5 replies to this topic

[Saffron]

If I've already done this thread, I stil,nwish to redo it.

This is a hypothetical thought. Rather than the strongest or most effective psychoactive, this is about the ones that would be the most compatible with the population.

The drugs that would have the highest percent of people have very mild to no side effects.

And the highest number of people desiring to stay on them, with the least amount of "drug-feeling" while still psychoactive and life enhancing in some way.

The "cleanest drugs" in existance albeit tendancg toward mildest.

And for even more perspective, the ones that could easily exceed caffeine in safety and compatibility,

That I would argue, could be aldo be carried for sale everywhere there is also coffee

The universal stackers for the general population as the first move in applied abolitionism

I believe these to be:

NSI-189

PPAP (PhenylPropylAminoPentane) A simple phenethylamine that is extremely clean

Bromantane

Oral Dihexa

Selank & Semax Gel

ITPP (Inositol trispyrophosphate)(the sole physical enhancer)


The Maybe Entry:

Perhaps some nasal spray with Naloxone, Low Dose Flumazenil & a single microgram of haloperadol & naltrexone, that's just one MICROgram of the h & n, folks. This would at least upregulate BZD receptors from the Flumazenil, if not having any other effect. But why not include the others anyway. No T.D. ftom one MICROgram. Only inverse agonists are sure to upregulate. Not silent antagonists as much.

Recap of list definition: the cleanest psychoactives with the highest guesstimate of safety in the longer term

Runners Up that I either dont believe are good enough to make the list, or am unsure:

Noopept
Neurosteroids (unsure)
Tianeptine (5 mg & 15 mg would make the list, but you can gather why it has to stay off this list. It should be made as widely cheap and available, yet NOT included on this list


Bet ya over 95% can take some modest dose of these, and out of that 5% left, most would have given up due to a coincidental side effect not from the drug. The compatibility number would be high, and higher than theobromine in chocolate, caffeine's castrated des-methyl analog; let alone caffeine its self, the most used drug.These specimens are just really clean, but none of them are powerful in a regular dose. Can't expect much, compatibility number might be considerably lower if you factor in lack of motive to continue due to efficacy strength and/or how gradual the weak neurotrophic effect is, like the counterpart to slow boil of a frog. .
This is meant for anyone to reply suggesting the cleanest drugs that exist

Edited by Saffron, 13 July 2018 - 02:54 PM.

[John250]

A little stronger but I’d say:

Ssri’s: Lexapro

Antipsychotics: Abilify

Anticonvulsants: Lamical

ACE: Lisinopril

Beta Blocker: Nebivolol

PDE5: Cialis

Dopamine antagonist: Ropinirole

Serotonin nootropics: Selank, Semax, Bacopa

Serotonin: 5-HTP

Dopamine nootropics: Bromantane, 9-me-bc

Dopamine: Jiaogulan, DanShen, Tri Butyrate

NMDA: Memantine

GABA Nootropics: Emoxypine

GABA: Skullcap, Valerian

Glutamate Nootropics : Noopept

Norepinephrine: DMAA, DMHA

Melanocortin: Agomelatine

Glucose: Metformin

Edited by John250, 13 July 2018 - 04:08 PM.

[Saffron]

There's no way some of those could make the list in this pointless but interesting thought experiment. Abilify and lexapro would never make it

Some stuff like Agomelatine might make the list but you've got dopamine agonists which caused a ton of people nausea and ssris a ton of side effects and incompatibility and you've got an anti-psychotic in there about things

Those things would never make a 90 95% compatibility. Psychoactive drugs are notorious for having only a portion of the population able to take them and like them so what this experiment is to list a few rare exceptions whereby practically every person to take them and wouldn't mind any side effects for a compatibility

Agomelatine agend melatonin even get a lot of complaints from people claiming that they're still drowsy when they get up. Drugs like nsi-189 and bromantane are rare exceptions. These could be used by the whole population practically. And you wouldn't see any complaints from them except for coincidence and very rare idiosyncrasies. That's it.

