2523 replies to this topic

[mbdrinker]

By the way vitamin c is #1 drug to support collagen and no wonder that Russian drugstores sell fake vit c without remorse

[Kelvin]

For those who want to drink alcohol after the have completed a C60 cycle I recommend taking pantethine with a meal a few hours before drinking.

 

Most of the damage alcohol causes to stem cells, and other parts of the body, is inflicted by acetaldehyde.

 

Pantethine protects stem cells by efficiently converting acetaldehyde into safer compounds before it can do its usual harm.

 

I personally wait 2 weeks before and 2 weeks after I am on C60 to start drinking again to make sure C60 has cleared my system.

 

Be careful, though, about drinking more than moderately because I find the protocol increases my tolerance for alcohol.

 

In order to not get an unpleasant surprise by unintentionally crossing over a new, higher, tolerance level, drink moderately and pace yourself even if you feel a delayed hangover effect.

Edited by Kelvin, 31 May 2022 - 10:33 PM.

[Turnbuckle]

Could the C60 protocol benefit parts of the brain like the frontal lobes which apparently cannot regenerate neurons by boosting the circulation of stem cells from nearby areas that have them in abundance such as the hippocampus?

 

Might stem cell circulation be promoted by taking something like lithium at the same time as the C60 + fusion part of the protocol? (assuming no negative interactions between lithium and C60, otherwise another supplement would be needed)

 

Perhaps if they had broader circulation across the brain, and if brain trauma is not excessive, they could find target cells in the frontal lobes and begin regenerating neurons.

 

If that could be done the main risk would be that unhealthy stem cells populate niches where they might do more harm than good.  But this risk could be mitigated by only adding lithium for a couple cycles every year, or few years, considering how long-lived neurons are.

 

I can't speak to specific brain regions, but the protocol can definitely produce improvements in brain function. You need to use a fusion agent that can cross the BBB, such as dihydromyricetin. Then you can use C60 and get effects that you won't see with stearic acid, which does not cross the BBB. You can also add other agents such as SSRIs. SSRIs are known to promote neurogenesis, and that is suspected to be their major mode of action. Such antidepressants can stop working after a while -- producing "breakthrough depression"--which is likely due to SC depletion. Use them with the protocol, however, and that will be unlikely. 

[mbdrinker]

Ghb is acetaldehyde-free but is prohibited everywhere... Good info about alcohol, I will be off it. I drank 2 months every day and it stopped stimulating gaba induced psychodelic pleasure. Even after a month of abstinence alcohol no longer gives stimulating effect and definitely suppresses creativity

[Kelvin]

Thanks, Turnbuckle.

 

There has been some speculation that the frontal lobe can, to a very limited extent, regenerate some of its neurons.

 

If it does have this ability at all then it is probably because it can "borrow" stem cells from elsewhere in the brain.

 

I have noticed a number of positive cognitive effects from the protocol which I used 6 times this February and March.  

 

I have been using the protocol exactly as you recommend with 4 grams dihydromyricetin and 50 mgs of sulforaphane.   

 

Some of those benefits are enhanced memory and reduced need for sleep.  I can now get by at work on just 5 and a half hours of sleep while 7 hours feels excessive.  Usually, 6 and a half hours is all I need to get through the day whereas before I struggled to manage with 8 hours of sleep.

 

If you had to choose an SSRI to increase the neural circulation of stem cells which supplement would you choose?

 

Licorice root reportedly has SSRI effects.

 

Lithium may also promote stem cell circulation.

Edited by Kelvin, 01 June 2022 - 04:58 AM.

[Kelvin]

I must say, speaking only from my own experience with C60, that despite the caveats I wrote about concerning alcohol and the protocol that C60 has improved my enjoyment of drinking.

 

The pleasant effects are similar except that it is delayed by about 30 minutes, the side effects from drinking are mitigated, and I somehow feel more lucid while inebriated.

 

My hand/eye coordination and balance are still affected, so please don't go driving if you have been drinking and used C60 in the past.

