18 replies to this topic

[experimenting]

First off, anyone still using it?

And has anyone seen this? Fatty Liver?

https://www.ncbi.nlm...les/PMC4720477/

[theobromananda]

Despite studies to the contrary, I got horrible horrible IBD flares every time I used it. Not sure why there are studies that say that uridine is positive in colitis. The p2x7 receptor which is stimulated by uridine is involved in its pathogenesis.

[experimenting]

Bumping this. I too noticed irritable bowel at high doses but that isn't a problem lower down.

Who's still using it? Are the effects permanent, does anyone have a handle on the dangers?

[brosci]

I've read that fatty liver is often an issue with an insufficient choline availability. With CDP-choline being a source of both choline + uridine, it seems like this could be a good way to get around that issue... unless TMAO / heart disease is some issue with supplementing choline.

[experimenting]

I've read that fatty liver is often an issue with an insufficient choline availability. With CDP-choline being a source of both choline + uridine, it seems like this could be a good way to get around that issue... unless TMAO / heart disease is some issue with supplementing choline.

Insufficient choline would be caused by uridine use? I'm using tiny doses (25mg) so I don't think this is an issue?

[dosquito]

Uridine was probably the most noticeable supplement I've ever taken. It would give me a few hours of great, clean focus every time. Then I bumped my head again and I never really felt the effects quite the same.

[experimenting]

Uridine was probably the most noticeable supplement I've ever taken. It would give me a few hours of great, clean focus every time. Then I bumped my head again and I never really felt the effects quite the same.

 

Right now I'm focused more on permanent healing rather than acute nootropics use. With that objective in mind uridine seems to stand out as one of the few supps out there that promises long-term results, without tolerance, etc etc. But threads on it seem to have died out here and recently a few dangers came to light so I'm not really sure how to proceed.

 

You have any familiarity with longer-term use, efficacy, and dangers?

[dosquito]

I don't know what the dangers are, but I remember the hype too and my friend used it too and we both agreed it was awesome. He stopped takin it when he started smoking weed again. I don't think they go well together. I used it for about 2 months and recently got a new bottle. Seems promising for recovering from drugs in particular. Something about restoring normal dopamine activity.

[experimenting]

I don't know what the dangers are, but I remember the hype too and my friend used it too and we both agreed it was awesome. He stopped takin it when he started smoking weed again. I don't think they go well together. I used it for about 2 months and recently got a new bottle. Seems promising for recovering from drugs in particular. Something about restoring normal dopamine activity.

That's my understanding too. Restores sensitivity of dopamine receptors, with permanent effect. The permanent part is what motivates me, of course. Sticking with my low doses and noticing a moderate improvement in mood and motivation. Not trying any of the cofactors yet because my dose is low and I like to isolate effects.

[John250]

https://www.selfhack...m/blog/uridine/


Is Uridine Right For You?

Uridine Triphosphate stimulates the P2Y2 receptor, which is the pathway by which it stimulates neurons.

A point I bring up often is cancer/autoimmune tradeoff. P2RY2 activation is good for autoimmune conditions, but not so great for most cancer:

P2RY2 enhances proliferation, adhesion, migration of cancer and increases the immune suppressive ability of Tregs.
Activation of T Regulatory Cells (Tregs) is on the whole bad for cancer, but good for autoimmune conditions.

Uridine SNPs:

If you have 23andme, you can check these SNPs out:

RS10898909 (P2RY2)
RS1783596 (P2RY2)
RS4944831 (P2RY2)

[experimenting]

Also uridine inhibits bone formation? In vitro. Worrying because I'm getting good effects so far. Anyone have a clue with this one?

[dosquito]

seems like the most reasonable solution is to take it for 1-2 months then stop

[brosci]

With CDP-Choline being a pro-drug for uridine with a 48-72hr half-life, do these concerns (cancer / bone health / liver health) also apply to CDP-choline, which I suppose inherits a new TMAO concern ?

Edited by brosci, 01 January 2019 - 09:20 AM.

[experimenting]

With CDP-Choline being a pro-drug for uridine with a 48-72hr half-life, do these concerns (cancer / bone health / liver health) also apply to CDP-choline, which I suppose inherits a new TMAO concern ?

 

 

Suppose so. FWIW I'm having trouble with Uridine. It does make you hypermotivated but it's a one-trick pony-dopamine only. My ability for higher thought basically disappeared on it. 

[dosquito]

That's interesting. I did notice it helped a lot for gaming and routine tasks at work, but never considered the higher level thinking

[experimenting]

That's interesting. I did notice it helped a lot for gaming and routine tasks at work, but never considered the higher level thinking

Yeah, you become a bit of a task killing zombie. I tend towards glutamate which makes you into a smart thinker but without dopamine, no motivation...this flipped me to the opposite.

Really at this point I'm trying to step around my warrior gene. So a single NT approach isn't quite the way to go-I probably need some sort of COMT inhibitor.

[dosquito]

where can i learn more about dopamine / glutamate?

[experimenting]

where can i learn more about dopamine / glutamate?

This site, I would think! I'm no expert. But if you post I'm sure people will jump on in.

[GABAergic]

i drank plenty of beer which is super high in uridine. i guess it probably worked not sure because of the alcohol influence hard to tell. i did read it can be cancer causing agent in some studies in really high doses tho. i cant find the study now sadly, but i read it, its out there.