LongeCityAdvocacy & Research for Unlimited Lifespans
Stack Submitter
Stack Details
- Submitted: Jun 21 2017 11:57 AM
- Date Updated: Jul 04 2017 10:12 AM
- Views: 13780
3
Multi- Vitamin and Mineral stack
magnesium vitamin d3 vitamin k1 + k2 (mk4 + mk7) omega 3 fish oil vitamin c vitamin b complex multi vitamin/mineral vitamin a alpha + gamma tocopherols mixed tocotrienols or coq10
Description
Hello everyone,
one common question on the forums is for the perfect Multivitamin and mineral. In my experience most likely there never will be one. We all are just too different in our individual nutritional needs.
These are just 'calculated' from nutrient-intake questionnaires. Calculations with a nutrient-software like cron-o-meter aren't much more dependable, since it again doesn't actually measure individual deficiencies in body stores. Additionally the definition of nutritional deficiency is based on a RDA for the prevention of the worse kind of deficiencies, but aren't representing intake levels for optimal physiological functioning. Which again, can be highly individual. Only a combination of lab-testing could access it somewhat accurately.
Then there are a couple of nutrients to really be aware of and possibly avoided. One always has to check for in the ingredients-list of any combination product:
Iron, Copper and Manganese: are probably fine less than 2 mgs per day - we already get multiples of that from diet. However - even with a multi without these - it's always advisable to get serum ferritin and copper tested (for example 2 mgs of additional copper gave me personally too high values, with 1 mg I'm fine). For about 5% of the population with probable Iron-overload the Iron from food is already too much to handle. Men and post-menopausal females are at higher risk too (while for me as vegetarian only betain-hcl brought iron stores up). Zinc and Copper have to be balanced (I seem to do best with a 10:1 ratio from diet and supplements combined).
Vitamin E: avoid synthetic dl-alpha tocopherol instead of natural l-alpha tocopherol. Which if taken alone would replace all other natural isomers of Vitamin E (β-, γ-, and δ-tocopherol). Therefore always good to supplement with the other tocopherols too by alternating their intake (ie. at alternating days; my diet alone gives me a 4:3 ratio between αlpha and other tocopherols). As well as the beneficial tocotrienols difficult to get from diet.
Vitamin B9: Folic acid is a synthetic form of Vitamin B9 which needs a number of internal reactions to be converted to its active form in the body, where up to 50% of the population have genetic variants which makes that more difficult to accomplish. Additionally with to high an intake (think about hidden in fortified food) folic acid blocks receptors for biological active Vitamin B9, read at about 1 mg per day. Which would make one deficient despite supplementing the right form. So really no good reason not to supplement with the better forms of folates, like l-methylfolate or folinic acid, and avoid folic acid as much as possible
Syntetic B Vitamins: though not that important as with folate, it's always better to get more bioavailable forms of the other B-Vitamins. Especially since they are available reasonable priced too. Benfotiamine or Sulbutiamine instead of Thiamine. Riboflavin-5-phosphate for B2. PPC, Citicoline or Alpha-GPC for Choline. Pyridoxal or Pyridoxamine instead of Pyridoxine (which needs much higher doses for same effects). Methylcobalamin, Adenosylcobalamin or Hydroxylcobalamin instead of the usual Cyanocobalamin.
Beta-Carotene: Again, in up to 50% of the population doesn't get's converted in the body into active Vitamin A. Additionally there are some infamous studies which showed an slight increase of lung cancer in former smokers with high dose Beta-Carotene. But due to a overestimated toxicity of preformed Retinol, most supplement producers now decreased it (like to 10% in LEFs two-per-day multi). Therefore check there isn't too much Beta-Carotene in yours, and if necessary get additional preformed Vitamin A (let serum tests guide you. Preformed Vitamin A is needed to be balanced with high Vitamin D)
Calcium: consider the often heard optimal ratio between Calcium and Magnesium of 2:1 dangerously high, unless otherwise indicated. Conversely, to supplement in a 1:2 ratio seems to be more appropriate.
Proprietary Blends: allegedly created to protect an innovative blend of synergistic nutrients from being imitated by the competition. In actuality they most often hide that expensive ingredients are in minute amounts, and inexpensive make the bulk. You ideally would want to know how much of each ingredient you're ingesting, and the different effects from varying doses.
