproteins protects rabbits

mammals might show visibly younger pliable tissue throughout the body as a result of collagenase with Freund's adjuvant

note how particularly valuable this would be to heart tissue

fluoroniacin would or could be like atherosclerosis removing niacin plus it would have longer plasma life; actually niacin is a molecule that would radically change with F; thats awesome as there are like seven places to put the fluorine plus you could move the nitrogen nearer or to a particular relation to the fluorine atom nfcoh fncoh; anyway its be nifty to see what these few compounds did physiologically with atherosclerosis; nicotine is highly similar to niacin; is there a less harmful atherosclerosis reducing fluoronicotine people could quit tobacco; youthify their arteries n have a nootropic all with the same drug

humor: USB TENS transcutaneous electrical nerve stimulation for the computer enthusiast that has everything; it would be nice if USB had the ability to be cardiobeneficial with the right software, then every PC would be a defibrillatorish thing; I say defibrillatorish as its possible a few capacitors with some TENS tape could be like a defibrillator; On-The-Go and Battery Charging Specification both add new powering modes to the USB specification. The latter specification allows USB devices to draw up to 1.5 A from hubs and hosts that follow the Battery Charging Specification; the thing is how quickly could a responder actually bring computer n person together, then start the software 7 minutes anything beyond 3 minutes is ischemic


yet I'm puzzled that there is not just a cheap house current defibrillator; plug n go; it might be an FDA thing about usability


Mg swaps with Ca; immanent calcitonin idea
calcification of the heart is associated with heart disease; stiffness; ions;
making Ca or Mg modified melatonin at the methyl group to use melatonin nuclear membrane transport preferentiality; a moderating effect on mitochrondria were subjected to ischemia followed by reoxygenation, a boost of calcium occurred in the mitochondria.

“Calcium levels went up like never before, which is unusual, because mitochrondria typically are able to tightly maintain a low level of calcium,” said Ghafourifar, also an investigator in the Davis Heart and Lung Research Institute. That glut of calcium, in turn, triggered an enzyme to begin churning out toxic levels of the free radical nitric oxide – much more than the mitochondria could handle. And that excess of nitric oxide led to the release of a mitochondrial protein that then goes to cytodeath http://www.eurekaler...u-msd110807.php

much reperfusion trouble is about hydration spacing stickification as the proteins gather near enough to electrostatically hint at coagulation ; kind of like partially dried wet pom poms going from nonfunctional persistent stickiness to optimally nearest neighbored functionality is maybe a blood pH adressable thing also albumin of different molecular weigh could have a lighter touch; they could even try reperfusion with a fluoro blood replacer blended with the patients blood


make an additive like MSG that provides cardiovascular benefit;


lasers
so during the 20th century theres these millions of people walking around about have fibrillation; of which typically a person per 20 lived; A way to reach these millions of people prior to their fibrillation is to have UAVs flying around lasering people to detect cardiovascular events prior to MI; they could do raman spectroscopy to detect chemicals predictive of MI
or they could have them on highways scanning drivers faces through windshields;curing a disease that has a 3 minute treatment window requires new strategies computerized system that can predict a cardiac arrhythmia or sudden death up to eight hours prior to the onset of symptoms To develop the program, Dr. Shusterman and colleagues examined EKGs ; well you can record pulse with a laser; maybe the difference between laser pulses at wrists n faces suggests congestion or dangerous blood pressure; [Predictive value of differential pulse pressure in the diagnosis of silent myocardial ischemia in patients with type-2 diabetes] high odds ratio of prediction of silent ischemia the having of cardiac disease absent knowledge or symptoms prior to a suprise lethat MI is between 7 n 9 with 10 mm/hg pulse difference between arteries; I think lasers could spot that

anyway as things go there will be MEMS critters that can do enough of an EKG to warn people that are a few hours from MI

gas output correlates with MI activity; perhaps gas sensor detects rare volatiles to predict MI lasers detect breathing rhythm gas sensors detect gases these two references suggest a pluggable thing like a CO detector might tell people when they have treatable heart disease or an immanent event form factor could be like bathroom mirror or any other near face appliance although room based sensing is niftier
The minute ventilation/carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope.Arena R, Myers J, Hsu L, Peberdy MA, Pinkstaff S, Bensimhon D, Chase P, Vicenzi M, Guazzi M.
Department of Physical Therapy, Virginia Commonwealth University, Health Sciences Campus, Richmond, Virginia 23298-0224, USA.

