Personally I think that is a bit of a large daily dose.
The BioBlast human trials are as much as 27g IV per week. You'd be doing almost 3x that.
And there is the practical matter of how much volume of liposomal trehalose you'd be consuming. At 100mg/ml that's 100ml per day. The liposomal carrier is phosphatidylcholine. That's a lot of PC per day. I don't know if consuming that quantity per day would cause GI upset or other issues as I've never personally known someone that did it.
All good points. I guess I'm stuck in the mode where you need to up the dose a lot, but if this works similar to IV then the dose can be lower. I am also focusing in on the atherosclerosis mouse study, because it intrigues me the most, and they used over HED over 10G.
I'm going to look and see if there are any toxicity studies for PC. I'm not too worried about GI issues as I have an iron stomach. In lieu of a deep dive, here is what Wikipedia says about PC:
Possible health benefits
Senescence
Phosphatidylcholine is a vital substance found in every cell of the human body. Some researchers have used mutant mouse models with severe oxidative damage as a model of "accelerated aging" to investigate the possible role of phosphatidylcholine supplementation as a way of slowing down aging-related processes[8] and improving brain functioning and memory capacity in dementia.[9] However, a 2009 systematic review of clinical trials in humans found that there was not enough evidence to support the use of lecithin or phosphatidylcholine supplementation for patients with dementia. The study found that a moderate benefit could not be ruled out until further large scale studies are performed.[10]
Liver repair
Studies have examined potential benefits of phosphatidylcholine for liver repair. Results are mixed in animal models,[11] and no clinical evidence shows a health benefit in humans. One study shows the healing effect of phosphatidylcholine in mice with hepatitis A, hepatitis B, and hepatitis C. The administration of phosphatidylcholine for chronic, active hepatitis resulted in significant reduction of disease activity in mice.[12][full citation needed][unreliable source?]
Lipolysis
Some organizations[clarification needed] promote the use of injected phosphatidylcholine, otherwise known as injection lipolysis, claiming the procedure can break down fat cells, and thus serve as an alternative to liposuction. While the procedure cites early experiments that showed lipolysis in cases of fat emboli,[13] no peer-reviewed studies have shown any amount of lipolysis even remotely comparable to liposuction.[14][15] Injection of phosphatidyl choline in small numbers of patients has been reported to reduce or completely resolve a majority of lipomas, although some actually increased in size. There were side-effects, which resolved without complication. Long-term studies are deemed necessary to judge efficacy.[16][17] Dr. Patrick Treacy has used phosphatidylcholine and deoxcholate successfully in the treatment of infraorbital fat pads.[18]
Ulcerative colitis
Phase IIa/b clinical trials performed at the Heidelberg University Hospital have shown that delayed release purified phosphatidylcholine is an anti-inflammatory agent, and a surface hydrophobicity increasing compound with promising therapeutic potential in the treatment of ulcerative colitis.[19]
Possible health risks
A report in 2011 has linked the microbial catabolites of phosphatidylcholine with increased atherosclerosis in mice through the production of choline, trimethylamine oxide, and betaine.[20]
I was surprised at the possible benefits, but he last part is a little concerning, and more than a little ironic considering what I want to use it for. I will dig deeper into that and see if I can find anything definitive.