Therefore, especially with already some health difficulties showing up, the first I would recommend would be to get rid of always possible unnecessary nutrient deficiencies first:
1) Magnesium
2) Vitamin D3
3) Vitamin K-Complex
4) Omega-3 Fish oil
5) Vitamin C
6) Vitamin B-Complex
7) Multivitamin/mineral
8) Vitamin A (linked to affordable products available in the EU, since in the US most is reasonable available anyway. The following aren't:
9) Tocopherols
10) Tocotrienols
And after having covered the bases this way, go from there. Always start with lowest possible doses and gradually increase. Found in my case only a fraction of the Multi is best to avoid particular nutrients at too high a dose for me, and other nutrients needed at higher doses again added individually.
There you have it, the not so perfect multi, due to having to take at least 10 individual supplements.
Obligatory disclaimer for Orwellian times: “These statements have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, mitigate or prevent any disease.”
one common question on the forums is for the perfect Multivitamin and mineral. In my experience most likely there never will be one. We all are just too different in our individual nutritional needs.
How Much is Too Much? : Appendix B: Vitamin and Mineral Deficiencies in the U.S.
Nutrient from food alone, ranked by the occurrence of dietary inadequacy among adults | Percentage of dietary intakes below the estimated average requirement for a specific population* | Naturally occurring sources of nutrient**
2-to-8-year-old children | 14-to-18-year-old girls | Adults 19 and older
Vitamin D | 81% | 98% | 95% | Fatty fish, mushrooms [vitamin D is naturally formed in the body when skin is exposed to sunlight; vitamin D is added to fortified milk]
Vitamin E | 65% | 99% | 94% | Nuts, seeds, vegetable oils, green leafy vegetables
Magnesium | 2% | 90% | 61% | Whole grains, wheat bran and wheat germ, green leafy vegetables, legumes, nuts, seeds
Vitamin A | 6% | 57% | 51% | Preformed vitamin A: liver, fatty fish, milk, eggs; provitamin A carotenoids: carrots, pumpkins, tomatoes, leafy green vegetables
Calcium | 23% | 81% | 49% | Milk, yogurt, cheese, kale, broccoli
Vitamin C | 2% | 45% | 43% | All fruits and vegetables, particularly citrus fruits and tomatoes
Vitamin B6 | 0.1% | 18% | 15% | Many foods; highest levels in fish, beef, poultry, potatoes and other starchy vegetables, and fruit other than citrus
Folate | 0.2% | 19% | 13% | Many foods; highest levels in spinach, liver, asparagus, Brussels sprouts [mandatory, standardized addition to enriched flour and flour products]
Zinc | 0.2% | 24% | 12% | Red meat, poultry, beans, nuts, some seafood, whole grains
Iron | 0.7% | 12% | 8% | Highest amounts in meat and seafood; lower levels in nuts and beans [mandatory, standardized addition to enriched flour and flour products]
Thiamin | 0.1% | 10% | 7% | Whole grain products [mandatory, standardized addition to enriched flour and flour products]
Copper | 0% | 16% | 5% | Shellfish, whole grains, beans, nuts, potatoes, organ meats (kidneys, liver)
Vitamin B12 | 0% | 7% | 4% | Animal products: fish, meat, poultry, eggs, milk
Riboflavin | 0% | 5% | 2% | Milk and dairy products, eggs, meat, green leafy vegetables, legumes [mandatory, standardized addition to enriched flour and flour products]
Niacin | 0.1% | 4% | 2% | Meat, fish, seeds and nuts, whole grains [mandatory, standardized addition to enriched flour and flour products]
Selenium | 0% | 2% | 1% | Found in different plant and animal foods; highest levels in seafood and organ meats (kidneys, liver)
These are just 'calculated' from nutrient-intake questionnaires. Calculations with a nutrient-software like cron-o-meter aren't much more dependable, since it again doesn't actually measure individual deficiencies in body stores. Additionally the definition of nutritional deficiency is based on a RDA for the prevention of the worse kind of deficiencies, but aren't representing intake levels for optimal physiological functioning. Which again, can be highly individual. Only a combination of lab-testing could access it somewhat accurately.
Then there are a couple of nutrients to really be aware of and possibly avoided. One always has to check for in the ingredients-list of any combination product:
Iron, Copper and Manganese: are probably fine less than 2 mgs per day - we already get multiples of that from diet. However - even with a multi without these - it's always advisable to get serum ferritin and copper tested (for example 2 mgs of additional copper gave me personally too high values, with 1 mg I'm fine). For about 5% of the population with probable Iron-overload the Iron from food is already too much to handle. Men and post-menopausal females are at higher risk too (while for me as vegetarian only betain-hcl brought iron stores up). Zinc and Copper have to be balanced (I seem to do best with a 10:1 ratio from diet and supplements combined).
