2523 replies to this topic

[Kelvin]

The mitochondria protocol minimizes hangover effects because the mitochondria assist breaking down acetaldehyde into less harmful compounds -

https://www.ncbi.nlm...les/PMC6527027/

Acetaldehyde is metabolized mainly by aldehyde dehydrogenase 2 (ALDH2) in the mitochondria to form acetate and NADH.

Edited by Kelvin, 02 June 2024 - 11:14 PM.

[eighthman]

Is there any evidence for this avoidance of alcohol specifically?  Or is this just a precaution?  I skip a before dinner drink on the day I do the 2 day regimen but is there any reason to skip weeks?

[Kelvin]

More of a precaution.  I want to avoid exposing proliferating stem cells to alcohol so they can mature without any potential external interference. 

[kurt9]

I found a paper from 2018 for a group of Korean researchers that provide evidence that the so-called "liver spots" are due to an accumulation of senescent fibroblasts. If this is true, it seems likely that this protocol ought to eliminate or at least reduce these "liver spots". Have any of you using this protocol have observed this result?

 

A competing theory is they are due to the accumulation of lysosomal (lipofuscin) aggregates. This is the theory that SENS advocates like Aunrey de Grey advance.