This topic is lockedSo per other discussion threads outlining the problems with NAD+ precursors (not enough NAMPT for salvage, NAM byproduct, salvage cycle dysregulation) there have been notable strides by startups to pursue ways to improve NAD+ levels by indirect means. One of these would be CD38 inhibition and while Apigenin has been discussed off topic in NAD+ threads I don't think it's been discussed in this capacity and context on its own. At least not according to a forum search.
Is there harm in CD38 inhibition? Complete inhibition? Probably, but apigenin is likely a weak inhibitor. Quercetin as well.
Mouse study:
https://www.ncbi.nlm...les/PMC3609577/
AbstractMetabolic syndrome is a growing health problem worldwide. It is therefore imperative to develop new strategies to treat this pathology. In the past years, the manipulation of NAD(+) metabolism has emerged as a plausible strategy to ameliorate metabolic syndrome. In particular, an increase in cellular NAD(+) levels has beneficial effects, likely because of the activation of sirtuins. Previously, we reported that CD38 is the primary NAD(+)ase in mammals. Moreover, CD38 knockout mice have higher NAD(+) levels and are protected against obesity and metabolic syndrome. Here, we show that CD38 regulates global protein acetylation through changes in NAD(+) levels and sirtuin activity. In addition, we characterize two CD38 inhibitors: quercetin and apigenin. We show that pharmacological inhibition of CD38 results in higher intracellular NAD(+) levels and that treatment of cell cultures with apigenin decreases global acetylation as well as the acetylation of p53 and RelA-p65. Finally, apigenin administration to obese mice increases NAD(+) levels, decreases global protein acetylation, and improves several aspects of glucose and lipid homeostasis. Our results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways.
This article mentions the above in vivo mouse study in passing, perhaps just as an avenue of exploration. No big patent money can be made off apigenin so nobody's paying for the research.
https://www.scienced...550413116302248
That's it, that's all there is above. Nothing else on apigenin published in this context of research. It's in vitro and both quercetin AND apigenin have absolutely terrible bioavailability problems. The study referenced uses injection to deliver the apigenin. Other studies show 11mg / 100mg at best in terms of absorption. It's fat soluble so ways to improve absorption may be black pepper extract or certain fats taken with or perhaps a liposomal solution.
Yet for now, it's all we have. If CD38 is in fact inhibited, in humans, in vivo, with apigenin, then maybe, just maybe it might be a better, cheaper alternative to NAD+ precursors.
Anybody on this board aged 60+ want to try washing out and using some agreed upon formulation of apigenin? The only brand that sells this is Swanson, so unfortunately we have to rely on the hope that their labels are accurate.
This article mentions the above in vitro study in passing, perhaps just as an avenue of exploration. No big patent money can be made off apigenin so nobody's paying for the research.
https://www.scienced...550413116302248
That's it, that's all there is above. Nothing else on apigenin published in this context of research. It's in vitro and both quercetin AND apigenin have absolutely terrible bioavailability problems. The study referenced uses injection to deliver the apigenin. Other studies show 11mg / 100mg at best in terms of absorption. It's fat soluble so ways to improve absorption may be black pepper extract or certain fats taken with or perhaps a liposomal solution.
Yet for now, it's all we have. If CD38 is in fact inhibited, in humans, in vitro, with apigenin, then maybe, just maybe it might be a better, cheaper alternative to NAD+ precursors.
Anybody on this board aged 60+ want to try washing out and using some agreed upon formulation of apigenin? The only brand that sells this is Swanson, so unfortunately we have to rely on the hope that their labels are accurate.
Edited by Nate-2004, 31 August 2018 - 08:01 PM.
