Parkinson's, MSA & Neurodegeneration Natural Stack

Important Note:
This is my personal stack and positive results are based on personal experience and current studies. It is not intended nor suggests to cure, treat or prevent any disease or medical condition. Actual supplementation and dosage differ based on each individual's needs, tolerance, clinical condition and current medication. Patients should consult their healthcare specialist before initiating any supplementation.

Suggested ways to minimize possible adverse effects of supplementation and avoid possible interaction are:

a) start with a lower dose and then gradually increase

b) gradually add more supplements through time and observe for possible interactions

c) take one week off every 4 weeks OR begin with a medium to full dose supplementation for a period of 1-2 months and then continue with a lower maintenance dose every other day

d) take with food when possible to minimize gastrointestinal side effects

e) not recommended long-term high-dose supplementation as the safety profile of many supplements is limited to short-term studies

f) preferebly choose natural over synthetic versions

g) add probiotics in diet to boost immunity and maintain healthy gut

The purpose of this stack is to possibly:

• induce mitochondrial biogenisis ( PQQ, Nicotinamide Riboside )
• prohibit a-synuclein aggregation ( PQQ, NAC, Bacopa monnieri, EGCG, flavonoids: Nobiletin, Apigenin, Fisetin )
• increase / sustain dopamine levels ( Citicoline, NAC, Mucuna Pruriens, Bacopa Monieri )
• increase glutathione levels in mitochondria (NAC)
• offer neuroprotection ( PQQ, NAC, Ubiquinol Q10, EGCG, Curucumin solid lipid / micellar, Lipoic Acid, Oleuropein, Taurine, Acetyl-Carnitine, Anthocyanins, Bacopa monnieri, Vitamin D3, L-Theanine, Omega-3, flavonoids: Apigenin, Nobiletin, Fisetin, Genistein )
• exhibit anti-inflammatory activity ( Curucumin solid lipid / micellar, Omega-3, NAC, Flavonoids, Anthocyanins, Oleuropein, NAC )
• offer overall antioxidant protection. ( Ubiquinol Q10, PQQ, NAC, Flavonoids, Anthocyanins, Lipoic Acid, EGCG, Vitamin C with bioflavonoids )
• lower homocystein levels ( Folate, B12, NAC )
• Improve mitochondria function & energy ( Nicotinamide Riboside, PQQ, Ubiquinol Q10, NAC, Taurine, Acetyl-Carnitine, Omega-3, Phosphatidylserine )

Recommended Physical Exercise to improve balance and motor control :

Tai Chi & Qigong

Tai Chi and Postural Stability in Patients with Parkinson's Disease (N Engl J Med, 2012)
https://www.ncbi.nlm...les/PMC3285459/
Effects of Tai Chi on balance and fall prevention in Parkinson's disease: a randomized controlled trial. (Clin Rehabil. 2014 )
https://www.ncbi.nlm...pubmed/24519923
A Meta-Analysis on the Efficacy of Tai Chi in Patients with Parkinson's Disease between 2008 and 2014
https://www.ncbi.nlm...les/PMC4306407/

Effects of Health Qigong Exercises on Relieving Symptoms of Parkinson's Disease.(2016)
https://www.ncbi.nlm...pubmed/27891159

References:

1) Ubiquinol CoQ10

Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease. (Parkinsonism Relat Disord. 2015 )
https://www.ncbi.nlm...pubmed/26054881
Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum (Barca E1, Kleiner G1, 2016)
https://www.ncbi.nlm...pubmed/27235405

2) PQQ Pyrroloquinoline Quinone (BioPQQ)

Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions (Adv Exp Med Biol., 2016)
https://www.ncbi.nlm...pubmed/26782228
Neuroprotective effects of pyrroloquinoline quinone against rotenone injury in primary cultured midbrain neurons and in a rat model of Parkinson's disease (Neuropharmacology, 2016)
https://www.ncbi.nlm...pubmed/27108097
Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression
https://www.ncbi.nlm...les/PMC2804159/

3) Acetyl Carnitine + Lipoic Acid

Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. (J Cell Mol Med., 2010)
https://www.ncbi.nlm...pubmed/20414966

4) NAC (N-acetyl-cysteine )

Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice (PLoS One. 2010)
https://www.ncbi.nlm...pubmed/20808797
N-Acetylcysteine boosts brain and blood glutathione in Gaucher and Parkinson diseases. (Clin Neuropharmacol. 2013)
https://www.ncbi.nlm...pubmed/21587143