If you start putting things like the Menmantine on the list, youve got stuff that's going to make people say they have a dissociative feeling in their head area and are foggy. The goal is to list the ones that are unusually Universal. I can tell you these are it. they don't even feel like drugs in anybody

[Saffron]

Personally I myself would need something strong with all of these like 150 mg tianeptine or Suboxone

[Saffron]

In the separate issue of what would be most helpful for depression that would probably be Suboxone sadly. Because it's so happens to block the dysphoric Kappa receptor yet partially stimulate the mu receptor, and that's exactly what you want in dysphoric depression. Fill agonists would be so compatible and sustainable and they don't block kappa, but some depressives would need a full Agonist.

In the separate topic of most compatible with treating depression I would say that Suboxone. Again that's a separate topic that I wanted to add. And the original topic is for all people compatibility rather than severe depression compatibility

In other words I'm saying that the drugs I listed in the original post we get the highest favorable rate with the lowest side effects in the general population. But when it comes to severe depression that's endogenous, the drug that we get the highest efficacy rate is probably Suboxone

Depression is an ambiguous term that refers to a handful of different disorders that are completely different from each other. Because of this, there is no treatment for lifelong endogenous dysphoria. If you separated out the separate disorders that are labeled as depression and tested this latter group, the antidepressants would then all fail and everything would fail until they allowed things like Suboxone.

There's no such thing as treatment-resistant depression because those people are just all the people who have a separate disorder with the drug is targeting the wrong mechanism. And the people with the other stuff going on give the false response rate for the antidepressants.

It would be like testing antihistamines with people having both allergies and a common cold, then all the people with the cold are still sick when all the people with the allergies are treated, then they say the people with the cold are treatment-resistant because they're giving them the wrong medication.. if they tested the people with the cold or other disease separately from the allergy people they would get a zero efficacy rate and be forced to develop or release other drugs instead.

I hope people can understand this analogy and concept. It is true that would cause great cognitive dissonance in the Psychiatry world and one of the great medical tragedies

Edited by Saffron, 13 July 2018 - 08:11 PM.

[John250]

In the separate issue of what would be most helpful for depression that would probably be Suboxone sadly. Because it's so happens to block the dysphoric Kappa receptor yet partially stimulate the mu receptor, and that's exactly what you want in dysphoric depression. Fill agonists would be so compatible and sustainable and they don't block kappa, but some depressives would need a full Agonist.

In the separate topic of most compatible with treating depression I would say that Suboxone. Again that's a separate topic that I wanted to add. And the original topic is for all people compatibility rather than severe depression compatibility

In other words I'm saying that the drugs I listed in the original post we get the highest favorable rate with the lowest side effects in the general population. But when it comes to severe depression that's endogenous, the drug that we get the highest efficacy rate is probably Suboxone

Depression is an ambiguous term that refers to a handful of different disorders that are completely different from each other. Because of this, there is no treatment for lifelong endogenous dysphoria. If you separated out the separate disorders that are labeled as depression and tested this latter group, the antidepressants would then all fail and everything would fail until they allowed things like Suboxone.

There's no such thing as treatment-resistant depression because those people are just all the people who have a separate disorder with the drug is targeting the wrong mechanism. And the people with the other stuff going on give the false response rate for the antidepressants.

It would be like testing antihistamines with people having both allergies and a common cold, then all the people with the cold are still sick when all the people with the allergies are treated, then they say the people with the cold are treatment-resistant because they're giving them the wrong medication.. if they tested the people with the cold or other disease separately from the allergy people they would get a zero efficacy rate and be forced to develop or release other drugs instead.

I hope people can understand this analogy and concept. It is true that would cause great cognitive dissonance in the Psychiatry world and one of the great medical tragedies

I think it would matter what form of depression. Depression can be serotonin related, dopamine related, GABA related, etc.