Vitamin E: avoid synthetic dl-alpha tocopherol instead of natural l-alpha tocopherol. Which if taken alone would replace all other natural isomers of Vitamin E (β-, γ-, and δ-tocopherol). Therefore always good to supplement with the other tocopherols too by alternating their intake (ie. at alternating days; my diet alone gives me a 4:3 ratio between αlpha and other tocopherols). As well as the beneficial tocotrienols difficult to get from diet.
Vitamin B9: Folic acid is a synthetic form of Vitamin B9 which needs a number of internal reactions to be converted to its active form in the body, where up to 50% of the population have genetic variants which makes that more difficult to accomplish. Additionally with to high an intake (think about hidden in fortified food) folic acid blocks receptors for biological active Vitamin B9, read at about 1 mg per day. Which would make one deficient despite supplementing the right form. So really no good reason not to supplement with the better forms of folates, like l-methylfolate or folinic acid, and avoid folic acid as much as possible
Syntetic B Vitamins: though not that important as with folate, it's always better to get more bioavailable forms of the other B-Vitamins. Especially since they are available reasonable priced too. Benfotiamine or Sulbutiamine instead of Thiamine. Riboflavin-5-phosphate for B2. PPC, Citicoline or Alpha-GPC for Choline. Pyridoxal or Pyridoxamine instead of Pyridoxine (which needs much higher doses for same effects). Methylcobalamin, Adenosylcobalamin or Hydroxylcobalamin instead of the usual Cyanocobalamin.
Beta-Carotene: Again, in up to 50% of the population doesn't get's converted in the body into active Vitamin A. Additionally there are some infamous studies which showed an slight increase of lung cancer in former smokers with high dose Beta-Carotene. But due to a overestimated toxicity of preformed Retinol, most supplement producers now decreased it (like to 10% in LEFs two-per-day multi). Therefore check there isn't too much Beta-Carotene in yours, and if necessary get additional preformed Vitamin A (let serum tests guide you. Preformed Vitamin A is needed to be balanced with high Vitamin D)
Calcium: consider the often heard optimal ratio between Calcium and Magnesium of 2:1 dangerously high, unless otherwise indicated. Conversely, to supplement in a 1:2 ratio seems to be more appropriate.
Proprietary Blends: allegedly created to protect an innovative blend of synergistic nutrients from being imitated by the competition. In actuality they most often hide that expensive ingredients are in minute amounts, and inexpensive make the bulk. You ideally would want to know how much of each ingredient you're ingesting, and the different effects from varying doses.
Therefore, especially with already some health difficulties showing up, the first I would recommend would be to get rid of always possible unnecessary nutrient deficiencies first:
1) Magnesium
2) Vitamin D3
3) Vitamin K-Complex
4) Omega-3 Fish oil
5) Vitamin C
6) Vitamin B-Complex
7) Multivitamin/mineral
8) Vitamin A (linked to affordable products available in the EU, since in the US most is reasonable available anyway. The following aren't:
9) Tocopherols
10) Tocotrienols
And after having covered the bases this way, go from there. Always start with lowest possible doses and gradually increase. Found in my case only a fraction of the Multi is best to avoid particular nutrients at too high a dose for me, and other nutrients needed at higher doses again added individually.
There you have it, the not so perfect multi, due to having to take at least 10 individual supplements.
Obligatory disclaimer for Orwellian times: “These statements have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure, mitigate or prevent any disease.”
| Ingredient | Dosage | Frequency | Administration |
|---|---|---|---|
| Magnesium | 500 mg | Daily | adjust dose according to RBC level, spread out, with or without food |
| Vitamin D3 | 2.000 IU | Daily | adjust dose according to serum level, with fatty meals |
| Vitamin K1 + K2 (mk4 + mk7) | 1.700 µg | Daily | adjust dose according to risk factors, with fatty meals |
| Omega 3 fish oil | 4 gram | Daily | adjust dose according to risk factors, with fatty meals |
| Vitamin C | 4 gram | Daily | adjust dose according to risk factors, 20 minutes before meals |
| Vitamin B complex | 1-2 pill(s) | Daily | with or without meals |
| Multi Vitamin/Mineral | 1-2 pill(s) | Daily | with meals |
| Vitamin A | 1-2 pill(s) | Daily | adjust dose according to serum level, with fatty meals |
| Alpha + Gamma Tocopherols | 1 pill(s) | 3x weekly | with meals |
| Mixed Tocotrienols or CoQ10 | 1 pill(s) | 3x weekly | with meals |
high intake of preformed vitamin A increases fracture risk.
