8 replies to this topic

[labrat70]

Hi Everyone,

 

I have been on the site for a couple of years but decided to start my own thread to track my annual test results.  In general my plan is:

 

1.  I have a normal stack of supplements.

2.  Each year I try one new exotic supplement

3.  Every January, I re-take a standard set of tests (currently teloyears and mydnage).

 

Overall background:

 

48yo caucasian male, non-smoker, I rarely get sick, I get extensive blood work done every 6 months.  I generally try to follow a low carb, low sugar, low grain type diet with 17/7 intermittent fasting but still eat a lot of junk/restaurant food.

 

Generally in good health except for:

1. overweight (5'11" 195 lbs) but working on it

2. small dose medication for high blood pressure

3. Undergoing surgery for periodontal disease in Jan. 2019.

 

My normal daily supplement stack looks like the following and varies slightly.  You can assume I'm taking it unless specified otherwise during any experimental period:

 

Jarrow D3 5000 IU

Life Extension Magnesium 500 mg

Life Extension Super K + K2 Complex 2x or 4x capsules

C: 0-2000 mg, any brand, could be liposomal or not

Iodoral 1/2 tablet every 10 days (it was every other day but measured way high on blood work)

Jarrow Krill Oil 600mg

Jarrow CarotenAll 1 capsule

Natural Factors SelenoExcell Selenium Yeast 200mcg

Jarrow Methyl B12 5000mcg

 

From time to time I may also mix in Kyloic garlic, BioPQQ, or Berberine.

 

I also have taken the ALCAT food sensitivity test so I know my food kryptonite.  I had several items in the severe category including tomatoes (yikes! Hard to avoid!) and tumeric (so I don't have that as a supplement).

 

I have data going back to 2017 so I will be adding that soon.

Edited by labrat70, 01 January 2019 - 07:36 PM.

[labrat70]

Backfilling the 2017-2018 data...

 

January 2017 baseline:

Age: 46

Teloyears: 1.02x expected length, est. age 34

mydnage: not tested

 

2017 experiment:  use astragalous-based telomere supplement to try to lengthen telomeres

 

See details in this thread:

Confusing Telomere Result

 

January 2018 re-test:

Age: 47

Teloyears: 1.25x expected length, estimated age 20

mydnage: estimated age 44

 

Conclusion: It seems to have worked, despite my controversial choice of supplement.  Teloyears reported a decrease age of 14 years.  Whether that's real or helpful is unknown.  I'm curious to see how it will measure next time, if the changes stick or if they revert to the old level.

 

Comments: One of the reasons I started with telomeres is that it's something that can be measured (although problematically).  I wish we had measurements for things like stem cell pool size/activity, and senescent cell quantity.

 

Next up will be results from 2018-2019 sometime in late January.

[labrat70]

Early 2019 update:

 

Age: 48

Teloyears: 1.06x expected length, est. age 25

myDNAge: est. age: 46

Calcium score: 0

 

2018 Experiment:  Tried C60oo from carbon60oliveoil.com.  Tried starting a 1ml/day 6 days/week, and increased to 5 ml/day for about 8 months.  I was hoping for some improvement in hair, skin, nails, or subjective observation.  Unfortunately, there was no effect that I noticed.  I never took more than 5ml/day.  Reporting negative results is frustrating, but it's important if we're going to be honest experimenters.

 

Conclusion #1:  C60oo was ineffective for me.  Whether that's too low a dose, or just didn't work, I don't know.

 

Conclusion #2:  Some of the telomere lengthening seemed to persist.  I didn't take any telomere supplments in 2018.

 

In 2019 I'm thinking of trying NMN with ABN's booster supplement.

[labrat70]

Jan 2020 Update
Age: 49
Teloyears: 0.95x expected length, est. age 50
myDNAge: est. age: 46

2019 Experiment:  Tried ABN sublingual NMN, 500mg/day, 4 days on/3 days off, for the year.
Results:  I didn't feel any different, but it seemed like it re-grew a few hairs along my receding hairline.  The surprising thing is that it took 8 months to see any effect.  See more details in my post in the NMN experience thread.

I didn't do anything with telomeres this year, but they really fell off a cliff.  This would have bothered me before, but after reading some of the more recent discussions on here as well as Mittendorf's site, I now think that the Horvath/methylation measure is the measure to use going forward.  To me the definitive test of an age measurement, is that if you do some intervention that rewinds your age, then stop the intervention, I would expect to see it age forward 1 year per year.  I don't plan to do any more telomere interventions, but I will continue to measure them once a year to see if there's any positive or negative correlation to other things I'm doing.

[labrat70]

Jan 2021 Update

Age: 50

Teloyears: Sample lost?

mydnage: 47 (85th percentile, -3.5 years from chronological age)

 

I didn't do anything special this year, just continued with the NMN although at a somewhat lower dose, because I simply kept forgetting to take it.

 

[labrat70]

August 2021 Update

Age: 50

Teloyears: not tested

mydnage: 47 (83rd percentile, -4.0 years from chronological age)

 

I tried the renewing stem cells protocol from Turnbuckle's post 1447 with the following modifications:

I used Zaturals mango butter instead of the stearic flakes.  13-16g mango butter should yield 5+ grams stearic.

I melted the mango butter in hot water, the taste is mild, just kinda of waxy water.  Funny story, I was recently

at an Asian restaurant and ordered the hot tea and it tasted exactly like that.

I used the low end of the supplement dosages, as low as 1/2 of what was suggested.

For the senolytic step I either skipped it or used a lowered dose (1/2 ish)

C60 was from carbon60oliveoil.com

 

This year I also lost 15+ pounds, I am now at a healthy 168 and doing yoga 4-5 times per week.  This is the best shape

I've been in in 25 years.

 

I did 10 rounds of the protocol, 2 weeks apart.  My results were 'meh.'  My age didn't revert, although the delta against chronological age improved by 6 months, over a 6 month period, so I guess I just stayed in place, lol.

 

Next time I try I will use the full supplement dosages, and/or revisit the thread for changes to the protocol.

 

[labrat70]

January 2023 update

age: 52

mydnage: 46 (93 percentile, -6.0 from chronological)

 

This is the first time it's actually gone down.  (I forgot to post Jan 2022 results, which was 47.5)

 

What's different this time is I did 12 rounds of Turnbuckle's protocol as listed in post 1711 and modified by the "what's the minimum ingredients" post in post 1781.  In previous years I tried to get the stearic acid from mango butter, and that didn't work for me.

 

I hope to do about 36 rounds of the protocol in 2023.

 

 

 

[labrat70]

January 2024 update

Age: 53

MyDNAge: 48

 

Ah, bitter setback!  I aged forward 2 years this time.  I was so hoping that this year would be a confirmation of the success last year.

 

I did 31 cycles of the stem cell (brownie) protocol as before.

 

Other things that happened last year, were that I got divorced (big stressor).  I also didn't take my NMN as consistently as I had been before.  I don't take it during the protocol, but in between cycles.

 

So minor disappointment, but I'll keep going.  I'm in good shape 5-11, 165, yoga every day.  My diet isn't great though.

[Mind]

Thanks for the update! It is great when people post their objective data.

 

Sorry to see your biological age has crept upward, but you are correct, stress is a big factor in aging, thankfully usually temporary.