6 replies to this topic

[Sith]

Hey everyone!

 

My regimen was quite up-to-date, however, due to increased commitments; my reading into the new supplements and new science has decreased. So, just how relevant are my supplements today? Are there any new recommendations?

 

 

Longevity:

1. 2 x 500mg Metformin.
2. 20,000IU Vitamin D3.
3. 1000mg Resveratrol with piperine. 
4. 15mg Astaxanthin. 
5. 500mcg Vitamin K2/MK7.
6. 15-20g Astragalus root. 

This is all taken in combination with a Mcdougall syle vegan diet, some further 'dietary' supplements for general health are:

• Vitamin B complex.
• Milled flaxseed.
• Amla powder.
• 1000mg Vitamin C.
• Algae Omega 3 (500mg)

 

And unfortunately... 1mg of Finasteride. Absolutely no side effects, thankfully.

 

Details:

Male, early 20s.

 

[Andey]

20k Vit D is kinda big, are you taking regular blood tests to check for overload?

Metformin is kinda controversial because it increases risk of neurodegenerative diseases. I would not take it on constant basis. (I actually take 500mg XR but for off label effect on gut health, and dont plan to do it for more then 3 month)

 

 

[sthira]

I think, in early 20s, healthy living to promote lifespan extension may be more about what you *don't do* than about what you do. Don't step on your own feet, trip yourself up with poor information from hucksters. Don't be your own worst enemy by overdoing unproven supplements.

Assuming you're healthy and eating well to promote RDA, I'd nix all of these supplements (except, maybe -- big maybe -- the B-complex if you're B-deficient). Instead, focus on consistently eating minimally processed plants. If you document your daily eating habits on a program like cronometer, and stick with it, be consistent, you'll save money, frustration, and dashed hopes when the supplements you thought would "do something" to slow aging in fact "do nothing" to slow aging.

Unless you're diabetic, taking metformin in your early 20s is misguided. There just isn't any evidence at all that in normally healthy young people metformin will do anything to lift you out of aging. Metformin may also contribute to male pattern baldness, which you appear to be fighting (e.g., finasteride).

Calorie restriction might help, but CR takes discipline and courage and commitment that most people just don't have. Fasting also might help, but it depends.

As Andey says above, over-consuming vitamin d is possibly harmful. Get blood tests, find the middle of the range, enjoy sunshine. Wear sunscreen. These boring mainstream interventions are all we have for now. Promising future treatments remain, for now, in the future.

Resveratrol with piperine, astaxanthin, astragalus, and extra vitamin c are all wasted money if you eat healthy plant food. Track your diet on an app. Discover your shortfalls. Supplement those daily shortfalls and pay attention to Recommended Daily Allowance.

Until more *human evidence* from multiply replicated, disinterested studies *in humans* prove their worth for whatever complex metabolic pathway you're seeking to target, supplements pitched at you are a waste of money for an early 20s healthy person. Save your money instead, put money away, seek compound interest from your money, time is on your side, so that you'll be able to afford real (expensive) proven regenerative therapies when real proven regenerative therapies become widely available.

The things not to do you already know: don't drink too much booze, don't access too many street drugs, don't have too much unprotected sex, don't sit in too much skin cancer causing sun, don't drive your bike or your car recklessly, don't eat junk food, don't drink junk drinks, don't not exercise, do something worth living for, find your passion. These are the boring, proven truths that few people want to follow.

The flaxseed is good for you. Amla is probably overly hyped, vitamin K2/MK7 might be good -- or just keep on consistently eating leafy greens. Algal supplements or algal oil might be good if you're vegan (and if daily diet tracked on cronometer indicates you're omega 3 deficient). Again: cronometer and dietary consistency are what we have -- until actual real, proven reparative therapie$$$ emerge from mainstream clinical trials (which may be decades away, and even then, wildly priced...)

[Andey]

+sthira

 

  I would say that lifestile interventions would be a more safe and promising. It would be wise to include some type of catabolic periods, exercise etc. I you were to take supplements anyway - make you make cycling on and off.

And...beware of deficiencies, vegan is kinda an extreme diet of sorts. 

Edited by Andey, 09 April 2018 - 10:34 AM.

[Sith]

Can I possibly get some more scientific opinions on this? 

[Kentavr]

20,000 vitamin D is very much.

Reduce to 5000 (and better to 2000).

And be sure to check for 25-hydroxy vitamin D

 

Persons consuming more than 2000 IU / day of vitamin D (from diet and supplements) should periodically receive a measurement of 25-hydroxy vitamin D in the serum.

 

Instead of vitamin D, use more omega-3 in the form of triglycerides.

 

15 mg Astaxanthin lower to 12 mg. And only three months a year.

 

Also, you can greatly reduce the intake of astragalus root if you take it with chitosan (chitosan increases the absorption of astragalosides 60 times (!)). It is better in this case to switch to an extract of astragalus, where astragalosides are more. You will calculate the dose yourself, as well as you will find information on the astragalosides pacing during joint admission with chitosan.

 

Rasveratrol increases the production of the hormone estrogen, so it can be dangerous for men, especially in this dosage. It is better to replace with other polypenols. There are a lot of them, pick them yourself.

 

Crushed flaxseed is best not to be consumed, unless you grind it yourself before use. The reason: the crushed flaxseed is very strongly oxidized, and the fatty acids of flaxseed oil turn into poison.

 

Also would advise to add tocotrienols (a course on 2 months 2 times a year)

 

Once a month for 8 months - FMD-diet.

If you drink coffee - drink decaffeinated (coffee without caffeine extends telomeres).

Edited by Kentavr, 08 May 2018 - 07:52 PM.

[John250]

20,000 vitamin D is very much.
Reduce to 5000 (and better to 2000).
And be sure to check for 25-hydroxy vitamin D

Persons consuming more than 2000 IU / day of vitamin D (from diet and supplements) should periodically receive a measurement of 25-hydroxy vitamin D in the serum.

Instead of vitamin D, use more omega-3 in the form of triglycerides.

15 mg Astaxanthin lower to 12 mg. And only three months a year.

Also, you can greatly reduce the intake of astragalus root if you take it with chitosan (chitosan increases the absorption of astragalosides 60 times (!)). It is better in this case to switch to an extract of astragalus, where astragalosides are more. You will calculate the dose yourself, as well as you will find information on the astragalosides pacing during joint admission with chitosan.

Rasveratrol increases the production of the hormone estrogen, so it can be dangerous for men, especially in this dosage. It is better to replace with other polypenols. There are a lot of them, pick them yourself.

Crushed flaxseed is best not to be consumed, unless you grind it yourself before use. The reason: the crushed flaxseed is very strongly oxidized, and the fatty acids of flaxseed oil turn into poison.

Also would advise to add tocotrienols (a course on 2 months 2 times a year)

Once a month for 8 months - FMD-diet.
If you drink coffee - drink decaffeinated (coffee without caffeine extends telomeres).

What’s the reason for cycling the Astaxanthin and tocotrienols?