BDNF expressed in motor neurons
https://en.wikipedia...ki/Motor_neuron
(Selank/Semax)
Posted 08 April 2019 - 02:02 AM
Posted 08 April 2019 - 12:30 PM
The most obvious thing to me is excessive tension, if you have that it can interfere.
One thing I always seem to notice while taking Cerebroylsin (main part of it is akin to CNTF I believe but also BDNF, etc), at least the first few days is that my general movement in daily tasks is smoother, easier and not requiring much thought/efforts. I'm guessing that's mostly due to it having some sort of mild relaxing effect, but it might also be far beyond that.
On the other hand something like oral tobacco seems to cause worsened coordination and a lot of tension for me. Also that happened when I supplemented CDP Choline.
Posted 08 April 2019 - 01:20 PM
GDNF and NGF etc has involvement in movement?
Posted 12 April 2019 - 01:38 PM
One thing that causes my hands to feel shakey is exercise. So resting helps with that.
Posted 24 April 2019 - 12:08 PM
Familial multiple system atrophy etc
Posted 30 April 2019 - 08:40 AM
https://www.ncbi.nlm...pubmed/26054881
ubiquinol (COQ10) (ATP)
https://www.ncbi.nlm...pubmed/29797183
adenosine A1-Dopamine D1 Receptor Heteromers Control the Excitability of the Spinal Motoneuron.
Cerebrolysin
Cerebrolysin nanospheres slowed disease progression in a mouse model of Parkinson’s [R].
Additionally, cerebrolysin promoted the survival of brain cells and improved motor symptoms in rats with Parkinson’s disease [R].
It also reduced oxidative stress, restored brain dopamine levels, and improved behavior in rats with Parkinson’s disease [R].
Edited by farshad, 30 April 2019 - 09:34 AM.
Posted 30 April 2019 - 10:05 AM
Dopamine, nitric oxide, ATP, acetylcholine , adrenaline and noradrenaline
https://www.verywell...smitter-2795394
what else?
Posted 30 April 2019 - 07:13 PM
Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality.
Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. And it also inhibits Nitric Oxide which could have further implications in movement.
what neurotransmitters control the spinal cord?
Edited by farshad, 30 April 2019 - 07:15 PM.
Posted 01 May 2019 - 09:03 PM
https://www.webmd.co...is-akathisia#2
valproate perhaps helps movement
Edited by farshad, 01 May 2019 - 09:05 PM.
Posted 06 May 2019 - 01:25 PM
Probiotics may have beneficial effects in Parkinson’s disease: in vitro evidence
Enzyme linking Parkinson's & Alzheimer's: AEP. The enzyme is called asparagine endopeptidase or AEP. In healthy brains, AEP is found only in lysosomes, the structures in the cells that act as a waste removal system, digesting excess or worn out materials, viruses, or bacteria
Posted 07 May 2019 - 04:45 AM
Progesterone reduces spasm and relaxes smooth muscle. Bronchi are widened and mucus regulated. (PRs are widely present in submucosal tissue.
Anti-inflammatory (curcumin longvida etc) drugs may prevent Parkinson disease (PD) by inhibiting a putative underlying neuroinflammatory process.
Collectively, these results indicate that during stress, CRH leads to the activation of skin mast cells through the CRH1 receptor which triggers vasodilation and increased vascular permeability.
https://www.ncbi.nlm...les/PMC5143486/
https://www.ncbi.nlm...pubmed/25987207
Edited by farshad, 07 May 2019 - 05:02 AM.
Posted 07 May 2019 - 04:37 PM
anything that improves bone health? https://takecareof.c...nts-bone-health
https://en.wikipedia...wiki/Cerebellum
Edited by farshad, 07 May 2019 - 04:53 PM.
Posted 08 May 2019 - 02:31 AM
Posted 09 May 2019 - 03:03 AM
Nine patients who had Parkinson’s disease were treated with tyrosine and probenecid. These patients showed an increase in homovanillic acid in the cerebrospinal fluid. The presence of homovanillic acid, a product of dopamine energy production, correlates to the fact that dopamine is being released in the brain [14].
Because Parkinson’s is strongly linked to the degeneration of neurons that release dopamine, increased levels of homovanillic acid could be good proof that tyrosine may be used to treat the disease [14].
Posted 09 May 2019 - 08:44 PM
I believe all these things that improve movement in any way shape of form can also increase strength, mobility, speed and such via the spinal cord mainly.
Posted 12 May 2019 - 03:55 AM
7,8-DHF improved motor function and prevents the loss of dopamine-related neurons in a mouse model of Parkinson’s disease [30, 31, 32].
It also prevents the death of dopamine-sensitive neurons in monkey models of Parkinson’s disease [33].
Probably MAO-Inhibitors too
https://en.wikipedia...hyl-β-carboline
Posted 12 May 2019 - 08:50 PM
Synthesis of anandamide seems to be related to dopamine. https://www.ncbi.nlm...les/PMC4404240/
Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. https://www.ncbi.nlm...pubmed/26244281
Thyroid hormone level is associated with motor symptoms in de novo Parkinson's disease.
Edited by farshad, 12 May 2019 - 08:54 PM.
Posted 15 May 2019 - 06:26 AM
Posted 20 May 2019 - 01:53 PM
8) TUDCA May Help Treat Parkinson’s Disease
TUDCA protected nerve cells in a mouse model of Parkinson’s disease [28].TUDCA prevented c-Jun N-terminal kinase (JNK) activation. The JNK pathway leads to the death of neurons in Parkinson’s disease [29].
