Interesting. Some take Colostrum powder as they think it can benefit immunity, gut issues and enhance exercise effects. Two of the types on the market are 6 hour full fat products which are left intact:,and second is where they remove the fat, process with Lecithin, and MCT and sell it without dairy fat. I wonder if the de-fatted brands might be safer hormone wise. Would Prolactin hurt exercise results/performance in a male athlete? I prefer full fat, as it whips into drinks with a stick blender as if it was cream. The modified products stay granular to some extent.
"The highest concentration of PRL were found in the milk of cows and women during the first days after parturition (6). Concentration of PRL in composite milk of Holstein × Sim-mental cows in day 2 (colostrum) and week 4 (mature milk) of lactation were found as 120 ± 16 and 15.4 ± 1 μg/L, respectively (17). In cows, there is no significant difference in PRL content of the milk between different milking. In contrast, season dose have a strong influence on PRL concentration, as the highest concentrations of PRL were found during July and the lowest levels obtained during November (6)." PRL is Prolactin
"IGF-1 is a 70 amino acid-linked polypeptide produced mainly by mammary gland and liver (24), but in general by all tissues and can act as an endocrine as well as paracrine and or autocrine fashion (25). This hormone is exist at higher concentrations in colostrums (103 ± 21ng/mL) than in blood, however, after parturition milk IGF-1 drops below blood levels (17, 26). The physiologic concentration of cows’ milk IGF-1 has been determined using immunoassay method (3). The authors reported that the physiologic levels of milk IGF-1 in cows are ranged from 4 ± 1 ng/ml. The broad area between minimum and maximum concentrations of IGF-1 in caws, milk could be due to differences in body weight, milk composition, diet, management practices, and other environmental factors. Since treatment of lactating cows with bovine somatotropin showed significant increase of milk IGF-1 concentration (27). No significant relationship between IGF-1 level in milk and milk production was reported. However, concentration of milk IGF-1 dramatically dropped during the lactation period as 6.3 ng/ml was detected on days 6–15 and 1.6 ng/ml was measured on days 210. As milk IGF-1 is not destroyed by milk processing especially pasteurization, thus it will be present in shelf milk, too (3).
Benefits of IGF-1: Benefits Dangers?
"The physiological role of IGF-1 on glucose metabolism and growth was demonstrated early in the 1980s (29). IGF-1 like as insulin play a central role in cellular glucose metabolism, amino acid uptake, glycogen synthesis, lipogenesis, and mitogenesis (30). Physiological effects of IGF-1 mediated via binding of IGF-1 to the type-1 IGF receptor, which is a heterotetramer with α-and two β-subunits linked by disulfide bonds. IGF-1 receptor is a member of the tyrosine kinase family, which following binding to agonist compounds (IGF-1), causes autophosphorylation of tyrosine residues in the carboxyl end of the intracellular domain and eventually leads to a cellular response (31). At the same time, the anabolic signals by IGF-1 (or insulin) can promote tumour development by anti-apoptosis effect and also by stimulating cell proliferation (30). During the last years according to the epidemiological evidence accuracy of the hypothesis is promoting, which indicates the risk of the colon, pancreas, endometrium, breast and prostate tumours are associated to the high level of IGF-1, insulin, or both"
