4 replies to this topic

[REBUILDER]

I take 600mg/day of Kirkland CoQ10 for M.S. My plasma CoQ10 levels are elevated but my inflammation biomarkers were also (still) elevated on my last blood test:

• My CoQ10 level is 2.98 ug/mL, as reported by True Health Diagnostic$. (Optimal levels are > 0.73)
• Homocysteine is 13 umol/L. (optimal is 10-12, 15+ is high)
• hs-CRP (C-reactive protein) is 6.8 mg/L (>2,9 is abnormal)

I cannot find many research papers on PubMed where scientists have used Ubiquinol or MitoQ for actual research, instead I just find unproven claims that these CoQ10 variants are more biovailable. The research that I have found on these substances have all been performed by the manufacturers themselves. I also just discovered yet anothervariation, called AQUA Q10, the "Water Soluble Form of CoQ10". I'm thinking about raising my dose and also buying a combination Ubiquinol/PQQ product to supplement my Coq10 intake, but I'd prefer to have solid research to back up my purchases.

[pamojja]

Has anyone here had any luck lowering their C-reactive protein levels using CoQ10?

 

Not only with CoQ10, but comprehensive nutrients supplementation, herbals and diet (including those prescribed for example in this blog post). My CRP + ESR-history:

year   CRP   ESR
2006   96     74
2009    1.6    8
2010    3.2   26
        3.5    5
2011    2.7    4
2012    2.7    -
        7.6    -
2013    6.6  130
        0.7    7
2014    4.8   15
        3      -
2015    3.2   16
        1.8    7
2016    1.3   12
        0.8    5
2017    2.7   32
        0.7    3
2018    1.8   32

The highest CRP in '06 I wasn't even aware of. Only 2 years later with a PAD diagnosis and a 60% walking disability I started to take my health in my own hands, and requested copies of these older results. Was treated a myo-pericarditis with antibiotics in a hospital at that time.

 

With the new diagnosis I started with Orthomolecular medicine and changed diet. With which I made great progress by improving my pain-free walking distance from 3-400 meter at worst, up to 1 hour in the first year. 2 hrs the second. In 2012 suffered the whole year a chronic bronchitis, and by the end of the year with still no improvement I drew the towel and went for 5 months to a South-Indian beach to recover with the aid of warm sea-air (walking-distance having reduced to 1/2 hr again). From then onward also utilizing copious amounts of Ayurvedics.

 

Beginning of '13 - at the time of the highest ESR of 130 and short after the highest CRP of 7.6 I got for 1 month really sick (high fever, nausea, vomiting - probably typhoid fever) and suddenly improved again. From then onward seeing a yearly further decline in CRP proceeding.

 

Though I also observed a paradoxical pattern. Since 2012 I returned each January for 6 weeks to the same beach for vacations. And all those times had the higher CRP and ESR each year. With the second measurement at home always lower. Contrarily, liver and kidney marker always lower there, while borderline high at home.

 

 

PS: In 2015 my walking-disabilty has been revoked, from that year also had my only CoQ10 serum level tested at 3.3 µg/ml. Have been taken in average 110 mg of ubiquinone along with 50 mg/d of ubiquinol for the last 10 years. Also had the experience that stress-related (physical or mental) angina-like chest-pain ceased with about 160 mg of ubiquinone, or half that amount in ubiquinol. That has hold true and worked for me now for 10 years.

Edited by pamojja, 03 October 2018 - 06:10 PM.

[REBUILDER]

Not only with CoQ10, but comprehensive nutrients supplementation, herbals and diet (including those prescribed for example in this blog post). .. Have been taken in average 110 mg of ubiquinone along with 50 mg/d of ubiquinol for the last 10 years. Also had the experience that stress-related (physical or mental) angina-like chest-pain ceased with about 160 mg of ubiquinone, or half that amount in ubiquinol. That has hold true and worked for me now for 10 years.

 

Thanks for replying. I've seen that blog post, but I didn't find it helpful or appropriate for me since I have Multiple Sclerosis.  I'm really more interested in your diet because I'm trying to create one of my own.  Right now I'm going with the "Best bet diet" (for multiple sclerosis) and adding tons of spices for antioxidants and their anti-inflammatory effects.

 

My C-Reactive protein is expected to be high because of systemic inflammation from my bodies reaction to the disease, but I'm hoping to keep my inflammation under control so that it doesn't cause other health problems in addition to my M.S.  I have no proof that this can actually be done.  My only real hope is to live long enough for scientists to find a cure - basically I'm shooting for longevity-escape-velocity. 

 

As for CoQ10 and PQQ, now I'm currently taking 500mg CoQ10, 20 mg PQQ, twice a day for a total dose of 1000mg CoQ10 and 40mg PQQ each day. I'm avoiding alternative forms of CoQ10 because I don't trust the research and don't believe we have an accurate "systems biology" understanding of how supplementation alters either normal biochemistry or a diseased system

[MikeDC]

Ubiquinol is better than COQ10. COQ10 is useless in the body until it is converted to Ubiquinol. Old people can’t convert COQ10 to Ubiquinol efficiently. So you may have high levels of COQ10, but it is not doing any good for your body.

I have taken Ubiquinol for over 10 years. I think it is useful. But I can’t feel any effects. NR is quite different. I felt it after two weeks. So I rate NR much higher than Ubiquinol. If my money is limited, I would choose NR first.

[MikeDC]

MS can be treated with NR.

https://www.ncbi.nlm...e sclerosis nad