 

But, overall, the experience is improved provided I drink moderately.

The reason I raised the warning about not testing one's alcohol threshold is because over the course of 6 hours one weekend I accidentally drank about 40% of a 750 ml bottle of scotch that is 45% ABV before I noticed how much I drank.

 

Miraculously I had no hangover the next morning, was only slightly dehydrated, and didn't vomit.

 

[Kentavr]

 

Epigenetic age reduction occurs when you replace telomerically aged out cells (that are also epigenetically old) with new somatic cells that derive from stem cells with near zero age. You can't reverse epigenetic age past a certain point because cells first have to age out and commit suicide to be replaced, and thus the best you can achieve will have a mixed population of ages. As for the extracellular matrix, if it is being properly and continuously remodeled, then crosslinks will get recycled. If the body gets behind on maintenance and it reaches a certain level of crosslinks, then I expect you might have a problem. But I don't think this is central to aging. It doesn't explain findings like this --

 

 

Nor do I understand how the reduced elasticity of the extracellular matrix might prevent replacement of aged out cells. Can you point to actual evidence of this? I can imagine that a person with a lot of crosslinking due to smoking or alcohol abuse might also have depleted stem cell niches. But that would be a correlation, not a causation.

 

 

You're only approaching aging from one side. 

 

You also provided a quote:

 

 

About 5 percent of adults aged substantially faster than others (i.e., epigenetic age was more than 10 years older than chronological age), leading to a nearly 50 percent increased risk of death.

 

The results were adjusted for mortality-related risk factors, including smoking, obesity, and health conditions such as cancer, high blood pressure, and diabetes. The associations also held across sex and racial groups, as the analysis encompassed data from 13,089 non-Hispanic whites, Hispanics, and blacks.

https://www.nia.nih....dicts-mortality (the previously linked paper)

 

 

If you think the rigid extracellular matrix won't "flatten" you, I will show you the information on how the extracellular matrix controls the activity of your genes. Watch this video to illustrate:

 

https://www.youtube....h?v=2mNyV6tCPsw

 

This video has Russian voiceover, I will translate it for you. I also included timecodes for your convenience, to make it easier for you to analyze.

 

 

(0:00 – 0:21) «Our bodies are made up not only of cells, but also of a special environment surrounding cells called the extracellular matrix. The structures of the extracellular matrix - such as muscles, or blood vessels - are largely formed by elastin and collagen fibers, which mechanically press on the surface of the cells. 

 

(0:21 – 0:29) And there are various receptors on the surface of the cells - for example, integrins (which are marked here in yellow).

 

(0:30 – 0:43) When the cell moves along the fiber, these receptors eventually bind to the fibers of the extracellular matrix. And the cell, which thanks to these receptors gets hooked on the fiber, begins to change its shape - to stretch.

 

(0:44 – 1:23) As a result of such tension, signal proteins inside the cell are activated, through which these tension signals are transmitted by the outer cell membrane to the very center of the cell, where the nucleus with the genetic code recorded in DNA is located. 

 

(1:24 – 1:40) If the extracellular matrix is young, elastic, soft, and the matrix fibers are easy to stretch, it does not cause a lot of tension in the cell itself (you will soon see this).

 

(1:41 – 1:49) Here, it shows how when the extracellular matrix is young, the fibers stretch quite easily and the cell itself can deform.

 

(1:50 – 2:13) However, in a rigid matrix (even more so in a matrix with a suboptimal amount of collagen fibers) this interaction with the cell receptors leads to more tension. As a result, the cell adequately responds to the stiffer properties of the matrix, and the stiffness signals are also transmitted via signaling molecules to the cell nucleus, where the DNA code is located.

 

(1:50 – 2:13) Also, depending on the stiffness of the extracellular matrix, the throughput of the ion channels, through which various ions of the intercellular medium enter the cell, also affects the work of the cell's signaling molecules. 