5) Omega 3 Fatty Acids

Neuroprotective effect of omega-3 polyunsaturated fatty acids in the 6-OHDA model of Parkinson's disease is mediated by a reduction of inducible nitric oxide synthase. (Nutr Neurosci, 2017)
https://www.ncbi.nlm...pubmed/28221817
Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA (Front Aging Neurosci. 2015)
https://www.ncbi.nlm...les/PMC4404917/

6) Green Tea (EGCG)

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties (Genes Nutr. 2009)
www.ncbi.nlm.nih.gov/pmc/articles/PMC2775893/

7) Anthocyanins

Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease. (Brain Res. 2014)
https://www.ncbi.nlm...pubmed/24502982

8) Citicoline (CDP-Choline)

Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. (Rev Neurol Dis. 2008)
https://www.ncbi.nlm...pubmed/19122569
Citicoline in the treatment of Parkinson's disease.
https://www.ncbi.nlm.../pubmed/2289218

9) Solid Lipid Curcumin

Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations. (J Med Food. 2015)
https://www.ncbi.nlm...pubmed/25490740

10) Taurine

Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment.
https://www.ncbi.nlm...pubmed/26004911
Mechanism of neuroprotective function of taurine. (Adv Exp Med Biol, 2009)
https://www.ncbi.nlm...pubmed/19239147

11) Folate, B12

Plasma Homocysteine, Vitamin B12 and Folate Levels in Multiple System Atrophy: A Case-Control Study. (Zhang S1, 2015)
https://www.ncbi.nlm...pubmed/26291976
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study.
https://www.ncbi.nlm...pubmed/16801668
High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine.
https://www.ncbi.nlm...pubmed/22610053

12) Probiotics

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease (Cell. 2016)
http://www.cell.com/...8674(16)31590-2
Use of probiotics for the treatment of constipation in Parkinson's disease patients.
https://www.ncbi.nlm...pubmed/21587143
The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies (Eur J Pharmacol. 2017)
http://www.sciencedi...917303734#bib66

13) Milk Thistle (silymarin)

Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease via mitochondrial stabilization.
https://www.ncbi.nlm...pubmed/25677261

14) Fisetin

The neuroprotective effect of fisetin in the MPTP model of Parkinson's disease. (J Parkinsons Dis. 2012)
https://www.ncbi.nlm...pubmed/23938259

15) Apigenin

Curcumin and Apigenin – novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease (Neural Regen Res. 2015)
https://www.ncbi.nlm...les/PMC4590215/
Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis.
https://www.ncbi.nlm...pubmed/28389404

16) Nicotinamide Riboside (NR) (NAD+ precursor)

Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease (Biol Open. 2017)
https://www.ncbi.nlm...les/PMC5312101/
Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders (Clin Transl Med. 2016)
https://www.ncbi.nlm...les/PMC4963347/

17) Nobiletin & Tangeretin
Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease. (J Med Food. 2015)
https://www.ncbi.nlm...pubmed/25325362
Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.
https://www.ncbi.nlm...pubmed/28474543

18) Bacopa monnieri

Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease.(Biochem Biophys Res Commun. 2011)
https://www.ncbi.nlm...pubmed/21925152

19) L-theanine

l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes
https://www.ncbi.nlm...les/PMC5018574/

20) Vitamin D

Serum vitamin D and the risk of Parkinson disease.
https://www.ncbi.nlm...pubmed/20625085
Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease (J Parkinsons Dis. 2016)
https://www.ncbi.nlm...les/PMC4927872/

21) Phosphatidylserine (PS)

Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT).
https://www.ncbi.nlm.../pubmed/2690093

22) Olive Oil & Oleuropein

Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model (Int. J. Mol. Sci. 2016)
http://www.mdpi.com/...7/17/8/1293/htm

23) Mucuna Pruriens

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study. (J Neurol Neurosurg Psychiatry. 2004)
https://www.ncbi.nlm...pubmed/15548480
An alternative medicine treatment for Parkinson's disease: results of a multicenter clinical trial. HP-200 in Parkinson's Disease Study Group. (J Altern Complement Med. 1995)
https://www.ncbi.nlm.../pubmed/9395621

24) Magnesium L-threonate

Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial (J Alzheimers Dis. 2016)
https://www.ncbi.nlm...les/PMC4927823/