Health Last Updated: 25 December 2024 - 12:07 PM

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TAC is a TERT activator compound that delays aging through two pathways: by extending telomeres and regulating gene expression.

Hong Seok Shim et al., TERT activation targets DNA methylation and multiple aging hallmarks.

Cell Doi: https://doi.org/10.1...ell.2024.05.048

I get A LOT out of Nicotine:

• it's given me the stress relief I needed to get through a few challenging personal life things this year.
• it consistently clarifies my thoughts and pushes me in a positive direction, personally and professionally.
• it's better for my HRV than any other Nootropic I've tried.
• It seems to be good for my immune system: The only times I've got ill in the past almost 10 years were the two very easy cases of COVID-19, which I powered right through on Nicotine.
• And nothing unleashes my creativity (which my work and career depend on) more than Nicotine. I'm about 2/3 of the way through my first science fiction novel, thanks to NIcotine!

Like, last night, I did 10mg of melatonin and woke up for some stupid reason at 3:30AM. Did I think 10mg melatonin more, fell back asleep, woke up and 6:30 AM, tossed and turned

Lots of nights are like last night. This is bad, I know.

I'm doing a lot of sleep hacks: blue blockers, no bright screens before bed, red light therapy, mouth taping, but my body just demands I get up at the asscrack of my dawn.

Please spare me the obvious advice of: QUIT NICOTINE DUDE - I'll do that when I finish writing my novel. What I'm looking for is something that might offset Nicotine's effect, a sleep supplement that will keep me asleep.

I'm married, and sometimes in marriage, you don't get what you want. My wife refuses to go to bed before midnight, so I'm running on 6 hours of sleep a lot of days.

I take Nicotine daily, but I'm not a voracious consumer: I take a maximum of 3 small .25ml hits of 10% USP solution and a few 2mg lozenges daily. That's how I often start the day.

Leave me some suggestions of more potent sleep hacks (I think I'm already doing all the mainstream ones) or some pharmacological suggestions for offsetting Nicotine's effect on sleep duration. Something to do with GABA I'm thinking...

I'm hoping I don't have to choose between finishing my novel and getting the sleep I need, because, to quote Eddie from the Limitless movie: "What's my excuse for looking like this? I'm a writer!"

Prohealth is using them for their COA.  Is this a real lab?  I can't find anything online other than their website.  They used to use another lab I had heard of.

The new COA looks very Excel.

So, how would one correct this imbalance?

https://www.salk.edu/news-release/your-immune-cells-are-what-they-eat/

LA JOLLA—The decision between scrambled eggs or an apple for breakfast probably won’t make or break your day. However, for your cells, a decision between similar microscopic nutrients could determine their entire identity. If and how nutrient preference impacts cell identity has been a longstanding mystery for scientists—until a team of Salk Institute immunologists revealed a novel framework for the complicated relationship between nutrition and cell identity.

The answers came while the researchers were exploring different kinds of immune cells. The immune system relies on specialized “effector” T cells to fight off pathogens, but in chronic infections like HIV or cancers, the perpetual activation of these cells can turn them into “exhausted” T cells unable to continue fighting. In the new study, Salk scientists discovered that a nutritional switch from acetate to citrate plays a key role in determining T cell fates, shifting them from active effector cells to exhausted cells. This finding highlights how metabolic changes influence T cell identity and opens avenues for interventions to sustain immune function.

The discovery that different nutrients can change a cell’s gene expression, function, and identity significantly advances scientists’ understanding of the relationship between nutrition and cellular health throughout the body. It may also be possible to develop new therapies that target these nutrient-dependent mechanisms to help T cells stay active and energetically optimized against chronic diseases like cancer or HIV.

The findings were published in Science on December 12, 2024.

“You know the saying, ‘You are what you eat?’ Well, we uncovered a way in which this actually operates in cells,” says Professor Susan Kaech, senior author of the study and holder of the NOMIS Chair at Salk. “This is really exciting on two levels: on a fundamental level, our findings show that a cell’s function can be directly linked to its nutrition; on a more specific level, this sheds new light on how T cells become dysfunctional or exhausted and what we could do to prevent that.”

Glucosamine inhibits myoblast proliferation and differentiation, and stimulates myotube atrophy through distinct signal pathways