 

(2:28 – 2:24) Stiffness signals from the cell surface and signals of ions entering the cell affect transcription factors located in the cell nucleus - these are the factors that affect the operation of DNA. They, in turn, change how our genes work. 

 

(2:45 – 3:06) Thus, the elasticity and rigidity properties of the extracellular matrix directly and rigidly govern the work of genes, govern the entire fate of the cell. How the DNA molecules are read depends very much on the extracellular matrix.

 

(3:07 – 3:34) If the extracellular matrix is too rigid and inelastic, cell can start to "not feel good", divide slower and slower, produce proteins that don't work properly, age, and lose its ability to divide at all (like the one in the video now)».

 

So by affecting the stiffness of the extracellular matrix, you can affect the workings of the genes inside the cell and probably reduce your epigenetic age more.

Edited by Kentavr, 01 June 2022 - 10:10 AM.

[QuestforLife]

 

1. You cannot remodel the extracellular matrix if it is too strongly cross-linked with glucosepane cross-links. The matrix just becomes "like a dandelion", the degradation products do not leave the place of destruction, because the detachment of degradation products does not happen until the end. Look at the links above.

2. If your niches where the stem cells sit cannot leave it, you are doomed.

 

Also: 

Your pulse pressure is still high, which means that there is a structural change in the body that can impair the function of all organs and tissues.

 

I also assume that you do not have a further decrease in epigenetic age, because you have reached the limit of the stem cells' ability to decrease epigenetic age. But you haven't been dealing with the matrix. Integrins affect the activity of genes in cells, and they affect all systems of the body very strongly, increasing the epigenetic age. 

 

I assume that if you reduce the rigidity of the extracellular matrix, you will have a synergistic effect: your age will decrease even more: I assume even more than if you continue to use your default protocol. 

 

 

What came first, the chicken or the egg?

 

Cells produce metabolic byproducts, some of which cause stiffening of the ECM, and this might limit stem cell motility. This is essentially Aubrey de Grey's thesis of aging.

 

Or you could argue that in-built cellular aging, such as telomere shortening, causes a fall in the rate of the turnover of bio-molecules, including ECM components. And therefore cellular aging in primary. This is essentially the position of someone like Micheal Fossel.

 

I am of the opinion that both avenues should be pursued. But it is unclear practically speaking, how much the aged ECM will prevent cell-lead rejuvenation. If it does prevent it, then clearly it needs to be addressed. It hasn't stopped TB reducing his epigenetic age by nearly 30 years. But epigenetic measures of methylation age could be misleading in some circumstances. This is why I encourage Turnbuckle and others to monitor real biomarkers.

[Kentavr]

That is, it turns out that epigenetic changes are a consequence of the interaction between the extracellular matrix and genes. 

 

And this does not contradict the information in the link you gave earlier. Yes, indeed, increased epigenetic age can correlate with mortality from multiple causes.

But the cause (exactly the cause!) of mortality could be different, have you thought about that?

 

And the epigenetic changes that occur in the cell are only a "reflection", a "witness" to death. Like a security camera in the street that recorded a murder and left information about it on the hard drive. 

 

It turns out that we can really confuse cause and effect. The cause of death as we age can be the extracellular matrix, and the consequence is the trace left behind in gene changes.

Therefore, it is not surprising that increased epigenetic age can correlate with mortality from multiple causes.

 

 

Edited by Kentavr, 01 June 2022 - 10:41 AM.

[Turnbuckle]

 

If you had to choose an SSRI to increase the neural circulation of stem cells which supplement would you choose?

 

 

I'd pick one with a shorter half-life, though that might not make much difference to SCs when used with C60, which has a much shorter activity. Prozac (Fluoxetine) has the longest half-life while Luvox (Fluvoxamine) has the shortest, and 5-HTP has a shorter half-life than any SSRI. It is a serotonin precursor and not an SSRI, but is known to stimulate neurogenesis via increased serotonin. 100 mg might be an appropriate starting point.