BACKGROUND: Ventilatory efficiency, commonly assessed by the minute ventilation (VE)-carbon dioxide production (VCO2) slope, has proven to be a strong prognostic marker in the heart failure (HF) population. Recently, the oxygen uptake efficiency slope (OUES) has demonstrated prognostic value, but additional comparisons to established cardiopulmonary exercise test (CPET) variables are required. METHODS AND RESULTS: A total of 341 subjects were diagnosed with HF participated in this analysis. The VE/VCO2 slope and the OUES were calculated using 50% (VE/VCO2 slope(50) or OUES(50)) and 100% (VE/VCO2 slope(100) or OUES(100)) of the exercise data. Peak oxygen consumption (VO2) was also determined. There were 47 major cardiac-related events during the 3-year tracking period. Receiver operating characteristic (ROC) curve analysis demonstrated the classification schemes for both VE/VCO2 slope and OUES calculations as well as peak VO2 were statistically significant (all areas under the ROC curve: > or = 0.74, P < .001). Area under the ROC curve for the VE/VCO2 slope(100) was, however, significantly greater than OUES(50), OUES(100), and peak VO2 (P < .05). CONCLUSIONS: Although the OUES was a significant predictor of mortality, the VE/VCO2 slope maintained optimal prognostic value. An elevated VE/VCO2 slope may be the single best indicator of increased risk for adverse events.

Cardiac chest pain is accompanied by oxidative stress, which generates alkanes and other volatile organic compounds (VOCs). These VOCs are excreted in the breath and could potentially provide a rational diagnostic marker of disease. The breath methylated alkane contour (BMAC), a 3-dimensional surface plot of C4-C20 alkanes and monomethylated alkanes, provides a comprehensive set of markers of oxidative stress. In this pilot study, we compared BMACs in patients with unstable angina pectoris and in healthy volunteers. Breath VOCs were analyzed in 30 patients with unstable angina confirmed by coronary angiography and in 38 age-matched healthy volunteers with no known history of heart disease (mean age +/- SD, 62.7 +/- 12.3 years and 62.5 +/- 10.0, not significant). BMACs in both groups were compared to identify the combination of VOCs that provided the best discrimination between the 2 groups. Forward stepwise entry discriminant analysis selected 8 VOCs to construct a predictive model that correctly classified unstable angina patients with sensitivity of 90% (27 of 30) and specificity of 73.7% (28 of 38). On cross-validation, sensitivity was 83.3% (25 of 30) and specificity was 71.1% (27 of 38). We conclude that the breath test distinguished between patients with unstable angina and healthy control subjects.


niacn works at least partially reducing lipolysis; another thing that reduces lipolysis is swimming; one of the peculiarities of swimmers is that they retain body curves compared with other fitness activities of equivalent energy use is published ; there may be a different lipolysis that is to say lipid mobilization as food nhibitor with swimming, or more likely a cold water reaction cytokine cascade that could be recreated as a pill; strong refs support different lipolysis with swimming as well as the high density lipoprotein benefit
runners: runner has completed 80 km in a 12-hour run. Prior and shortly after the run, fat and skeletal muscle mass were determined non invasively both by the bioelectrical impedance analysis and the classic skin fold method. In addition, blood and urine samples were taken in order to assess fluid balance. By applying the bioelectrical impedance analysis, the runner has increased body mass by 1.5 kg, fat-free body mass by 4.2 kg and muscle mass by 1.0 kg, whereas fat mass decreased by 4.4 kg
swimmers: 12-hour swimming event, an athlete with constant body weight lost 1.1 kg of muscle mass and 21 of total body fluids whereas fat mass remained stable
is swimming or a functional equivalent drug high density lipoprotein active; 9.7 pt more high density lipoprotein with 3 or 4 months of swimming http://www.ncbi.nlm....Pubmed_RVDocSum
note that with various dry fitness activities like resistance and combination The concentration of total cholesterol (TC), TRI, HDL-C and low density lipoprotein-cholesterol in the blood did not change during the study in RTG, XTG and CG http://www.ncbi.nlm....tractPlusDrugs1 note that aerobics was very high density lipoprotein active with near a third more beneficial lipoprotein

not plausible:cntact lenses against cardiovascular disease Inoculation via eye-drop and drinking water was safe, and the levels of protective efficacy were comparable with intratracheal inoculation

chewing tobacco that is a cardioprotective vaccine plus a source of niacin; niacin was the 20th century's most effective known atherosclerosis reduction drug; just minimize the taxes on chewing tobacco that minimizes heart disease; if it can be proven that GM tobacco chewers have less mortality than the general population then its valuable;maybe I can think of a cure fo noncancerous leukoplakia; its a vaccine that spreads automatically; is highly likely to be repeated;might reduce the more dangerous s'oking

aerosol vaccine; I just like the idea of genetically engineered puff mushrooms that have spores that are effective aerosol vaccines; slightly different than food vaccine; form factor might go well with developing nations; the oral rehydration therapy thing happened because the physicians gave up on diagnosing n prescribing; to know the difference between GM rice n regular rice suggests passing along more knowledge than a Mushrooms cure disease idea;humor value: plus it works well with RPG; the pooled seroconversion rate with aerosolized vaccine was 93.5% (89.4-97.7%) and 97.1% (92.4-100%) with subcutaneous vaccine; you have found a +7 mushroom against heart disease; eat mushroom; nothing appears to happen but you live 30 years longer


what happens if people simply eat high density lipoprotein; does it pass the GI tract; its considered strongly heart protective http://en.wikipedia....ity_lipoprotein ; Algae could be engineered to make