Ref: Excess Vitamin A Can Thwart Vitamin D
Osteoporosis is caused by a mismatch between vitamin A, D, and K2. The ideal A/D ratio wt/wt is about 5 to 1 which corresponds to an iu/iu ratio of 1 to 2.4 since 1 mg of vitamin A is 3,333 iu and 1 mg of vitamin D3 is 40,000 iu so 5 g to 1 g = (5)(3,333 iu)/40,000 iu = 1 to 2.4 iu/iu
Example: vitamin A retinol at 1,000 iu per day needs 2,400 iu per day of D3.
The "more is better" supplements are ridiculous--a quick look a Amazon show "vitamin A" in 5,000 to 25,000 iu capsules (likely mostly beta-carotene). A 25,000 iu dose of retinol would need to be balanced with 2.4 x 25,000 = 60,000 iu of D3. Perhaps you could take one 25,000 iu vitamin A (as retinol) per month and balance it with 2,000 iu of vitamin D3 daily.
Thanks for both comments, only saw them now.
I'm thinking more in line with Chris Masterjohn. And got his ideas confirmed through vitamin A and D serum testing, while aiming at the middle of normal ranges. In that I actually need at least a A to D IU ratio of 2 to 1 (the opposite RWhigham suggests). With the higher intake of preformed vitamin A, always slowly titrating and measuring, also infrequent psoriasis outbreaks have ceased (above 24.000 IU/d). But everyone is different, where only individual testing counts.
The problem I have with all the references you both provide, is that they look completely unrealistically at one vitamin - A or D in isolation only. That's how I never would even think of them, or further excluding vitamin K2 in all their synergistic effects.
In principle, I'd agree that we'd want to be able to evaluate the whole system working together — but I don't know of any proper data on the subject, even in animals. The studies cited in the posts that you and RWhigham link cite are biochemistry, acute toxicity, and rather speculative inductions (eg, that the reason why trials conducted in the 1930s showed that cod liver oil reduced incidence of common colds and respiratory infections but that a 2004 trial yielded mixed results is that the cod liver oils differed in A and D content, and should have had higher D and lower A than the 2004 trial — or that the reason for low 25(OH)D3 in LEF members is excessive vitamin A supplementation from non-LEF multivitamins, even though the article itself says that "Most Foundation members take the Two-Per-Day or Life Extension Mix multi-nutrient formulas," which by their notions of a correct vitamin A dose do not suffer this problem).
Are either of you aware of any long-term studies in otherwise-normal, aging mammals testing the effects of different ratios of vitamins A, D3, and K2 against hard health outcomes?
I'm still searching, but I doubt there is any research of A, D3 and K2 in combination with hard health outcomes yet. Only have my own anecdotal case of being plagued with a number of devastating chronic diseases, and without much to loose, therefore was more than willing to experiment while monitoring. I didn't regret.
However, you might be absolutely right in that the A:D ratio which worked for me, might turn out completely off in a healthy person. Therefore always worthwhile testing serum retinol and retinol binding protein for confirmation. As an example of a very healthy person, what kind of serum levels you get with A and D?
With all due respect, but Vitamin A for European inhabitants is totally overkill. There's an overdose of dairy-intake and dairy-use in our daily consumption patterns here as it stands. Besides, if not from dairy, we have carrots, pastinaak, not to mention the eggs, liver, fish people eat a lot of here. We don't need Vit A supplemented at all.
Or, better put:
If you can pay for regular use of supplements, you probably consume enough foods with vitamin A already. Or you're living a very strange hermit lifestyle or something like that, but a deficiency, I really would like to see the peer reviewed study suggesting there is one for rich humans on this planet.
I really would like to see the peer reviewed study suggesting there is one for rich humans on this planet.
Experimentally supplementing with increasing doses, while monitoring serum retinol levels and thereby experiencing increasing health benefits, convinced me (in my case, with multiple health issues). I didn't have the luxury of having the time to wait for a study probably never done.
Even without health issues, the study finding up to 50% of the population having difficulty in converting beta-carotene into vitamin A, would at least have me enough concerned, to have serum retinol tested.
Even without health issues, the study finding up to 50% of the population having difficulty in converting beta-carotene into vitamin A, would at least have me enough concerned, to have serum retinol tested.
