hi, ive been doing a little bit of looking. I found out I have high CRH-CRHR1 signaling, so since CRHR1 can only be activated with CRH I thought why not take a drug that reduces CRH which clomipramine does by up to 74% CRH mRNA expression in the PVN. Anyhow my question is has anyone been on this drug for Social anxiety?
I also did a bit reading what could possibly cause high CRH-CRHR1 and I found something called hypermorphic mutations which means increased gene function and another possible cause could be CRH-Secreting tumor.
On wikipedia it states:A hypermorph can result from an increase in gene dose (a gene duplication), from increased mRNA or protein expression, or constitutive protein activity.
would clomipramine reduce CRH in all these cases? Becuase it is different ways of CRH being produced and clomipramine only reduces mRNA , It will of course help with increased CRH mRNA , but what about the other three?
Also what about CRH-Secreting tumor, would clomipramine help in this case too in reducing the CRH?
CRH has to go the mRNA route also right? but what if you have a tumor that secrets CRH in your kidney? thus clomipramine wouldnt reduce CRH there cause clomipramine only does such in the PVN . But CRH cant cross the BBB right becuase it is a peptide and needs certain proteins? so I wouldnt worry about the CRH-tumor unless it is in the brain right for causing high CRH?
currently im taking st johns wort which does the same as clomipramine but only reduce CRH up to 22%, only after 8 weeks, im only like 40 days in so but doesent seem to be working so far.
Edited by farshad, 08 September 2018 - 09:17 PM.