 

 

 

I must say, speaking only from my own experience with C60, that despite the caveats I wrote about concerning alcohol and the protocol that C60 has improved my enjoyment of drinking.

 

 

C60 is an excellent anti-oxidant and will protect against ROS while drinking, however, using it as a drinking aid will stimulate stem cells into differentiation and deplete them. Thus not recommended as a general practice.

[Kentavr]

Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics

 

https://ncbi.nlm.nih...les/PMC5866410/

 

 

 

 

Edited by Kentavr, 01 June 2022 - 10:53 AM.

[Turnbuckle]

 

 

And the epigenetic changes that occur in the cell are only a "reflection", a "witness" to death. Like a security camera in the street that recorded a murder and left information about it on the hard drive. 

 

 

I don't agree. The epigenetic code determines which mix of proteins each of the 200 cell types of the body makes from the identical underlying genetic code. Epimutations are far more frequent than genetic mutations, and result in cells making the wrong mix of proteins. An individual cell might be happy, but the function of the organ in which it resides is degraded. Multiply that by trillions of cells going off script due to their growing burden of epimutations, and the result is aging and an increased risk of mortality. Epigenetic age is thus not a reflection; it is the root cause.

[Kentavr]

I don't agree. The epigenetic code determines which mix of proteins each of the 200 cell types of the body makes from the identical underlying genetic code. Epimutations are far more frequent than genetic mutations, and result in cells making the wrong mix of proteins. An individual cell might be happy, but the function of the organ in which it resides is degraded. Multiply that by trillions of cells going off script due to their growing burden of epimutations, and the result is aging and an increased risk of mortality. Epigenetic age is thus not a reflection; it is the root cause.

 

I want to be understood correctly. 

 

1. I am not denying that epigenetic changes also increase the risk of mortality.

2. I do not deny that telomere shortening also increases the risk of mortality

3. I am not denying that "factor N" increases the risk of mortality.

 

I am not saying that the extracellular matrix alone is the cause of increased mortality and there are no other causes. No.

 

I am not denying the fact that epigenetic changes can occur for a variety of reasons:

 

1. due to telomere shortening.

2. because of increased inflammation (SASP)

3. because of the number and type of extracellular vesicles

4. because of the influence of the extracellular matrix.

5. Because of the cause of N...etc. 

 

I know very well that inflammation in the body leads to atherosclerosis, and eventually death. Inflammation is an increased risk of death.

I know very well that many cancers can also be formed not because of increased rigidity of the extracellular matrix, and this also leads to death. There are even childhood cancers.

I know all that. 

 

I'm talking about a different thing!

 

I'm talking about a fundamental thing here.

 

1. The gradual increase in stiffness of the extracellular matrix increases the proportion of deaths resulting from the extracellular matrix. 

2. After age 90, rigid extracellular matrix is the leading cause of death in humans. In fact, it is a verdict. It is a fundamental limitation. 

3. Many people who died earlier may indeed have died from diseases unrelated to the extracellular matrix.

 

But the proportion of diseases related to the extracellular matrix is increasing with each year of life.

 

Turnbuckle invented a wonderful protocol to roll back epigenetic age, and many are grateful for it (myself included), but he still suffers from high blood pressure.

The high blood pressure is not only the work of the angiotensin 2 receptors, but also the result of increased rigidity of the extracellular matrix. 

 

Did the protocol help him get rid of his high blood pressure? No. Even if it did increase the number of stem cells many times over.

It didn't. And blood pressure is a major mortality factor. It's a risk of heart failure, as well as a lot of diseases for other reasons.

 

And it turns out that a person can have a lot of healthy cells and the next day die of a stroke. If we look at life extension as reducing the risk of dying as we age, the extracellular matrix is something we have to do.

You can't do it without it. With a rigid matrix, you can die like a dog under the fence with all your new and young stem cells.

 

Now next. 

