MitoMouse support

Sep 30 2019 12:44 PM | ImmInst in LongeCity

LongeCity supports the new SENS MitoMouse fundraiser at Lifespan.io led by the MITOSENS team in collaboration with the Buck Institute.

update: Oct 29th

Many thanks to all who contributed to the effort, through facebook and twitter, by writing quizzes and to those members who donated.
The campaign is now in its last stretch. The best news: the main funding goal has been achieved! This will allow the team to create the MITOMOUSE as a valuable new research resource.
Donations have also almost reached ‘Stretch Goal I’ – in this step, the team will evaluate factors that are important to the life extension community - like frailty and fitness.
With just a few days remaining, this goal is well within reach!
However, ‘Stretch Goal II’ is also very important: this is because the scientific community has noted one particular characteristic of the mitochondrally deficient mice: they have a reduced fertility – smaller litter sizes. By demonstrating that this characteristic could also be ‘cured’ through the genetic modifications passed on through the MITOMOUSE the team will pass a ‘gold standard’ test of validation.

For this reason LongeCity makes the following pledge:

If we reach Stretch Goal I, LongeCity will fund StrechGoal II as well.

This commitment comes with a proviso: we will review the data from the main goal and StrechGoal I – using independent peer reviewers as necessary. If at the time the fertility testing is required as expected, it will be funded as planned. However if we find in dialogue with the MITOSENS team that instead the results from the earlier phases need further development, funds earmarked for the second stretch goal will be offered to SENS to be used for that alternative purpose. We think this is the best route to ensure that every donation, large and small is used to maximum effect. LongeCity will work with the teams at SENS and lifespan.io to ensure that the progress of the research is reported back to the community and remains open to community feedback.

Since our founding in 2003 as a small a non-profit community forum we have been excited to watch the emergence of the SENS approach and Foundation leading the fight against the blight of involuntary death. While originally dismissed as ‘too radical’ many of the strategies proposed by Dr.deGrey have since gained widespread recognition in scientific circles.
The MITOSENS approach has always been among the most ambitious ideas and therefore in special need of community funding. LongeCity is proud to have been the first to organise such funding in 2013 and to contribute to the Lifespan.io inaugural fundraiser for the team in 2015.
Based on the breakthrough results from these projects, MITOSENS is now on the verge of establishing conclusive proof of principle for the strategy.

To support this effort, LongeCity will

A. match any donation up to $1000 by an Immortality Institute member.
Members who made a donation please post here.

and

B. contribute to the fundraiser
• $30 for a tweet by anyone mentioning @longecity_org and the fundraiser*
• $30 for a post by anyone on the LongeCity facebook page*
• $300 for each MOUSE 'bought' here with LongeCity ‘community points’
• $800 for each new member of the Immortality Institute (reply ‘mitosens’ to the introductory email)
• $1000 for a new quiz accepted at LongeCity (send us a PM when the quiz was created)

*(one per person - we'll monitor our twitter/facebook accounts and keep a tally)

Support in each case is at the sole discretion of LongeCity and subject to remaining funds in our community budget.