February 2021 Longevity Review

Posted by Chris Pollyanna , 28 March 2021 · 1,656 views

supplements nmn fisetin curcumin resveratrol senolytics

Hello and welcome again to this month’s (delayed) longevity review. It turns out that slicing off a chunk of your right index finger is not a good idea. Who knew? Finally been able to touch type & use a pen again the past week.
Keeping the intro brief so that I can get this out before the end of the month, suffice to say that perhaps what will be the most important news to come out this year was announced by the NIA in February - check out the Round-Up for details.
A reminder that I have set up a Patreon account at the behest of a reader. Anyone wishing to buy me a cup of coffee is greatly appreciated! As an extra bonus, every month I’ll send you a PDF of all the studies which didn’t quite make the cut for this newsletter. There are still a lot of gems to be found! You can see a free example on Patreon.
Follow me on Twitter @ChrisPollyanna1 for the latest updates.
I hope you will also join my longevity Facebook group.
Stay safe!
**Once again this post has been cut-off due to space constraints - the full, unabridged version can be found at https://www.facebook...005813397/files or directly to your inbox if you subscribe at my Patreon account**
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Round-Up:
Starting off with some incredibly important news: the National Institute of Aging in the USA is for the first time soliciting grant proposals to test longevity therapies in humans! The significance cannot be overstated as too many potential treatments have been languishing in animal models for want of funding and official support. Although only $4.5 million is allocated and the earliest the selected trials can begin is April 2022, this could mark a phase change in finally getting proven results in humans.
The NIA Is Funding Clinical Trials Against Aging

Continuing the positive news, a paper came out showing that there has been exponential growth in the number of treatments which can extend lifespan in model organisms (over 2000 now), as well as the number of companies trying to bring them to market. Although the original paper is behind a paywall, here is a summary and interview with the author.
Longevity Pharmacology has Come of Age
Longevity Pharmacology with Dr. João Pedro de Magalhães

This opinion piece is a full throated declaration in support of extending lifespan and is also a nice concise overview of the substances which can do so in mammals.
The goal of geroscience is life extension Full Text

Good news for the wine lovers out there, this study involved flies and some lucky French nuns, who got the chance to have a couple glasses of red wine everyday with meals.
*Moderate Red Wine Consumption Increases the Expression of Longevity-Associated Genes in Controlled Human Populations and Extends Lifespan in Drosophila melanogaster Full Text

Here, two molecules I’ve been closely following, J147 & CMS121, derived from Curcumin & Fisetin respectively, have also been shown to extend fly lifespans as well as improving brain and kidney function in mice.
Geroprotective effects of Alzheimer's disease drug candidates Full Text

Finally, for the follically challenged among you, CASIN, a molecule discovered to increase lifespan in mice last year, was also shown to rejuvenate hair stem cells.
A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells Full Text

Covid-19 Longevity Related Papers:

COVID-19, cytokines, inflammation, and spices: How are they related? Full Text
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19 Full Text
Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review) Full Text
Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity Full Text
The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19 Full Text
Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders Full Text

Videos to watch & Audio to listen to:
The International Longevity Alliance held an online conference on longevity therapies and moving them into people, with a number of interesting talks:
International Longevity Alliance Conference: Clarifying whether and to what degree the current anti-aging approaches work in mice or people

Peter Attia’s popular podcast had a great interview with Richard Miller of the ITP:
Richard Miller - The gold standard for testing longevity drugs: the Interventions Testing Program
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Supplemental Information

***Disclaimer 1 – As should be self-evident to anyone receiving these emails, I am NOT a doctor or indeed a scientist. All the information pertained within is for information purposes only; use at your own risk. Please consult with a healthcare practitioner if needing medical advice.***
**Disclaimer 2 – In no way should supplements be a replacement for an unhealthy diet or lifestyle. A varied, plant dominant dietary pattern is the cornerstone for health. Try to eat the rainbow – the greater the variety, the greater the benefit. Even though I might take a supplement derived from a plant source, I still eat the plant in question. Also, make sure you move as much as possible – that is what we evolved to do.**
*Also bear in mind that most of the studies mentioned below are in rodents, not humans. Rodents, needless to say, do not always react the same way to drugs as humans do – witness the countless times cancer or another disease has been cured in rodents only to subsequently fail human trials. I have *bolded any human trials.*
Lifestyle
Fasting/Dietary Restriction
*Five Days Periodic Fasting Elevates Levels of Longevity Related Christensenella and Sirtuin Expression in Humans Full Text
Two-meal caloric restriction induces 12-hour rhythms and improves glucose homeostasis Full Text
The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver Full Text

Diet
*Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases Full Text
*Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial Full Text
*Nuts and Older Adults' Health: A Narrative Review Full Text