56 replies to this topic

[Daniel Cooper]

For it's anti-atherosclerosis effect?

 

I don't see anyone selling it as a supplement yet, but I have see Urolithin A powder up for sale on Amazon on occasion (unfortunately don't see any now).

 

Ideally what I'd really like to supplement with is the proper strain of gordonibacter urolithinfaciens then consume ellagic acid, but I can find no once sell a probiotic or even the raw bacterial strain.

 

So, anyone thinking about consuming Urolithin A and if so do you have a source and dose in mind?

 

 

 

 

[Oakman]

I've just received some Meeker Red Raspberry Powder, so it's raw material for making Urolithin A, if your gut can act on it. Perhaps the right raw material encourages natural gordonibactor growth?

 

[Daniel Cooper]

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens. 

 

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

 

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?

 

 

 

 

 

[William Sterog]

It would be awesome if someone would sell a probiotic with gordonibacter urolithinfaciens.

I'm frankly shocked that no one has such a product on the market. Barring that, Urolithin A is orally available and could be supplemented directly, and you wouldn't have to wonder if the bacteria actually did it's thing on the raw material.

Why is it that half the supplements that I think really might positively impact your health are unobtainable but all sorts of sketchy worthless things are out there in droves?

Care to talk about the supplements that you consider truly effective?

[normalizing]

how come only specific type of bacteria can make this thing? so how about the generally good bacteria we get from yogurt for example, what do they do with this?

[CHanderson]

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 

[Daniel Cooper]

Anti-aging Effects Of Urolithin A On Replicative Senescent Human Skin Fibroblasts.

https://www.ncbi.nlm...pubmed/30215291

 

Is worth a read.

 

Good info.

 

This is a very interesting compound.

 

If only we had a source for supplemental urolithin A or a gordonibacter urolithinfaciens probiotic.

[Nate-2004]

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.

[classicstrat]

If I had the means I'd find some way to isolate this bacteria and synthesize Urolithin A and find some way to isolate it. I don't know what kind of equipment that takes. Probably more than I can afford.

https://www.nutraing...ite-urolithin-A

[Nate-2004]

https://www.nutraing...ite-urolithin-A

 

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin. 

Edited by Nate-2004, 24 September 2018 - 11:28 PM.

[classicstrat]

Not so simple as just eating pomegranates and hoping you have the *right* gordonibacter species that can produce specifically (and only) the A variety of urolithin.

That trial in the link assumes you don't need to, from what I gather.

Amazentis delivered lab produced Urolithin A directly to people with no toxic effects.

[John250]

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP

[normalizing]

with all the titanium dioxide in there, you are likely to find mostly negative long term

[classicstrat]

I use the following product but haven’t noticed anything positive or negative.

https://www.amazon.c...n/dp/B076XQM7HP

That doesn't contain Urolithin A

[John250]

That doesn't contain Urolithin A

Oops it was Urolithin B.

[Jim Morrison]

Oops it was Urolithin B.

In the Ryu paper UB also extended lifespan in the worms. "We found that feeding worms from eggs until death with UA, UB, UC or UD at a standard concentration of 50 μM extended lifespan by 45.4, 36.6, 36.0 and 19.0%, respectively, as compared to the vehicle-treated population".  In the paper, they just focused on UA since its the most prevalent EA-derived metabolite observed in humans.

 

https://www.nature.c...rticles/nm.4132

Edited by Jim Morrison, 30 October 2018 - 06:58 PM.

[Daniel Cooper]

I have this vague memory of reading that urolithin B not being as good for atherosclerosis and maybe even having some negative impact.  However, I don't seem to find anything to back that up.

 

Am I just mis-remembering?

 

Also, has anyone found a source for urolithin A?

 

 

[John250]

I have this vague memory of reading that urolithin B not being as good for atherosclerosis and maybe even having some negative impact. However, I don't seem to find anything to back that up.

Am I just mis-remembering?

Also, has anyone found a source for urolithin A?

Isn’t urolithin A in pomegranate? Maybe Pomella powder from nootropicsdepot.

[Jim Morrison]

Isn’t urolithin A in pomegranate? Maybe Pomella powder from nootropicsdepot.

 

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/

Edited by Jim Morrison, 31 December 2018 - 03:11 PM.

[Daniel Cooper]

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/

 

 

I assume that Amazentis is going for a prescription drug versus a supplement.  If so, this seems years away.

