413 replies to this topic

[smithx]

Because they used ER niacin and inositol hexanicotinate interchangeably.

 

If you are just saying that with no data, it's very irresponsible and could injure someone who believes you.

If you do have data, please provide references.

 

With regard to the link I posted to FDA prescribing data, they are clearly discussing only actual niacin. There is no mention of any other form and they go into detail about flush reactions.

Edited by smithx, 10 January 2021 - 08:24 AM.

[aribadabar]

Nobody will injure themselves at normal doses (<=500mg/d) be it instant or ER version.

At 2-3g/d continuously, one needs to monitor their liver enzymes regardless of the form used. In other words, excessive amounts of anything can lead to injury.

[McQueen]

Can anyone tell me what happened to the group buy for Trodusquemine. I couldn’t tell, trying to leaf through all the pages, what became of this. I noticed the link no longer goes to the original paper on Trodusquemine. Also, is Squalamine a viable alternative? Was the original claim about Trodusquemine proven to be too good to be true?

[Rocket]

Nobody will injure themselves at normal doses (<=500mg/d) be it instant or ER version.

At 2-3g/d continuously, one needs to monitor their liver enzymes regardless of the form used. In other words, excessive amounts of anything can lead to injury.

Whoever marked this post as dangerous needs to get educated on niacin. High levels of niacin DO cause liver damage.

If anyone is going run niacin in grams per day then they should be on TUDCA simultaneously for liver support.

[PatrickW]

Whoever marked this post as dangerous needs to get educated on niacin. High levels of niacin DO cause liver damage.

If anyone is going run niacin in grams per day then they should be on TUDCA simultaneously for liver support.

 

Thanks for the advice Rocket.  I see that TUDCA comes in 500 mg pills, with a recommended max daily dose of 2g.  What daily dose would you recommend for liver protection when taking 2g per day of Niacin?  Oh I'm also taking 1g per day of NAC (N-Acetyl-Cysteine) which I see is used synergistically with TUDCA, so maybe that would reduce my need and/or dosage requirements for TUDCA.  Thanks!

[Rocket]

Thanks for the advice Rocket. I see that TUDCA comes in 500 mg pills, with a recommended max daily dose of 2g. What daily dose would you recommend for liver protection when taking 2g per day of Niacin? Oh I'm also taking 1g per day of NAC (N-Acetyl-Cysteine) which I see is used synergistically with TUDCA, so maybe that would reduce my need and/or dosage requirements for TUDCA. Thanks!

1 gram a day completely fixed my liver enzymes that run high from some of my supplements.

My doctor was pretty astounded and when i told him my secret he poo pooed it and brushed it off.

[Daniel Cooper]

Did you guys ever get a group buy for Trodusquemine together?

[Rocket]

1 gram a day completely fixed my liver enzymes that run high from some of my supplements.

My doctor was pretty astounded and when i told him my secret he poo pooed it and brushed it off.

What references do you want? Its clearly visible in my blood work for 6 straight years. When I don't take tudca my liver enzymes are high from my supplements. When intake tudca my liver enzymes are perfect.

End of story. All I can do is pass on knowkedge and experience.

[MangekyōPeter]

The equipotent and equi-efficacious Trodusquemine analogue Claramine is available.  PM if interested for info. Thanks.

[ZCKZ]

Have you any successful anecdotes, Peter? Wasn’t able to pm you.

[Daniel Cooper]

The equipotent and equi-efficacious Trodusquemine analogue Claramine is available.  PM if interested for info. Thanks.

 

References for the equal potency and efficacy of claramine?

 

I assume you're talking about Team TLR and their claramine.

[MangekyōPeter]

If you look at the studies in the published literature that assay both trodusquemine and claramine they denote the basic equivalencies

[Daniel Cooper]

If you look at the studies in the published literature that assay both trodusquemine and claramine they denote the basic equivalencies

 
There are some studies for certain specific applications that seem to show equivalence. For instance, off the top of my head I can think of a study that shows that claramine probably works as well as trodusquemine for restoring blood sugar control in Type 2 diabetic patients. And it seems to have a similar PTP1B inhibition activity.
 
But, we don't have a study that I'm aware of for atherosclerosis. We only have that one study on trodusquemine and it has some very odd results - a one time dose of trodusquemine seems to regress arterial plaques, but chronic doses don't. That's a very unexpected, which implies it's just an experimental fluke or that we really don't understand the underlying mechanism. We assume it's PTP1B inhibition, but that's a guess. If it is, claramine probably works as well.
 
