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Chris Linnell's Longevity Review Newsletter



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September 2022 Longevity Review

Posted by Chris Pollyanna , 17 October 2022 - - - - - - · 1,165 views
supplements, rapamycin, metformin and 5 more...
After last month’s blockbuster, there was a slight slowdown in the longevity field as the summer wound down and the leaves contemplated their journey earthwards. As a counterpoint to August’s plasma dilution lead item, a study came out this month showing the reverse with the use of umbilical cord plasma concentrate giving a small reduction in GrimAge. Vy...



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August 2022 Longevity Review

Posted by Chris Pollyanna , 10 September 2022 - - - - - - · 1,881 views
supplements, rapamycin, nmn, nad+ and 6 more...
So much for the dog days of summer - after a fallow July, August was a blockbuster month in the longevity field with the first human results for plasma dilution therapy, a placebo controlled trial showing benefits for GlyNAC, and a potential breakthrough for epigenetic reprogramming. And that’s just scratching the surface!  In the supplemental sec...



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July 2022 Longevity Review

Posted by Chris Pollyanna , 04 August 2022 - - - - - - · 1,589 views
rapamycin, nmn, resveratrol, nad+ and 4 more...
As the dog days of summer are upon us, and productivity takes a nosedive in the sweltering heat (OK, maybe that’s just me!), it appears that there has been a spillover effect in the longevity field with not many exciting breakthroughs to choose from for the Round Up. However, having said that, there were of course still plenty of interesting results. Apar...



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June 2022 Longevity Review

Posted by Chris Pollyanna , 11 July 2022 - - - - - - · 1,721 views
nmn, nad, curcumin, reseveratrol and 4 more...
Welcome to a slightly truncated Longevity Review. As I started putting this together, I came down with COVID for the first time, which has set me back several days. I’ve recently been feeling that I’m falling behind where I want to be with the CLA and want to change that, so I will keep the written portions of this review brief and let the studies speak f...



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May 2022 Longevity Review

Posted by Chris Pollyanna , 09 June 2022 - - - - - - · 1,683 views
nmn, nad+, rapamycin, metformin and 6 more...
Another month, another step towards our longevity future, with plenty of advances to showcase. In the Round-Up you will find a human trial of a new supplement, a novel combination of drugs, gene therapy and more. There are also some more human results with Glucosamine, NMN, Metformin and others. Unfortunately, there was a disappointing human trial resu...



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April 2022 Longevity Review

Posted by Chris Pollyanna , 11 May 2022 - - - - - - · 1,776 views
supplements, rapamycin, nmn, nad+ and 4 more...
Although not as crazy as March, April nonetheless trumped March by producing the preprint paper I’ve been waiting a long time for - the combination of two major longevity modalities for the first time: senolytics and partial-reprogramming. I’ve said it a thousand times and I’ll say it several thousand times more: we will only make a large impact on ageing...



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March 2022 Longevity Review

Posted by Chris Pollyanna , 06 April 2022 - - - - - - · 1,804 views
supplements, fasting, nmn and 6 more...
March Madness! There was such an abundance of great studies out in March that my head is still spinning, and made for some nice tricky selection decisions for this month’s Round-Up. For example, there were several interesting senolytic studies including another human result and, just like buses, three exciting reprogramming papers, along with three new li...



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February 2022 Longevity Review

Posted by Chris Pollyanna , 16 March 2022 - - - - - - · 2,282 views
supplements, fasting, nmn and 5 more...
Welcome to another month of progress in the field of longevity. Although the geopolitical news has turned bleak, hopefully some solace, or at least some distraction can be found in science.  This month you'll find a couple of actionable studies relating to diet and exercise in the Round-Up, as well as a good overview of the clinical trials targeti...



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January 2022 Longevity Review

Posted by Chris Pollyanna , 06 February 2022 - - - - - - · 1,739 views
supplements, nmn, crispr and 6 more...
The new year has started off with some very interesting and exciting developments in areas I don’t normally cover in my newsletters, namely xenotransplantation, limb regeneration and AI robo-surgery, as you will see in the round-up. Maybe too late for your new year’s resolutions, but there were also a number of useful dietary/fasting studies, including th...



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2021’s Longevity End of Year Review

Posted by Chris Pollyanna , 25 January 2022 - - - - - - · 2,117 views
supplements, lifestyle, nmn and 6 more...
Introduction  Sitting down to write 2021’s End of Year Review, I had a look at the previous four I’ve done and saw that each followed a different format! Not wishing to break tradition, I’ve once again taken a different tack. Instead of breathlessly selecting the top advances in mouse healthspan, this time I’ve only included human studies (sorry...



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