Baati et al. used rats. Grohn et al. used mice.
Grohn has some interesting observations:
"Finally, we conduct a lifespan and health span study in males and females C57BL/6 J mice comparing oral treatment with pristine C60-EVOO and EVOO alone versus untreated controls. We failed to observe significant lifespan and health span benefits of C60-EVOO or EVOO supplementation compared to untreated controls, both starting the treatment in adult or old age. Our results call into question the biological benefit of C60-OO in aging."
"Commercial C60-OO has unpredictable concentration and activity
We first obtained samples C60-OO from 4 popular online sources (labeled Source 1–4) and formulated pristine C60-OO in-house. C60-OO should be a transparent deep purple (f. 1a). However, there was marked discrepancy in the visual appearance of the commercial formulations, appearing dark brown and almost black (Fig. 1a). We performed HPLC on the samples and found a notable increase in impurity peaks in the commercial samples (Fig. 1b, inset). Again, with HPLC, we measured the concentration of C60 in each sample and compared it to the claimed concentration of the label. We again found remarkable variability in C60 concentration and in deviation from the stated concentration. The highest concentration found was in the freshly made in-house Pristine C60-OO at 1.4 mg mL-1, with the lowest being Source 3, at 0.57 mg mL−1 (Fig. 1c). When we compared these concentrations with the claimed concentrations on the labels, we found deviations ranging from negligible for Source 4, to > 38.5% for Source 2, with all except Source 4 deviating by > 18%."
For those who had experimented with C60, did you make your own, or purchase? I passed on C60 because of concerns about purity issues of both the C60 and the extra virgin olive oil (EVOO).
Remember the old internet axiom (which I just now made up): "There is about 3 times as much EVOO sold as there is produced". (Some sources say that claims of fake olive oil are overstaed but, in the interest of preserving urban legend, I'll maintain that those claims of overstatement are overstated.)
And, in other news:
"A sophistical rhetorician [Gladstone], inebriated with the exuberance of his own verbosity, and gifted with an egotistical imagination that can at all times command an interminable and inconsistent series of arguments to malign an opponent and to glorify himself"
That famous line was coined by Benjamin Disraeli (1804–1881), the British Prime Minister and novelist, to mock William Gladstone, his political rival.
Edited by Advocatus Diaboli, 25 April 2025 - 07:34 AM.