 

Turnbuckle has done quite a large number of stem cell division protocols. So large that there is no longer a noticeable epigenetic shift to a younger state. I believe that to further reduce epigenetic age and mortality, the stem cell renewal protocol is no longer effective at this stage. The number of extracellular vesicles formed by young stem cells is already so large that it no longer has a significant impact on further epigenetic rollback.

In earlier posts I showed how the stiffness of the extracellular matrix affects gene function. And, if you improve the elasticity of the extracellular matrix, you can affect the function of these genes.

 

The epigenetic changes that have occurred through protocols to improve mitochondrial function and increase the number of stem cells are tremendous. But beyond that, in fact, there is no further change. My guess is that there is no further change because Turnbuckle has too rigid an extracellular matrix.

 

I believe that if Turnbuckle begins to increase the elasticity of the extracellular matrix, it will further reduce epigenetic age (because the extracellular matrix affects it) and also reduce the risk of Turnbuckle itself dying. 

 

Here's what I meant. 

 

I suggest Turnbuckle start a new topic related to changing the elasticity of the extracellular matrix, and start forming a new protocol.

[mbdrinker]

It's funny to see how you all fight for hypothetical additional couple of dayse/years to live Just stay calm and unnervous and it probably will give you better results. I personally don't trust to veremeenko, petric or anyone. Ageing is part of genes and can't be stopped. But some unholy try to financially benefit from cherished desire to live longer and they are eager to help with theories. Just buy this or that and we will cardially invent for you any theory you want. Your body will probably fight against all your cherished supplements trying to neutralize the harm violating the biological clock

[Turnbuckle]

 

2. After age 90, rigid extracellular matrix is the leading cause of death in humans. In fact, it is a verdict. It is a fundamental limitation. 

 

Evidence? And even if it were true, it would be the result of a failure of maintenance, and not the root cause. Damage to the extra cellular matrix (ECM) can contribute to decreased SC numbers and potency, while aged and epigenetically damaged cells can contribute to ECM dysfunction. A vicious feedback loop that begins with cells aging out and failing to maintain the ECM because of the failure of SCs to replace them.

 

Did the protocol help him get rid of his high blood pressure? No. Even if it did increase the number of stem cells many times over.

It didn't. And blood pressure is a major mortality factor. It's a risk of heart failure, as well as a lot of diseases for other reasons.

 

Blood pressure is controlled from the brain stem, and the stearic acid I was initially using does not penetrate there. When I began using BBB-penetrating fusion agents, I saw an improvement in cognitive abilities and also a reduction in my BP. I have not stopped taking BP medications, but now I often see pressures like 107/67, whereas years ago I was happy just to keep the systolic below 140.

 

 

 

Extracellular Matrix Degradation and Remodeling in Development and Disease

The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. 

https://www.ncbi.nlm...les/PMC3225943/

 

 

 

The ECM doesn't exist in isolation. It is dependent on the secretions of enzymes and other proteins by surrounding cells. If the surrounding cells are epigenetically young, then the ECM should stay healthy. Though scaring/fibrosis may make that impossible in certain situations, such as with cirrhosis of the liver.

Edited by Turnbuckle, 01 June 2022 - 01:33 PM.

[Answers]

Hi, I haven't read the whole thread as I have focus issues and wouldn't understand it well enough anyway.

Can c60(or anything for that matter) help reprogram or reset cells/pathways? Can it help with autoimmune disease and inhibit disease causing micro RNAs? Basically can it reverse epigenetic changes I guess. I've got a myriad of issues such as anhedonia,caused by ADs that won't go away.


And is it safe to take if you're quite young?

[Turnbuckle]

Hi, I haven't read the whole thread as I have focus issues and wouldn't understand it well enough anyway.

Can c60(or anything for that matter) help reprogram or reset cells/pathways? Can it help with autoimmune disease and inhibit disease causing micro RNAs? Basically can it reverse epigenetic changes I guess. I've got a myriad of issues such as anhedonia,caused by ADs that won't go away.


And is it safe to take if you're quite young?

