33 replies to this topic

[able]

I'm not doubting your numbers but would be interested to hear if others also think the numbers are like 200,000 compared to a few thousand.   If that's the case then why is that?  Is it because NR is easier to obtain, because it came out first, because it's cheaper or simply because it's considered to work better than NMN.   How about sublingual NMN compared to NR?

 

 

NR has been sold for 4 years at least.

 

NMN did not become even remotely affordable until late 2017.  And doesn’t have the big corporations like Chromadex and Elysium spending millions to advertise it,  so of course it doesn’t have the large customer base.

 

We argue about the science  lot here, but I often feel like a chimpanzee trying to understand what makes a  race car go faster.   Maybe we'll hear in a few years what the research says comparing them.  But so far, there is no research with direct comparisons on effectiveness.

 

I do notice the NMN powder has a 4 1/2 star average on amazon.  The tablets don’t seem quite as popular, with 4 star average, followed by the NMN capsules.

 

Even though it cost less, Tru Niagen is at 3 1/2 stars.  I don't know if that is an indicator of customer satisfaction, or some other market forces I don't understand.

Edited by able, 04 December 2018 - 02:27 AM.

[Nate-2004]

If you read some of the 1 star reviews that bring the rating down, you'll see that they complain of damaged packaging and effects that may or may not be attributable to the supplement at all. In addition to this, some complaints were similar to those here on the board "I took it and felt nothing". I don't know what people expect to feel when replacing lost NAD+ that has dropped an indeterminate amount relative to a younger age. There is no telling what their lifestyle is like. Most people are absolutely stupid, not being arrogant here it's just a fact. Plus, the most common fallacy committed by the general lay public is the post hoc ergo propter hoc fallacy, this means that people are attributing something that happens after an event or change and cause and effect are assumed with great bias and no consideration for other confounding variables.

 

Also, it should really, *really* only be taken on days in which there is NAMPT increasing activity such as exercise.  I do not believe that any of the precursor NAD+ supplements will pan out in the long run because nobody will take it properly. Ultimately the goal should be to boost NAMPT and/or resolve the increase in NAD+ consumption, not just create more NAD+. This is obvious. 

[MikeDC]

Increasing NAMPT will not be easy and will likely cause side effects. Blocking CD38 could also have side effects. These interventions will need long term clinical trials. NAD+ precursors are the easy and safe way to deal with it for now.

[Nate-2004]

NAMPT is known to increase with exercise and may explain why the rats fed NR who exercised had the best outcomes.

 

https://www.ncbi.nlm...pubmed/19887595

https://www.scienced...047637409001523

 

Also, HSF1 improves NAMPT levels, and from that we may be able to conclude that NAMPT is increased by sauna use, since sauna use boosts HSF1

 

http://jcb.rupress.o...ntent/216/3/551

https://www.hindawi....m/2018/1857413/

 

Apigenin, as a CD38 inhibitor, has low bioavailability to begin with. On top of that, just because something is an inhibitor doesn't mean it is strong, or enough to reduce levels altogether. It's probably a mild enough inhibitor to be safe. Then again nobody's looking at it.

 

 

Edited by Nate-2004, 08 December 2018 - 05:41 AM.