9 replies to this topic

[ryukenden]

I understand Fisetin goes through extensive hepatic metabolism.

I am thinking of how to make Fisetin skin cream as there are so many senescent cells in our skin,

What do you think of making a Fisetin skin cream? How to make such cream?

[able]

Stir it in some DMSO and roll on?

 

Worked well for me with NMN.  

 

Not a cream, but it likely would do the job of carrying it into the skin, which is what you are after, isn't it?

Edited by able, 10 October 2018 - 06:59 AM.

[ryukenden]

Stir it in some DMSO and roll on?

Worked well for me with NMN.

Not a cream, but it likely would do the job of carrying it into the skin, which is what you are after, isn't it?

Thank you

[QuestforLife]

Very good idea!

 

There seems to be disagreement on exactly how soluble Fisetin is in DMSO; I've seen a range from 10-57mg/ml quoted. Nevertheless even at only 10mg/ml, you could dissolve a gram of fisetin in 100ml of DMSO.

 

Of course it might just go straight into the blood stream rather than remain in the skin for long enough to exert it's effects there. But either way you'd have avoided liver first pass metabolism. If you wanted to specifically hit the senescent cells in the skin maybe you'd need to reapply this multiple times a day to make sure the dermis is getting the benefit.

[ryukenden]

Very good idea!

There seems to be disagreement on exactly how soluble Fisetin is in DMSO; I've seen a range from 10-57mg/ml quoted. Nevertheless even at only 10mg/ml, you could dissolve a gram of fisetin in 100ml of DMSO.

Of course it might just go straight into the blood stream rather than remain in the skin for long enough to exert it's effects there. But either way you'd have avoided liver first pass metabolism. If you wanted to specifically hit the senescent cells in the skin maybe you'd need to reapply this multiple times a day to make sure the dermis is getting the benefit.

Thank you. I have ordered both Fisetin and DSMO and will try to dissolve 1 gram in 100 ml.

[XRT doc]

Does anyone know if it would better to use dmso liquid vs gel. Also, can adding edta increase absorption?

Edited by XRT doc, 15 October 2018 - 03:06 PM.

[ryukenden]

I found the following study using topical Fisetin on mice.

https://www.ncbi.nlm...00/#!po=23.2143

[Daniel Cooper]

I found the following study using topical Fisetin on mice.

https://www.ncbi.nlm...00/#!po=23.2143

 

 

In that study they used polyethylene glycol (PEG) 400 as the vehicle.  I think I'd use that instead of DMSO since we have no test data on that combination.

[ambivalent]

Anyone know of the excipient in Swanson's Fisetin and associated risk-profile?

[ryukenden]

In that study they used polyethylene glycol (PEG) 400 as the vehicle. I think I'd use that instead of DMSO since we have no test data on that combination.

Good point, thank you.