23 replies to this topic

[kurdishfella]

So I think something in my body is causing high levels of either ACTH OR CRH.... I dont know how but thats why I made this thread maybe someone here can help me find out what could be causing either of these 2 in excess? The only thing I can think of is a CRH/ACTH -Secreting tumor? I found some studies and it is very rare but say   I had it, am I correct in thinking that it would cause 24/7 anxiety? I did a bran scan recently but it was normal but next im doing a FULL body scan. Im wondering would a CRH/ACTH-Secreting tumor cause anxiety? Or cant it Cross the BBB? Im assuming the CRH or ACTH released from the tumor if it is outside of the brain would have to make its way into the brain if its in like the stomach?

And again what else could cause high CRH/ACTH levels caused by the body'? 

[kurdishfella]

So I have mutations in CRHR1, MGC57346-CRHR1 2.35 & CRHR1-IT1 (CRHR1 intronic transcript 1), Wtf  are the last 2????

Edited by farshad, 17 May 2018 - 05:37 AM.

[kurdishfella]

If you are able to increase cortisol will that decrease CRH? Since its like a negative feedback? 

[kurdishfella]

So only things I can think of that could cause too much CRH that your body cant handle would be autoimmune disease, CRH-secreting tumor or HPA Axis  disease. Am I correct?

 

[kurdishfella]

So I saw this: http://www.psypost.o...l-anxiety-47544

Researchers discover how the brain turns chronic stress into pathological anxiety-CB1-CRHR1 Mutations

 

I have mutations both in my CB1  ( cannabinoid 1 receptors ) and on selfdecode it says its better to have this increased, but I dont know if the mutations means I have low or high CB1 , assuming its low,+ I have CRHR1 mutations , it says on selfdecode that its best to have this decreased but then again  it doesent mention if my mutation causes the crhr1 gene to be increased or decreased... assuming it causes the CB1 to be decreased then I assume it causes the CRF1 to be decreased also? then my anxiety wouldnt stem from this, But if CB1 mutation is decreased and the CRHR1 mutation is increased then this could be the potential cause of my anxiety,

 

So all in all if we look at these mutations I have and then look at the article..... either I have a CRH tumor or my anxiety stems from the 2 mutations...

 

Edited by farshad, 19 May 2018 - 02:12 PM.

[kurdishfella]

The HPA axis
Corticotropin-releasing hormone (CRH) is secreted by a hypothalamic
region called the paraventricular nucleus (PVN) and
acts on CRH receptors in the anterior pituitary to cause the
release of adrenocorticotropic hormone (ACTH) into the
blood. ACTH acts on the adrenal cortex, which produces
and releases cortisol into the blood and participates in maintaining
homeostasis throughout the body. CRH also activates
the locus ceruleus (LC) which utilizes norepinephrine (NE) and
causes further stimulation of the PVN and subsequent release
of CRH. It also stimulates the amygdala, which is part of the
limbic system.

 

Hypothalamic Disease

A disease or disorder of the hypothalamus is known as a hypothalamic disease. A physical injury to the head that impacts the hypothalamus is one of the most common causes of hypothalamic disease.
Hypothalamic diseases can include appetite and sleep disorders, but because the hypothalamus affects so many different parts of the endocrine system, it can be hard to pinpoint whether the root cause of the disorder is actually related to another gland.
In particular, the hypothalamus and pituitary gland are so tightly connected that it’s often difficult for doctors to determine whether the condition is associated with the hypothalamus or pituitary gland. These are known as hypothalamic-pituitary disorders. However, there are hormone tests that help shed light on which part of the body is the root cause.
The hypothalamus is arguably the most essential of the endocrine system. By alerting the pituitary gland to release certain hormones to the rest of the endocrine system, the hypothalamus ensures that the internal processes of your body are balanced and working as they should.

 

[kurdishfella]

hmmm im trying to find out if I have a CRH secreting tumor or CRF1 secreting tumor...  (dont think there any wrong with my CRF2)

Edited by farshad, 29 May 2018 - 03:15 PM.

[kurdishfella]

so I have also https://www.selfdecode.com/gene/ace/ mutation

 

 

 

Description:

Having genes that increase ACE or angiotensin converting enzyme increase the stress response, causing the release of adrenaline and noradrenaline (Ref, Ref2)

The Renin-Angiotensin System (and ACE) increases the fight or flight nervous system, HPA axis (Ref), vasoconstriction, blood pressure, aldosterone, cortisol, vasopressin (Ref).

Secretion of CRH, ACTH, and cortisol is increased by stimulation of angiotensin AT(1) receptors.(Ref)

 

so CB1 mutations + CRF1 mutation + ACE mutation 

ALL 3 which increases the CRH.. So either my anxiety is caused by these 3 or I have a CRF1 secreting tumour...

 

I also have this mutation https://www.selfdeco....com/gene/il6/ (dont know if this affects my mood tho)

 

 

Studies have found that IL-6 aggravates the effects of stress hormones (CRH) on our gut mucosa

 

I heard autoimmune disease are caused by vaccines, no idea how true that is or if that can even cause elevated CRH...

