The whole is greater than the sum of its parts.
Don't go crazy looking for a single item that will have this effect, unless you have access to state of the art genetic editing allowing you to upregulate genes encoding for MitoCatalase and MitoSOD.
The name Protandim was later put to some shame but IIRC that was some other formulation or just somebody using the same name.
The safest way is probably to simply buy the ingredients stand alone and dose them yourself.
This is the reason I eat curry powder with turmeric roots, black pepper, drink a glass of red wine, coffee and green tea on the same day.
Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model
Oxidative stress is an important contributor to cancer development. Consistent with that, antioxidant enzymes have been demonstrated to suppress tumorigenesis when being elevated both in vitro and in vivo, making induction of these enzymes a more potent approach for cancer prevention. Protandim, a well-defined combination of widely studied medicinal plants, has been shown to induce superoxide dismutase (SOD) and catalase activities and reduce superoxide generation and lipid peroxidation in healthy human subjects. To investigate whether Protandim can suppress tumor formation by a dietary approach, a two-stage mouse skin carcinogenesis study was performed. At the end of the study, the mice on a Protandim-containing basal diet had similar body weight compared with those on the basal diet, which indicated no overt toxicity by Protandim. After three weeks on the diets, there was a significant increase in the expression levels of SOD and catalase, in addition to the increases in SOD activities. Importantly, at the end of the carcinogenesis study, both skin tumor incidence and multiplicity were reduced in the mice on the Protandim diet by 33% and 57% respectively, compared with those on basal diet. Biochemical and histological studies revealed that the Protandim diet suppressed tumor promoter-induced oxidative stress (evidenced by reduction of protein carbonyl levels), cell proliferation (evidenced by reduction of skin hyperplasia and suppression of PKC/JNK/Jun pathway), and inflammation (evidenced by reduction of ICAM-1/VCAM-1 expression, NF-κB binding activity, and nuclear p65/p50 levels). Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer prevention.
Each ingredient of Protandim has shown antioxidant activities (Bacoside [27]; silymarin [28]; W. somnifera powder [29]; green tea [30]; curcumin [31]). However, the combination of ingredients creates a synergistic effect and lowers the concentration of each ingredient in the induction of Nrf2-regulated antioxidant enzymes [13].
https://journals.plo...al.pone.0005284