But, they aren't identical. For one, as far as I can tell, claramine doesn't cross the BBB. That's an important difference for people interested in trodusquemine's apparent ability to treat Parkinson's Disease. It probably doesn't work at all for that.
 
I guess what I'm saying here is that we're on the bleeding edge, we don't have confirmation that trosdusquemine actually does regress arterial plaques, but the only testing we have is on trodusquemine so therefore claramine is a further step removed from something we aren't entirely sure works in the first place.
 
BTW - the study for diabetes:  Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound

 

 

[Rocket]

Ptp1 inhibition is also achieved by supplementing with squalamine. I've been on it for a few months now. I've seen a consistent lowering of blood pressure. I didnt have high bph to begin with but my numbers are better. Does that mean there were some plaques forming that are now gone? I can't answer that. My n=1 experiment for your consideration.

[ryukenden]

Ptp1 inhibition is also achieved by supplementing with squalamine. I've been on it for a few months now. I've seen a consistent lowering of blood pressure. I didnt have high bph to begin with but my numbers are better. Does that mean there were some plaques forming that are now gone? I can't answer that. My n=1 experiment for your consideration.

 

Does it lower both systolic and diastolic pressures? How much reduction? Can you please share where I can get it?

Thanks

[ryukenden]

I wonder some of you who take Squalamine can share where I can get it?
Thanks

[Lionve_2011]

Does anyone know where to get claramine

[Rocket]

Does anyone know where to get claramine

Contact TeamTlR. Someone here had done that and they were willing to compound it for us.

I suspect like most things that benefit mice it may not translate to humans 1 to 1. After all when something dies of old age at 2 years old its fairly easy to get 25 and 50% increases in life and healthspan.

I would be more confident if there had been primate studies like CR.

Until then the only other ptp1b inhibitor I know you can buy is squalamine.

[Snapper]

Following on from the posts about AMPK activators, here are some points which may be of interest.

 

Reading about Berberine and Conjugated Linoleic Acid (both AMPK activators), I read that CD36 (a receptor which binds fatty acids and oxidized LDL among other things) is upregulated by these substances.  This would appear to lead towards fatty liver and atherosclerosis.

 

https://www.osti.gov...ocase-cd36-mice

 

https://www.ncbi.nlm...les/PMC3160137/

 

https://www.scienced...041008X16303957

 

However, there are conflicting reports for both substances, as positive studies for atherosclerosis can also be found.

 

https://www.ncbi.nlm...les/PMC4261588/

 

https://bpspubs.onli....1111/bcp.12948

 

AMPK activation may also decrease cholesterol production, which would explain the reduced plaque formation in cases of supplementation of activators.

 

https://journals.plo...al.pone.0124951

 

CD36 appears to have a modulatory effect on AMPK. If CD36 is blocked or downregulated, AMPK is activated.  In theory, with CD36 blocking and AMPK activation, atherosclerosis could be reversed.

 

ttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037633

 

There are some available CD36 inhibitors.

 

https://journals.sag...087057109359686

 

Rosmarinic acid, from Rosemary, Lemon Balm, Sage etc., being one.

 

https://www.jmcc-onl...0065-5/fulltext

Edited by Snapper, 26 October 2021 - 12:39 PM.

[DougClean]

Did you guys ever get a group buy for Trodusquemine together?

 

Hi Guys I was looking for some trodusquemine just to see if find someone that sells it. I'm pretty good at finding thing online.

 

well these guys say that you can buy some for $500.00  per Mg Kinda steep but they do have a add to cart button.

 

I don't know anything about them I just found the website today so I thought I would pass it on

 

You will need to add the real dot com I am a newb so I cant post links

 

aobious Dot Com  /aobious/enzyme-inhibitors/13083-trodusquemine-msi-1436.html

 

And I found these guys not sure if its the same stuff its $675.00 for 160mg

 

teamtlr DOT COM /home/179-claramine-98-trodusquemine-analog.html#/amount-160mg
 

Edited by DougClean, 29 October 2021 - 07:10 AM.

[Moondancer]

Did everyone loose interest in Trodusquemine, or are there still people interested in a group buy?

[Beetlejuice]

Did this buy go ahead? Seems I dropped out somewhere. So interested in outcome etc

[Wookie]

Did this buy go ahead? Seems I dropped out somewhere. So interested in outcome etc

 

Anybody have interest in Claramine? Easy to get and inexpensive. Anyone hazard a guess at an effective dose?

[Daniel Cooper]

Anybody have interest in Claramine? Easy to get and inexpensive. Anyone hazard a guess at an effective dose?

 

Easy to get where? 

 

Would much rather have Trodusquemine which is actually studies for the applications most have in mind.