"Issues" doesn't mean meaningful issues, and omnivores of course get preformed vitamin A already. In any case, as I've pointed out before, serum retinol and RBP don't seem to be reliable indicators of vitamin A status.
If omnivores get enough preformed vitamin A, than the US must be a nation of vegetarians (just joking).
51% of adults there are estimated from their food-intake to remain below their average daily requirement of vitamin A! The nation with the comparatively highest industrial meat production in this world.
But anyway. Michael, do you know how many month after continous supplementation 'serum retinol and RBP don't seen to be reliable indicator of vitamin status'? Couldn't find it. Because for deficiency it seems:
When dietary vitamin A is provided to vitamin A-deficient children, plasma retinol concentration increases rapidly, even before liver stores are restored (Devadas et al., 1978; Jayarajan et al., 1980). Thus, a low concentration of plasma retinol may indicate inadequacy of vitamin A status, although median or mean concentrations for plasma retinol may not be well correlated with valid indicators of vitamin A status.
In my case I supplemented for years, and intake did reflect in serum levels:
(retinol 425-831; RBP 30-60 lab normal ranges)
year vitA RBP A/RBC intake(avg. for previous 3 years)
µg/l mg/l ≥7 µg/d
2012 501 44 11.4 1,3
2015 597 53 11.4 5,4
2018 705 47 14.9 6,7
Calculated (though already many years ago) that I got in average about 0.13 µg/d retinol from diet, and in avg. about 4.6 µg/d from supplements. Beta-carotene 1.5 µg/d RE from supplements, and 1.3 µg/d RE from diet.
Now with serum 25(OH)D probably few would doubt the validity of this test, because in 2012 it took me double the intake for reaching half the serum levels, than 5 years later in 2018. Simply too many co-factors posibly affecting absorption and metabolism. While preformed vitamin A is still widely seen in something as a mysterious limbo.
I'm still searching, but I doubt there is any research of A, D3 and K2 in combination with hard health outcomes yet.
Main reason why there are no nutrient-combination studies is, because the scientific method only tests 1 or 2 agents at a time, for limiting confounders. However, just came accross this surprising outcome of the TACT trial:
Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)
Intervention
Daily high-dose oral multivitamins and multiminerals (6 tablets, active or placebo).
Results
The primary end point occurred in 137 nonstatin participants (30%), of which 51 (23%) of 224 were in the active group and 86 (36%) of 236 were taking placebo (hazard ratio, 0.62; 95% confidence interval, 0.44-0.87; P = .006). Results in the key TACT secondary end point, a combination of cardiovascular mortality, stroke, or recurrent MI, was consistent in favoring the active vitamin group (hazard ratio, 0.46; 95% confidence interval, 0.28-0.75; P = .002). Multiple end point analyses were consistent with these results.
After 55 months there was a 9% absolute risk decrease in mortality compared to placebo!
Though for some nutrients they used a crazy dose (like 20mg of Manganese), the fat solubles were:
25,000 IU Vitamin A
100 IU Vitamin D3
400 IU Vitamin E
60 μg Vitamin K1
So the vitamin D and K amounts again almost not worth mentioning. Still such encouraging results, if for once they stop testing supplemented nutrients in isolation, but as they are actualy taken in combinations.
Where did you get the notion 5-8:1 A:D was on a gram:gram basis? That is, source?
Ref: Excess Vitamin A Can Thwart Vitamin D
Osteoporosis is caused by a mismatch between vitamin A, D, and K2. The ideal A/D ratio wt/wt is about 5 to 1 which corresponds to an iu/iu ratio of 1 to 2.4 since 1 mg of vitamin A is 3,333 iu and 1 mg of vitamin D3 is 40,000 iu so 5 g to 1 g = (5)(3,333 iu)/40,000 iu = 1 to 2.4 iu/iu
Example: vitamin A retinol at 1,000 iu per day needs 2,400 iu per day of D3.
The "more is better" supplements are ridiculous--a quick look a Amazon show "vitamin A" in 5,000 to 25,000 iu capsules (likely mostly beta-carotene). A 25,000 iu dose of retinol would need to be balanced with 2.4 x 25,000 = 60,000 iu of D3. Perhaps you could take one 25,000 iu vitamin A (as retinol) per month and balance it with 2,000 iu of vitamin D3 daily.
Where did you get the notion 5-8:1 A:D was on a gram:gram basis? That is, source?
