1. 08-25-2019: A brief update as I usually went over the literature and began to mull my head over in a pointless waste of time day as was today, I began to contemplate what else could I have missed in relationship to ADHD-PI? Well, I began to study tourette syndrome another co-morbidity disorder with a high inheritance of a whopping 75% with ADHD-PI and tourette syndrome. Their is also another group of ADHD people with hyperactive who had DSYLEXIA or dyscalcuia which is another seperate region impaired in the brain entirely. This makes sense, because for the longest of time I could no figure out WHY one group had more motivation and yet seemed to demonstrate incredibly SIMILAR impairments. This, i believe may be the defining characteristic between a true neurogenetic cause of ADHD, ask them did they or did they NOT have tourette syndrome as a kid? I had ALL of the symptoms, chronic eye blinking, clearing of the throat and other impulsive tendencies that I could not STOP and eventually they went away with time but I believe left permanent neurological differences, that were masked but NOT CHANGED and this is what the ADHD-PI is. I suspect, that the tourette syndrome may have preceded the ADHD at least on a neurological level and over-time the consequences of executive deficits manifested but the underlying neuro-genetic neurochemical cause of tourette syndrome remained. Which explains WHY people like JOHN sonomez, seem to have ADHD like thought process but seem to somehow have TOO MUCH energy and an INTACT executive system yet display similar conditions. He did NOT have tourette syndrome and this is what we should be using to separate the groups of children depending upon their original neurological condition.
2. So whats the big deal? Well, are first problem is that all stimulants have diminishing utility of return over long periods of time which has long sense been established in the literature and through repeated anecdotal experiments committed by various longecity members with the same complaints of emotional blunting, zombie effect etc. We already know all this and increasing energy in the entire BRAIN is NOT specifically targeting the real areas that are impaired. This is why all psychotropic interventions will fail because if you are not selectively getting the medication towards the correct part of the brain then it is meaningless. So, sense ADHD-PI is MORE DEBILITATING and HARDER to treat than ADHD-Hyperactive then what is the solution? Well, I believe the first condition we must investigate into is NO longer the ADHD-PI but rather the neurological underpinnings of what causes Tourette syndrome and what type of dysfunctions or permanent residual damages have been left from these developmental delays? I suspect, this would involve brain scans of adolescent boys which it PRIMARILY falls into and NOT girls and to see what areas are being impaired and is it consistently the basal ganglia? Then, we would analyze what groups with ADHD do and DO NOT have the tourette syndrome and do they display these tendencies? Keep in mind this happens in only 1% of children and this means I'm a very very small Minority of children. This should be the SINGLE defining factor of whether you have REAL ADHD, Did you have a neurogenetic BRAIN DELAY? If you did NOT, you probably do NOT have ADHD-PI. End of discussion. This allows us to censor the fucking idiots claiming to have this condition and to separate the REAL individuals . Next, I suspect, that SUSTAINABLE long-term treatments that truly target the deficits of ADHD must target the impairments of what tourette syndrome has seemed to damage. Potentially, this would allow for neurogenetic SPECIFIC treatment than neurogenetic GENERAL treatment which is akin to a caveman chemically lobotomizing you hoping you feel a little better. As we know, stimulants do not appear to fix the executive deficits but only the ability to sustain your focus over a long time span. Thus, this begs the question, if we are to achieve greater functioning to neurotypical functions, it can only be attained through an external device that mimics the PFC/Basal ganglia or directly attacks the deficit through neurochemical means, which might provide sustained treatment over the patients life-time until that individuals genes should have been genetically filtered from the defect. Thus, this explains why ADHD is not QUITE a diabetes of the brain because dopamine stimulants should Totally correct the dsyfunction of the brain but it DOES NOT DO IT like in the case of insulin towards diabetes which achieves 100% of normal blood sugar regulation that is dependent on INSULIN. If, we had these neurogenetic treatments that acknowledged and addressed the Tourette Dsyfunction in ADHD-PI, then it's probably that sustained treatments could correct these deficits to say 80% of neurotypical functioning, at least in speculative terms.
3. Tourette syndrome shares many similarities towards parkinson disease, huntingtons disease, psychopathy and conduct disorder and their are overlaps with many other disorders such as skizotypal, skizoid personality disorder, and borderline personality disorder where many psychiatric diseases seem to have high neurogenetic overlap. Thus, it's highly probably that many of these conditions share very similar real biological brain dysfunctions. In the case of tourette syndrome the basal ganglia and cerebellum are often noted to be overactive sending impulsive and inappropriate social gestures without regards to context of other individuals. These individuals have involuntary ticks and are often noted to be impulsive without regard to the context of the impulse. Perhaps, it may also be worth investigating what are the long-term manifestations of tourette syndrome that have gone dormant in adults and what are the long-term health consequences. Sadly, their is very little tourette syndrome literature and an over-flowing abundance of ADHD-PI literature that seems to potentially neglect is co-morbid cousin.
4. Within the next 5 to 10 years, with appropriate funding, I believe it's perfectly reasonable for SUSTAINABLE TREATMENTS to be neurogenetically SPECIFIC to the actual neurocognitive damage that CORRECTS the damage rather than generalizing the dysfunction across the entirety of the brain to be developed. Primarily, their is a great consumer demand for these treatments and their is sufficient economic incentive towards developing them with right investments. Unfortunately, these treatments will not develop without advances into the specific causes of tourette syndrome may lead to the breakthroughs in ADHD-PI sufficiently needed to truly understand what is really going on beyond the typical dopamine imbalance theory that is utterly outdated and does not explain the deeper developmental delays of the disorder. If we, have sufficient funding and lobbying this could be a reality only through sufficient support would lead to these breakthroughs just in time to achieve your potential while we are still young. 2 other potential developments could come from the field of CRISPR and genetic-modification of ADHD genes could lead to a theoretical cure to this disorder or even some type of eletronic head-device that allows for artificial PFC prefrontal cortex reinforcements that might mimic inhibition similar to the basal ganglia perhaps. How this would be created or implemented is unclear. We are rapidly reaching the middle of the 21st century and these technologies WILL be available well before 2050.
P.S As the years wear onward I implore you to reconsider and invest into the future of ADHD-PI treatments, for without these treatments development your life may become a waste if you are not careful. If are goal is to achieve all of are potential, then this must be an ultimatum to rapidly speed up treatments and new developements lest, your one life be a waste and you simply will NOT achieve your potential. If I'd like to remind you all, that you have only one life and then you will be dead. You will not get a second chance. So reconsider, investigate and advocate for ADHD-PI, for this is the only way towards speeding up the process. Lest, you ignore this message your fate will be the same as mine. You will go through tons of jobs, be an outcast, be low on the economic ladder and live for the day to day instant-gratification while you chronically exhaust yourself everyday brute-forcing life but it never works no matter how hard you work. Without new treatments with such proposals we may all be doomed to life of medicocrity.
/TLDR New insights On Tourette Syndrome/ Basal Ganglia, Neurogenetic-specific treatments, READ THE MESSAGE/SPREAD, New studies to the cause of tourette syndrome? What's the significance of Tourette syndrome? Is it the underlying causes of ADHD-PI?
Edited by MichaelFocus22, 26 August 2019 - 01:11 AM.