 

So right now im trying to find if there are other causes for so much CRH that the HPA axis feedback lop cant produce enough cortisol to inhibit. (what else can cause excess CRF1)

Edited by farshad, 30 May 2018 - 03:42 PM.

[kurdishfella]

Im wondering are there any diseases that can make you have too much CRH (cortisol releasing hormone)? I think my anxiety is caused my too much CRH but someone said that is unlikely becuase there is a feedback loop if there is too much CRH then cortisol will be increased which will shut down CRH release. But I started looking up and I found a rare case of Cushings syndrome, rare case of CRH-secreting tumors (without ACTH secretion) have been reported, which stimulates pituitary ACTH production. There is like 15 reports of CRH tumor very rare.

So this would be the only plausible explanation for which there is too much CRH that there is not enough cortisol that would be able to inhibit it. A tumor that secrets CRH. 

 

If we look at this picture: https://bengreenfiel...._HPA_Axis.jpeg

 

If there is a CRH tumor that would mean it releases CRH 24/7, which would be impossible for the cortisol to inhibit becuase CRH would make you in a constant fight/flight mode and your anxiety would just get worse and worse and eventually the ACTH would go down becuase the anxiety would be so much the pituitary would give up. The cortisol would just stay high. But the CRH would still keep being released. Any experts here that can explain to me more about this CRH-secreting tumor? Im just trying to learn more about this CRH stuff. 

 

I read this SelfHacked article and everything fits how I feel: https://www.selfhack....e-role-of-crh/

the article also mentions there is In Hashimotos and UC(Ulcerative colitis?), inflamed tissues contained large amounts of CRH.

Im gonna have an full body MRI soon. I had a Brain scan Only and it was fine but im thinking the tumor is somewhere else.

 

What else can cause so much CRH that your body can not handle? just a tumor? 

 

Also Is it more plausible to have a CRH or CRF1 secreting tumor? Is the second even possible? CRH is a peptide hormone and CRF1 is a protein.. have not seen any study with CRF1 secreting tumor just CRH.

[kurdishfella]

how many different kind of cortisol tumors are there? I suspect I have a CRH/CRF1 tumor but im looking at others, wtf is a deoxycorticosterone producing tumor?

 

1. cortisol tumor

2. CRH/CRF1/CRF2 tumor

 

what else?

 

 

 

 

list: https://en.wikipedia...corticosteroids

 

which one would fit me? or should I say which ones have the capability  of causing anxiety? I still think I have a crh/cf1 tumor

Edited by farshad, 11 June 2018 - 12:28 AM.

[kurdishfella]

and these two...

 

GABA-B mutation https://www.selfdeco...om/gene/gabbr2/

 

NRG1 https://www.selfdecode.com/gene/nrg1/

[kurdishfella]

Neurofibromatosis type I

https://en.wikipedia...omatosis_type_I

[kurdishfella]

I just wanna say, if you watch Xanax Withdrawal or other benzo withdrawal videos of people or read about their experiences how they feel after they quit.. thats how I feel naturally before i even had taken any drugs and i have never taken a benzo. 

 

So from what I can understand, I say I have a crh tumor ok, i feel pressure in the middle of my head ok, hypothalmaus, the crh tumor must have reduced my gaba-a to very low cause im constantly relasing huge levels of cortisol releasin hormone. Now not only is my GABA-A very low but im now releasing even more crh due to stress + the tumor. 

my situation has  similar  properties with people who take xanax n quit, first the xanax increase GABA-A to high lvls then when quit their gaba goes down and their CRH goes higher and they feel worse than before.

 

xanax must have some long lasting damage on your GABA-A receptors, so thus CRH levels you feel are more intense.

 

Im only comparing xanax withdrawl people to me becuase that is the closest thing I have found so far to this crh tumor situation i  have.

 

 

 

 

[kurdishfella]

Encephalomyelitis https://en.wikipedia...cephalomyelitis

 

Multiple sclerosis https://en.wikipedia...tiple_sclerosis

 

[kurdishfella]

I have narrowed it down to these 3 plausible explanations...

 

1. hypermorphic mutation,  A hypermorphic mutation causes an increase in normal gene function. Hypermorphic alleles are gain of function alleles. A hypermorph can result from an increase in gene dose (a gene duplication), from increased mRNA or protein expression, or constitutive protein activity. (Increased CRF1 Activity)

https://en.wikipedia...rphs#Hypermorph

The phenotype of a hypermorph is worsened by increasing the wildtype gene dose, and is reduced by lowering wildtype gene dose.

 

m/Dp > m/+ > m/Df

 

hypermorphic (genetics, of a mutation) causing an increase in otherwise normal gene function. (Increased CRF1 Activity)

A type of mutation in which the altered gene product possesses an increased level of activity, or in which the wild-type gene product is expressed at a increased level. 

