6 replies to this topic

[kurdishfella]

That touches the most dopamine receptors.

 I know about Pramipexole  but it only activates D2,D3 and D4. Any other that does this but  + D1 and D5 too?

Edited by farshad, 16 March 2018 - 07:54 PM.

[Galaxyshock]

I take Mucuna (L-DOPA) and it's almost too much of a dopaminergic. Not a direct agonist but as a direct precursor to dopamine it's pretty powerful. Note that synthetic dopamine agonists are linked to horrible withdrawal syndrome (DAWS).

[kurdishfella]

I take Mucuna (L-DOPA) and it's almost too much of a dopaminergic. Not a direct agonist but as a direct precursor to dopamine it's pretty powerful. Note that synthetic dopamine agonists are linked to horrible withdrawal syndrome (DAWS).

really? would you say L-DOPA is comparable to adderall or whatever smart drug you have taken?

[Galaxyshock]

Mucuna alone isn't that stimulating at least compared to psychostimulants - probably because lack of direct noradrenergic activation - but can provide feelings of motivation, confidence, euphoria and sense of being alive. I mix my Mucuna in coffee to make it more similar to amphetamine or other DNRI stimulants. It also has a hormonal effect strongly suppressing prolactin and possibly increasing testosterone and even HGH.

[BioHacker=Life]

Forget agonists natural quinolines are where it's at for dopamine upregulation.

[BioHacker=Life]

Piribedil is studied for brain aging with positive results.

[kurdishfella]

does Fructus Akebiae or blackseed oil increase dopamine?