Hi, guys and gals!
I'm vegetarian, 32 y.o., male, lifestyle: did 10 min of fitness each day, last week or two—no fitness, just walking a lot due to exhaustion, prefer a whole food plant based diet.
I got insomnia, surprisingly, after taking C60OO (bought on Amazon from manufacturer with good reviews, 99.95% purity), I think it's not a coincidence because after I started taking C60 (1-3ml), during the period of around 3 weeks, my sleep progressively got worse (as well as headache) until it disappeared, I stopped taking C60, but my sleep hasn't recovered since. I had some sleep issues before (for about one year), I'd have a deep good night sleep for something like a week, and then one day wouldn't sleep because my head would be tense, I'm sleepy, but consciousness is present throughout the night, now it's tense every night. In addition to sleep issues, some other symptoms: constant tension headache, tinnitus, blinking in the eyes, fatigue (for about ten years). Doctors were treating the symptoms with sedatives, nootropics, and antidepressants and then I stopped taking those 3-5 years ago.
Then after one week of minimal sleep I decided to take some blood tests (do not include hormones other than of thyroid and parathyroid) and it turned out I had a severe vitamin D deficiency 9.4 ng/ml (probably for many years because of little sun exposure), and it's linked to sleep problems and more. Other abnormalities in blood test: low ferritin—28 ng/ml (the lab recommends 30-400), HoloTC—53 pmol/l (a bit higher than minimal '> 50'), folic acid—4.67 (3.89—26.8), glucose always near the top border because gallbladder was removed—5.78 mmol/l (4.11-5.89), PLT—154 cells/l (180-360), MPV—13.3 (6-13), eosinophils per 100—0.4% (0.5-5.0), eosinophils abs—0.03 (0.04-0.54), HDL—0.73 mmol/l (>1.45), KA—3.96 (<3), creatinine—59 mkmol/l (62-106). Normal results: homocysteine, calcium ionized, magnesium, potassium, zinc, iron, phosphorous, ALP, thyroid/parathyroid hormones, thrombin time, LDL, triglycerides, cholesterol, GGT, complete blood count (except few above), transferrin, and albumin. Took methylation test: MTHFR C677T +/-, MTHFR A1298C +/-, MTR: 2756 +/-, MTRR: 66 -/- (homozygous).
Now one month later after taking 10k IU of D3, the 25-(OH)D level is 37.69 ng/ml, calcium ionized is a tiny bit higher than upper limit, but my sleep hasn't improved, now I plan to take less - 5k IU each day. Can't take much methylcobalamin, from previous experience it caused worse sleep and I became more emotional, waiting for methylfolate to arrive. Some say it takes one year for the symptoms of deficiency to disappear, but still, quite suspicions that with this level no improvement with sleep.
Do you think C60OO could speed up a depletion (that the body used more than ) of some nutrients that might have caused this insomnia? Even though I'm vegetarian, I'm willing to take some supplements from meat or meat itself temporarily for few weeks/months because I'm desperate if it can potentially help.
I tried different supplements without much success, can't take magnesium glycinate or other forms because my nose becomes stuffed and it doesn’t seem to improve sleep, CoQ10 helped me to get non deep sleep throughout the night with three awakenings, but I think it lowered my blood pressure because my breathing was a bit suppressed and blinking in the eyes was more intense. K2—bigger headache, less sleep, gelatin (it has glycine) and glycine itself helped me the first day, but not the next (today), don't know what I did wrong. L-tryptophan, took tiny dose (1/8 of a 500 mg capsule) in the morning and during the night had dome light symptoms of serotonin toxicity—hyperventilation + racing heart, I guess I don't need serotonin boosting drugs? L-lysine—felt weird and has a lot of red in the eyes, from choline bitartrate—depression for two days, similar reaction from inositol, melatonin 2mg didn't seem to have much effect, maybe if I take it each day for a prolonged period of time, it'd show some effect or combine with, say, 500mg of valerian root + melatonin + maybe gelatin. Also tried something a little bit more serious - Doxepin, 2mg, but managed to fall asleep in 6AM, slept till 7, then woke up and were in zombie state for half a day with suppressed breathing. Some people say that MK-677 has a good night sleep as a side effect, I have it but hasn't tried, because it can significantly effect different hormones so I'm extra careful, seen also Ipamorelin might have same side effect but it requires shots under the stomach skin .
A neurologist prescribed me Quetiapine (Seroquel, etc) 1/2 of 25 mg, and then 25 mg for one week. From some drugs I get sleep apnea/hyperventilation, I'm afraid I won't wake up from something as powerful as Quetiapine, and CPAPs are expensive.
I'm not from an economically developed country and don't know if I'll be able to find a high quality doctor. Not saying that my neurologist is bad I just don't yet know. Another reason for insomnia—psychological, I didn't have any psychological trauma, maybe just stress, but I suspect a severe vit D deficiency is the cause for these symptoms that look like they're stress related.
I'd be extremely grateful for your advice.
Thank you.
Edited by spike, 18 August 2018 - 10:12 AM.