 

The treatment on this thread is for reversing aging, and is intended for people over 50. Use of it for treating autoimmune diseases is not entirely out of the question, but I would strongly advise you against it, especially if you've diagnosed yourself. The potential for making things worse seems very possible.

 

Here is a recent overview on the subject: Cell Based Treatment of Autoimmune Diseases in Children. If your problem lies in your genes, then expanding your own SCs would not cure you, and could make things worse. From the above linked paper--

 

... it has been suggested that autoimmune diseases may in part be propagated by abnormal properties of MSC. There is limited evidence in support of this concept when ex vivo expanded MSC from patients with various autoimmune diseases are examined by a battery of tests including cell morphology, doubling time, signs of senescence, cell surface markers, and functional studies on immune modulation and angiogenesis. For instance, bone marrow derived MSC from patients with SLE [systemic lupus erythematosus] showed evidence of distorted cell morphology, early senescence, and slow growth to confluence in vitro even though the surface markers and differentiation potential remain compatible to those from healthy controls. Functionally, the immunomodulatory activities may vary from normal to impaired. 

 

 

In which case, using allogeneic SCs (derived from other people, not you) is the way to go. In this treatment, your own SCs are proliferated endogenously.

[Kentavr]

Turnbuckle, what is your blood pressure when you are not using blood pressure medication?

[Daniel Cooper]

 

 

mbdrinker - some of your posts are off topic. Please make an extra effort to keep to the topic of this thread which is "Stem cell self-renewal with C60".

 

That said, mbdrinker is not the only one drifting off topic from time to time. An occasional diversion is ok (we want to have as free of expression as possible and minimize hall monitoring) but threads have topics for a reason so please be reasonable.

[Empiricus]

I'd pick one with a shorter half-life, though that might not make much difference to SCs when used with C60, which has a much shorter activity. Prozac (Fluoxetine) has the longest half-life while Luvox (Fluvoxamine) has the shortest, and 5-HTP has a shorter half-life than any SSRI. It is a serotonin precursor and not an SSRI, but is known to stimulate neurogenesis via increased serotonin. 100 mg might be an appropriate starting point.

 

 

What about Saint John's Wort?  

 

"facilitated differentiation of neural progenitor cells, but also increased the efficiency of differentiation into serotonergic neurons"

https://pubmed.ncbi....h.gov/30015171/

 

 Some sources suggest half-life of hyperforin is 20 hours, this one says 9-12 hours

https://pubmed.ncbi....ih.gov/9684946/

 

Edited by Empiricus, 02 June 2022 - 09:36 PM.

[Turnbuckle]

What about Saint John's Wort?  

 

"facilitated differentiation of neural progenitor cells, but also increased the efficiency of differentiation into serotonergic neurons"

https://pubmed.ncbi....h.gov/30015171/

 

 Some sources suggest half-life of hyperforin is 20 hours, this one says 9-12 hours

https://pubmed.ncbi....ih.gov/9684946/

 

 

Give it a shot. I want to make a point about anything that stimulates stem cells, and especially those in the brain. If my hypothesis about SSRIs is right -- that they eventually fail to work because they deplete stem cells -- then it would be wise to take a fusion agent with them to ensure proliferation. But not every day, even if you take them every day for depression, because constant fusion will allow mitochondrial problems to develop. 

[Kelvin]

What do you think of taking nicotine during off periods from C60?

I smoked a bit in college and then switched to Swedish snus which I normally enjoy once a week.

Research on Swedish snus indicates it has an excellent safety profile.

nicotine is also known to be neuroprotective against Parkinson’s but I wouldn’t combine it during the C60 protocol.

[Kelvin]

Whichever SSRI one chooses you should probably start at a moderate dose on the protocol, and use the SSRI every couple of cycles, because SAM-e also generates serotonin.

[Kelvin]

Another option is to substitute 500 mgs of TMG to replace SAMe as a methyl donor whenever an SSRI is added to the protocol.