In hypermorphic mutation, the mutation results in an increase in gene activity, such as the expression of mRNA or protein, with respect to the wild-type allele. An example of hypermorphic mutation is that in the dominant alleles of the C. elegans gene lin-12 involved in cell-fate determination. Increased gene dose of lin-12 results in more cells transforming to another cell type.

Hypermorphic mutation follows the same reasoning: Any mutation that confers a phenotype as if there were over-expression or over-activity (relative to wild type) of the relevant protein. 

 

Opposite to Hypermorphic: Hypomorphic describes a mutation that causes a partial loss of gene function. A hypomorph is a reduction in gene function through reduced (protein, RNA) expression or reduced functional performance, but not a complete loss.

 

2.  autoimmune CRF1 disease

 

3. crf1 tumor

 

any tips are welcome.....

Edited by farshad, 24 July 2018 - 07:15 PM.

[kurdishfella]

so I have a mutation that causes too much mRNA or protein expression (not sure on what a wild type allele is, im guessing a natural mutation? or normal mutation). I have too many mutations stacking up resulting   in lots of activity in CRF1? idk my english is bad... point is I have high CRF1 activity..

 

 

 

Hypomorph Reduced, or partial reduced gene activity (opposite of what I have)

 

Hypermorph Increased or partial increased parent gene activity

 

 

 

some more SNP mutations I found:

XBP1 (X-box binding protein 1) - https://www.selfdecode.com/gene/xbp1/

FTO (FTO, alpha-ketoglutarate dependent dioxygenase) - https://www.selfdecode.com/gene/fto/

NPSR1-AS1 (NPSR1 antisense RNA 1) - https://www.selfdeco...gene/npsr1-as1/

NPSR1 (Neuropeptide S receptor 1) - https://www.selfdecode.com/gene/npsr1/

[kurdishfella]

hpa hyperactivity?

 

[kurdishfella]

Any process that involves the hypothalamus and interferes with corticotrophin-releasing hormone (CRH) secretion, such as hypothalamic tumors, surgery and irradiation, and autoimmune hypothalamic disease, will result in tertiary adrenal failure.

[kurdishfella]

Overactive Sympathetic Nervous System.

[kurdishfella]

So I don't think it's an autoimmune disease, becuase my only symptom is anxiety nothing else, if it was an autoimmine disease I would have my immune system fighting against me which I don't think it is...

 

but it says on wikipedia 1. Altered organ function so idk if that means you can have increased CRF1 activity to the point it is 24/7, surely it does have some effect but not to the extend my issue is at. So I will disclude this as I feel like my body is Okay besides this damn anxiety and the health effect it has caused: fatigue etc the normal problems you would see from an overactive CNS.

 

also  I don't think it is an crh tumor. for one i dont think it would affect my mood becuase of the BBB (blood brain barrier) cant cross and second i dont even think a tumor that secrets CRH would work in the same way as CRH is created and used ... idk so i will disclude this too. but i will still have an full Mri Scan.

 

so that leaves hypermorphic mutation which seems to be the only option that makes sense.

 

is it possible to have a hypermorphic mutation that increase protein activty  to CRF1? if thats a yes does it bypass the CRH ? im asking cause normally CRF1 is activated through the binding of CRF/CRH  so. 

 

CRF1 is a protein itself so im thinking yes it can bypass  without needing to go trough CRH? hm....

 

if hypermorphic is my problem and since it increases protein to CRF1 more due to mutations then that makes me ask does that mean im getting less protein to somewhere else and were would that be?

 

Edited by farshad, 16 August 2018 - 03:53 PM.

[PandorasBox]

You ever solve this problem?

[kurdishfella]

You ever solve this problem?

I think so, I believe my anxiety is caused by an mutation in my LMO3 gene causing excess CRHR1 levels in the basal amygdala. https://www.ncbi.nlm...les/PMC5924609/

[PandorasBox]

So how did you solve it tho?

Also hows your hair?

Edited by PandorasBox, 11 August 2020 - 08:01 AM.

[kurdishfella]

I have lost a lot of my hair due to the stress and it grows very slowly. I used to have very big curls and like an afro but it won't grow that much anymore. Why do you ask?

I also have bald spots. I haven't started treatment for my anxiety yet because I have encountered another problem. But I have Valproic acid and lithium carbonate in my desk waiting, which I ordered long time ago. Valproic acid decreases LMO3 and therefore it should decrease CRHR1 in the basal amygdala. Lithium itself decrease CRHR1 in the whole amygdala I guess.

https://www.research...euronal_Systems

 

hopefully they are synergetic together, since lithium decrease crhr1 in the amygdala but not receptor binding, but valproic doesnt decrease crhr1 in the basal amygdala (at least not in this study above but it should) but decrease receptor binding, together they will hopefully work well .

 

according to selfdecode it does https://selfdecode.c...o-decrease-gene

 

but not sure if valproate decreases  crf1 everywhere (especially in basal amygdala) or just one part of the brain?

Edited by kurdishfella, 11 August 2020 - 08:39 AM.