7 replies to this topic

[Clavius]

What does it mean if my premature ejaculation is non-existent in the morning, but very severe in the evening? The difference is so very significant that I wish it was the other way around!

But what does it mean? Just the fatigue? Or is it dropping serotonin levels during the day? Does anybody recognize this?

 

I have to add that I deal with a lot of anxiety due to aspergers. So that won't go away.

[CalmDown]

Serotonin usually rises as it gets closer to bed time as adrenaline/norepinephrine/dopamine levels lower so you can get to sleep.

From a general standing, it sounds like you have elevated(or standard) levels of adrenaline in the morning that delay ejaculation and in the evening they are much lower. Could be related to cortisol levels and adrenal output, could be related to a handful of other things.

However, all of this is base speculation as you haven't given a detailed overview of what your daily regimine is, if this has always happened, any stressors in your life, current supplements, any other symptoms or health issues you currently have.

[airplanepeanuts]

I would guess that you tense up during the day and relax in your sleep (free from your conscious mind at that time).

[Clavius]

Serotonin usually rises as it gets closer to bed time as adrenaline/norepinephrine/dopamine levels lower so you can get to sleep.

From a general standing, it sounds like you have elevated(or standard) levels of adrenaline in the morning that delay ejaculation and in the evening they are much lower. Could be related to cortisol levels and adrenal output, could be related to a handful of other things.

However, all of this is base speculation as you haven't given a detailed overview of what your daily regimine is, if this has always happened, any stressors in your life, current supplements, any other symptoms or health issues you currently have.

 

Thanks for the response. And sorry for being vague a bit.

 

Yes, this has always happened to me. Full control in the mornings, none in the evenings. Also, full control when I'm alone. None when with a partner in the evenings. 

 

Currently my regimen consists of Modafinil, ALCAR and Agmatine Sulfate. Modafinil was perscribed to me by my psychiatrist recently. None of these substances have had any positive or negative effect on my problem. Although Modafinil does make me feel more focused / more "into it".

 

On blood tests my cortisol is always elevated. Which correlates with my chronic anxiety. Lowering that anxiety has been the main focus of my therapy in the past years. I've given it my best, but all those tricks that I learned in therapy just don't seem to alleviate it at all.

[CalmDown]

Thanks for the response. And sorry for being vague a bit.

Yes, this has always happened to me. Full control in the mornings, none in the evenings. Also, full control when I'm alone. None when with a partner in the evenings.

Currently my regimen consists of Modafinil, ALCAR and Agmatine Sulfate. Modafinil was perscribed to me by my psychiatrist recently. None of these substances have had any positive or negative effect on my problem. Although Modafinil does make me feel more focused / more "into it".

On blood tests my cortisol is always elevated. Which correlates with my chronic anxiety. Lowering that anxiety has been the main focus of my therapy in the past years. I've given it my best, but all those tricks that I learned in therapy just don't seem to alleviate it at all.

A few things come to mind. Given cortisol levels are naturally more elevated in the morning than the evening could give reason. As cortisol is known to delay it in high levels.

It almost sounds like you are more predisposed to have PE, and the things you take currently just delay it in the morning before they start to wear off in the evening setting you back to your normal self.(referencing modafinil for its norepinephrine reuptake)

As far as with/without a partner present, have you tested that concept both in the morning and in the evening?
I don't want to give an input on that part unless I know about that, because that could pertain to serotonin levels seeing as people on the autistic spectrum can have rapidly fluctuating serotonin levels

What I would try though to test if it is in fact cortisol related is to take something that lowers cortisol in the morning and see if that causes PE as well. Something like 25mg of zinc which will temporarily stop cortisol production as well as lower prolactin so that you can get in the mood.


Side bar- how do you like the agmatine? I just got mine in today to try out with my stack. Just took 1g no more than 15 mins ago

[Clavius]

A few things come to mind. Given cortisol levels are naturally more elevated in the morning than the evening could give reason. As cortisol is known to delay it in high levels.