Frustrating basic vitamin ratios arent well established. This page talks about that ratio with some evidence, but its hardly conclusive. - Link
"Dr. Linday and her colleagues offer a suggestion: poultry studies suggest optimal A-to-D ratios between four and eight. Similarly, in her own studies showing that cod liver oil protects against upper respiratory tract infections, Linday supplied her patients with A-to-D ratios between five and eight.
They also point out that rat studies showing that vitamin A is toxic and antagonizes the effects of vitamin D used much higher ratios, ranging from 5,000 to 55,000!"
However I dont think the 5-8 ratio holds up if Weston Price's vitamin A daily intake is true. - Link
"The US Recommended Daily Allowance of vitamin A is currently 5,000 IU per day (and may possibly be lowered to 2500 IU per day). From the work of Weston Price, we can assume that the amount in indigenous diets was about 50,000 IU per day"
See also thehealthbeat.com where he gives a summary chart. - Link
"1. Native Eskimos: 5.4x calcium, 1.5x iron, 7.9x magnesium, 1.8x copper, 49x iodine, 10x vitamin A, 10x vitamin D
2. Indians of Northern Canada: 5.8x calcium, 5.8x phosphorus, 2.7x iron, 4.3x magnesium, 1.5x copper, 8.8x iodine,10x vitamin A, 10x vitamin D
3. High Mountain Swiss: 3.7x Calcium, 2.2x phosphorus, 2.5x magnesium, 3.1x iron, 10x vitamin A, 10x vitamin D
4. Gaelics in the Outer Hebrides: 2.1x calcium, 2.3x phosphorus, 1.3x magnesium, 1x iron, 10x vitamin A, 10x vitamin D
5. Aborigines of Austrailia: 4.6x calcium, 6.2x phosphorus, 17x magnesium, 50.6x iron, 10x vitamin A, 10x vitamin D
... there are more at the link"
I would welcome anymore thoughts on it.
As already repeatedly said, I would go by blood-testing to assure one's supplementation is in line with one's bio-chemical individuality. The only problem with blood-testing itself is, that normal reference ranges are usually established by assuming the middle 95% as normal. Therefore with decreasing intake of nutrients, normal reference ranges are of course trending downwards. Which I could already observe in the short time of a decade since doing blood-work.
Would be really telling to have access to historical nutrient reference ranges, like for example 50 years ago, or even ealier, when vitamins have been discovered.
For users in the EU, meanwhile found also an exceptional German shop, some with even better options as listed in the OP:
2) D3: https://www.sunday.d...opfen-1000.html (many different versions available)
3) K2-mk7: https://www.sunday.d...-vegan-set.html (different versions, but no K2-mk4 or K1)
4) Omega-3: https://www.kraeuter...el-lemon-250-ml (different versions)
5) Vit C: https://shop-breinba...0/Products/1011 (up to 25kg)
6) Bs: https://www.sunday.d...2-mh3a-set.html (different versions)
8) A: https://www.sunday.d...ropfen-set.html (different versions)
10) E: https://www.sunday.d...formen-set.html (134mg tocopherols, of which ~20% non-alpha, and 100mg tocotrienols)
Didn't find real alternatives for:
1) Mg: Sunday.de does sell one including 7 forms at 100mg per capsule. Though with no disclosure of amounts as in propietary blends. This bulk shop might be an alternative for some: https://diacleanshop.../magnesium/?p=1 Also this expensive mineral water: https://en.wikipedia.org/wiki/Donat_Mg (1g per liter).
7) The multi-vitamin versions all suffers from too much iron, with the exception of this very incomplete only: https://www.sunday.d...-forte-set.html (also available low doses)
8) Other Tocopherols at high enough doses to balance the inhibition by alpha-tocopherol?
Full disclosure: No financial gains whatsoever through any of the presented options. Not even through referrals.
Edit re: 1) Mg: Sunday.de... amazing company, already within 1 month of writting this, they added high dose Mg-oxide (365 caps glass bottle), Mg-glycinate, Mg-malate, Mg-citrate and other forms to their sortiment. Some even as less expensive powdwers.
A note of caution on preformed vitamin A. You're right that the acute toxicity of very high levels of retinol has possibly been overestimated, but there is significant evidence that high intake of preformed vitamin A increases fracture risk. The studies aren't totally consistent; notably, studies based on serum levels are far less likely to find an association, but that may be because serum retinyl esters poorly track high dietary intake. Even so, a meta-analysis of prospective studies concluded that both high dietary and high blood retinol are associated with elevated fracture risk.