 

Does anyone have a contact as Amazentis?  I've tried to contact them to no avail.

 

 

 

Edited by Daniel Cooper, 21 January 2019 - 03:12 PM.

[GABAergic]

my question is, why is there no probiotic with the species Gordonibacter? How do you make sure you have this bacteria otherwise? its likely most of us do not have it

 

anyway, this is in relation to amazentis, it seems Nestle is involved with them now; https://www.nutraing...aging-potential

[Daniel Cooper]

my question is, why is there no probiotic with the species Gordonibacter?

 

 

I've asked this question many times.  If it exists I haven't found it.  

 

I haven't even found a laboratory source of Gordonibacter urolithinfaciens.  

[GABAergic]

so, whats left is to just do a test and see if one has that specific type bacteria then. is there such a test yet? i heard there are already tests to check your microbiome but im not sure if they can do that for all of them. in fact, im not even sure where i read there is a test at all but im certain ive seen it somewhere...

[JPY]

According to this press release Amazentis is partnering with Nestle and will release Urolithin A as a supplement. Still no indications on the timeline, though. 

 

http://pdf.amazentis...pril_2_2019.pdf

[Mind]

Maybe Urolithin A contributes to mitophagy and cellular health: https://www.longecit...l-and-cellular/

[Daniel Cooper]

Maybe Urolithin A contributes to mitophagy and cellular health: https://www.longecit...l-and-cellular/

 

I suspect that is the mechanism by which it improves cardiovascular health and decreases age related muscle wasting.

 

Unfortunately Urolithin A seems to be unobtainium at the moment.

 

Amazentis is working on it, but it's unclear to me whether they are developing it as a drug or a supplement.  I reached out to them a couple of years ago but never got a response back.

 

I believe that I have seen a body building supplement in Vitamin Shoppe or someplace similar that purported to contain Urolithin B.  I'm unclear if the B variety carries the same cardiovascular benefits.  But, that does give me some hope that it could potentially be marketed as a supplement as opposed to a drug. 

 

We have a number of specialty supplement makers/retailers (TRL, RevGenetics, Relentless Improvement, etc) here.  I wonder if one of them might be enticed into looking into bringing a Urolithin A supplement to market.

Edited by Daniel Cooper, 16 June 2019 - 05:10 PM.

[OP2040]

Also can't wait for this.  Since it seems to be a potentially cheap and effective game-change, it should be ready just in time for our great to the power of 100 grandchildren.  The good news is that I'm primed and ready as my microbiome test shows that I have a whopping .04% of the Gordonibacter  species needed to pump this stuff out.  That sounds low, but it's all relative and it could be a lot for all I know.  To be fair, no one said these are the only species that produce Urolithins, they are just the only ones known so far. 

 

Anyway, I'll get some pomegranate extract and give the little buggers plenty to chow down on

[AIP]

Good discussion. Thanks for all the beta ( rock climbing reference)... this looks promising. Currently I just take a pretty hefty dose of pomegranate extract with a high concentration ( reported ) of ellagic acid so perhaps a small amount metabolizes into urolithin A but if not pomegranate has its upsides and its just part of my stack. 

[sedentary]

Pomegranate contains ellagitannins that are metabolized by the microbiome (of some) to UA. Sadly most of the ellagitannins are in the white parts of the pomegranate. So, IMO, even if you have the right microbiota genotypes consuming the juice will be rather inefficient. May have to go for (hole) fruit powder as suggested, or a smoothie of the entire interior of the fruit

 

I haven't found any commercial UA source except analytical standards. We may have to wait for Amazentis to launch their product. AFAIK its in Phase II now for Cachexia.

 

Edit: Link: https://www.amazentis.com/

 

uhm actually the ellagitannins are present in the seeds, some in the white parts but also a lot in the peel which is impossible to consume. but you can chew on the seeds and get some of it. not sure if fruit juices contain any of those parts except the juice surrounding the seeds. but it might contain some of the seed breakdown products just like wine does because i can sense the dryness of tannins on my tongue. perhaps its best to for pomegranate wine since it contains less sugar due to fermentation. its probably healthier versus juice, just in the case of wine vs grape juice.

[Brundel]

I can make ellagic acid cyclodextrin complex available to you guys probably.
I believe urolithin a is a metabolite.