I usually take 2 grams of TMG anyway after every 3 cycles of theC60 or mito fission fusion protocols to rebuild my methyl stores which are sometimes depleted from using all of that AKG. It seems to work as well for methyl replenishment as 1 gram of SAMe.

[Empiricus]

Give it a shot. I want to make a point about anything that stimulates stem cells, and especially those in the brain. If my hypothesis about SSRIs is right -- that they eventually fail to work because they deplete stem cells -- then it would be wise to take a fusion agent with them to ensure proliferation. But not every day, even if you take them every day for depression, because constant fusion will allow mitochondrial problems to develop. 

 

 

There are plenty of anecdotes of people reporting severe bad effects from SSRI's a relatively short time after starting them.  Could too-rapid stem cell depletion explain these horror stories?    

 

This anonymous MD describes how SSRI drug trials were rigged, and shares observations about SSRI side-effects:  https://amidwesternd...-the-dangers-of

 

By the way, aside from this topic, the context this substack brings to covid-19 controversies is second-to-none. 

Edited by Empiricus, 03 June 2022 - 08:32 AM.

[Turnbuckle]

There are plenty of anecdotes of people reporting severe bad effects from SSRI's a relatively short time after starting them.  Could too-rapid stem cell depletion explain these horror stories?    

 

This anonymous MD describes how SSRI drug trials were rigged, and shares observations about SSRI side-effects:  https://amidwesternd...-the-dangers-of

 

By the way, aside from this topic, the context this substack brings to covid-19 controversies is second-to-none. 

 

 

I really doubt that SC depletion could cause psychosis. That would take a long time, whereas some people have dangerous reactions to SSRIs within hours.

[johnhemming]

For those who want to drink alcohol after the have completed a C60 cycle I recommend taking pantethine with a meal a few hours before drinking.

 

Most of the damage alcohol causes to stem cells, and other parts of the body, is inflicted by acetaldehyde.

 

Pantethine protects stem cells by efficiently converting acetaldehyde into safer compounds before it can do its usual harm.

 

I personally wait 2 weeks before and 2 weeks after I am on C60 to start drinking again to make sure C60 has cleared my system.

 

Be careful, though, about drinking more than moderately because I find the protocol increases my tolerance for alcohol.

 

In order to not get an unpleasant surprise by unintentionally crossing over a new, higher, tolerance level, drink moderately and pace yourself even if you feel a delayed hangover effect.

 

Thank you for this helpful suggestion.  I will experiment with this.

[mbdrinker]

Good turn I mean discussing psychodelic stuff instead of questionable life extenders

[Kentavr]

Turnbuckle, I think you are wrong. Stem cells will not be able to remodel the old extracellular matrix. There is no way they can remove the glucosepane cross-links. 

 

You got the pressure under control by remodeling the receptors and some areas of the brain. But you've hardly reduced vascular stiffness.

 

I concede that the stem cells may have helped in part with elastin production. Then maybe. Although I highly doubt it could help your pulse pressure.

 

What is your current pulse pressure? I think you are making a big mistake in thinking that stem cells can solve your pulse pressure problems.

 

[mbdrinker]

I have read that all cells of the body are totally renewed within a month or so. Which means that cell life period is short but they say nerve cells are not restorable which is real contradiction. Also my approach to taking supps is that the main of them are those affecting nervous system and sense of well being like psychostimulants or psychodelics or nootropicz. And supps from 2nd category are just health, strength improvers,inflammation supressors. Many men after 40 in russia have joints inflammation and you see it how they walk which is like their limbs are moved with strain. I bet its result of inflammation and not some matrix damage as you say. Just to prove my words i saw couple of old but beautiful women in moscow. They were above 70 and wrinkled but their bodies were slim and perfect like 20 years old and with young movement of limbs without strain. Myself being with artritis inflammation i know what it's like when joints lose mobility. However perfect skin or slenderness you have your age is clearly revealed by joints stiffness and damaged mobility