It almost sounds like you are more predisposed to have PE, and the things you take currently just delay it in the morning before they start to wear off in the evening setting you back to your normal self.(referencing modafinil for its norepinephrine reuptake)

As far as with/without a partner present, have you tested that concept both in the morning and in the evening?
I don't want to give an input on that part unless I know about that, because that could pertain to serotonin levels seeing as people on the autistic spectrum can have rapidly fluctuating serotonin levels

What I would try though to test if it is in fact cortisol related is to take something that lowers cortisol in the morning and see if that causes PE as well. Something like 25mg of zinc which will temporarily stop cortisol production as well as lower prolactin so that you can get in the mood.


Side bar- how do you like the agmatine? I just got mine in today to try out with my stack. Just took 1g no more than 15 mins ago

 

Thanks for following up again. Very much appreciated! You can imagine what a terrible problem this is.

 

I have been taking agmatine for 6 months now for its NO boost. So only when I hit the gym. The increase in pump is very noticeable. Only recently I read that it has nootropic capabilities, with anxiety reduction being one of its properties. So since a week, I changed my single big dose before the gym to multiple doses throughout the day every day. But I haven't noticed many effects yet. Though I might be the wrong person to judge, differing between crippling anxiety and somewhat less crippling anxiety is not that easy. 

 

Yes, in the morning I can take ages to finish, with or without partner. In the evenings it's the other way round. Also with or without.

 

I forgot to mention the zinc that I take in my regimen. I take ZMA before I go to sleep. I also found multiple articles about autistic people needing a lot of extra zinc because of copper dominance. So I'm going to up that and spread it through the days. Just to see what happens. When I google about PE and high cortisol I see contradicting stories though. Some say high cortisol slows men down. Other say high cortisol and anxiety just cause to speed things up. Still worth it to test the zinc out.

[CalmDown]

Thanks for following up again. Very much appreciated! You can imagine what a terrible problem this is.

I have been taking agmatine for 6 months now for its NO boost. So only when I hit the gym. The increase in pump is very noticeable. Only recently I read that it has nootropic capabilities, with anxiety reduction being one of its properties. So since a week, I changed my single big dose before the gym to multiple doses throughout the day every day. But I haven't noticed many effects yet. Though I might be the wrong person to judge, differing between crippling anxiety and somewhat less crippling anxiety is not that easy.

Yes, in the morning I can take ages to finish, with or without partner. In the evenings it's the other way round. Also with or without.

I forgot to mention the zinc that I take in my regimen. I take ZMA before I go to sleep. I also found multiple articles about autistic people needing a lot of extra zinc because of copper dominance. So I'm going to up that and spread it through the days. Just to see what happens. When I google about PE and high cortisol I see contradicting stories though. Some say high cortisol slows men down. Other say high cortisol and anxiety just cause to speed things up. Still worth it to test the zinc out.

Its not so much the cortisol itself that delays it, but the cascading adrenaline that comes with cortisol. I would however get your zinc/copper levels checked to verify the high copper theory.

I have personally noted that any time I take something the causes rebound high norepinephrine/adrenaline levels that it can delay me in getting off. Such as my daily high dose ginkgo(for NRI effects), a night time dose of lithium orotate causes rebound in the morning, even when I tested low dose abilify for the first 2 weeks I would get morning high adrenaline response that would either make me not even want to get off, or make it take longer.
the same effect can be attained with a dose of adderall, but not as heavily with Vyvanse. Probably due to l-amphetamine having more effect on the adrenergic system.

What I would def suggest as trials, as noted earlier, is to take something in the morning to reduce cortisol to see if that reduces time to get off. Or conversely take something in the evening that raises cortisol to see if that delays time.

Morning recommendations for a trial would be along the lines of low dose ashwagandha, or zinc as I said before. Potentially Gotu Kola as that is less sedating for most compared to ashwagandha.

Evening trial would be simply coffee, or rhodiola, as it does reduce cortisol, but dose also raise adrenaline via comT inhibition.

Recommendations are based solely on commonality of use of products with long track records

[CalmDown]

Completely forgot to add, Agmatine has a 12 hour half life in the brain so you should only need to dose once a day for mental effects. Standard dose is 1g on an empty stomach. However, some tests for therapeutic dosing has been done between 2 and 3 grams.
Just be cautious as it as an a2 agonist. But nmda antagonistic effects should help you as well speculatively speaking.