21 replies to this topic

[kurdishfella]

I know about Ginkgo biloba & Curcumin, what else?

 

 

[Omega 3 Snake Oil]

I didn't realize Gingko and curcumin decreased ACTH, source?  Also, I know low-dose naltrexone increases ACTH. 

[kurdishfella]

https://www.ncbi.nlm...les/PMC2853174/

 

http://jpp.krakow.pl..._02_article.pdf

 

Why would you point out that naltrexone  increases ACTH? thats not what I asked.

[kurdishfella]

mirtazapine inhibits acth

Hibiscus Sabdariffa inhibits aldosterone

Edited by farshad, 27 March 2018 - 03:56 AM.

[kurdishfella]

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts

https://www.ncbi.nlm...ubmed/20087857/

 

 

hmm this would be perfect in my case since I have a CRH releasing tumor but not only does curcumin inhibit tumor growth but also decrease ACTH. Wonder if curcumin also inhibits CRH?

 

Edited by farshad, 11 April 2018 - 11:04 PM.

[jaybird10 2]

testosterone

[kurdishfella]

Magnesium helps suppress the HPA axis (CRH, ACTH, Cortisol) [R].

[kurdishfella]

Melatonin reduces cortisol response to ACTH in humans.

https://www.ncbi.nlm...pubmed/19301769

 

btw ACTH is involved in anxiety.

https://www.mdbiopro...ticotropic-ACTH

 

also

Curcumin is more beneficial to very specific cases in which depression/anxiety is the result of brain atrophy that is caused by hyper-oxidative(stress) states.

 

"A diet enriched with curcumin impairs newly acquired and reactivated fear memories"

https://www.ncbi.nlm...pubmed/25430781

 

Edited by farshad, 10 May 2018 - 06:52 PM.

[kurdishfella]

Im sure curcumin inhibits or has an effect on CRH..

 

Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells

https://www.ncbi.nlm...les/PMC2394713/

 

Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats

https://www.ncbi.nlm...les/PMC5266814/

Curcumin seems very powerful for anxiety/Stress..

 

Edited by farshad, 10 May 2018 - 07:39 PM.

[kurdishfella]

Anybody know of any other stuff that reduce ACTH 

[Galaxyshock]

Bacopa normalizes ACTH levels in stress model:

https://www.ncbi.nlm...pubmed/27506204

[kurdishfella]

polygala extract reduced crh, acth, and Cort in the stressed rodents

https://www.research...ry-adrenal_axis

[kurdishfella]

1. Corticotropin-Releasing Hormone (CRH) Also referred to as corticotropin-releasing factor (CRF), this hormone is produced and secreted by the hypothalamus in response to stress, and it then stimulates your pituitary gland to secrete adrenocorticotropic hormone. The more stressed your body is (from diet, lifestyle, work, or anything else) the more CRH your hypothalamus will churn out.

 

2. Adrenocorticotropic Hormone (ACTH) ACTH is released by the pituitary gland, and travels to your kidneys to stimulate the adrenal glands to increase production of glucocorticoids.

 

3. Glucocorticoids The glucocorticoids produced in the adrenal glands are steroids that are necessary regulating metabolic rate, inflammation and immune response. You’ve already learned about the most notorious glucocorticoids: cortisol.

 

4. Cortisol Cortisol is best known for activating our physical response to stress, including injury, lack of sleep, excessive exercise, anxiety, and depression. It prepares your body to withstand these stressful triggers by stimulating norepinephrine (also known as noradrenaline) to active your fight-and-flight reaction. It’s important to understand is that  your HPA axis operates on feedback loops. A feedback loop occurs when the output of a system in your body somehow loops back to that system as input, and influences its functioning. A positive feedback loop would increase that system’s output, and a negative feedback loop would decrease it. So let’s take a look at how a feedback loop would take place in the HPA – in this case with regards to cortisol. At the same time that cortisol activates your fight and flight stress response, it also sends a signal back to your hypothalamus to inhibit CRH production and your pituitary gland to inhibit ACTH. In this feedback loop, cortisol is also able to reduce norepinephrine activity, gradually calming you down and creating a well-functioning checks-and-balances system . In healthy, low-stress individuals this entire HPA axis feedback loop works in harmony. But when cortisol and norepinephrine are chronically overproduced, the HPA axis eventually becomes desensitized to the negative feedback telling it to “calm down”, leading to chronic stress on the hypothalamus, pituitary gland and adrenal glands. Eventually, this leads to the neural failure that eventually causes all the nasty adrenal fatigue issues  and it is called HPA axis dysregulation.
 

Edited by farshad, 12 May 2018 - 08:07 PM.

[kurdishfella]

Selegiline lowers   ACTH.

 

Neuromodulatory drugs act primarily to decrease the release of ACTH from the pituitary. Bromocriptine (Parlodel), octreotide (Sandostatin), cyproheptadine (Periactin), pasireotide (Signfor) and cabergoline.

 

Ashwagandha Extract + Phosphatidylserine lowers ACTH.

 

[kurdishfella]

Probiotics?

https://www.ncbi.nlm...les/PMC2095678/

 

black seed oil?

https://scialert.net....104.109&org=11

 

Oxytocin?

https://en.wikipedia...ess_and_disease

 

 

Ginseng?

https://www.scienced...304394003003008

 

 

 

[kurdishfella]

By the way I think reducing ACTH will reduce norepinephrine so if you suspect you have high norepinephrine this maybe worth a shot.

[kurdishfella]

  does acth increase epinephrine/adrenaline (not norepinephrine/noradrenaline) or the other way around or am i thinking of something else

[kurdishfella]

GABA inhibits release of ACTH 

[John250]

Testosterone
progesterone
Forskolin
T3
THC
Caffeine
Nicotine
Prednisone
Manganese
Phosphatidylserine

[gamesguru]

n

Edited by gamesguru, 18 July 2018 - 02:00 AM.

[BlueCloud]

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts

https://www.ncbi.nlm...ubmed/20087857/

 

 

hmm this would be perfect in my case since I have a CRH releasing tumor but not only does curcumin inhibit tumor growth but also decrease ACTH. Wonder if curcumin also inhibits CRH?

 

How did you arrive at the conclusion that you have a CRH releasing tumor ?  Shouldn't you be dealing with the tumor first instead of trying to lower ACTH and stuff ?

Edited by BlueCloud, 18 July 2018 - 12:52 PM.

[kurdishfella]

How did you arrive at the conclusion that you have a CRH releasing tumor ?  Shouldn't you be dealing with the tumor first instead of trying to lower ACTH and stuff ?

CRH tumor is the only explanation I can find for this 24/7 anxiety cause.

At the time I made this thread I wasn't sure what I had, High ACTH, high crh, high cortisol or something else but now I have figured out my acth and cortisol is normal and I have tried various other things. Things that affect the CRH sysem have worked for my anxiety, so Now im looking to combine 2 major crh inhibitors to combat my anxiety. St johns wort has been shown to reduce crh by 20% and 5a-dhp an precursor to allopregnanolone which is an potent modulator of gaba-a which indirectly inhibits CRH. Just so I can get some relief finaly, during this time I will try to find a doctor and do a full body Mri scan And give them all the info I know if I do end up having a tumor. How it could be a crh tumor etc...

 

I just leave this thread up here so maybe it can help people that have high ACTH .