672 replies to this topic

[MikeDC]

The research does show NMNH and NRH to be much more bioavailable, but I'm not sure that makes them "better".

They both turn in to NADH.

Researchers agree that it is the NAD+ to NADH ratio that improves health, not the total NAD available.

Supplementation goal is to increase NAD+, not NADH.

So to me, it seems increasing NADH is not beneficial and could even be counterproductive.

I agree that liposomal delivery does make sense.

NRH and NMNH do increase NAD+. NAD+/NADH ratio also increases. https://pubmed.ncbi....h.gov/30948509/

But NRH is pro inflammatory in another study. So be careful using it

Edited by MikeDC, 24 July 2022 - 04:31 PM.

[soulprogrammer]

anyone done any lab test on the purity of nmn that they purchased? I dont want to buy nmn that is not pure or mixed with something else, that not only do not help to improve my body, but making more damages due to this impurity.

 

can recommend good brand that is pure nmn? thanks

[LawrenceW]

The last batch of NMN that I bought for our group came back at 99.9% pure.  For the past 5 years all of our NMN has come in at 99.+%. We use Micro Quality Labs in Burbank for all of our testing.

[Harkijn]

Buyer beware.

[LawrenceW]

Buyer beware.

 

Exactly. Trust but verify.

[parsons]

NRH and NMNH do increase NAD+. NAD+/NADH ratio also increases. https://pubmed.ncbi....h.gov/30948509/

But NRH is pro inflammatory in another study. So be careful using it

The pro inflammatory qualities are for NRH only or for NMNH as well?

Edited by parsons, 30 July 2022 - 02:07 PM.

[MikeDC]

The pro inflammatory qualities are for NRH only or for NMNH as well?

Only NRH was in the study.

[Learner056]

Hi, does anyone know why the following happens, what could be the underlying mechanism:

 

- when I take NMN, about 300mg, I get totally depleted off ATP (apparently that is a good thing for longevity, as it means higher AMPK).  I now take about 70-80mg daily, as that makes me feel slow (chilled out), but it does not knock me down.  I do feel good with NMN as I don't feel bloated.  Good effect: I become chiseled and I dont have to workout and keep my weight (which I like).  Bad effect: I "think" it ages me fast, increases hair greying, and if I workout, these negative effects increase.  So I find it optimal to take low dose NMN and dont workout. 

- when I take D-Ribose 500mg, I become energetic like a rocket, literally like a flying panther. People think I am the most athletic person they have ever seen (and I am a nerd that has seldom played sports).  Draw back: I gain weight despite working out.   So here drawback is I got to workout after taking D-Ribose.  Hair greying effect: I am not sure, I suspect it benefits (not sure)  

- when I take Carnitine-Tartrate: I get a similar effect to D-Ribose of increased energy.  I loose weight, though I seem to quickly burn my facial fat (which I dont like to).  Hair greying effect: I am not sure.

[Harkijn]

Hard to say what exactly causes your discomfort but a very real possibility is that you have been taking one the many scam NMN capsules in the market.....

[Learner056]

By definition, NMN is supposed to "deplete" energy (which is healthy, it signals AMPK activation) so the energy effect is as it "should be".  Note: Turnbuckle comments.  NMN is NOT supposed to give you lots of energy contrary to the misleading vids (and then narrated over and over like a parrot by naive consumers).

Hard to say what exactly causes your discomfort but a very real possibility is that you have been taking one the many scam NMN capsules in the market.....

 

[Consequences]

But it DOES give you energy, so much you can't sleep at first.

Just google

nmn insomnia site:reddit.com

tons of anectdotal experiences all the same; insomnia after starting NMN.

[LawrenceW]

I checked out what GAB.AI had to say about NMN compared to NR.

 

Here are 10 reasons why some people believe NMN (Nicotinamide Mononucleotide) is better than NR (Nicotinamide Riboside):

1. Bioavailability: NMN is more bioavailable than NR, meaning it is more easily absorbed by the body and can have a more significant impact on cellular health.
2. Efficacy: Some studies suggest that NMN may be more effective at increasing NAD+ levels in the body compared to NR, which could lead to improved cellular function and overall health.
3. Cellular Uptake: NMN is more efficiently taken up by cells than NR, allowing it to more directly influence cellular processes and potentially leading to greater health benefits.
4. Safety: Both NMN and NR are generally considered safe, but NMN has been shown to have fewer potential side effects compared to NR, making it a potentially safer option for some people.
5. Research: While both NMN and NR have been studied extensively, NMN has been the subject of more recent research, which may provide a better understanding of its potential benefits and risks.
6. Aging: Some studies suggest that NMN may be more effective at combating the effects of aging compared to NR, potentially leading to improved longevity and overall health.
7. Metabolism: NMN is more directly involved in the production of NAD+ than NR, which could make it a more efficient way to increase NAD+ levels and improve cellular function.
8. Availability: NMN is becoming increasingly available on the market, making it more accessible to those interested in its potential health benefits.
9. Natural Sources: NMN is found naturally in some foods, such as avocados, broccoli, and cucumbers, while NR is not as widely available in natural sources.
10. Personal Experience: Some individuals may find that they experience better results or fewer side effects when using NMN compared to NR, leading them to prefer NMN as a supplement.

[bluemoon]

Of course, David Sinclair's company pulled NMN off the market last year. Lawrence backs up none of his claims.

 

None are known to be true. "Some individuals find..." "Some studies suggest..."

 

Amateur hour.

 

Bryan Johnson, now worth $500 million claims his test on himself show no difference between NR and NMN.

Edited by bluemoon, 15 May 2024 - 02:33 AM.