Posted 26 May 2019 - 08:40 PM
Amyotrophic Lateral Sclerosis (ALS) is predominately a sporadic neurodegenerative disease affecting spinal motor neurons rapidly leading to paralysis and dysfunction in the respiratory system. R
CNTF may be dysregulated in ALS patients and rodents. R R R R
MANF (similarly to VEGF) can potently protect and restore dopamine neurons in the brain. R R R
For example, MANF can protect dopamine neurons and alleviate Parkinson's Disease (PD)-like symptoms in animal models exposed to the toxin 6-hydroxydopamine (6-OHDA, a toxin that destroys dopamine neurons in the substantia nigra). R R
By regulating ERS, MANF improves motor function more efficiently than other neurotrophic factors. R
MANF's effects improving PD are even more effective when combined with CDNF or GDNF. R R R R
CDNF (as well as GDNF and MANF) is commonly low in Parkinson's Disease (PD) patients. R R
Parkinson's Disease (PD) is characterized by a loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) as well as an accumulation of α-synuclein (a biomarker of PD) in the central and enteric nervous system. R
CDNF is able to restore dopamine and the function of brain lesions of PD models in vivo. R R
This effect is even greater when combined with GDNF or MANF. R R
CDNF can dissolve α-synuclein buildup in neurons. R R
It can decrease the damage of dopamine neurons from oxidopamine (6-OHDA). R R
It can decrease damage from MPTP (a neurotoxic precursor for dopamine neurons). R
CDNF also improves motor functions in animal models of PD. R R
Posted 27 May 2019 - 09:45 PM
In a mouse model of Parkinson’s disease, treatment with Lion’s Mane reduced dopaminergic cell loss and attenuated motor deficits [15], suggesting that Lion’s Mane can slow down the progression of Parkinson’s Disease.
https://www.ncbi.nlm...les/PMC5351233/ tylenol
https://www.ncbi.nlm...les/PMC2592845/ Uridine & DHA (Omega 3)
Edited by farshad, 27 May 2019 - 10:34 PM.
Posted 20 June 2019 - 11:50 PM
I think the spinal cord has a big role in accurate and STRONG movements.
Here we show that a loss-of-function approach, blocking BDNF results in a significant reduction in dendritic spine density, associated with an increase in spine length and a decrease in head width. These changes are associated with a decrease in F-actin levels within spine heads.
Dopamine-containing neurons in the spinal cord: anatomy and some functional aspects.
Posted 22 June 2019 - 11:31 AM
Someone probably already said this but "smooth muscle movements" is probably a very complicated thing in humans. So I would probably advice anyone who tries to "get better aim" in say counter strike or FPS games or maybe better performance in fighting games (moving their wrist or thumb better without accidental inputs) to not over-analyze various studies etc. you come across too much that deals with basic stuff in the body/brain.
I encourage experimenting and trying to figure things out, however I think first thing to be considered is the old-school ways of performance enhancing oneself. I don't know what pro gamers do, really, but various stimulants can probably have effectiveness overall at the right (low) dosage. Nicotine, caffeine, methylphenidate, etc.
However with those substance you can certainly run into the risk even with low dosages of causing too much muscle tension and thus getting worsened dexterity/fluidity/ease -of movement. And many situational factors matter. For example I have played a lot of Tekken 7 recently and one of the things that require a lot of dexterity (and muscle memory) is crouch canceled back dashes (korean backdashes). When I have been in stressful situations (playing against famous players or live on stream even without showing my face just 500+ people seeing my gameplay) and taking my regular dosage of methylphenidate (like 10mg IR, or 20 mg ER) that have caused me I'm sure to get worse performance overall in terms of dexterity, I think just due to overall stress being too high and so I got trouble with the KBD inputs cause my thumb got all stiff. IME some of the racetams can cause muscle tension too, just like regular stimulants.
Another thing some people use to get better performance in gaming is beta blockers (but those I'm pretty sure don't boost overall alertness, but might rather blunt reaction time (maybe, I don't know) they certainly can make one a bit more aloof and mildly fatigued/tired).
Anyway I guess my only real advice with this ramble is to pay attention to how you feel when you play, and if you do try some substance at some point don't understimate that it can cause things to go too far in one direction or have paradoxical effects. (The most extreme example of paradoxical effects with drugs I can think of is damphetamine and methylphenidate, that stuff in low doses can cause a lot of relaxation and tiredness for some people and from time to time. First time I got 10mg/day d-amphetamine prescribed the first week I felt super tired and relaxed, then it switched over to more expected effects. I still get rather tired from my prescribed methylphenidate right after I take it in the morning, on some days.)
Also disclaimer: some of these substances I mentioned are addictive, especially nicotine is super addictive. And may cause health problems. The biggest danger with low dose d-amphetamine or methylphenidate is shared with caffeine, may cause heart/blood pressure problems in certain individuals, including sudden unexpected death. Tbh I think anyone who drinks lots of caffeine (esp periodically like some kid gamers) should probably check to see if they dont have a heart problem beforehand, just go to a doctor and say you have "high heart rate often (or fatigue), I wonder if it might be something wrong with my heart" and maybe you can get an ultra sound and an electrocardiogram to check for any obvious defects. At the very least take a blood pressure if you use caffeine (or beforementioned stimulants) a lot.
Posted 24 June 2019 - 08:35 PM
Mild iodine deficiency causes abnormalities in movement
Posted 09 July 2019 - 02:29 PM
Valproic acid increases reelin mRNA levels. Reelin stimulates dendrite and dendritic spine development and regulates neuronal migration.
Posted 09 July 2019 - 03:37 PM
I mostly made this thread because I wanted to improve my aim in games.....
Posted 09 July 2019 - 08:09 PM
Valproic acid enhances recovery of motor function
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